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Author : Athanasios Papavassiliou
Publisher : International Thomson Publishing Services
Page : 388 pages
File Size : 53,8 Mb
Release : 1997
Category : Cellular signal transduction
ISBN : STANFORD:36105019363014
Author : David S. Latchman
Publisher : Academic Press
Page : 391 pages
File Size : 50,8 Mb
Release : 2003-11-21
Category : Medical
ISBN : 9780080531267
Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality. Major families of eukaryotic transcription factors described Mechanisms of gene activation and repression analysed Structure-function relationships indicated Interaction between transcription factors and chromatin structure described Roles in inducible and cell type-specific gene expression Roles in development, differentiation and human diseases including cancer Methods of study in vitro and in vivo
Author : Timothy R. Hughes
Publisher : Springer Science & Business Media
Page : 306 pages
File Size : 44,7 Mb
Release : 2011-05-10
Category : Medical
ISBN : 9789048190690
Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.
Author : Michael F. Carey,Stephen T. Smale
Publisher : CSHL Press
Page : 684 pages
File Size : 41,6 Mb
Release : 2000
Category : Medical
ISBN : 0879696354
In the genome era, the analysis of gene expression has become a critical requirement in many laboratories. But there has been no comprehensive source of strategic, conceptual, and technical information to guide this often complex task. Transcriptional Regulation in Eukaryotes answers that need. Written by two experienced investigators, Michael Carey and Stephen Smale at the UCLA School of Medicine, and based in part on the Gene Expression course taught at Cold Spring Harbor Laboratory, this book directly addresses all the concerns of a laboratory studying the regulation of a newly isolated gene and the biochemistry of a new transcription factor. This important and unique book is essential reading for anyone pursuing the analysis of gene expression in model systems or disease states.
Author : Edgar Wingender
Publisher : Wiley-Blackwell
Page : 452 pages
File Size : 41,8 Mb
Release : 1993
Category : Science
ISBN : UOM:39015029969725
A much-needed guide through the overwhelming amount of literature in the field. Comprehensive and detailed, this book combines background information with the most recentinsights. It introduces current concepts, emphasizing the transcriptional control of genetic information. Moreover, it links data on the structure of regulatory proteins with basic cellular processes. Both advanced students and experts will find answers to such intriguing questions as: - How are programs of specific gene repertoires activated and controlled? - Which genes drive and control morphogenesis? - Which genes govern tissue-specific tasks? - How do hormones control gene expression in coordinating the activities of different tissues? An abundant number of clearly presented glossary terms facilitates understanding of the biological background. Speacial feature: over 2200 (!) literature references.
Author : Eric Wong
Publisher : Axolotl Academic Publishing
Page : 283 pages
File Size : 47,9 Mb
Release : 2009
Category : Biology
ISBN : 9780985226114
"Yet another cell and molecular biology book? At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? First, it's a course that I have enjoyed teaching for many years, so I am very familiar with what a student really needs to take away from this class within the time constraints of a semester. Second, because it is a course that many students take, there is a greater opportunity to make an impact on more students' pocketbooks than if I were to start off writing a book for a highly specialized upper- level course. And finally, it was fun to research and write, and can be revised easily for inclusion as part of our next textbook, High School Biology."--Open Textbook Library.
Author : Carsten Carlberg,Ferdinand Molnár
Publisher : Springer Science & Business Media
Page : 210 pages
File Size : 47,6 Mb
Release : 2013-12-11
Category : Medical
ISBN : 9789400779051
This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences. Gene expression is essential in shaping the various phenotypes of cells and tissues and as such, regulation of expression is a fundamental aspect of nearly all processes in physiology, both in healthy and in diseased states. This pivotal role for the regulation of gene expression makes this textbook essential reading from students of all the biomedical sciences in order to be better prepared for their specialized disciplines. A complete understanding of transcription factors and the processes that alter their activity is a major goal of modern life science research. The availability of the whole human genome sequence (and that of other eukaryotic genomes) and the consequent development of next-generation sequencing technologies have significantly changed nearly all areas of the biological sciences. For example, the genome-wide location of histone modifications and transcription factor binding sites, such as provided by the ENCODE consortium, has greatly improved our understanding of gene regulation. Therefore, the focus of this book is the description of the post-genome understanding of gene regulation. The purpose of this book is to provide, in a condensed form, an overview on the present understanding of the mechanisms of gene regulation. The authors are not aiming to compete with comprehensive treatises, but rather focus on the essentials. Therefore, the authors have favored a high figure-to-text ratio following the rule which states that “a picture tells more than thousand words”. The content of the book is based on the lecture course, which is given by Prof. Carlberg since 2001 at the University of Eastern Finland in Kuopio. The book is subdivided into 4 sections and 13 chapters. Following the Introduction there are three sections, which take a view on gene regulation from the perspective of transcription factors, chromatin and non-coding RNA, respectively. Besides its value as a textbook, Mechanisms of Gene Regulation will be a useful reference for individuals working in biomedical laboratories.
