Transduction Mechanisms Of Drug Stimuli

Author : Francis C. Colpaert,Robert L. Balster
Publisher : Springer Science & Business Media
Page : 255 pages
File Size : 50,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642732232

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Transduction Mechanisms of Drug Stimuli by Francis C. Colpaert,Robert L. Balster Pdf

In this book the latest data available on transduction mechanisms of drug stimuli are presented. A common theme underlying the chapter in this volume is the recognition that drugs can act as stimuli, in much the same manner as external events do. Accordingly, the papers focus on the mechanisms by which these stimuli are transduced at different levels of analysis, such as the behavioral, pharmacological, and molecular levels. Some chapters discuss the mechanisms of transduction of the discriminative effects of several important classes of drugs, while others deal with the methods and research strategies by which these mechanisms can be analyzed. Collectively, the papers in this volume reflect the current status of knowledge in the rapidly expanding field of behavioral pharmacology.

Author : Paul Bevan
Publisher : Psychology Press
Page : 505 pages
File Size : 55,7 Mb
Release : 2013-05-13
Category : Psychology
ISBN : 9781134737666

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Behavioral Pharmacology of 5-ht by Paul Bevan Pdf

This volume reviews the current state of research within the behavioral pharmacology of 5-HT. The book opens exciting new approaches to the interdisciplinary study of behavior and pharmacology with special reference to ethology, endocrinology, neuroanatomy and comparative aspects of drug action, and notes new developments in therapeutic drugs of the future.

Author : Richard A. Glennon,Richard Young
Publisher : John Wiley & Sons
Page : 534 pages
File Size : 51,5 Mb
Release : 2011-08-04
Category : Medical
ISBN : 9781118023143

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Drug Discrimination by Richard A. Glennon,Richard Young Pdf

Drug discrimination: a practical guide to its contributions to the invention of new chemical entities and evaluations of new or known pharmacological agents Drug discrimination can be described as a "drug detection" procedure that uses a pharmacologically active agent as the subjective stimulus. Although the procedure does require some effort to implement, it can be an extremely important tool for understanding drug action. Whereas medicinal chemists should come to learn the types of information that drug discrimination studies can offer, pharmacologists and psychologists might come to realize how medicinal chemists can apply the types of information that the paradigm routinely provides. Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies provides in-depth analyses of the nature and use of drugs as discriminative stimuli and bridges some of the numerous gaps between medicinal chemistry, pharmacology, and psychology. Stressing the practical aspects of drug discrimination, including types of procedures, study design, data, and interpretation, the book details the advantages and limitations of drug discrimination studies versus other pharmacologic evaluations. Practical information from leading researchers in the field addresses specific topics and techniques that are of interest in drug discovery, evaluation, and development. A groundbreaking new guide to the applications of drug discrimination studies for medicinal chemistry and neuroscience, Drug Discrimination is essential for any scientist, researcher, or student whose interests involve the design, development, and/or action of drugs acting at the level of the central nervous system.

Author : Ronald P. Hammer, Jr.
Publisher : CRC Press
Page : 440 pages
File Size : 44,9 Mb
Release : 1992-11-24
Category : Science
ISBN : 0849379326

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The Neurobiology of Opiates by Ronald P. Hammer, Jr. Pdf

This collection of reports by eminent researchers provides a complete description of the effects of opiates on the central nervous system of developing and adult animals. The work is useful to investigators interested in opiate neurobiology and clinicians seeking to understand opiate abuse. The Neurobiology of Opiates is organized into sections which describe the wide diversity of opiate actions from cellular and molecular to developmental and behavioral. Normal functions of endogenous opioid peptides and functional effects of exogenous opiate exposure are examined using the latest in vivo and in vitro methods. Particular emphasis is placed on the physiological and pharmacological effects of opiate dependence and withdrawal, in addition to the mechanism of opiate reinforcement and molecular mechanisms of opiate regulation. Opiate actions on the developing brain and in the hypothalamo-pituitary-adrenal axis are also discussed. This comprehensive text provides readers with the latest results and challenges them with new directions for opiate research.

