Thermodynamics Of Membrane Receptors And Channels

Author : Meyer B. Jackson
Publisher : CRC Press
Page : 454 pages
File Size : 55,8 Mb
Release : 1992-11-18
Category : Science
ISBN : 0849369088

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Thermodynamics of Membrane Receptors and Channels by Meyer B. Jackson Pdf

Thermodynamics of Membrane Receptors and Channels synthesizes a wealth of new information regarding the biophysics of membrane proteins. New insights provided by molecular genetics, single channel recording, and high resolution structural techniques are discussed from a conceptual perspective. Basic theoretical topics are introduced, developed, and then extensively illustrated with recent results from the literature or data from the authors' own laboratories. Theoretical and experimental information is incorporated into in-depth discussions of ion permeation mechanisms, ion channel and receptor conformational changes, aggregate activity of complexes of lipids and proteins, and how coupling is achieved between different energy modes in the many transduction systems residing in biomembranes. Thermodynamics of Membrane Receptors and Channels will be valuable both as a learning aid and a reference for biophysicists, neuroscientists, cell biologists, physiologists, and other researchers investigating any aspects of biomembranes.

Author : Park S. Nobel
Publisher : Academic Press
Page : 518 pages
File Size : 49,7 Mb
Release : 1999
Category : Nature
ISBN : 0125200250

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Physicochemical & Environmental Plant Physiology by Park S. Nobel Pdf

In fundamental ways, the functioning of all living systems obeys the laws of physics and chemistry. This is true for all physiological processes that occur inside cells, tissues, organs, and organisms. This new edition of a classic text has been throughly revised while maintaining its unparalleled commitment to the clear presentation and student user-friendliness. Certain to maintain its leading role in the teaching of general and comparative physiological principles, Physicochemical and Environmental Plant Physiology, 2nd Edition establishes a new standard of excellence in the teaching of quantitative plant physiology.

Author : Vladimir B Bajic,Tin Wee Tan
Publisher : World Scientific
Page : 799 pages
File Size : 55,6 Mb
Release : 2005-06-01
Category : Science
ISBN : 9781783260270

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Information Processing And Living Systems by Vladimir B Bajic,Tin Wee Tan Pdf

Information processing and information flow occur in the course of an organism's development and throughout its lifespan. Organisms do not exist in isolation, but interact with each other constantly within a complex ecosystem. The relationships between organisms, such as those between prey or predator, host and parasite, and between mating partners, are complex and multidimensional. In all cases, there is constant communication and information flow at many levels.This book focuses on information processing by life forms and the use of information technology in understanding them. Readers are first given a comprehensive overview of biocomputing before navigating the complex terrain of natural processing of biological information using physiological and analogous computing models. The remainder of the book deals with “artificial” processing of biological information as a human endeavor in order to derive new knowledge and gain insight into life forms and their functioning. Specific innovative applications and tools for biological discovery are provided as the link and complement to biocomputing.Since “artificial” processing of biological information is complementary to natural processing, a better understanding of the former helps us improve the latter. Consequently, readers are exposed to both domains and, when dealing with biological problems of their interest, will be better equipped to grasp relevant ideas.

Author : Harold E. Layton,Alan M. Weinstein
Publisher : Springer Science & Business Media
Page : 438 pages
File Size : 51,7 Mb
Release : 2002-08-06
Category : Mathematics
ISBN : 0387954813

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Membrane Transport and Renal Physiology by Harold E. Layton,Alan M. Weinstein Pdf

The papers in this volume arose out of the workshop Membrane Transport and Renal Physiology, which was conducted as part of the IMA 1998-1999 program year, Mathematics in Biology. The workshop brought together physiologists, biophysicists, and applied mathematicians who share a common interest in solute and water transport in biological systems, especially in the integrated function of the kidney. Solute and water transport through cells involves fluxes across two cell membranes, usually via specialized proteins that are integral membrane components. By means of mathematical representations, transport fluxes can be related to transmembrane solute concentrations and electrochemical driving forces. At the next level of functional integration, these representations can serve as key components for models of renal transcellular transport. Ultimately, simulations can be developed for transport-dependent aspects of overall renal function. Workshop topics included solute fluxes through ion channels, cotransporters, and metabolically-driven ion pumps; transport across fiber-matrix and capillary membranes; coordinated transport by renal epithelia; the urine concetrating mechanism; and intra-renal hemodynamic control. This volume will be of interest to biological and mathematical scientists who would like a view of recent mathematical efforts to represent membrane transport and its role in renal function.

Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
Page : 467 pages
File Size : 44,6 Mb
Release : 2006-09-29
Category : Science
ISBN : 9781420005844

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TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by Wolfgang B. Liedtke, MD, PH.D. Pdf

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions. Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.