Author : Julianne Zedalis,John Eggebrecht
Publisher : Unknown
Page : 1923 pages
File Size : 43,5 Mb
Release : 2017-10-16
Category : Biology
ISBN : 1947172409
Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.
Author : Joseph Locker
Publisher : Garland Science
Page : 502 pages
File Size : 42,5 Mb
Release : 2003-12-16
Category : Science
ISBN : 9781135323622
Transcription factors are important in regulating gene expression, and their analysis is of paramount interest to molecular biologists studying this area. This book looks at the basic machinery of the cell involved in transcription in eukaryotes and factors that control transcription in eukaryotic cells. It examines the regulatory systems that modulate gene expression in all cells,a s well as the more specialized systems that regulate localized gene expression throughout the mammalian organism. Transcription Factors updates classical knowledge with recent advances to provide a full and comprehensive coverage of the field for postgraduates and researchers in molecular biology involved in the study of gene regulation.
Author : Lisa Bartee,Walter Shiner,Catherine Creech
Publisher : Unknown
Page : 128 pages
File Size : 40,7 Mb
Release : 2017
Category : Electronic
ISBN : 1636350410
The Principles of Biology sequence (BI 211, 212 and 213) introduces biology as a scientific discipline for students planning to major in biology and other science disciplines. Laboratories and classroom activities introduce techniques used to study biological processes and provide opportunities for students to develop their ability to conduct research.
Author : David S. Latchman
Publisher : Chapman & Hall
Page : 296 pages
File Size : 50,5 Mb
Release : 1995
Category : Medical
ISBN : UOM:39015047098168
Gene Regulation provides a complete and concise picture of the processes regulating gene expression in higher organisms and man. The second edition of this well reviewed textbook has been extensively updated to reflect the scientific progress made in this area over the last four years.
Author : Athanasios G. Papavassiliou
Publisher : Unknown
Page : 354 pages
File Size : 44,6 Mb
Release : 1997-01-01
Category : Transcription factors
ISBN : 3540615385
Transcription factors are central to the process of eukaryotic gene control. These proteins influence the basal level of gene expression in a cell and can modulate genetic programs by activating or repressing the transcription of particular genes in a cell-type specific or inducible manner. This book provides a state-of-the-art overview of the wide gamut of cellular and viral transcription factors, with emphasis on structure-function interrelations in the context of the nuclear environment, their modes of action in signal-dependent and tissue-specific gene regulation, and their involvement in various aspects of growth, differentiation and tumorigenesis/antioncogenesis.
Author : Anonim
Publisher : Elsevier
Page : 280 pages
File Size : 53,8 Mb
Release : 2004-03-19
Category : Science
ISBN : 0080522416
Protein Transcription is a key element of cellular and organ regulation. Proteins in Eukaryotic Transcription covers structure and function of all major elements associated with transcription. Mechanism of RNA polymerase I Transcription Structure and function of RNA Polymerase II Structure and function of the TFIID complex Functional properties of Chromatin Remodeling Enzymes Posttranslational modification
Author : Martin J. Tymms
Publisher : Springer Science & Business Media
Page : 304 pages
File Size : 51,9 Mb
Release : 2008-02-03
Category : Medical
ISBN : 9781592596867
The effort to sequence the human genome is now moving toward a c- clusion. As all of the protein coding sequences are described, an increasing emphasis will be placed on understanding gene function and regulation. One important aspect of this analysis is the study of how transcription factors re- late transcriptional initiation by RNA polymerase II, which is responsible for transcribing nuclear genes encoding messenger RNAs. The initiation of Class II transcription is dependent upon transcription factors binding to DNA e- ments that include the core or basal promoter elements, proximal promoter elements, and distal enhancer elements. General initiation factors are involved in positioning RNA polymerase II on the core promoter, but the complex - teraction of these proteins and transcriptional activators binding to DNA e- ments outside the core promoter regulate the rate of transcriptional initiation. This initiation process appears to be a crucial step in the modulation of mRNA levels in response to developmental and environmental signals. Transcription Factor Protocols provides step-by-step procedures for key techniques that have been developed to study DNA sequences and the protein factors that regulate the transcription of protein encoding genes. This volume is aimed at providing researchers in the field with the well-detailed protocols that have been the hallmark of previous volumes of the Methods in Molecular TM Biology series.
Author : Cold Spring Harbor Laboratory
Publisher : Unknown
Page : 214 pages
File Size : 44,7 Mb
Release : 1985
Category : Science
ISBN : UOM:39015023216982