Therapeutic Angiogenesis For Vascular Diseases

Author : Mark Slevin
Publisher : Springer Science & Business Media
Page : 438 pages
File Size : 41,8 Mb
Release : 2010-10-11
Category : Medical
ISBN : 9789048194957

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Therapeutic Angiogenesis for Vascular Diseases by Mark Slevin Pdf

Angiogenesis is the growth of new blood vessels and is a key process which occurs during pathological disease progression. Excessive and damaging angiogenesis occurs in diseases such as cancer, diabetic retinopathies, age-related macular degeneration and atherosclerosis. In other diseases such as stroke and myocardial infarction, insufficient or improper angiogenesis results in tissue loss and ultimately higher morbidity and mortality. In this book we will begin by providing the reader with an overview of the process of angiogenesis including normal embryological development of blood vessels. The following chapters will each focus on a key angiogenic disease incorporating current scientific knowledge concerning the causes of activation of the “angiogenic switch”, pathological consequences, current treatment options and future perspectives. Where appropriate, results from pre-clinical trials, novel imaging modalities and nanotechnological approaches will be incorporated into these sections. Finally, since it is now believed that the process of angiogenesis operated via different signalling mechanisms in different vascular beds, we will discuss our current understanding of this phenomenon. The target audience for this book would include researchers in all the basic sciences; post-graduate students at Universities and Institutes; pharmaceutical industries; clinicians working in vascular biology or tissue imaging; pathologists; neurologists; tumour biologists; ophthalmologists and cardiologists.

Author : Yukihito Higashi,Toyoaki Murohara
Publisher : Springer
Page : 266 pages
File Size : 51,8 Mb
Release : 2017-07-11
Category : Medical
ISBN : 9789811027444

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Therapeutic Angiogenesis by Yukihito Higashi,Toyoaki Murohara Pdf

The book discusses recent findings and current perspectives on therapeutic angiogenesis. Studies have shown that therapies such as cell implantation and transfer of gene encoding for angiogenic growth factors are effective in improving symptoms in patients with critical limb ischemia, who previously had no treatment option other than amputation. The book discusses these therapies and presents data collected in clinical studies over the past decade. Despite significant advances in therapeutic angiogenesis since the first clinical studies in the early 21st century, it has been largely ignored in the literature. This comprehensive book fills that gap, making it a valuable resource for both researchers and practitioners alike.

Author : Anonim
Publisher : Springer
Page : 448 pages
File Size : 52,8 Mb
Release : 2011-07-11
Category : Electronic
ISBN : 9048194962

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Therapeutic Angiogenesis for Vascular Diseases by Anonim Pdf

Author : Roger J. Laham,Donald S. Baim
Publisher : Springer Science & Business Media
Page : 372 pages
File Size : 43,6 Mb
Release : 2007-11-05
Category : Medical
ISBN : 9781592599349

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Angiogenesis and Direct Myocardial Revascularization by Roger J. Laham,Donald S. Baim Pdf

An interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis. The authors take advantage of new biological understanding, novel therapeutic targets, multiple available and well-studied therapeutic strategies, and the necessary imaging techniques to measure outcomes. Their in-depth discussions cover the identification of new therapeutic targets and pathways, the investigation of transcriptional factors, master switch molecules, cell-based approaches, chemokines, a better understanding of the effects of aging, endothelial dysfunction, and hypercholesterolemia in response to angiogenic stimuli. Highlights include examination of drug delivery problems, outcomes measure, stem therapy, high-risk interventions, development pathways, and future possibilities.

