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Author : Steven A. Rosenberg,John M. Barry Publisher : Putnam Publishing Group Page : 384 pages File Size : 41,7 Mb Release : 1992 Category : Cancer ISBN : UCSC:32106010727763
The Transformed Cell by Steven A. Rosenberg,John M. Barry Pdf
One of the nation's leading surgeons tells the compelling story of his headline-making experiments--scientific breakthroughs that may revolutionize the treatment of cancer. Haunted by the question "Can the body rid itself of cancer?" Dr. Rosenberg seized upon immunotherapy as the most promising path toward curing the disease and has since achieved worldwide renown for his work. 8 pages of photographs.
The Transformed Cell deals with many of the differences that may exist between transformed cells and their normal counterparts. Topics covered range from malignancy and the cell surface to cell cycle regulation in normal and transformed cells; phenotypic expression of malignant transformation and its relationship to energy metabolism; and virus-induced transformation. The involvement of cyclic nucleotides in transformation is also discussed, together with intracellular pH and growth control in eukaryotic cells. This book is comprised of 12 chapters and begins with a brief description of terminology and basic concepts relating to cancer cells, as well as some comments on tumorigenicity and cell transformation. The next two chapters explore the evidence for and against the possible correlation of in vivo tumorigenicity to in vitro changes in the cytoskeletal system; anchorage-dependent growth; plasminogen activator production; agglutinability by lectins; and cell surface and plasma membrane properties. The regulation of cell proliferation and the relationships between ion movement and energy metabolism in normal and transformed cells are then examined, along with the transformation of normal cells by infection with new genetic material from tumor viruses. The remaining chapters focus on selected cellular properties that have been purported to differ between the normal and transformed cell, with particular reference to cyclic nucleotides; polyamine metabolism; cell viscosity; mobility of cellular water; intracellular pH; and element concentration. This monograph will be of interest to biologists and medical practitioners devoted to understanding cancer cell biology and cancer therapy.
Development and Recognition of the Transformed Cell by M.I. Greene,T. Hamaoka Pdf
The study of the phenotypic and genetic features that characterize the malignant cell is a rapidly growing and changing field. Clearly new insights into the processes involved in normal and abnormal cell growth will facilitate our understanding of events relevant to cancer and cellular differentiation. Early studies on genetic fea tures associated with cancer focused on chromosomal abnormalities that were observable in several human malignancies. The more recent examination of onco genes and the proteins they encode has helped pinpoint many steps in different processes that might be involved in cancer. Immunologic studies of cancer have also developed from an imprecise series of investigations to a more detailed molecular examination of cell-surface struc tures that can be recognized immunologically. In the course of the development of modern tumor immunology, it has become clear that many of the antigens that can be recognized appear to be the products of genes involved in cell growth. Fur thermore, changes in the cell surface of malignant cells have often been found to include alteration of nonprotein constituents.
Adhesive Interactions in Normal and Transformed Cells by Yury A. Rovensky Pdf
Adhesive Interactions in Normal and Transformed Cells describes the basic mechanisms of the ability of tissue cells to attach to each other and to the extracellular matrix. These adhesive interactions are pivotal regulators of main cellular functions, such as proliferation, survival and migration. The adhesive interactions are involved in embryonic development, regeneration, and also in inflammation and degeneration processes, which are at the basis of many diseases. Serious alterations in cell adhesion caused by the oncogenic transformation play a key role in cancer invasion and metastasis. This volume provides comprehensive information about structural, mechanistic and signaling aspects of adhesive interactions in both normal and cancer cells in comparison. Integration of such aspects of the adhesive process as structure, relation to cell systems of receptors and cytoskeleton, function, signaling pathways, and the alterations in tumor cells constitutes the strongest point of this work. The results of the long-time author’s research are included in the book. The author was one of pioneers, who used scanning electron microscopy (SEM) to study the cell surface morphology of normal cultured cells and the cells underwent the oncogenic transformation, processes of their attachment to and spreading on the surfaces of a solid substratum, and also surprising ability of the cells to respond to various geometric configurations of the substrata surfaces. Adhesive Interactions in Normal and Transformed Cells has both biological and medical aspects and, therefore, it can be interesting not only for cell biologists, developmental biologists and cancer researchers, but also for physicians. It is intended for researchers, postdocs, undergraduate and graduate students.
