Translational Radiation Oncology

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Translational Radiation Oncology

Adam Eltorai,Jeffrey A. Bakal,Daniel Kim,David Wazer
Translational Radiation Oncology Book PDF

Author : Adam Eltorai,Jeffrey A. Bakal,Daniel Kim,David Wazer
Publisher : Elsevier
Page : 736 pages
File Size : 48,5 Mb
Release : 2023-08-01
Category : Science
ISBN : 9780323884242

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Translational Radiation Oncology by Adam Eltorai,Jeffrey A. Bakal,Daniel Kim,David Wazer Pdf

Translational Radiation Oncology covers the principles of evidence-based medicine and applies them to the design of translational research. The book provides valuable discussions on the critical appraisal of published studies and recent developments in radiation oncology, allowing readers to learn how to evaluate the quality of such studies with respect to measuring outcomes and make effective use of all types of evidence. By reading this book, researchers have access to a practical approach to help them navigate challenging considerations in study design and implementation. It is a valuable resource for researchers, oncologists and members of biomedical field who want to understand more about translational research applied to the field of radiation oncology. Translational medicine serves as an indispensable tool in grant writing and funding efforts, so understanding how to apply its principles to research is necessary to guarantee that results will be impactful to patients. Provides a clear process for understanding, designing, executing and analyzing clinical and translational research Presents practical, step-by-step guidance to help readers take ideas from the lab to the bedside Written by a team of oncologists, radiologists and clinical research experts that fully cover translational research in radiation oncology

Translational Research in Cancer

Sivapatham Sundaresan,Yeun-Hwa Gu
Translational Research in Cancer Book PDF

Author : Sivapatham Sundaresan,Yeun-Hwa Gu
Publisher : BoD – Books on Demand
Page : 212 pages
File Size : 40,7 Mb
Release : 2021-02-03
Category : Medical
ISBN : 9781838805340

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Translational Research in Cancer by Sivapatham Sundaresan,Yeun-Hwa Gu Pdf

Translational research in oncology benefits from an abundance of knowledge resulting from genome-scale studies concerning the molecular pathways involved in tumorigenesis. Translational oncology represents a bridge between basic research and clinical practice in cancer medicine. The vast majority of cancer cases are due to environmental risk factors. Many of these environmental factors are controllable lifestyle choices. Experimental cancer treatments are studied in clinical trials to compare the proposed treatment to the best existing treatment through translational research. The key features of the book include: 1) New screening for the development of radioprotectors: radioprotection and anti-cancer effect of β-Glucan (Enterococcus faecalis) 2) Translational perspective on hepatocellular carcinoma 3) Brachytherapy for endometrial cancer 4) Discovery of small molecule inhibitors for histone methyltransferases in cancer

Increasing the Therapeutic Ratio of Radiotherapy

Philip J. Tofilon,Kevin Camphausen
Increasing the Therapeutic Ratio of Radiotherapy Book PDF

Author : Philip J. Tofilon,Kevin Camphausen
Publisher : Springer
Page : 280 pages
File Size : 53,8 Mb
Release : 2016-11-21
Category : Medical
ISBN : 9783319408545

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Increasing the Therapeutic Ratio of Radiotherapy by Philip J. Tofilon,Kevin Camphausen Pdf

Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy. In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations. Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection). Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.

Clinical Radiation Oncology

William Small, Jr.,Nancy J. Tarbell,Min Yao
Clinical Radiation Oncology Book PDF

Author : William Small, Jr.,Nancy J. Tarbell,Min Yao
Publisher : John Wiley & Sons
Page : 944 pages
File Size : 55,9 Mb
Release : 2017-03-23
Category : Medical
ISBN : 9781119341215

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Clinical Radiation Oncology by William Small, Jr.,Nancy J. Tarbell,Min Yao Pdf

This fully updated and enhanced third edition offers a highly practical, application-based review of the biological basis of radiation oncology and the clinical efficacy of radiation therapy. Revised edition of the classic reference in radiation oncology from Dr. C.C. Wang, whose practical approach to clinical application was legendary Includes the latest developments in the field: intensity modulated radiation therapy (IMRT), image guided radiation therapy, and particle beam therapy Includes two brand new chapters Palliative Radiotherapy, and Statistics in Radiation Oncology Features a vibrant and extremely comprehensive head and neck section Provides immediately applicable treatment algorithms for each tumor

Radiobiology Self-Assessment Guide

Jennifer Yu, MD, PhD,Mohamed Abazeed, MD, PhD
Radiobiology Self Assessment Guide Book PDF

Author : Jennifer Yu, MD, PhD,Mohamed Abazeed, MD, PhD
Publisher : Springer Publishing Company
Page : 520 pages
File Size : 52,8 Mb
Release : 2016-11-03
Category : Medical
ISBN : 9781617052910

