Tnf Pathophysiology

Author : George Kollias,Petros P. Sfikakis
Publisher : Karger Medical and Scientific Publishers
Page : 223 pages
File Size : 40,8 Mb
Release : 2010-01-01
Category : Medical
ISBN : 9783805593830

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TNF Pathophysiology by George Kollias,Petros P. Sfikakis Pdf

TNF is a multifunctional proinflammatory cytokine central to the development and homeostasis of the immune system and a regulator of cell activation, differentiation and death. Recent decades have seen an enormous scientific and clinical interest in the function of TNF in physiology and disease. A vast amount of data has been accumulated at the biochemical, molecular and cellular level, establishing TNF as a prototype for in-depth understanding of the physiological and pathogenic functions of cytokines. This volume covers several current aspects of TNF regulation and function, including transcriptional and posttranscriptional control mechanisms, cellular modes of action, signaling networks that mediate its effect, involvement in pathogenesis and clinical outcomes of TNF antagonists. It combines basic science at the molecular and cellular level with research in animal models of disease and clinical findings to provide a comprehensive review of recent developments in TNF biology. A thorough understanding of the mechanisms by which this key molecular player is produced and functions to regulate cell biology, immunity and disease postulates novel paradigms on how genes contribute to the development and physiology of biological systems.

Author : G. Kollias,P.P. Sfikakis
Publisher : Karger Medical and Scientific Publishers
Page : 223 pages
File Size : 51,6 Mb
Release : 2010-02-18
Category : Medical
ISBN : 9783805593847

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TNF Pathophysiology by G. Kollias,P.P. Sfikakis Pdf

TNF is a multifunctional proinflammatory cytokine central to the development and homeostasis of the immune system and a regulator of cell activation, differentiation and death. Recent decades have seen an enormous scientific and clinical interest in the function of TNF in physiology and disease. A vast amount of data has been accumulated at the biochemical, molecular and cellular level, establishing TNF as a prototype for in-depth understanding of the physiological and pathogenic functions of cytokines. This volume covers several current aspects of TNF regulation and function, including transcriptional and posttranscriptional control mechanisms, cellular modes of action, signaling networks that mediate its effect, involvement in pathogenesis and clinical outcomes of TNF antagonists. It combines basic science at the molecular and cellular level with research in animal models of disease and clinical findings to provide a comprehensive review of recent developments in TNF biology. A thorough understanding of the mechanisms by which this key molecular player is produced and functions to regulate cell biology, immunity and disease postulates novel paradigms on how genes contribute to the development and physiology of biological systems. This book is mandatory reading for molecular and cell biologists, immunologists and clinicians interested in TNF function.

Author : Mohammed M. Sayeed
Publisher : CRC Press
Page : 186 pages
File Size : 41,7 Mb
Release : 1989-05-31
Category : Science
ISBN : 0849340616

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Cellular Pathophysiology by Mohammed M. Sayeed Pdf

In recent years, there has been increased research on cellular pathophysiology in animal and tissue models simulating human disease processes. The result of this research, which has been carried out primarily by physiologists, pharmacologists, biochemists, anatomists, pathologists, and clinicians, is now presented in this forum. A better understanding of how cellular, subcellular and molecular mechanisms initiate and progressively intensify organic/systemic disease processes is important in the development of rational therapies against these disease processes.

Author : A. Aasen
Publisher : CRC Press
Page : 480 pages
File Size : 47,8 Mb
Release : 1991-05-13
Category : Medical
ISBN : 371865038X

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Surgical Pathophysiology by A. Aasen Pdf

Author : Günther Schlag,Heinz Redl
Publisher : Springer Science & Business Media
Page : 1180 pages
File Size : 46,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642767364

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Pathophysiology of Shock, Sepsis, and Organ Failure by Günther Schlag,Heinz Redl Pdf

In this book current knowledge of the pathophysiology of shock, sepsis and multi organ failure is presented. The rapid progress which has been made and the results achieved in intensive care medicine are based on sound basic research, which is duly reflected in these chapters. Multiorgan failure is the foremost cause of postoperative and posttraumatic death and many complex mechanisms are involved. Only with a good foundation of basic research can abnormalities in the physiological, biochemical, and morphological course of shock be recognized and the necessary conclusions for treatment drawn. Therapy must proceed from profound knowledge of the multi variant physiological events in order to influence shock, sepsis and organ failure. Although numerous possibilities for therapy have arisen from pharmaceutical research in recent years, they are beyond the scope of this book and are not discussed here. To gain a better understanding of the pathophysiological events it was necessary to examine and to describe different models that simulate and reproduce these events. Here we describe the causative agents (shock) and the consequences (sepsis, organ failure) in two main sections, divided on the basis of their pathophysiology.

