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Author : Anonim
Publisher : Academic Press
Page : 746 pages
File Size : 53,8 Mb
Release : 2017-01-25
Category : Science
ISBN : 9780128034873
The Zebrafish: Disease Models and Chemical Screens
Author : Anonim
Publisher : Academic Press
Page : 616 pages
File Size : 47,5 Mb
Release : 2011-10-07
Category : Technology & Engineering
ISBN : 0123813204
This volume of Methods in Cell Biology is the 3e, and provides comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 2004. This new volume on Disease Models and Chemical Screens, covers two rapidly emerging and compelling applications of the zebrafish. Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls This volume concentrates on Disease Models and Chemical Screens
Author : H. William Detrich,Monte Westerfield,Leonard I. Zon
Publisher : Academic Press
Page : 591 pages
File Size : 49,5 Mb
Release : 2011-09-23
Category : Medical
ISBN : 9780123813206
This volume of Methods in Cell Biology is the 3e, and provides comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 2004. This new volume on Disease Models and Chemical Screens, covers two rapidly emerging and compelling applications of the zebrafish. Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls This volume concentrates on Disease Models and Chemical Screens
Author : Anonim
Publisher : Academic Press
Page : 386 pages
File Size : 44,9 Mb
Release : 2020-12-01
Category : Science
ISBN : 9780128226568
Fish Physiology, Volume 38 in this ongoing series, examines how the inherent potential of fish to express traits of economic value can be realized through aquaculture. Topics covered include the regulation of the reproductive cycle of captive fish, shifting carnivorous fish towards plant-based diets, defining the challenges, opportunities and optimal conditions for growth under intensive culture (including in Recirculating Aquaculture Systems), enhancing immune function and fish health during culture, identifying and managing maladaptive physiological responses to aquaculture stressors, establishing welfare guidelines for farmed fish, phenotypic and physiological responses to genetic modification, Zebrafish as a research tool, and the aquaculture of air-breathing fish. Contains contributions from an international board of authors, each with decades of aquaculture expertise Provides the most up-to-date information on the fundamental role that physiology plays in optimizing fish performance in aquaculture Provides the latest release in the Fish Physiology series that tackles how the manipulation of biological processes can be used to maximize the expression of beneficial production traits in fish aquaculture
Author : Anonim
Publisher : Academic Press
Page : 450 pages
File Size : 42,9 Mb
Release : 2015-02-04
Category : Science
ISBN : 9780128002933
This new volume of Methods in Cell Biology looks at methods for lysosomes and lysosomal diseases. Chapters focus upon practical experimental protocols to guide researchers through the analysis of multiple aspects of lysosome biology and function. In addition, it details protocols relevant to clinical monitoring of patients with lysosomal diseases. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come. Covers sections on model systems and functional studies, imaging-based approaches and emerging studies Chapters are written by experts in the field Cutting-edge material
Author : Trenton R Schoeb,Kathryn A Eaton
Publisher : Academic Press
Page : 428 pages
File Size : 49,8 Mb
Release : 2017-08-11
Category : Medical
ISBN : 9780128045831
Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource. Reviews and defines gnotobiotic animal species Analyzes microbiota in numerous contexts Presents detailed coverage of the protocols and operation of a gnotobiotic facility
Author : Anonim
Publisher : Academic Press
Page : 2138 pages
File Size : 55,7 Mb
Release : 2016-04-14
Category : Science
ISBN : 9780128004265
Encyclopedia of Evolutionary Biology, Four Volume Set is the definitive go-to reference in the field of evolutionary biology. It provides a fully comprehensive review of the field in an easy to search structure. Under the collective leadership of fifteen distinguished section editors, it is comprised of articles written by leading experts in the field, providing a full review of the current status of each topic. The articles are up-to-date and fully illustrated with in-text references that allow readers to easily access primary literature. While all entries are authoritative and valuable to those with advanced understanding of evolutionary biology, they are also intended to be accessible to both advanced undergraduate and graduate students. Broad topics include the history of evolutionary biology, population genetics, quantitative genetics; speciation, life history evolution, evolution of sex and mating systems, evolutionary biogeography, evolutionary developmental biology, molecular and genome evolution, coevolution, phylogenetic methods, microbial evolution, diversification of plants and fungi, diversification of animals, and applied evolution. Presents fully comprehensive content, allowing easy access to fundamental information and links to primary research Contains concise articles by leading experts in the field that ensures current coverage of each topic Provides ancillary learning tools like tables, illustrations, and multimedia features to assist with the comprehension process