Author : Mark A. Berkley,William C. Stebbins
Publisher : Wiley-Interscience
Page : 552 pages
File Size : 48,5 Mb
Release : 1990-01-16
Category : Medical
ISBN : UOM:39015017749618

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Comparative Perception, Basic Mechanisms by Mark A. Berkley,William C. Stebbins Pdf

This volume features sections on discrimination, localization and development, with chapters on several sensory modalities including vision, hearing, taste and touch. It covers a variety of problems related to such sensory and perceptual phenomena as contrast sensitivity, sound localization, movement discrimination and development. The section on development focuses on animal studies but also includes related studies on preverbal human children. The text has been aimed at biologists, psychologists, neuroscientists, graduate students in sensory biology and psychology, and researchers in related fields.

Author : Steven B. Karch, MD, FFFLM
Publisher : CRC Press
Page : 1156 pages
File Size : 47,6 Mb
Release : 2019-07-17
Category : Law
ISBN : 1420048295

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Drug Abuse Handbook by Steven B. Karch, MD, FFFLM Pdf

This is the handbook that professionals who deal with problems related to drugs and drug abuse have been waiting for. The impressive list of more than 80 contributors, each experts and leaders in their field, testifies to the importance of this outstanding new handbook. The volume contains detailed discussions of drug-related issues in criminalistics, pathology, and toxicology. Impairment testing and the pharmacokinetics of abused drugs are examined in detail, as is the field of workplace drug testing, the use of alternate testing matrices, drugs in sports, addiction medicine, and drug-related medical emergencies. The handbook focuses on the most urgent drug abuse-related problems of today An entire section is devoted to alcohol abuse, including a scientific appraisal of the most common drunk driving defenses, complete with sample calculations. Problems of postmortem toxicology are thoroughly detailed and an appendix lists key references for the most widely used analytic methods. An in-depth analysis of legal questions, including fetal rights and workplace testing Examination of the principles of addiction medicine and how doctors handle substance abuse problems A section addressing drug use by athletes, including a summary of current Olympic Committee Regulations regarding substance use and the latest information on detecting abuse of Human Growth Hormone and Erythropoietin Whether you are approaching the issue of drug abuse from a medical, psychological, toxicological, or legal perspective, the Drug Abuse Handbook is the most authoritative and complete resource available.

Author : Charles R. Schuster,Michael J. Kuhar
Publisher : Springer Science & Business Media
Page : 675 pages
File Size : 48,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642609633

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Pharmacological Aspects of Drug Dependence by Charles R. Schuster,Michael J. Kuhar Pdf

Now, in one volume, the latest research from the areas of molcular biology, neurochemistry and behavior analysis of drug abuse and dependence, with, wherever possible, an integration of the data from these various levels of analysis. The ensuing reports point to the complexity of the phenomenon of abuse and dependence and clearly demonstrate that it is determined by a variety of variables from molecular biology and genetics through behavioral history. This complexity is shown, however, to be responsive to rigorous scientific analysis and our success to date gives rise to hope that this distressing public health problem can ultimately be brought under control. Each of the chapters is written by a leading researcher in the field.

Author : United States. Food and Drug Administration
Publisher : Unknown
Page : 780 pages
File Size : 55,6 Mb
Release : 1996
Category : Advertising
ISBN : MINN:31951D01398220Q

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Regulation of Cigarettes and Smokeless Tobacco Under the Federal Food, Drug, and Cosmetic Act by United States. Food and Drug Administration Pdf

Author : Anonim
Publisher : Unknown
Page : 340 pages
File Size : 41,8 Mb
Release : 1995
Category : Cigarette habit
ISBN : MINN:31951D01191208T

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Nicotine in Cigarettes and Smokeless Tobacco Products is a Drug and These Products are Nicotine Delivery Devices Under the Federal Food, Drug, and Cosmetic Act by Anonim Pdf

Author : Barry Leonard
Publisher : DIANE Publishing
Page : 336 pages
File Size : 55,6 Mb
Release : 1999-09
Category : Electronic
ISBN : 9780788182228

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Nicotine in Cigarettes and Smokeless Tobacco Products Is a Drug and These Products Are Nicotine Delivery Devices and Under the Federal Food, Drug and Cosmetic Act - Appendices by Barry Leonard Pdf

Includes: background on nicotine pharmacology; corporate relationship between British-American Tobacco Co. and Brown and Williamson Tobacco Co.; FDA letters to tobacco manufacturers; bibliography of industry-funded research; marketing of cigarettes and smokeless tobacco in the U.S.; citizen petitions and submitted comments; statements by David A. Kessler, M.D., Commissioner of Food and Drugs, on nicotine-containing cigarettes and on the control and manipulation of nicotine in cigarettes; and remarks by David A. Kessler, M.D., The Samuel Rubin Program, The Columbia University School of Law, March 8, 1995.