Author : Yuanjian Fang,Lei Huang,Xiangsheng Zhang,Anwen Shao,Jiping Tang,Dirk M. Hermann
Publisher : Frontiers Media SA
Page : 363 pages
File Size : 52,9 Mb
Release : 2023-12-27
Category : Medical
ISBN : 9782832541463

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Crosstalk between Peripheral and Local Immune Response in the Pathophysiology of Stroke and Neurodegeneration Diseases by Yuanjian Fang,Lei Huang,Xiangsheng Zhang,Anwen Shao,Jiping Tang,Dirk M. Hermann Pdf

Author : Undurti N. Das
Publisher : John Wiley & Sons
Page : 282 pages
File Size : 40,5 Mb
Release : 2010-02-23
Category : Medical
ISBN : 9780813815534

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Metabolic Syndrome Pathophysiology by Undurti N. Das Pdf

Metabolic Syndrome Pathophysiology: The Role of Essential Fatty Acids provides current research exploring the links among insulin, insulin receptors, polyunsaturated fatty acids, brain growth and disease. Specific interactions of essential fatty acids and polyunsaturated fatty acids in brain development and several disease groups are described. The role of inflammation in disease and how fatty acids regulate low-systemic inflammation are examined and explained. Metabolic and neurologic dynamics are presented to provide a linkage between the presence of omega-3 and omega-6 and protection against diseases and conditions such as diabetes mellitus, obesity, autoimmune diseases and hypertension.

Author : HuaLin Cai,Pei Jiang,Xiang Yang Zhang
Publisher : Frontiers Media SA
Page : 173 pages
File Size : 55,6 Mb
Release : 2021-11-25
Category : Science
ISBN : 9782889716906

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Biomarker Exploration in Neuropsychiatry: Understanding of the Pathophysiology and Therapeutic Implications by HuaLin Cai,Pei Jiang,Xiang Yang Zhang Pdf

Author : Pawan K. Maurya,Kamal Dua
Publisher : Springer Nature
Page : 297 pages
File Size : 46,5 Mb
Release : 2020-06-15
Category : Science
ISBN : 9789811515682

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Role of Oxidative Stress in Pathophysiology of Diseases by Pawan K. Maurya,Kamal Dua Pdf

This book illustrates the importance and significance of oxidative stress in the pathophysiology of various human diseases. The book initially introduces the phenomenon of oxidative stress, basic chemical characteristics of the species involved and summarizes the cellular oxidant and anti-oxidant system and the cellular effects and metabolism of the oxidative stress. In addition, it reviews the current understanding of the potential impact of oxidative stress on telomere shortening, aging, and age-related diseases. It also examines the role of oxidative stress in chronic diseases, including cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders. Further, the book presents novel technologies for the detection of oxidative stress biomarkers using nanostructure biosensors, as well as in vitro and in vivo models to monitor oxidative stress. Lastly, the book addresses the drug delivery carriers that can help in combating oxidative stress.

Author : Carol Porth
Publisher : Lippincott Williams & Wilkins
Page : 1280 pages
File Size : 40,8 Mb
Release : 2011
Category : Medical
ISBN : 9781582557243

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Essentials of Pathophysiology by Carol Porth Pdf

Porth Pathophysiology: understanding made easy, delivered however you need it. Porth's "Essentials of Pathophysiology" 3e delivers exceptional student understanding and comprehension of pathophysiology. An expanded, robust and flexible suite of supplements makes it easy for you to select the best course resources, so you can meet your students' changing needs. For both discrete and hybrid courses, the flexibility and power of Porth allows you to customize the amount of pathophysiology that you need for effective teaching and learning. Including a resource DVD with text!

Author : Pablo Muriel
Publisher : Academic Press
Page : 914 pages
File Size : 43,8 Mb
Release : 2017-03-02
Category : Medical
ISBN : 9780128043219

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Liver Pathophysiology by Pablo Muriel Pdf

Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.

