Development And Recognition Of The Transformed Cell

Author : M.I. Greene,T. Hamaoka
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 46,7 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781461319252

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Development and Recognition of the Transformed Cell by M.I. Greene,T. Hamaoka Pdf

The study of the phenotypic and genetic features that characterize the malignant cell is a rapidly growing and changing field. Clearly new insights into the processes involved in normal and abnormal cell growth will facilitate our understanding of events relevant to cancer and cellular differentiation. Early studies on genetic fea tures associated with cancer focused on chromosomal abnormalities that were observable in several human malignancies. The more recent examination of onco genes and the proteins they encode has helped pinpoint many steps in different processes that might be involved in cancer. Immunologic studies of cancer have also developed from an imprecise series of investigations to a more detailed molecular examination of cell-surface struc tures that can be recognized immunologically. In the course of the development of modern tumor immunology, it has become clear that many of the antigens that can be recognized appear to be the products of genes involved in cell growth. Fur thermore, changes in the cell surface of malignant cells have often been found to include alteration of nonprotein constituents.

Author : Ivan Cameron
Publisher : Elsevier
Page : 452 pages
File Size : 52,6 Mb
Release : 1981-01-01
Category : Science
ISBN : 9780323162968

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The Transformed Cell by Ivan Cameron Pdf

The Transformed Cell deals with many of the differences that may exist between transformed cells and their normal counterparts. Topics covered range from malignancy and the cell surface to cell cycle regulation in normal and transformed cells; phenotypic expression of malignant transformation and its relationship to energy metabolism; and virus-induced transformation. The involvement of cyclic nucleotides in transformation is also discussed, together with intracellular pH and growth control in eukaryotic cells. This book is comprised of 12 chapters and begins with a brief description of terminology and basic concepts relating to cancer cells, as well as some comments on tumorigenicity and cell transformation. The next two chapters explore the evidence for and against the possible correlation of in vivo tumorigenicity to in vitro changes in the cytoskeletal system; anchorage-dependent growth; plasminogen activator production; agglutinability by lectins; and cell surface and plasma membrane properties. The regulation of cell proliferation and the relationships between ion movement and energy metabolism in normal and transformed cells are then examined, along with the transformation of normal cells by infection with new genetic material from tumor viruses. The remaining chapters focus on selected cellular properties that have been purported to differ between the normal and transformed cell, with particular reference to cyclic nucleotides; polyamine metabolism; cell viscosity; mobility of cellular water; intracellular pH; and element concentration. This monograph will be of interest to biologists and medical practitioners devoted to understanding cancer cell biology and cancer therapy.

Author : Alecsandru Ioan Baba,Cornel Cătoi
Publisher : Unknown
Page : 787 pages
File Size : 50,5 Mb
Release : 2007
Category : Electronic books
ISBN : 9732714573

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Comparative Oncology by Alecsandru Ioan Baba,Cornel Cătoi Pdf

Author : Morikazu Onji,Sk. Md. Fazle Akbar
Publisher : Springer Science & Business Media
Page : 199 pages
File Size : 45,8 Mb
Release : 2008-10-16
Category : Medical
ISBN : 9784431794660

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Dendritic Cells in Clinics by Morikazu Onji,Sk. Md. Fazle Akbar Pdf

Great advances have taken place in basic research and the clinical usefulness of dendritic cells (DCs). It has now been clearly established, for instance, that these cells play a crucial role in immune responses against infectious diseases and cancers. Antigen-presenting DCs are widely distributed in the body and regulate both immunity and immune tolerance. Experimental studies have provided important insights into DCs and how they can be used for treating animal models of various diseases that occur in humans. The role of these cells in pathogenesis and the treatment of human diseases is elaborately set forth in this valuable book. Researchers in the field are optimistic that DCs, already in use for treating patients with cancers, soon can be used therapeutically for patients with chronic infections, autoimmune diseases, and allergic manifestations. This volume provides a working definition of DCs and also explains the phenotypes and functions of DCs so that these can be readily understood not only by clinicians but by immunologists, researchers, and students as well.

Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 42,6 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846

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Holland-Frei Cancer Medicine by Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland Pdf

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Author : H. Awwad
Publisher : Springer Science & Business Media
Page : 706 pages
File Size : 46,9 Mb
Release : 1990-06-30
Category : Medical
ISBN : 0792307836

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Radiation Oncology: Radiobiological and Physiological Perspectives by H. Awwad Pdf

During the past four decades knowledge about biological effects of ionizing radiations on mammalian cells, normal tissues and tumours has increased enormously and has enabled radiotherapists to obtain a better insight into the advantages and disadvantages of cancer treatments with modified regimens of irradiations and combinations with chemotherapeutic agents. Even for the older scientists and clinicians who have wit nessed all these developments and have contributed to the vast amount of information, it is difficult to integrate this knowledge and to apply it in their daily work. For younger workers it is often difficult to select the important main concepts and results from the overwhelming number of publications. It is evident that a book which provides an integrated view of basic and applied radiation oncology can be of great value to students, scientists and, most importantly, to clinicians who can devote only part of their time to the task of understanding the radiobiological background of their application of radiation in cancer treatment. This book "Radiation Oncology" is written by a radiotherapist who has for a long time participated in the integration of basic knowledge and clinical experience. He has selected radiobiological information which is considered important to radiotherapy and in the description and interpretation of normal tissue tolerance and tumour eradication probability, he illustrates how basic knowledge can be applied clinically.

Author : Anonim
Publisher : Academic Press
Page : 353 pages
File Size : 51,5 Mb
Release : 1984-11-01
Category : Medical
ISBN : 0080562248

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Advances in Cancer Research by Anonim Pdf

Advances in Cancer Research

Author : Weiguo Cui,Carmen Gerlach,Klaas Van Gisbergen
Publisher : Frontiers Media SA
Page : 171 pages
File Size : 52,9 Mb
Release : 2020-06-16
Category : Electronic
ISBN : 9782889637959

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Differentiation, Tissue Adaptation and Function of Memory T Cells by Weiguo Cui,Carmen Gerlach,Klaas Van Gisbergen Pdf

Upon antigen encounter, naïve T cells differentiate into (i) effectors that combat infected or malignant cells, and at later time points, into (ii) memory cells that provide long-lasting immunity. This differentiation process allows some T cells to leave the confines of secondary lymphoid organs and to enter peripheral tissues in search of pathogens or tumor cells. These different environments pose specific challenges for effector and memory T cells to maintain homeostasis. T cells directed into the lungs are likely to encounter higher levels of oxygen, but lower amounts of nutrients than those directed into the intestinal epithelium. In addition to oxygen tension and nutrient concentrations, other key factors, such as the commensal flora and stromal components, create unique conditions that require tissue-specific adaptations of T cells. These steady state conditions can dramatically change during infection when inflammatory mediators and T cell growth factors are released, requiring the immediate response of T cells. The gradual changes imposed by growing tumors can also be challenging for T cells due to competition with rapidly cycling tumor cells that deplete essential resources of oxygen and glucose. The strategies that T cells employ to respond to the diverse cues from their surroundings are the focus of current research. It appears that next to circulating memory T cells that are confined to the circulation and those that survey all of the peripheral tissues, dedicated populations of resident memory T cells exist that can optimally adapt to the local circumstances within each tissue. Restrictions on the metabolic requirements of T cells residing in tumor tissue have been found to directly impact on effector functions such as cytokine production. The fundamental principles of how the machinery of T cells can translate local cues into tissue-specific differentiation processes are fascinating and warrant further investigation.