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Radiobiology Self-Assessment Guide by Jennifer Yu, MD, PhD,Mohamed Abazeed, MD, PhD Pdf

Radiobiology Self-Assessment Guide--a companion to the Radiation Oncology Self-Assessment Guide and Physics in Radiation Oncology Self-Assessment Guide--is a comprehensive review for practitioners of radiation oncology looking to enhance their knowledge of radiobiology. It covers in depth the principles of radiobiology as applied to radiation oncology along with their clinical applications. To foster retention of key concepts and data, the resource utilizes a user-friendly "flash card" question and answer format with over 700 questions. The questions are supported by detailed answers and rationales along with reference citations for source information. The guide is comprised of 29 chapters and cover topics commonly found on the radiation and cancer biology portion of the radiation oncology board examination. Aspects of basic radiobiology covered include fundamentals such as cell cycle, cell survival curves and interactions of radiation with matter, and acute and long-term sequelae of radiation. Modern concepts such as immunotherapy, radiogenomics, and normal and cancer stem cells are also included. Focused and authoritative, this must-have review provides the expertise of faculty from the Department of Radiation Oncology at the Cleveland Clinic Taussig Cancer Institute and Lerner Research Institute. Key Features: Provides a comprehensive study guide for the Radiation and Cancer Biology portion to the Radiation Oncology Board Exam Includes more than 700 questions with detailed answers and rationales on flip pages for easy, flash card-like review Includes essential review of cancer biology concepts such as immunotherapy, stem cells, gene therapy, chemotherapy and targeted agents Content provided by a vast array of contributors, including attending radiation oncology physicians, physicists, and radiation oncology residents

Stereotactic Body Radiation Therapy

Simon S. Lo,Bin S. Teh,Jiade J. Lu,Tracey E. Schefter
Stereotactic Body Radiation Therapy Book PDF

Author : Simon S. Lo,Bin S. Teh,Jiade J. Lu,Tracey E. Schefter
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 55,9 Mb
Release : 2012-08-28
Category : Medical
ISBN : 9783642256042

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Stereotactic Body Radiation Therapy by Simon S. Lo,Bin S. Teh,Jiade J. Lu,Tracey E. Schefter Pdf

Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.

Immunotherapy in Translational Cancer Research

Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran
Immunotherapy in Translational Cancer Research Book PDF

Author : Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran
Publisher : John Wiley & Sons
Page : 306 pages
File Size : 45,9 Mb
Release : 2018-05-01
Category : Medical
ISBN : 9781118123225

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Immunotherapy in Translational Cancer Research by Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran Pdf

A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

Experimentation with Human Subjects

Paul Abraham Freund
Experimentation with Human Subjects Book PDF

Author : Paul Abraham Freund
Publisher : George Braziller
Page : 492 pages
File Size : 55,8 Mb
Release : 1970
Category : Medical
ISBN : 0807605425

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Experimentation with Human Subjects by Paul Abraham Freund Pdf

Most of the essays appeared in the spring 1969 issue of Dædalus.

Advances in Radiation Oncology in Lung Cancer

Branislav Jeremić
Advances in Radiation Oncology in Lung Cancer Book PDF

Author : Branislav Jeremić
Publisher : Springer Nature
Page : 1128 pages
File Size : 51,6 Mb
Release : 2023-08-14
Category : Science
ISBN : 9783031348471

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Advances in Radiation Oncology in Lung Cancer by Branislav Jeremić Pdf

This is the third, completely updated edition of a comprehensive book in which many of the world’s leading lung cancer specialists discuss the recent advances in the radiation oncology of lung cancer and reflect on the latest research findings in lung cancer and other intrathoracic malignancies. Lung cancer remains the major cancer killer in both sexes worldwide. It is so despite significant progress in recent decades in both diagnostic and treatment approaches. New biological and technological advances in this field are now faster incorporated in the overall decision-making process and are bringing fast and substantial improvements in both survivals and quality of life of lung cancer patients. Optimized patient-oriented approaches are reality of the third decade of this millennium and thoracic oncologists strive towards nothing but seamlessly delivering it in a continuous battle with lung cancer. The first three sections of the work cover the basic science of lung cancer, clinical investigations, including histology and staging, and a wide range of fundamental treatment considerations. Current treatment strategies for small cell and non-small cell lung cancer as well as other intrathoracic malignancies are then explained and evaluated in detail, with due attention to novel approaches that promise further improvements in outcome. The various types of treatment-related toxicity are discussed, and quality of life studies and prognostic factors are also considered. After evaluating the latest technological and biological advances, including stereotactic radiotherapy, and particle therapy, the book concludes by thorough consideration of specific aspects of clinical research in lung cancer. This concise yet comprehensive book is an invaluable resource for radiation oncologists.

