Transcription Factors

Author : Timothy R. Hughes
Publisher : Springer Science & Business Media
Page : 306 pages
File Size : 40,7 Mb
Release : 2011-05-10
Category : Medical
ISBN : 9789048190690

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A Handbook of Transcription Factors by Timothy R. Hughes Pdf

Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.

Author : Daniel H Gonzalez
Publisher : Academic Press
Page : 434 pages
File Size : 45,9 Mb
Release : 2015-07-07
Category : Science
ISBN : 9780128011270

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Plant Transcription Factors by Daniel H Gonzalez Pdf

Plant Transcription Factors: Evolutionary, Structural and Functional Aspects is the only publication that provides a comprehensive compilation of plant transcription factor families and their complex roles in plant biology. While the majority of information about transcription factors is based on mammalian systems, this publication discusses plant transcription factors, including the important aspects and unifying themes to understanding transcription factors and the important roles of particular families in specific processes. Provides an entry point for transcription factor literature Offers compilation of information into one single resource for rapid consultation on different plant transcription factor features Integrates the knowledge about different transcription factors, along with cross-referencing Provides information on the unique aspects surrounding plant transcription factors

Author : Gregg L. Semenza
Publisher : Oxford Monographs on Medical G
Page : 396 pages
File Size : 52,7 Mb
Release : 1998
Category : Health & Fitness
ISBN : 0195112393

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Transcription Factors and Human Disease by Gregg L. Semenza Pdf

Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that participate in specific physiologic responses. Transcription Factors and Human Disease presents the basic science of transcriptional regulation and then describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites. The involvement of transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is briefly discussed. The effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis are also explored. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.

Author : David Latchman,David S. Latchman
Publisher : Academic Press
Page : 488 pages
File Size : 50,6 Mb
Release : 2010-07-28
Category : Science
ISBN : 0080561039

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Eukaryotic Transcription Factors by David Latchman,David S. Latchman Pdf

Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events. Potential of transcription factors as therapeutic targets in human disease Importance of histone modifications Use of genome-based sequence analysis and high-throughput methods Applications of the chromatin immunoprecipitation (ChIP) assay Transcriptional elongation Regulation by post-translational modifications Regulatory networks and bioinformatics

Author : Joseph Locker
Publisher : Garland Science
Page : 502 pages
File Size : 42,5 Mb
Release : 2003-12-16
Category : Science
ISBN : 9781135323622

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Transcription Factors by Joseph Locker Pdf

Transcription factors are important in regulating gene expression, and their analysis is of paramount interest to molecular biologists studying this area. This book looks at the basic machinery of the cell involved in transcription in eukaryotes and factors that control transcription in eukaryotic cells. It examines the regulatory systems that modulate gene expression in all cells,a s well as the more specialized systems that regulate localized gene expression throughout the mammalian organism. Transcription Factors updates classical knowledge with recent advances to provide a full and comprehensive coverage of the field for postgraduates and researchers in molecular biology involved in the study of gene regulation.

Author : Willis X. Li,Louise Silver-Morse
Publisher : Springer Nature
Page : 62 pages
File Size : 52,7 Mb
Release : 2023-04-25
Category : Science
ISBN : 9783031290299

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The Secret Lives of Transcription Factors by Willis X. Li,Louise Silver-Morse Pdf

This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.

Author : Athanasios Papavassiliou
Publisher : International Thomson Publishing Services
Page : 388 pages
File Size : 54,9 Mb
Release : 1997
Category : Cellular signal transduction
ISBN : STANFORD:36105019363014

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Transcription Factors in Eukaryotes by Athanasios Papavassiliou Pdf

Author : David Latchman
Publisher : OUP Oxford
Page : 326 pages
File Size : 47,7 Mb
Release : 1999-04-08
Category : Science
ISBN : 9780191565793

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Transcription Factors by David Latchman Pdf

Since the publication of the first edition five years ago, a wide range of new methodologies have been developed to facilitate studies on both isolated parts of the genome and the genome as a whole. This new edition has been updated and expanded so that it provides a comprehensive guide to the methods currently available to characterize the function and activity of an individual transcription factor. All the original chapters have been fully updated or rewritten and additional chapters cover the use of in vitro transcription assays, analysis of chromatin structure, use of the genomic binding site assay and analysis of transcription factor modifications. As with the previous edition, the book starts with a series of chapters concerned with characterizing the proteins binding to a specific DNA sequence and then a chapter on more detailed characterization of the protein itself. The next two chapters describe the isolation of cDNA clones encoding a transcription factor using oligonucleotides predicted from protein sequence and screening of a cDNA expression library. Chapter 6 deals with identification of transcription factors based on sequence homology analysis by both experimental screening and database searches. Chapter 7 is a new chapter that describes methods of identifying the target genes of a previously uncharacterized factor. The next chapters deal with analysis of transcription factor function. Chapter 8 deals with general techniques, and then the following chapters cover the specialized techniques of in vitro transcription assays using transcriptionally active nuclear extracts derived from rat brain, and analysis of the effect of transcription factors on chromatin structure. The final chapter describes methods for detecting the phosphorylation and glycosylation state of transcription factors.