Winner of the 2023 PROSE Award for Excellence in Biological and Life Sciences and the 2023 Chautauqua Prize! Named a New York Times Notable Book and a Best Book of the Year by The Economist, Oprah Daily, BookPage, Book Riot, the New York Public Library, and more! In The Song of the Cell, the extraordinary author of the Pulitzer Prize–winning The Emperor of All Maladies and the #1 New York Times bestseller The Gene “blends cutting-edge research, impeccable scholarship, intrepid reporting, and gorgeous prose into an encyclopedic study that reads like a literary page-turner” (Oprah Daily). Mukherjee begins this magnificent story in the late 1600s, when a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek looked down their handmade microscopes. What they saw introduced a radical concept that swept through biology and medicine, touching virtually every aspect of the two sciences, and altering both forever. It was the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves—hearts, blood, brains—are built from these compartments. Hooke christened them “cells.” The discovery of cells—and the reframing of the human body as a cellular ecosystem—announced the birth of a new kind of medicine based on the therapeutic manipulations of cells. A hip fracture, a cardiac arrest, Alzheimer’s dementia, AIDS, pneumonia, lung cancer, kidney failure, arthritis, COVID pneumonia—all could be reconceived as the results of cells, or systems of cells, functioning abnormally. And all could be perceived as loci of cellular therapies. Filled with writing so vivid, lucid, and suspenseful that complex science becomes thrilling, The Song of the Cell tells the story of how scientists discovered cells, began to understand them, and are now using that knowledge to create new humans. Told in six parts, and laced with Mukherjee’s own experience as a researcher, a doctor, and a prolific reader, The Song of the Cell is both panoramic and intimate—a masterpiece on what it means to be human. “In an account both lyrical and capacious, Mukherjee takes us through an evolution of human understanding: from the seventeenth-century discovery that humans are made up of cells to our cutting-edge technologies for manipulating and deploying cells for therapeutic purposes” (The New Yorker).
Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Publisher : John Wiley & Sons Page : 2008 pages File Size : 51,7 Mb Release : 2017-03-10 Category : Medical ISBN : 9781119000846
Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author : J. E. Celis Publisher : Springer Science & Business Media Page : 439 pages File Size : 51,7 Mb Release : 2013-06-29 Category : Medical ISBN : 9781468445411
Gene Expression in Normal and Transformed Cells by J. E. Celis Pdf
This volume is based on the proceedings of a NATO-Gulbenkian Foundation sponsored Summer School held in May-June 1982 in Sintra Estoril, Portugal. Given the accelerated growth of knowledge in the field of eukaryotic gene expression, it seemed timely to hold a NATO Advanced Study Institute to discuss current developments in this area of biology and to evaluate the potential of emerging technologies such as gene transfer, recombinant DNA cloning and quantitative high resolution two-dimensional gel electrophoresis. The initial articles in t~is volume describe various differentiation models and address questions such as the relationships between differentiation and cell proliferation, biochemical changes accompanying differen tiation, expression of differentiated gene products and their regulation as well as gene organization of cytoskeletal proteins. The second section describes properties of neoplastic cells, surveys current assays for transformation and offers some new insights into the mechanisms involved in carcinogenesis. The third part is dedicated to viral oncogenesis and to the role of onco genes in cell transformation. Particular emphasis is given to the role of tyrosine kinases in cell transformation. The concluding section deals with various aspects of gene expression in normal and transformed cells with special emphasis given to studies using two dimensional gel electrophoresis, cell hybridization, gene transfer and immunological techniques.