Author : Anonim
Publisher : Elsevier
Page : 448 pages
File Size : 41,6 Mb
Release : 2011-09-21
Category : Science
ISBN : 0080488633

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Mechanosensitive Ion Channels by Anonim Pdf

Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include The Mechanical Properties of Bilayers; Molecular Dynamic Modeling of MS Channels; Structures of the Prokaryotic Mechanosensitive; Channels MscL and MscS; 3.5 Billion Years of Mechanosensory Transduction: Structure and Function of Mechanosensitive Channels in Prokaryotes; Activation of Mechanosensitive Ion Channels by Forces Transmitted through Integrins and the Cytoskeleton; Thermodynamics of Mechanosensitivity; Flexoelectricity and Mechanotransduction; Lipid Effects on Mechanosensitive Channels; Functional Interactions of the Extracellular Matrix with Mechanosensitive Channels; MSCL: The Bacterial Mechanosensitive Channel of Large Conductance; The Bacterial Mechanosensitive Channel MscS: Emerging Principles of Gating and Modulation; Structure function relations of MscS; The MscS Cytoplasmic Domain and its Conformational Changes upon the Channel Gating; Microbial TRP Channels and Their Mechanosensitivity; MSCS-Like Proteins in Plants; Delivering Force and Amplifying Signals in Plant Mechanosensing; MS Channels in Tip Growing Systems.

Author : Peter Lauf,Norma Adragna
Publisher : Springer Science & Business Media
Page : 441 pages
File Size : 44,9 Mb
Release : 2006-11-30
Category : Science
ISBN : 9780387237527

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Cell Volume and Signaling by Peter Lauf,Norma Adragna Pdf

In front of you is the finished product of your work, the text of your contributions to the 2003 Dayton International Symposium on Cell Volume and Signal Transduction. As we all recall, this symposium brought together the Doyens of Cellular and Molecular Physiology as well as aspiring young investigators and students in this field. It became a memorable event in an illustrious series of International Symposia on Cell Volume and Signaling. This series, started by Professors Vladimir Strbák, Florian Lang and Monte Greer in Smolenice, Slovakia in 1997 and continued by Professors Rolf Kinne, Florian Lang and Frank Wehner in Berlin in 2000, is projected for 2005 in Copenhagen to be hosted by our colleague, Professor Else Hoffmann and her team. We dearly miss Monte Greer to whom this symposium was dedicated and addressed so eloquently by Vladimir Strbák in his Dedication to Monte. Monte and I became friends in Smolenice and had begun to discuss the 2003 meeting only a few days before his tragic accident in 2002. There are others who were not with us, and we missed them, too. We would not have been able to succeed in this event without the unflagging support of our higher administration at Wright State University, the NIDDKD of the National Institute of Health, and the Fuji Medical System (see Acknowledgments).

Author : Ole G. Mouritsen
Publisher : Springer Science & Business Media
Page : 296 pages
File Size : 46,6 Mb
Release : 2004-11-30
Category : Science
ISBN : 3540232486

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Life - As a Matter of Fat by Ole G. Mouritsen Pdf

Presents a multi-disciplinary perspective on the physics of life and the particular role played by lipids and the lipid-bilayer component of cell membranes. Emphasizes the physical properties of lipid membranes seen as soft and molecularly structured interfaces. By combining and synthesizing insights obtained from a variety of recent studies, an attempt is made to clarify what membrane structure is and how it can be quantitatively described. Shows how biological function mediated by membranes is controlled by lipid membrane structure and organization on length scales ranging from the size of the individual molecule, across molecular assemblies of proteins and lipid domains in the range of nanometers, to the size of whole cells. Applications of lipids in nano-technology and biomedicine are also described.

Author : Erik Mosekilde,Ole G. Mouritsen
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 51,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642792908

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Modelling the Dynamics of Biological Systems by Erik Mosekilde,Ole G. Mouritsen Pdf

The development of a proper description of the living world today stands as one of the most significant challenges to physics. A variety of new experimental techniques in molecular biology, microbiol ogy, physiology and other fields of biological research constantly expand our knowledge and enable us to make increasingly more detailed functional and structural descriptions. Over the past decades, the amount and complexity of available information have multiplied dramatically, while at the same time our basic understanding of the nature of regulation, behavior, morphogenesis and evolution in the living world has made only modest progress. A key obstacle is clearly the proper handling of the available data. This requires a stronger emphasis on mathematical modeling through which the consistency of the adopted explanations can be checked, and general princi ples may be extracted. As an even more serious problem, however, it appears that the proper physical concepts for the development of a theoretically oriented biology have not hitherto been available. Classical mechanics and equilibrium thermody namics, for instance, are inappropriate and useless in some of the most essen tial biological contexts. Fortunately, there is now convincing evidence that the concepts and methods of the newly developed fields of nonlinear dynam ics and complex systems theory, combined with irreversible thermodynamics and far-from-equilibrium statistical mechanics will enable us to move ahead with many of these problems.