Author : Ron Milo,Rob Phillips
Publisher : Garland Science
Page : 400 pages
File Size : 53,6 Mb
Release : 2015-12-07
Category : Science
ISBN : 9781317230694

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Cell Biology by the Numbers by Ron Milo,Rob Phillips Pdf

A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid

Author : Timothy R. Hughes
Publisher : Springer
Page : 306 pages
File Size : 55,8 Mb
Release : 2011-05-26
Category : Medical
ISBN : 9048190703

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A Handbook of Transcription Factors by Timothy R. Hughes Pdf

Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.

Author : Etsuko Miyamoto-Sato,Hiroyuki Ohashi,Hirotaka Sasaki,Jun-ichi Nishikawa,Hiroshi Yanagawa
Publisher : Humana Press
Page : 220 pages
File Size : 45,8 Mb
Release : 2014-06-14
Category : Medical
ISBN : 1493908065

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Transcription Factor Regulatory Networks by Etsuko Miyamoto-Sato,Hiroyuki Ohashi,Hirotaka Sasaki,Jun-ichi Nishikawa,Hiroshi Yanagawa Pdf

Transcription Factor Regulatory Methods details various techniques ranging from cutting-edge to general techniques use to study transcription factor regulatory networks. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Transcription Factor Regulatory Methods aids scientists in the further study into post-genomic or the personal genomic era.

Author : Kenneth Maiese
Publisher : Springer Science & Business Media
Page : 283 pages
File Size : 43,8 Mb
Release : 2010-07-29
Category : Medical
ISBN : 9781441915993

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Forkhead Transcription Factors by Kenneth Maiese Pdf

Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their knowledge and insights to offer a novel perspective for translational medicine that highlights the role of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders. Equally important, Forkhead Transcription Factors: Vital Elements in Biology and Medicine clearly sets a precedent for the necessity to understand the diverse and complex nature of forkhead proteins since this family of transcription factors can limit as well as foster disease progression depending upon the cellular environment. The presentation and discussion of innovative studies and especially those that examine previously unexplored pathways that may influence clinical survival and longevity offer an exciting approach to address the potential of forkhead transcription factors for new therapeutic avenues in multiple disciplines.

Author : Martin J. Tymms
Publisher : Springer Science & Business Media
Page : 304 pages
File Size : 48,6 Mb
Release : 2008-02-03
Category : Medical
ISBN : 9781592596867

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Transcription Factor Protocols by Martin J. Tymms Pdf

The effort to sequence the human genome is now moving toward a c- clusion. As all of the protein coding sequences are described, an increasing emphasis will be placed on understanding gene function and regulation. One important aspect of this analysis is the study of how transcription factors re- late transcriptional initiation by RNA polymerase II, which is responsible for transcribing nuclear genes encoding messenger RNAs. The initiation of Class II transcription is dependent upon transcription factors binding to DNA e- ments that include the core or basal promoter elements, proximal promoter elements, and distal enhancer elements. General initiation factors are involved in positioning RNA polymerase II on the core promoter, but the complex - teraction of these proteins and transcriptional activators binding to DNA e- ments outside the core promoter regulate the rate of transcriptional initiation. This initiation process appears to be a crucial step in the modulation of mRNA levels in response to developmental and environmental signals. Transcription Factor Protocols provides step-by-step procedures for key techniques that have been developed to study DNA sequences and the protein factors that regulate the transcription of protein encoding genes. This volume is aimed at providing researchers in the field with the well-detailed protocols that have been the hallmark of previous volumes of the Methods in Molecular TM Biology series.

Author : Vikas Srivastava,Sonal Mishra,Shakti Mehrotra,Santosh Kumar Upadhyay
Publisher : Elsevier
Page : 478 pages
File Size : 43,8 Mb
Release : 2022-11-09
Category : Science
ISBN : 9780323908276

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Plant Transcription Factors by Vikas Srivastava,Sonal Mishra,Shakti Mehrotra,Santosh Kumar Upadhyay Pdf

Plant Transcription Factors: Contribution in Development, Metabolism, and Environmental Stress provides comprehensive coverage of plant TFs and their various functions, evaluating their crucial role in growth and development, signaling, stress management and other key plant processes. Sections cover the significance of plant TFs in functional genomics, the influence of phyto-hormones on the modulation of plant TFs, plant development and metabolism, including shoot development, flowering development and alkaloid biosynthesis. The book's final section reviews the role of TFs in various plant stresses, including temperature, water and heavy metal stress. Written by leading experts around the globe, this book is an essential read to researchers interested in plant signaling and plant genomics. Presents the latest advances in plant transcription factors and their functions Discusses the influence of phyto-hormones on the modulation of plant transcription factors Highlights the relationship between plant TFs and plant development

Author : Joseph Locker
Publisher : Garland Science
Page : 345 pages
File Size : 46,6 Mb
Release : 2003-12-16
Category : Science
ISBN : 9781135323639

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Transcription Factors by Joseph Locker Pdf

This book focuses on the DNA-binding transcription factors and the proteins with which they directly interact. It examines the regulatory systems that modulate gene expression in all cells and the more specialized systems that regulate localized gene expression throughout the mammalian organism.