One of Time Magazine’s Top 100 Inventors in History shares an insider’s story of the cellphone, how it changed the world—and a view of where it’s headed. While at Motorola in the 1970s, wireless communications pioneer Martin Cooper invented the first handheld mobile phone. But the cellphone as we know it today almost didn’t happen. Now, in Cutting the Cord, Cooper takes readers inside the stunning breakthroughs, devastating failures, and political battles in the quest to revolutionize—and control—how people communicate. It’s a dramatic tale involving brilliant engineers, government regulators, lobbyists, police, quartz crystals, and a horse. Industry skirmishes sparked a political war in Washington to prevent a monopolistic company from dominating telecommunications. The drama culminated in the first-ever public call made on a handheld, portable telephone—by Cooper himself. The story of the cell phone has much to teach about innovation, strategy, and management. But the story of wireless communications is far from finished. This book also relates Cooper’s vision of the future. From the way we work and the way children learn to the ways we approach medicine and healthcare, advances in the cellphone will continue to reshape our world for the better.
Forty years ago, three medical researchers--Oswald Avery, Colin MacLeod, and Maclyn McCarty--made the discovery that DNA is the genetic material. With this finding was born the modern era of molecular biology and genetics.
What Your Doctor Won't Tell You by Jane Heimlich Pdf
Take Charge of Your Own Health From hypertension to hardening of the arteries, cancer to cataracts, Heimlich's authoritative guide surveys the latest nonconventional medical treatments for today's most prevalent diseases. What Your Doctor Won't Tell You is an objective, up-to-the minute sourcebook on the most significant alternative approaches to health, including: Antioxidants • Bach Flower Remedies • Biomagnetism/dtColon Detoxification • Electrodiagnosis • Fish Oils • HomeopathyKinesiology • Live Cell Therapy • MacrobioticsOrthomolecular Medicine • Ozone Therapy • Vitamin C Infusiondt• And much more What Your Doctor Wont Tell You introduces you to a new world of medical doctors trained in nutrition and preventive medicine. Heimlich offers objective appraisals of dozens of mainstream medical treatments, from chemotherapy to bypass surgery, and describes why the medical establishment continues to rely on toxic drugs and ineffective treatments owing to its ties with big business and government. Covering both time-honored and cutting-edge procedures, What Your Doctor Won't Tell You is an in-depth overview of the best that alternative medicine has to offer.
2022 NATIONAL INDIE EXCELLENCE AWARDS FINALIST — HEALTH: GENERAL “It is exceptionally well organized and presented, making it an ideal and highly recommended addition to personal, community, college, and university library Health/Medicine collections.” —Midwest Book Review Nature puts a “survival switch” in our bodies to protect us from starvation. Stuck in the “on” position, it’s the hidden source of weight gain, heart disease, and many other common health struggles. But you can turn it off. Dr. Richard Johnson has been on the cutting edge of research into the cause of obesity for more than a decade. His team’s discovery of the fructose-powered survival switch—a metabolic pathway that animals in nature turn on and off as needed, but that our modern diet has permanently fixed in the “on” position, where it becomes a fat switch—revolutionized the way we think about why we gain weight. In Nature Wants Us to Be Fat, he details the mounting evidence on how this switch is responsible both for excess fat storage and for many of the major diseases endemic to the Western world, including heart disease, cancer, and dementia. Dr. Johnson also reveals the surprising link between the survival switch and health conditions such as gout, kidney disease, liver disease, stroke—and even behavioral issues like addiction and ADHD. And, most important, he shares a science-based plan to help readers fight back against nature. Guided by ongoing clinical research—plus fascinating observations from the animal kingdom, evolution, and history—Dr. Johnson takes you along on an eye-opening investigation into: What you can do to turn off your survival switch What we have in common with hibernating bears, sperm whales, and the world’s fattest bird Why it’s fructose (not glucose) that drives insulin resistance and metabolic disease The foods we eat that trigger the body to make its own fructose The surprising role salt and dehydration play in fat accumulation The surprising link between the survival switch and health conditions such as gout and liver and kidney diseases, and even behavioral issues like addiction and ADHD Dr. Johnson not only provides new recommendations for how we can prevent or treat obesity, but also how we can use this information to reduce our risk of developing disease. Nature wants us to be fat, and when we understand why, we gain the tools we need to lose weight and optimize our health.