Author : Jawahar L. Mehta,Pankaj Mathur,Naranjan S. Dhalla
Publisher : Springer
Page : 548 pages
File Size : 50,9 Mb
Release : 2017-08-28
Category : Medical
ISBN : 9783319611150

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Biochemical Basis and Therapeutic Implications of Angiogenesis by Jawahar L. Mehta,Pankaj Mathur,Naranjan S. Dhalla Pdf

This book covers the latest developments in the therapeutic implications of angiogenesis, ranging from angiogenesis in the brain, angiogenesis in cancer, angiogenesis’ role in atherosclerosis and heart disease as well as metabolic disorders and peripheral vascular disease. The book is comprehensive in its coverage of angiogenesis in a diverse set of diseases and examines the role of cellular and subcellular structures during the development of angiogenesis. Well-organized and thorough, this is an ideal book for researchers and biomedical engineers working in the field of therapeutic implications of angiogenesis. This book also: Covers the basics of the physiology of angiogenesis, including VEGF pathways in angiogenesis, integr ins in angiogenesis, angiogenesis and exercise physiology, and more Details the role of angiogenesis in atherosclerosis and heart disease, including vascular endothelial growth factor and atherosclerotic plaque progression as well as angiogenesis and heart failure Illustrates in detail brain angiogenesis after stroke and the relationship between angiogenesis and Alzheimer's disease

Author : J.A. Dormandy,W.P. Dole,G.M. Rubanyi
Publisher : Springer
Page : 208 pages
File Size : 47,5 Mb
Release : 1999-09
Category : Medical
ISBN : CHI:55329709

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Therapeutic Angiogenesis by J.A. Dormandy,W.P. Dole,G.M. Rubanyi Pdf

Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease. Lack of sufficient angiogenesis (new capillary development) and collateral formation (remodeling of existing blood vessels) in adult tissues (e. g. , heart, brain, skeletal muscle) during criti cal ischemia has prompted novel therapeutic strategies to stimulate/fa cilitate angiogenesis and collateral formation in ischemic conditions ("therapeutic angiogenesis"). Therapeutic angiogenesis describes a strategy of inducing new col lateral vessels that can bypass vascular obstructions caused by atherosclerotic disease and stimulating new capillaries that can en hance tissue oxygen exchange. Naturally occurring growth factors (e. g. , FGFs, VEGFs) have been identified and demonstrated to induce new blood vessel formation in the adult organism. The therapeutic ap plication of these growth factors has been demonstrated to enhance these natural processes and have been shown in a number of animal models to increase blood flow and oxygen exchange to ischemic tis sues. Therapeutic angiogenesis therefore represents a new medical principle that is anticipated to be used as an adjunct or alternative to angioplasty and/or bypass surgery. A number of strategies have been proposed and tested to deliver growth factors. One strategy is the direct administration of the growth factor protein by intramuscular, intraarte rial or intravenous delivery.

Author : Tulio Pinho Navarro,Lara Lellis Navarro Minchillo Lopes,Alan Dardik
Publisher : Springer Nature
Page : 425 pages
File Size : 54,6 Mb
Release : 2020-11-05
Category : Medical
ISBN : 9783030569549

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Stem Cell Therapy for Vascular Diseases by Tulio Pinho Navarro,Lara Lellis Navarro Minchillo Lopes,Alan Dardik Pdf

Vascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers.

Author : Dan Simionescu,Agneta Simionescu
Publisher : BoD – Books on Demand
Page : 466 pages
File Size : 46,9 Mb
Release : 2017-04-05
Category : Medical
ISBN : 9789535130239

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Physiologic and Pathologic Angiogenesis by Dan Simionescu,Agneta Simionescu Pdf

The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.

Author : Paul Quax,Elisabeth Deindl
Publisher : Mdpi AG
Page : 230 pages
File Size : 41,8 Mb
Release : 2022-01-13
Category : Medical
ISBN : 3036527168

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Arteriogenesis and Therapeutic Angiogenesis by Paul Quax,Elisabeth Deindl Pdf