Author : Hans H. Althaus,Wilfried Seifert
Publisher : Springer Science & Business Media
Page : 807 pages
File Size : 41,6 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783642713811

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Glial-Neuronal Communication in Development and Regeneration by Hans H. Althaus,Wilfried Seifert Pdf

This comprehensive volume is a contribution to a new se ries initiated by the NATO Panel on "Gell to Gell Signals in Plants and Animals". The book reflects the outcome of an NATO work shop and bri ngs to mi nd two im portant questions: consideri ng the mass of relevant I iteratu reavai- able, is there any necessity for a new series of books - and considering the flood of compa rable meetings - is there any point in workshops of this nature and their publication? In order to deal with such questions adequately, much more space would be needed than is available in a foreword. Thus, the answers must remain rather superficial and, of course, rather subjective. To simplify the issue, the question of publication can be narrowed down to two fac tors - the financial risk, undertaken by the publisher, and the scientific risk, borne by the editor. If the book is good (with respect to lay-out and content) it will be a success - nothing will be lost the people involved will enhance their reputation! We are left with the question of the usefulness of workshops. Without doubt, it is indeed a useful procedure for experts to come together, in an atmosphere of harmony, and freedom from external pressures and time limitations, to discuss a well-defined theme. Wether in agreement or disagreement, a fair and open forum can be expectet for a variety of contributions.

Author : Anonim
Publisher : Unknown
Page : 1064 pages
File Size : 50,6 Mb
Release : 1992
Category : Medicine
ISBN : MINN:31951P00216728F

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Biomedical Index to PHS-supported Research: pt. A. Subject access A-H by Anonim Pdf

Author : Gary L. Kimmel,Devendra M. Kochhar
Publisher : CRC Press
Page : 190 pages
File Size : 42,9 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000006261

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In Vitro Methods in Developmental Toxicology by Gary L. Kimmel,Devendra M. Kochhar Pdf

First Published in 1990, this text brings together the work of several investigators who used in vitro techniques to probe the nature of embryonic cell response to a diverse group of chemical agents. It focuses on the approaches, limitations, usefulness and applicability of defining mechanisms underlying altered development. This work includes discussions on pharmacodynamic principles and placental transfer mechanisms. It also examines the potential for in vitro systems to serve as an adjunct to the risk assessment process. Ideal for both the layman and the expert in this area, this volume provides a general understanding of the types of approaches that can be used and specific approaches in investigating altered development.

Author : Sonia B. Jakowlew
Publisher : Springer Science & Business Media
Page : 785 pages
File Size : 49,9 Mb
Release : 2008-02-28
Category : Medical
ISBN : 9781588297150

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Transforming Growth Factor-Beta in Cancer Therapy, Volume II by Sonia B. Jakowlew Pdf

Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.

Author : Robert F. Goldberger
Publisher : Springer Science & Business Media
Page : 635 pages
File Size : 45,6 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781468499339

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Biological Regulation and Development by Robert F. Goldberger Pdf

The motivation for us to conceive this work on regulation was mainly our belief that it would be fun, and at the same time productive, to approach the subject in a way that differs from that of other treatises. We thought it might be interesting and instructive-for both author and reader-to examine a particular area of investigation in a framework of many different problems. Cutting across the traditional boundaries that have separated the sub jects in past volumes on regulation is not an easy thing to do-not because it is difficult to think of what interesting topics should replace the old ones, but because it is difficult to find authors who are willing to write about areas outside those pursued in their own laborato ries. Anyone who takes on the task of reviewing a broad area of interest must weave together its various parts by picking up the threads from many different laboratories, and attempt to produce a fabric with a meaningful design. Finding persons who are likely to succeed in such tasks was the most difficult part of our job. In the first volume of this treatise, most of the chapters dealt with the mechanisms of regulation of gene expression in microorganisms. This second volume involves a somewhat broader area, spanning the prokaryotic-eukaryotic border.

Author : Anonim
Publisher : Unknown
Page : 776 pages
File Size : 53,9 Mb
Release : 1989
Category : Medicine
ISBN : UOM:39015014022589

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Research Awards Index by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 1284 pages
File Size : 54,9 Mb
Release : 1988
Category : Medicine
ISBN : OSU:32436011073143

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Cumulated Index Medicus by Anonim Pdf