Author : Ralph E. Tarter,Robert T. Ammerman,Peggy J. Ott
Publisher : Springer Science & Business Media
Page : 582 pages
File Size : 43,6 Mb
Release : 2013-03-09
Category : Medical
ISBN : 9781475729139

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Handbook of Substance Abuse by Ralph E. Tarter,Robert T. Ammerman,Peggy J. Ott Pdf

A review of the literature pertaining to the neurobehavioral pharmacology of abusable drugs, this is the only book to survey each of the eleven classes of addictive drugs from the perspectives of neurological, behavioral, and clinical pharmacology. Designed to serve as a companion text to the DSM-IV manual, the Handbook provides comprehensive information about each drug and drug class having abuse potential with respect to their pharmaceutical mechanisms and actions.

Author : Elaine Sanders-Bush
Publisher : Springer Science & Business Media
Page : 394 pages
File Size : 55,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461245605

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The Serotonin Receptors by Elaine Sanders-Bush Pdf

Serotonin (5-HT) was isolated and chemically characterized nearly four decades ago, and is now generally accepted to function as a neurotransmitter and neuromodulatory agent. Early research focused on the measurement of concentrations, synthesis, and metabolism of 5-HT, and only recently has the focus shifted to characterization of 5-HT receptors. Gaddum and Picarelli first sug gested in 1957 that the effect of 5-HT in the guinea pig ileum is mediated by two pharmacologically distinguishable receptors; however, the possibility of dual5-HT receptors was not explored systematically or successfully until the past decade. It is now clear that more, perhaps many more, subclasses of 5-HT receptors exist. The purpose of this book is to provide an up-to-date report on 5-HT receptors. This is a difficult task considering the astonishing speed at which research in this field is expanding. As the first of what we can expect to be a steady stream of monographs focusing on 5-HT receptors, the book confirms that we are in an exciting time in the history of 5-HT. For those of us who have been work ing on 5-HT for many years, our dream of equal progress and recognition with the more extensively studied catecholamines is finally being realized. We now have a Serotonin Club that held its first international scientific meeting in 1987, and several more international meetings are in the planning stages.

Author : Ali S. Faqi
Publisher : Elsevier
Page : 1074 pages
File Size : 43,5 Mb
Release : 2024-02-11
Category : Medical
ISBN : 9780323984621

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A Comprehensive Guide to Toxicology in Nonclinical Drug Development by Ali S. Faqi Pdf

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy Includes the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology

Author : Committee to Study Medication Development and Research at the National Institute on Drug Abuse,Institute of Medicine
Publisher : National Academies Press
Page : 271 pages
File Size : 55,5 Mb
Release : 1995-02-03
Category : Medical
ISBN : 9780309587914

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The Development of Medications for the Treatment of Opiate and Cocaine Addictions by Committee to Study Medication Development and Research at the National Institute on Drug Abuse,Institute of Medicine Pdf

Pharmacotherapy, as a means of treating drug addiction in combination with other treatment modalities, has received too little attention from the research community, the pharmaceutical industry, public health officials, and the federal government. Medications to combat drug addiction could have an enormous impact on the medical consequences and socioeconomic problems associated with drug abuse, both for drug-dependent individuals and for American society as a whole. This book examines the current environment for and obstacles to the development of anti-addiction medications, specifically those for treating opiate and cocaine addictions, and proposes incentives for the pharmaceutical industry that would help overcome those obstacles and accelerate the development of anti-addiction medications.

Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
Page : 502 pages
File Size : 40,6 Mb
Release : 2006-09-29
Category : Medical
ISBN : 9781420005844

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TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by Wolfgang B. Liedtke, MD, PH.D. Pdf

Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st