Author : G. W. Richter,Kim Solez
Publisher : Academic Press
Page : 248 pages
File Size : 51,6 Mb
Release : 2013-10-22
Category : Health & Fitness
ISBN : 9781483282305

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Cytokine-Induced Pathology by G. W. Richter,Kim Solez Pdf

International Review of Experimental Pathology, Volume 34: Cytokine-Induced Pathology Part B: Inflammatory Cytokines, Receptors, and Disease presents experimental findings obtained from the most recently studied cytokines and growth factors. The book is organized into three sections. Section I contains studies on pathology induced by inflammatory cytokines. Topics covered include the biological effects of interferon-γ, tumor necrosis factor- α (TNF), interleukin-8, transforming growth factor-β, and leukemia inhibitory factor on experimental animals; TNF-induced pathophysiologic alterations; and the biological activity of leukemia inhibitory factor (LIF). The papers in Section II examine cytokine receptors, including their structure and signal transduction; interferon-γ (IFN-γ) activity; and immunoregulatory role of TNF-α. Section III is devoted to cytokine receptors, including studies on TNF properties relevant to tissue injury and its role in T cell-mediated immunopathological reactions in vivo; the role of cytokines in experimental pulmonary fibrosis induced in mice; and the role of cytokines in bacterial meningitis.

Author : Anonim
Publisher : Frontiers Media SA
Page : 1671 pages
File Size : 43,7 Mb
Release : 2023-01-25
Category : Medical
ISBN : 9782889741014

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Coronavirus Disease (COVID-19): Pathophysiology, Epidemiology, Clinical Management and Public Health Response by Anonim Pdf

Volume I.A An outbreak of a respiratory disease first reported in Wuhan, China in December 2019 and the causative agent was discovered in January 2020 to be a novel betacoronovirus of the same subgenus as SARS-CoV and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) has rapidly disseminated worldwide, with clinical manifestations ranging from mild respiratory symptoms to severe pneumonia and a fatality rate estimated around 2%. Person to person transmission is occurring both in the community and healthcare settings. The World Health Organization (WHO) has recently declared the COVID-19 epidemic a public health emergency of international concern. The ongoing outbreak presents many clinical and public health management challenges due to limited understanding of viral pathogenesis, risk factors for infection, natural history of disease including clinical presentation and outcomes, prognostic factors for severe illness, period of infectivity, modes and extent of virus inter-human transmission, as well as effective preventive measures and public health response and containment interventions. There are no antiviral treatment nor vaccine available but fast track research and development efforts including clinical therapeutic trials are ongoing across the world. Managing this serious epidemic requires the appropriate deployment of limited human resources across all cadres of health care and public health staff, including clinical, laboratory, managerial and epidemiological data analysis and risk assessment experts. It presents challenges around public communication and messaging around risk, with the potential for misinformation and disinformation. Therefore, integrated operational research and intervention, learning from experiences across different fields and settings should contribute towards better understanding and managing COVID-19. This Research Topic aims to highlight interdisciplinary research approaches deployed during the COVID-19 epidemic, addressing knowledge gaps and generating evidence for its improved management and control. It will incorporate critical, theoretically informed and empirically grounded original research contributions using diverse approaches, experimental, observational and intervention studies, conceptual framing, expert opinions and reviews from across the world. The Research Topic proposes a multi-dimensional approach to improving the management of COVID-19 with scientific contributions from all areas of virology, immunology, clinical microbiology, epidemiology, therapeutics, communications as well as infection prevention and public health risk assessment and management studies.

Author : Xiuming Jin,Jiaxu Hong,Takenori Inomata,Lei Gu
Publisher : Frontiers Media SA
Page : 389 pages
File Size : 53,7 Mb
Release : 2022-06-06
Category : Medical
ISBN : 9782889763290

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Advances in the Pathophysiology, Diagnosis, And Treatment of Dry Eye Disease by Xiuming Jin,Jiaxu Hong,Takenori Inomata,Lei Gu Pdf

Author : Michel Mignon,J. F. Colombel
Publisher : John Libbey Eurotext
Page : 374 pages
File Size : 41,6 Mb
Release : 1999
Category : Medical
ISBN : 2742002545

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Recent Advances in the Pathophysiology and Management of Inflammatory Bowel Diseases and Digestive Endocrine Tumors by Michel Mignon,J. F. Colombel Pdf

John Libbey Eurotext is continuing to publish the gastroenterology course organised in Europe by leading international experts. The July 1999 course will examine the latest progress in treating the inflammatory bowel disease and digestive endocrine tumours with which doctors are often confronted. The following aspects are discussed: Epidemiological and genetic aspects; The immunological basis of inflammatory bowel disease; Extra-intestinal symptoms; Types of treatment. Edited by Professor Galmiche, chairman of the EAGE, the book gathers together biological and clinical information in a synthetic form aimed especially at young practitioners throughout Europe.