Author : E. Anibal Disalvo,Sidney A. Simon
Publisher : CRC Press
Page : 288 pages
File Size : 41,5 Mb
Release : 2017-12-14
Category : Science
ISBN : 9781351425391

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Permeability and Stability of Lipid Bilayers by E. Anibal Disalvo,Sidney A. Simon Pdf

This book presents a comprehensive and coherent picture of how molecules diffuse across a liquid that is, on average, only two molecules thick. It begins by characterizing bilayers structurally, using X-ray diffraction, and then mechanically by measuring elastic moduli and mechanisms of failure. Emphasis is placed on the stability and mechanical properties of plant membranes that are subject to very large osmotic and thermal stresses. Using this information, the transport of molecules of increasing complexity across bilayers is analyzed.

Author : G.W. Gokel
Publisher : Elsevier
Page : 338 pages
File Size : 40,9 Mb
Release : 1997-09-22
Category : Science
ISBN : 0080550894

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Advances in Supramolecular Chemistry by G.W. Gokel Pdf

Part of a series which presents reports of efforts in all areas of supramolecular science, this volume discusses a variety of topics in the field.

Author : Roger J. Crossley
Publisher : CRC Press
Page : 216 pages
File Size : 50,5 Mb
Release : 1995-09-11
Category : Medical
ISBN : 0849391407

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Chirality and Biological Activity of Drugs by Roger J. Crossley Pdf

This book brings together the theoretical, commercial, and practical aspects of chirality and biological activity of drugs and acts as a ready reference for the effects of enantiomers of drug substances.

Author : Jacky J. Cosson
Publisher : Bentham Science Publishers
Page : 457 pages
File Size : 51,7 Mb
Release : 2015-11-04
Category : Science
ISBN : 9781681081281

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Flagellar Mechanics and Sperm Guidance by Jacky J. Cosson Pdf

Experimental research using spermatozoa, a highly specialized cell with organelles involved in gene transfer, energy supply and cellular motility, has always occupied the forefront of studies in cell and reproductive biology. Several spermatological experiments have focused on the attraction of a spermatozoon toward the egg – sperm chemotaxis or sperm guidance. This process ubiquitously occurs in the reproductive system of many organisms. After its discovery in the late 19th century in plants, sperm chemotaxis is known to play a crucial role in fertilization success in both plants and animals. Spermatology has expanded in focus in recent years, as the structure of molecules relevant to sperm chemotaxis has been recently determined in several species of invertebrates and vertebrates, which promises remarkable progress for understanding events relevant to sexual reproduction. Reflecting upon these trends in the long history of sperm chemotaxis, Flagellar Mechanics and Sperm Guidance gathers leaders in the field of spermatology, who have presented their experimental research on the chemical cues behind flagellate behavior in a variety of organisms including bikonts and spermatozoa of marine invertebrates and vertebrates (fish, amphibians and mammals). Reviews presented in this monograph provide both basic and detailed information on the initiation and activation of sperm motility at spawning, sperm thermotaxis, and other mechanics such as mathematical models of a spermatozoon swimming. A comparison between features of sperm chemotaxis among different organisms is also given. Flagellar Mechanics and Sperm Guidance will stir interest in spermatology research among a broad variety of readers including researchers, Ph.D. students studying reproductive biology and teachers involved in advanced biology courses.

Author : National Library of Medicine (U.S.)
Publisher : Unknown
Page : 1328 pages
File Size : 51,7 Mb
Release : 1993
Category : Medicine
ISBN : MINN:31951D01092869N

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National Library of Medicine Current Catalog by National Library of Medicine (U.S.) Pdf

Author : Mauro Ferrario,Giovanni Ciccotti,Kurt Binder
Publisher : Springer
Page : 592 pages
File Size : 49,9 Mb
Release : 2007-04-16
Category : Science
ISBN : 9783540352846

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Computer Simulations in Condensed Matter: From Materials to Chemical Biology. Volume 2 by Mauro Ferrario,Giovanni Ciccotti,Kurt Binder Pdf

This extensive and comprehensive collection of lectures by world-leading experts in the field introduces and reviews all relevant computer simulation methods and their applications in condensed matter systems. Volume 2 offers surveys on numerical experiments carried out for a great number of systems, ranging from materials sciences to chemical biology, including supercooled liquids, spin glasses, colloids, polymers, liquid crystals, biological membranes and folding proteins.