Author : Samuel Cartner,Judith S. Eisen,Susan F. Farmer,Karen J. Guillemin,Michael L. Kent,George E. Sanders
Publisher : Academic Press
Page : 720 pages
File Size : 49,8 Mb
Release : 2019-11-22
Category : Science
ISBN : 9780128124321
The Zebrafish in Biomedical Research: Biology, Husbandry, Diseases, and Research Applications is a comprehensive work that fulfills a critical need for a thorough compilation of information on this species. The text provides significant updates for working vivarium professionals maintaining zebrafish colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using the species to gain critical insights into human physiology and disease. As the zebrafish has become an important model organism for the study of vertebrate development and disease, organ function, behavior, toxicology, cancer, and drug discovery, this book presents an important resource for future research. Presents a complete view of the zebrafish, covering their biology, husbandry, diseases and research applications Includes the work of world-renowned authors Provides the first authoritative and comprehensive treatment of zebrafish in biomedical research as part of the ACLAM series
Author : Lynn C. Anderson,Glen Otto,Kathleen R. Pritchett-Corning,Mark T. Whary
Publisher : Elsevier
Page : 1727 pages
File Size : 41,6 Mb
Release : 2015-07-04
Category : Technology & Engineering
ISBN : 9780124166134
Laboratory Animal Medicine, Third Edition, is a fully revised publication from the American College of Laboratory Medicine’s acclaimed blue book series. It presents an up-to-date volume that offers the most thorough coverage of the biology, health, and care of laboratory animals. The book is organized by species, with new inclusions of chinchillas, birds, and program and employee management, and is written and edited by known experts in the fields. Users will find gold-standard guidance on the study of laboratory animal science, as well as valuable information that applies across all of the biological and biomedical sciences that work with animals. Organized by species for in-depth understanding of biology, health, and best care of animals Features the inclusion of chinchillas, quail, and zebra finches as animal models Offers guidance on program and employee management Covers regulations, policies, and laws for laboratory animal management worldwide
Author : Stephen M. King
Publisher : Academic Press
Page : 530 pages
File Size : 42,6 Mb
Release : 2017-11-28
Category : Science
ISBN : 9780128097014
Dyneins: Structure, Biology and Disease, Second Edition, offers a broad view of dyneins mechanics, dysfunction, and disease, providing an overview of dyneins from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development. To account for these enormous strides, the second edition is extensively revised. Additionally, the coverage has expanded from 24 to 42 chapters, and is now housed in two volumes. Much of the expanded coverage occurs in Volume 2 which focuses on dynein dysfunction and disease, such as the role of dynein and cancer. Volume 1 covers the history and evolution of dyneins, dyneins in ciliary biology, and cytoplasmic dynein biology, while Volume 2 covers the structure and mechanics of dynein motors and dynein dysfunction and disease. Presents a broad-based and up-to date view of dynein mechanics, dysfunction, and disease Contains approaches from genetics, molecular biology, biochemistry, and biophysics discussed Provides companion website with movies of dynamic cell behavior Includes extensive chapters written by leading, global experts
Author : Martin K. Childers
Publisher : Humana Press
Page : 336 pages
File Size : 44,7 Mb
Release : 2015-12-19
Category : Science
ISBN : 9781493932283
This book compiles and explores cutting-edge research in degenerative skeletal disorders, such as Duchenne muscular dystrophy and congenital myopathy, and new stem-cell based therapies and gene replacement therapy. Twelve expertly-authored chapters navigate the nuances of these treatments in an array of contexts and biological systems. The topics covered include: How are urine cells from a patient with Duchenne muscular dystrophy transformed into beating heart cells? What can reprogrammed cells tell us about heart muscle failure? What do gene mutations mean for those born with a muscle disease? How are manufacturing methods applied to human stem cells? Does therapeutic exercise benefit those patients who receive engineered limb muscle? Is there practical advice about nutrition to enhance muscle function for the Duchenne patient? Can microRNAs be useful to regenerate diseased muscle? Regenerative Medicine for Degenerative Muscle Diseases is ideal for scientists and clinicians from varying disciplines in genetics, cell biology, virology, cell-based manufacturing, rehabilitation medicine, nutrition, veterinary medicine and neurosurgery. The reader will see how transformative changes occur in medicine that can powerfully impact the future for patients suffering from inherited disorders affecting muscles of the body, including the heart.
