Translational Research In Cancer

Author : Dong-Young Noh,Wonshik Han,Masakazu Toi
Publisher : Springer Nature
Page : 630 pages
File Size : 42,7 Mb
Release : 2021-05-13
Category : Medical
ISBN : 9789813296206

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Translational Research in Breast Cancer by Dong-Young Noh,Wonshik Han,Masakazu Toi Pdf

This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.

Author : Sivapatham Sundaresan,Yeun-Hwa Gu
Publisher : Unknown
Page : 128 pages
File Size : 51,5 Mb
Release : 2021
Category : Cancer
ISBN : 1789848377

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Translational Research in Cancer by Sivapatham Sundaresan,Yeun-Hwa Gu Pdf

Author : Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson
Publisher : John Wiley & Sons
Page : 396 pages
File Size : 47,8 Mb
Release : 2015-12-21
Category : Medical
ISBN : 9781118468579

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Targeted Therapy in Translational Cancer Research by Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson Pdf

Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities

Author : Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran
Publisher : John Wiley & Sons
Page : 306 pages
File Size : 41,9 Mb
Release : 2018-05-01
Category : Medical
ISBN : 9781118123225

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Immunotherapy in Translational Cancer Research by Laurence J. N. Cooper,Elizabeth A. Mittendorf,Judy Moyes,Sabitha Prabhakaran Pdf

A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care Filled with the concepts, examples, and approaches for developing individualized therapy Explores the breath of treatments that reflect the complexity of the immune system itself Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

Author : Rakesh K. Srivastava
Publisher : World Scientific
Page : 766 pages
File Size : 43,5 Mb
Release : 2014
Category : Medical
ISBN : 9789814489072

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Lost in Translation by Rakesh K. Srivastava Pdf

This book is all about the definition and finding ways to prioritize and accelerate translation research in biomedical sciences and rapidly turning new knowledge into first-in-human studies. It represents an effort to bring together scientists active in various areas of translational research to share science and, hopefully, generate new ideas and potential collaborations. The book provides a comprehensive overview of translational work that includes significant discoveries and pioneering contributions, e.g., in immunology, gene therapy, stem cells and population sciences. It may be used as an advanced textbook by graduate students and even ambitious undergraduates in biomedical sciences. It is also suitable for non-experts, i.e. medical doctors, who wish to have an overview of some of the fundamental models in translational research. Managing the translational enterprise remains a work in progress. The world is changing rapidly, and the scientific world needs to seek new ways to ensure that discoveries get translated for patients efficiently and as quickly as possible. In addition, everyone expects the investment in biomedical research should pay dividends through effective therapeutic solutions. This unique project provides a broad collaborative approach of the international scientific team to present its view and opinion how to cross barriers to incentives for translational research in medical sciences. Contributing to the book is an international team of prominent co-authors. The book consists of unique and widely treated topics, and includes new hypotheses, data and analyses. Sample Chapter(s). Foreword (41 KB). Chapter 1: Translational Research: Lost in Complexity (305 KB). Contents: Barriers to Incentives for Translational Research; Integrating Emerging Science into Clinical Practice; Organization, Prioritization, Review and Funding for the Translational Research; Translational Sciences in Cancer Research; Translational Science in Infectious Diseases; Translation Research in Endocrinology and Nutrition; Translation Research and Neuroscience; Stem Cells and Translation Research; The Role of Translational Research in Public Health and Behavioral Sciences; Translational Epidemiology, Biostatistics and Informatics; Translational Research Outcomes and Resources. Readership: Graduate students and researchers in cancer research, pharmacology/drug discovery/pharmaceuticals, immunology, infectious diseases and public health.

Author : Erika Ruiz-Garcia,Horacio Astudillo-de la Vega
Publisher : Springer Nature
Page : 171 pages
File Size : 53,6 Mb
Release : 2019-11-11
Category : Science
ISBN : 9783030241001

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Translational Research and Onco-Omics Applications in the Era of Cancer Personal Genomics by Erika Ruiz-Garcia,Horacio Astudillo-de la Vega Pdf

Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory into clinical application to reduce incidence of cancer, morbidity and mortality. On the other hand, personalized medicine in cancer is the concept that selection of a treatment should be tailored according to the individual patient’s specific genomic characteristics, including mutations, chromosomal aberrations, protein interactions, and SNPs, and even more, taking into account the inmume system, the metabolism and maybe in the next future also the microbiome.

Author : Erwei Song,Hai Hu
Publisher : Springer
Page : 0 pages
File Size : 53,5 Mb
Release : 2018-12-11
Category : Medical
ISBN : 9811355509

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Translational Research in Breast Cancer by Erwei Song,Hai Hu Pdf

This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer. With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer. In addition, major advances in cancer biology, immunology, genomics and metabolism have broken new ground for designing therapeutic approaches and selecting appropriate treatments on the basis of more precise information on the individual patient. As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research.