Radiation Oncology Physics

International Atomic Energy Agency
Radiation Oncology Physics Book PDF

Author : International Atomic Energy Agency
Publisher : IAEA
Page : 704 pages
File Size : 43,6 Mb
Release : 2005
Category : Business & Economics
ISBN : UOM:39015060547364

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Radiation Oncology Physics by International Atomic Energy Agency Pdf

This publication is aimed at students and teachers involved in teaching programmes in field of medical radiation physics, and it covers the basic medical physics knowledge required in the form of a syllabus for modern radiation oncology. The information will be useful to those preparing for professional certification exams in radiation oncology, medical physics, dosimetry or radiotherapy technology.

Adaptive Radiation Therapy

X. Allen Li
Adaptive Radiation Therapy Book PDF

Author : X. Allen Li
Publisher : CRC Press
Page : 404 pages
File Size : 47,7 Mb
Release : 2011-01-27
Category : Medical
ISBN : 9781439816356

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Adaptive Radiation Therapy by X. Allen Li Pdf

Modern medical imaging and radiation therapy technologies are so complex and computer driven that it is difficult for physicians and technologists to know exactly what is happening at the point-of-care. Medical physicists responsible for filling this gap in knowledge must stay abreast of the latest advances at the intersection of medical imaging an

Textbook of Radiation Oncology

Steven A. Leibel,Theodore L. Phillips
Textbook of Radiation Oncology Book PDF

Author : Steven A. Leibel,Theodore L. Phillips
Publisher : Unknown
Page : 0 pages
File Size : 48,6 Mb
Release : 2004
Category : Medical
ISBN : 0721600263

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Textbook of Radiation Oncology by Steven A. Leibel,Theodore L. Phillips Pdf

Thoroughly revised and updated, the 2nd Edition presents all of the latest advances in the field, including the most recent technologies and techniques. For each tumor site discussed, readers will find unparalleled coverage of multiple treatment plans, histology and biology of the tumor, its anatomic location and routes of spread, and utilization of specialized techniques. This convenient source also reviews all of the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Comprehensively reviews each topic, with a distinct clinical orientation throughout. Serves as a foundation for the basic principles that underlie the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, intraoperative irradation, and more. Guides readers through all stages of treatment application with step-by-step techniques for the assessment and implementation of radiotherapeutic options. Presents latest information on brachytherapy * 3-dimensional conformal treatment planning * sterotactic radiosurgery * and radiolabeled antibodies. Discusses the recent use of radiotherapy in the treatment of primary lymphoma, leukemia, multiple myeloma, and cancers of the prostate and central nervous system. Includes the latest AJCC staging system guidelines. Offers the latest advances in techniques, allowing you to deliver doses precisely to areas affected by malignancy and spare healthy tissue. Presents new chapters on the hottest topics including Three Dimensional Conformal Radiotherapy * Intensity Modulated Radiotherapy * Breathing Synchronized Radiotherapy * Plasma Cell Tumors: Multiple Myeloma and Solitary Plasmacytoma * Extracranial Stereotactic Radioablation * and [Imaging of the] Head and Neck * Thorax * Abdomen * and Pelvis.

Imaging and Interventional Radiology for Radiation Oncology

Regina G.H. Beets-Tan,Wim J. G. Oyen,Vincenzo Valentini
Imaging and Interventional Radiology for Radiation Oncology Book PDF

Author : Regina G.H. Beets-Tan,Wim J. G. Oyen,Vincenzo Valentini
Publisher : Springer
Page : 0 pages
File Size : 40,5 Mb
Release : 2020-08-11
Category : Medical
ISBN : 3030382605

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Imaging and Interventional Radiology for Radiation Oncology by Regina G.H. Beets-Tan,Wim J. G. Oyen,Vincenzo Valentini Pdf

This book, edited by leading experts in radiology, nuclear medicine, and radiation oncology, offers a wide-ranging, state of the art overview of the specifics and the benefits of a multidisciplinary approach to the use of imaging in image-guided radiation treatments for different tumor types. The entire spectrum of the most important cancers treated by radiation are covered, including CNS, head and neck, lung, breast, gastrointestinal, genitourinary, and gynecological tumors. The opening sections of the book address background issues and a range of important technical aspects. Detailed information is then provided on the use of different imaging techniques for T staging and target volume delineation, response assessment, and follow-up in various parts of the body. The focus of the book ensures that it will be of interest for a multidisciplinary forum of readers comprising radiation oncologists, nuclear medicine physicians, radiologists and other medical professionals.

