Translational Regulation Of Gene Expression

Author : Marianne Grunberg-Manago
Publisher : Elsevier
Page : 537 pages
File Size : 42,5 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780444601247

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Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression by Marianne Grunberg-Manago Pdf

Interaction of Translational and Transcriptional Controls in the Regulation of Gene Expression presents the proceedings of the Fogarty International Conference on Translational/Transcriptional Regulation of Gene Expression, held at the National Institutes of Health in Bethesda, Maryland, on April 7-9, 1982. Speakers discussed the molecular strategies at work during the modulation of gene expression following transcriptional initiation. They also discussed recent developments in a number of key areas in which transcriptional and translational components interact. Organized into five sections encompassing 36 chapters, this volume explores both prokaryotic and eukaryotic systems, as well as structure-function correlations. It begins with an overview of translational/transcriptional controls in prokaryotes, the regulation of gene expression by transcription termination and RNA processing, and the structure and expression of initiation factor genes. It then examines the effect of the codon context on translational fidelity, including mistranslation of messenger RNA; protein synthesis for the construction of cell architecture; regulation of initiation factor activity; and translational regulation in cells. This book is a valuable resource for Fogarty International Scholars who want to broaden their knowledge and contribute their expertise to the National Institutes of Health community.

Author : J. Ilan
Publisher : Springer Science & Business Media
Page : 508 pages
File Size : 54,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461528944

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Translational Regulation of Gene Expression 2 by J. Ilan Pdf

This book, which results from the dramatic increase in interest in the control mechanism employed in gene expression and the importance of the regulated proteins, presents new information not covered in Translational Regulation of Gene Expression, which was published in 1987. It is not a revision of the earlier book but, rather, an extension of that volume witl, special emphasis on mecha nIsm. As the reader will discover, there is enormous diversity in the systems employing genes for translational regulation in order to regulate the appearance of the final product-the protein. Thus, we find that important proteins such as protooncogenes, growth factors, stress proteins, cytokines, lymphokines, iron storage and iron-uptake proteins, and a panorama of prokaryotic proteins, as well as eukaryotic viral proteins, are translationally regulated. Since for some gene products the degree of control is greater by a few orders of magnitude than their transcription, we can state that for these genes, at least, the expression is translationall y controlled. Translational regulation of gene expression in eukaryotes has emerged in the last few years as a major research field. The present book describes mechanisms of translational regulation in bacteria, yeast, and eukaryotic viruses, as well as in eukaryotic genes. In this book we try to provide in-depth coverage by including important examples from each group rather than systematically including all additional systems not described in the previous volume.

Author : J. Ilan
Publisher : Springer Science & Business Media
Page : 495 pages
File Size : 52,7 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9781468453652

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Translational Regulation of Gene Expression by J. Ilan Pdf

Author : Nahum Sonenberg,John W. B. Hershey,Michael B. Mathews
Publisher : CSHL Press
Page : 1034 pages
File Size : 49,5 Mb
Release : 2001
Category : Gene expression
ISBN : 0879696184

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Translational Control of Gene Expression by Nahum Sonenberg,John W. B. Hershey,Michael B. Mathews Pdf

Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translation control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translation machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.

Author : Eric Wong
Publisher : Axolotl Academic Publishing
Page : 283 pages
File Size : 55,5 Mb
Release : 2009
Category : Biology
ISBN : 9780985226114

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Cells: Molecules and Mechanisms by Eric Wong Pdf

"Yet another cell and molecular biology book? At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? First, it's a course that I have enjoyed teaching for many years, so I am very familiar with what a student really needs to take away from this class within the time constraints of a semester. Second, because it is a course that many students take, there is a greater opportunity to make an impact on more students' pocketbooks than if I were to start off writing a book for a highly specialized upper- level course. And finally, it was fun to research and write, and can be revised easily for inclusion as part of our next textbook, High School Biology."--Open Textbook Library.

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 47,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Jun Ma
Publisher : Springer
Page : 0 pages
File Size : 55,7 Mb
Release : 2010-12-24
Category : Science
ISBN : 1441922032

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Gene Expression and Regulation by Jun Ma Pdf

This book offers a comprehensive look at the science of gene expression and regulation. Focusing on topics such as actions of nuclear receptors, RNA processing, and DNA methylation and imprinting, Gene Expression and Regulation is edited by a leading biologist and includes contributions by experts in the field. The focus is on scientific concepts and issues, rather than specific organisms or experimental approaches.