Although advances in therapeutic interventions improved outcomes, vascular occlusive diseases are still challenging not only afflicted but also attending physicians, requiring novel therapeutic strategies. Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body's own capacity to create a natural bypass around a narrowing or occluded arterial vessel. This book gives an insight into current knowledge and advances in vascular sciences and future prospects of therapeutic options. The utility and relevance of circulating biomarkers together with the potential of machine learning methods are discussed as well as the challenges and prospects of novel therapies such as protein- gene-, and stem cell therapy along with multicistronic multigene vectors and the use of microRNAs, exosomes, and secretomes. Vascular smooth muscle phenotype switch as a target to promote arteriogenesis is critically addressed, highlighting the problem of promoting atherosclerosis in parallel. Two articles even deal with cold-inducible RNA-binding protein CIRP/CIRPB presenting it as promising target to promote vascularization concomitant the reduction in ischemic tissue damage. BMPR kinase inhibition is introduced to improve tissue repair in a hereditary form of vascular disorder, and the role of the AP-1 transcription factor JunB in blood vessel formation is described. Some more experimental oriented articles deal with the relevance of choosing the appropriate mouse strain for investigations as well as in vitro Matrigel plug assay as a potent method to investigate angiogenesis. Last but not least, two-photon intravital microscopy is presented as suitable tool to assess plaque angiogenesis in atherosclerotic lesions.

Author : Thomas Joseph Stegmann
Publisher : Cardiovascular Biotherapeutics Incorporated
Page : 138 pages
File Size : 53,6 Mb
Release : 2005
Category : Cardiovascular system
ISBN : 0976558300

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New Vessels for the Heart by Thomas Joseph Stegmann Pdf

Author : Paul Quax,Elisabeth Deindl
Publisher : Unknown
Page : 230 pages
File Size : 50,7 Mb
Release : 2022
Category : Electronic
ISBN : 3036527176

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Arteriogenesis and Therapeutic Angiogenesis by Paul Quax,Elisabeth Deindl Pdf

Although advances in therapeutic interventions improved outcomes, vascular occlusive diseases are still challenging not only afflicted but also attending physicians, requiring novel therapeutic strategies. Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body's own capacity to create a natural bypass around a narrowing or occluded arterial vessel. This book gives an insight into current knowledge and advances in vascular sciences and future prospects of therapeutic options. The utility and relevance of circulating biomarkers together with the potential of machine learning methods are discussed as well as the challenges and prospects of novel therapies such as protein- gene-, and stem cell therapy along with multicistronic multigene vectors and the use of microRNAs, exosomes, and secretomes. Vascular smooth muscle phenotype switch as a target to promote arteriogenesis is critically addressed, highlighting the problem of promoting atherosclerosis in parallel. Two articles even deal with cold-inducible RNA-binding protein CIRP/CIRPB presenting it as promising target to promote vascularization concomitant the reduction in ischemic tissue damage. BMPR kinase inhibition is introduced to improve tissue repair in a hereditary form of vascular disorder, and the role of the AP-1 transcription factor JunB in blood vessel formation is described. Some more experimental oriented articles deal with the relevance of choosing the appropriate mouse strain for investigations as well as in vitro Matrigel plug assay as a potent method to investigate angiogenesis. Last but not least, two-photon intravital microscopy is presented as suitable tool to assess plaque angiogenesis in atherosclerotic lesions.

Author : J. Anthony Ware,Michael Simons
Publisher : Unknown
Page : 384 pages
File Size : 40,6 Mb
Release : 1999
Category : Blood-vessels
ISBN : 0195112350

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Angiogenesis and Cardiovascular Disease by J. Anthony Ware,Michael Simons Pdf

Angiogenesis and Cardiovascular Disease provides a comprehensive review of the basic scientific and clinical advances in the field of angiogenesis, and its role in the human cardiovascular system. The material presented draws from multiple disciplines, integrating information in a singlesource. Topics addressed focus first on aspects of development and normal biology of the vasculature, and then on angiogenesis and how it is involved in the pathophysiology and therapy of ischemic cardiovascular disease. Vascular development, endothelial cell biology, the vascular matrix, and growthfactors are discussed. Up to date information on current clinical trials, and practical advice concerning application to cardiovascular therapeutic options, are also stressed.