Author : Perumana R. Sudhakaran,Oommen V. Oommen,M. Radhakrishna Pillai
Publisher : Springer Science & Business Media
Page : 168 pages
File Size : 52,6 Mb
Release : 2013-10-25
Category : Medical
ISBN : 9788132215332

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Perspectives in Cancer Prevention-Translational Cancer Research by Perumana R. Sudhakaran,Oommen V. Oommen,M. Radhakrishna Pillai Pdf

Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory or population studies into clinical application to reduce incidence of cancer , morbidity and mortality. It is becoming increasingly evident that cancer is a preventable disease. The IVth International Symposium on Translational Cancer Research held in Udaipur, India in December 2011, discussed various aspects of the biological processes in cancer cells and approaches to cancer prevention. A few contributions from this meeting are presented in this book, providing an in depth analysis of data on cancer prevention and therapeutics. These contributions are either critical reviews or research reports. The topics discussed include evidence-based nutritional recommendations for cancer patients and survivors, risk factors such as stress, enrichment of tumour stem cells by anticancer drug treatment contributing to tumour recurrence and the mechanism of anticancer effects of various natural products. Chemosensitizing effect of curcumin, anti-cancer effect of products from neem, action of sulforaphane and cytotoxic effect of a number of novel synthetic coordination complexes of trace metals have been discussed. Novel molecular targets of angiogenesis and molecular basis of the gender bias to thyroid cancer have also been discussed . This book provides useful information on translational cancer research to clinicians and biomedical scientists.

Author : Håkan Mellstedt,Dirk Schrijvers,Dimitrios Bafaloukos,Richard Griel
Publisher : CRC Press
Page : 192 pages
File Size : 54,6 Mb
Release : 2007-05-21
Category : Medical
ISBN : 9780203092422

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ESMO Handbook on Principles of Translational Research by Håkan Mellstedt,Dirk Schrijvers,Dimitrios Bafaloukos,Richard Griel Pdf

Using state-of-the-art and evidence-based literature references and reviews, the authors present an overview of translational research that is both reliable and easily understood. The book begins with principles of normal cell biology and normal immunology. It examines tumor biology and basic tumor immunology. It then discusses limitless replicativ

Author : Daniela Spano,Aniello Cerrato,George Mattheolabakis
Publisher : Frontiers Media SA
Page : 206 pages
File Size : 48,7 Mb
Release : 2022-03-03
Category : Science
ISBN : 9782889745708

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Combinatorial Approaches for Cancer Treatment: from Basic to Translational Research by Daniela Spano,Aniello Cerrato,George Mattheolabakis Pdf

Author : Vasyl Vasko,Electron Kebebew,Sheue-Yann Cheng,Kirk Ernest Jensen
Publisher : Frontiers Media SA
Page : 97 pages
File Size : 41,7 Mb
Release : 2020-06-05
Category : Electronic
ISBN : 9782889637638

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Translational Research in Thyroid Cancer by Vasyl Vasko,Electron Kebebew,Sheue-Yann Cheng,Kirk Ernest Jensen Pdf

Author : Erwei Song,Hai Hu
Publisher : Springer
Page : 418 pages
File Size : 49,8 Mb
Release : 2017-12-28
Category : Medical
ISBN : 9789811060205

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Translational Research in Breast Cancer by Erwei Song,Hai Hu Pdf

This book offers a comprehensive introduction to translational efforts in breast cancer, addressing the latest approaches to precision medicine based on the current state of understanding of breast cancer. With the latest developments in breast cancer research, our understanding of the genomic changes and the oncogenic signaling cascade of breast cancer has made considerable strides. Further, the immuno-environment has been demonstrated as the barrier to clinical cancer. In addition, major advances in cancer biology, immunology, genomics and metabolism have broken new ground for designing therapeutic approaches and selecting appropriate treatments on the basis of more precise information on the individual patient. As a result of these two trends, a clearer picture of the molecular landscape of breast cancers has facilitated the development of diagnostic, prognostic and predictive biomarkers for clinical oncology. All these aspects are addressed in this volume, which offers a comprehensive resource for researchers, graduate students and oncologists in cancer research.

Author : Sivapatham Sundaresan,Yeun-Hwa Gu
Publisher : Unknown
Page : 128 pages
File Size : 53,9 Mb
Release : 2021
Category : Cancer
ISBN : 1838805354

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Translational Research in Cancer by Sivapatham Sundaresan,Yeun-Hwa Gu Pdf

Author : Dirk Schrijvers
Publisher : CRC Press
Page : 0 pages
File Size : 51,8 Mb
Release : 2010-05-20
Category : Medical
ISBN : 1841847690

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ESMO Handbook by Dirk Schrijvers Pdf

First published in 2010. Routledge is an imprint of Taylor & Francis, an informa company.

Author : Adam Eltorai,Jeffrey A. Bakal,Daniel Kim,David Wazer
Publisher : Elsevier
Page : 736 pages
File Size : 52,6 Mb
Release : 2023-08-01
Category : Science
ISBN : 9780323884242

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Translational Radiation Oncology by Adam Eltorai,Jeffrey A. Bakal,Daniel Kim,David Wazer Pdf

Translational Radiation Oncology covers the principles of evidence-based medicine and applies them to the design of translational research. The book provides valuable discussions on the critical appraisal of published studies and recent developments in radiation oncology, allowing readers to learn how to evaluate the quality of such studies with respect to measuring outcomes and make effective use of all types of evidence. By reading this book, researchers have access to a practical approach to help them navigate challenging considerations in study design and implementation. It is a valuable resource for researchers, oncologists and members of biomedical field who want to understand more about translational research applied to the field of radiation oncology. Translational medicine serves as an indispensable tool in grant writing and funding efforts, so understanding how to apply its principles to research is necessary to guarantee that results will be impactful to patients. Provides a clear process for understanding, designing, executing and analyzing clinical and translational research Presents practical, step-by-step guidance to help readers take ideas from the lab to the bedside Written by a team of oncologists, radiologists and clinical research experts that fully cover translational research in radiation oncology