Big Data in Radiation Oncology

Jun Deng,Lei Xing
Big Data in Radiation Oncology Book PDF

Author : Jun Deng,Lei Xing
Publisher : CRC Press
Page : 355 pages
File Size : 54,7 Mb
Release : 2019-03-07
Category : Science
ISBN : 9781351801119

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Big Data in Radiation Oncology by Jun Deng,Lei Xing Pdf

Big Data in Radiation Oncology gives readers an in-depth look into how big data is having an impact on the clinical care of cancer patients. While basic principles and key analytical and processing techniques are introduced in the early chapters, the rest of the book turns to clinical applications, in particular for cancer registries, informatics, radiomics, radiogenomics, patient safety and quality of care, patient-reported outcomes, comparative effectiveness, treatment planning, and clinical decision-making. More features of the book are: Offers the first focused treatment of the role of big data in the clinic and its impact on radiation therapy. Covers applications in cancer registry, radiomics, patient safety, quality of care, treatment planning, decision making, and other key areas. Discusses the fundamental principles and techniques for processing and analysis of big data. Address the use of big data in cancer prevention, detection, prognosis, and management. Provides practical guidance on implementation for clinicians and other stakeholders. Dr. Jun Deng is a professor at the Department of Therapeutic Radiology of Yale University School of Medicine and an ABR board certified medical physicist at Yale-New Haven Hospital. He has received numerous honors and awards such as Fellow of Institute of Physics in 2004, AAPM Medical Physics Travel Grant in 2008, ASTRO IGRT Symposium Travel Grant in 2009, AAPM-IPEM Medical Physics Travel Grant in 2011, and Fellow of AAPM in 2013. Lei Xing, Ph.D., is the Jacob Haimson Professor of Medical Physics and Director of Medical Physics Division of Radiation Oncology Department at Stanford University. His research has been focused on inverse treatment planning, tomographic image reconstruction, CT, optical and PET imaging instrumentations, image guided interventions, nanomedicine, and applications of molecular imaging in radiation oncology. Dr. Xing is on the editorial boards of a number of journals in radiation physics and medical imaging, and is recipient of numerous awards, including the American Cancer Society Research Scholar Award, The Whitaker Foundation Grant Award, and a Max Planck Institute Fellowship.

Surface Guided Radiation Therapy

Jeremy David Page Hoisak,Adam Brent Paxton,Benjamin James Waghorn,Todd Pawlicki
Surface Guided Radiation Therapy Book PDF

Author : Jeremy David Page Hoisak,Adam Brent Paxton,Benjamin James Waghorn,Todd Pawlicki
Publisher : CRC Press
Page : 515 pages
File Size : 54,5 Mb
Release : 2020-02-13
Category : Medical
ISBN : 9780429951800

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Surface Guided Radiation Therapy by Jeremy David Page Hoisak,Adam Brent Paxton,Benjamin James Waghorn,Todd Pawlicki Pdf

Surface Guided Radiation Therapy provides a comprehensive overview of optical surface image guidance systems for radiation therapy. It serves as an introductory teaching resource for students and trainees, and a valuable reference for medical physicists, physicians, radiation therapists, and administrators who wish to incorporate surface guided radiation therapy (SGRT) into their clinical practice. This is the first book dedicated to the principles and practice of SGRT, featuring: Chapters authored by an internationally represented list of physicists, radiation oncologists and therapists, edited by pioneers and experts in SGRT Covering the evolution of localization systems and their role in quality and safety, current SGRT systems, practical guides to commissioning and quality assurance, clinical applications by anatomic site, and emerging topics including skin mark-less setups. Several dedicated chapters on SGRT for intracranial radiosurgery and breast, covering technical aspects, risk assessment and outcomes. Jeremy Hoisak, PhD, DABR is an Assistant Professor in the Department of Radiation Medicine and Applied Sciences at the University of California, San Diego. Dr. Hoisak’s clinical expertise includes radiosurgery and respiratory motion management. Adam Paxton, PhD, DABR is an Assistant Professor in the Department of Radiation Oncology at the University of Utah. Dr. Paxton’s clinical expertise includes patient safety, motion management, radiosurgery, and proton therapy. Benjamin Waghorn, PhD, DABR is the Director of Clinical Physics at Vision RT. Dr. Waghorn’s research interests include intensity modulated radiation therapy, motion management, and surface image guidance systems. Todd Pawlicki, PhD, DABR, FAAPM, FASTRO, is Professor and Vice-Chair for Medical Physics in the Department of Radiation Medicine and Applied Sciences at the University of California, San Diego. Dr. Pawlicki has published extensively on quality and safety in radiation therapy. He has served on the Board of Directors for the American Society for Radiology Oncology (ASTRO) and the American Association of Physicists in Medicine (AAPM).