Author : Elisabeth Deindl,Paul H. A. Quax,Thomas Schmitz-Rixen
Publisher : MDPI
Page : 220 pages
File Size : 55,8 Mb
Release : 2020-11-04
Category : Medical
ISBN : 9783039365937

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Arteriogenesis and Therapeutic Neovascularization by Elisabeth Deindl,Paul H. A. Quax,Thomas Schmitz-Rixen Pdf

For many years, arteriogenesis, also called collateral formation, has been regarded as being a beneficial process to restore blood flow to distal tissues in occluded arteries. Therefore, it is frequently referred to in relation to therapeutic angiogenesis. Despite the big clinical potential and the many promising clinical trials on arteriogenesis and therapeutic angiogenesis, the exact molecular mechanisms involved in the multifactorial processes of arteriogenesis are still not completely understood. A better understanding is needed in order to define successful clinical therapies. In this Special Issue, multiple aspects of arteriogenesis and therapeutic angiogenesis will be addressed, ranging from the role of inflammatory processes and immune cells, to growth factors, microRNAs and environmental factors like hypoxia. Therapeutic angiogenesis will also be discussed in relation to the atherosclerosis and intraplaque angiogenesis in hypoxic lesions, as well as specific forms of arteriogenesis in relation to spinal cord blood supply and aorta surgery. The effects of exercise, a frequently prescribed therapy for PAD patients, on arteriogenesis are also discussed. Overall, the papers in this Special Issue on arteriogenesis and therapeutic angiogenesis provide important new insights in the underlying pathophysiological mechanism of these complex processes and may be helpful to define a successful future intervention directed at therapeutic angiogenesis.

Author : Christopher G. Kevil,Shyamal C. Bir,Christopher B. Pattillo
Publisher : Biota Publishing
Page : 84 pages
File Size : 47,5 Mb
Release : 2013-08-01
Category : Science
ISBN : 9781615045990

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Peripheral Arterial Disease by Christopher G. Kevil,Shyamal C. Bir,Christopher B. Pattillo Pdf

Peripheral arterial disease (PAD) is a cardiovascular disorder of the peripheral vasculature due to progressive atherosclerotic stenosis of conduit arteries restricting blood flow to tissues. PAD is typically a disease of older individuals, and the incidence of PAD continues to rise due to an increase in cardiometabolic disease and an aging population. Importantly, “all cause” and cardiovascular morbidity and mortality are significantly increased in PAD patients. PAD diagnosis remains a significant challenge, as a large number of patients are asymptomatic. Moreover, PAD results in a significant financial and societal burden with underutilized diagnostics and limited effective therapies. Here we discuss PAD signs and symptoms, pathophysiological mechanisms, current management, and future disease targets and possible therapeutic treatments for PAD.

Author : Józef Dulak,Alicja Józkowicz,Agnieszka Łoboda
Publisher : Springer Science & Business Media
Page : 414 pages
File Size : 49,5 Mb
Release : 2014-02-10
Category : Medical
ISBN : 9783709114285

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Angiogenesis and Vascularisation by Józef Dulak,Alicja Józkowicz,Agnieszka Łoboda Pdf

The book presents the overview of the current knowledge in some fields of vascular biology, addressing cellular and molecular aspects of blood-vessel formation and their role in health and disease. The major factors involved in the formation of blood vessels are presented by scientists actively involved in this area of research. Special emphasis is put on the presentation of various molecular mechanisms not addressed in similar works to date. The book is divided into three parts. The first part describes the cells and mediators in angiogenesis. The significance of various populations of potential endothelial progenitors is particularly highlighted. The chapters of the second part focus on molecular mechanisms, with special emphasis on the role of hypoxia, gasotransmitters and reactive oxygen species as well as microRNAs in regulation of angiogenic processes. In the third part, the pathological aspects of disturbed – aggravated or impaired – vascularization are discussed and new modalities for potential therapies are presented. The book is intended for scientists and PhD students in the fields of vascular biology and cancer research. It may be of interest for medical professionals in the fields of cardiovascular disease, diabetes, oncology and rheumatoid arthritis.