Author : Richard Nass,Serge Przedborski
Publisher : Elsevier
Page : 686 pages
File Size : 41,8 Mb
Release : 2011-04-28
Category : Psychology
ISBN : 0080559581
Parkinson’s disease is the second most prevalent neurodegenerative disease and is characterized by the irreversible loss of dopamine neurons. Despite its high prevalence in society and many decades of research, the origin of the pathogenesis and the molecular determinants involved in the disorder has remained elusive. Confounding this issue is the lack of experimental models that completely recapitulate the disease state. The identification of a number of genes thought to play a role in the cell death, and development of both toxin and genetic models to explore the function of the genes both in unaffected and diseased cells are now providing new insights into the molecular basis of the neurodegeneration, as well as therapeutic approaches. In this reference, we will describe the advances and the advantages that various invertebrates, cell culture, rodents, and mammals provide in the identification of the molecular components and mechanisms involved in the cell death, and outline the opportunities that these systems provide in drug discovery. Comprehensive and critical assessment of the utility of various model systems to identify the molecular components and pathways involved in Parkinson’s disease Describes the power of toxin and genetic models to identify novel therapeutic targets and compounds that can be used in PD Current overviews of current status of PD research and discovery from bench-to-bedside Provides novel insights and views on where the future of PD research may lead Provides a powerful teaching tool and template to explore the utility of model systems to identify molecular pathways, molecular targets, and therapeutics that are applicable to a variety of neurological diseases
Author : Anonim
Publisher : Elsevier
Page : 498 pages
File Size : 54,9 Mb
Release : 2013-11-26
Category : Science
ISBN : 9780124171831
This new volume of Methods in Cell Biology looks at methods for analyzing of golgi complex function. Chapters cover such topics as in vitro reconstitution systems, fluorescence-based analysis of trafficking in mammalian cells and high content screening. With cutting-edge material, this comprehensive collection is intended to guide researchers for years to come. Covers sections on model systems and functional studies, imaging-based approaches and emerging studies Chapters are written by experts in the field Cutting-edge material
Author : Anonim
Publisher : Academic Press
Page : 614 pages
File Size : 54,5 Mb
Release : 2015-03-26
Category : Science
ISBN : 9780128026403
The goal of this book is to collect methods and protocols for studying cilia in a wide range of different cell types, so that researchers from many fields of biology can start exploring the role of cilia in their own system. Chapters are written by experts in the field Cutting-edge material
Author : Greenfield Sluder,David E. Wolf
Publisher : Academic Press
Page : 672 pages
File Size : 46,9 Mb
Release : 2013-08-07
Category : Science
ISBN : 9780124078925
The previous edition of this book marked the shift in technology from video to digital camera use with microscope use in biological science. This new edition presents some of the optical fundamentals needed to provide a quality image to the digital camera. Specifically, it covers the fundamental geometric optics of finite- and infinity-corrected microscopes, develops the concepts of physical optics and Abbe s theory of image formation, presents the principles of Kohler illumination, and finally reviews the fundamentals of fluorescence and fluorescence microscopy. The second group of chapters deals with digital and video fundamentals: how digital and video cameras work, how to coordinate cameras with microscopes, how to deal with digital data, the fundamentals of image processing, and low light level cameras. The third group of chapters address some specialized areas of microscopy that allow sophisticated measurements of events in living cells that are below the optical limits of resolution. Expands coverage to include discussion of confocal microscopy not found in the previous edition Includes "traps and pitfalls" as well as laboratory exercises to help illustrate methods