Author : Jiaqian Wu
Publisher : Springer
Page : 185 pages
File Size : 46,5 Mb
Release : 2015-11-17
Category : Science
ISBN : 9789401774505

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Transcriptomics and Gene Regulation by Jiaqian Wu Pdf

This volume focuses on modern computational and statistical tools for translational gene expression and regulation research to improve prognosis, diagnostics, prediction of severity, and therapies for human diseases. It introduces some of state of the art technologies as well as computational and statistical tools for translational bioinformatics in the areas of gene transcription and regulation, including the tools for next generation sequencing analyses, alternative spicing, the modeling of signaling pathways, network analyses in predicting disease genes, as well as protein and gene expression data integration in complex human diseases etc. The book is particularly useful for researchers and students in the field of molecular biology, clinical biology and bioinformatics, as well as physicians etc. Dr. Jiaqian Wu is assistant professor in the Vivian L. Smith Department of Neurosurgery and Center for Stem Cell and Regenerative Medicine, University of Texas Health Science Centre, Houston, TX, USA.​

Author : E. C. C. Lin,A. Simon Lynch
Publisher : Springer Science & Business Media
Page : 917 pages
File Size : 51,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468486018

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Regulation of Gene Expression in Escherichia coli by E. C. C. Lin,A. Simon Lynch Pdf

This up-to-date guide focuses on the understanding of key regulatory mechanisms governing gene expression in Escherichia coli. Studies of E. coli not only provide the first models of gene regulation, but research continues to yield different control mechanisms.

Author : Gary H. Perdew,Jack P. Vanden Heuvel,Jeffrey M. Peters
Publisher : Springer Science & Business Media
Page : 334 pages
File Size : 47,8 Mb
Release : 2008-08-17
Category : Science
ISBN : 9781597452281

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Regulation of Gene Expression by Gary H. Perdew,Jack P. Vanden Heuvel,Jeffrey M. Peters Pdf

The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select “Courses. ” The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.

Author : Ekkehard K.F. Bautz,P. Karlson,H. Kersten
Publisher : Springer Science & Business Media
Page : 351 pages
File Size : 46,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783642657252

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Regulation of Transcription and Translation in Eukaryotes by Ekkehard K.F. Bautz,P. Karlson,H. Kersten Pdf

This volume represents the proceedings of the 24th Mos bach Colloquium on "Regulation of Transcription and Trans lation in Eukaryotes" which was held April 26-28, 1973, in Mosbach, Germany, under the auspices of the Gesellschaft fiir Biologische Chemie. To the three of us (H. KERSTEN, P. KARLSON and myself) who were commissioned with the invitation of speakers, it was a difficult decision as to whether we should attempt to cover with some twenty contributions as many aspects of this broad topic as possible, or to sacrifice the intellectually perhaps more pleasing but more specula tive concepts and to concentrate on a few aspects of gene expression in reasonable detail. We unanimously decided on the latter course, leaving such important and timely topics as for example, hormone action, cyclic AMP and reverse transcription to the proceedings of other symposia, and con centrating on the four questions which are most basic to an understanding of the mechanisms of transcription and trans lation and for which fragmentary but nonetheless reliable experimental results have become available within the last few years. These are the structure of chromatin, the syn thesis of messenger RNA, the structure of the active ribo some, and the role of initiation factors in protein synthesis.

Author : Gerard Marshall Raj,Ramasamy Raveendran
Publisher : Springer Nature
Page : 410 pages
File Size : 52,7 Mb
Release : 2019-11-16
Category : Medical
ISBN : 9789813297791

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Introduction to Basics of Pharmacology and Toxicology by Gerard Marshall Raj,Ramasamy Raveendran Pdf

This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.

Author : Michael B. Mathews
Publisher : Unknown
Page : 210 pages
File Size : 44,7 Mb
Release : 1986
Category : Science
ISBN : PSU:000012736348

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Translational Control by Michael B. Mathews Pdf

Author : Jonathan D. Dinman
Publisher : Springer Science & Business Media
Page : 325 pages
File Size : 41,8 Mb
Release : 2012-07-27
Category : Medical
ISBN : 9781461439905

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Biophysical Approaches to Translational Control of Gene Expression by Jonathan D. Dinman Pdf

This book highlights major advances in researching a cell’s molecular machinery through analytical, computational, and imaging methods. It focuses on developing biophysical approaches to studying control of gene expression at the translational level.

Author : Joe B. Harford,David R. Morris
Publisher : John Wiley & Sons
Page : 372 pages
File Size : 45,6 Mb
Release : 1997-03-28
Category : Science
ISBN : 0471142069

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mRNA Metabolism & Post-Transcriptional Gene Regulation by Joe B. Harford,David R. Morris Pdf

mRNA METABOLISM & POST-TRANSCRIPTIONAL GENE REGULATION Edited by Joe B. Harford and David R. Morris Gene expression is a process that begins with the transcription ofDNA to an RNA messenger (mRNA), which is then translated into aprotein. Historically, attention has been focused on the regulationof RNA synthesis (transcription); however, there is a growingrecognition of and appreciation for the importance of the manyregulatory mechanisms that take place after RNA synthesis has beencompleted. mRNA Metabolism and Post-Transcriptional Gene Regulation is thefirst comprehensive overview of the various modes of generegulation that exist post-transcriptionally. Collecting studies bysome of the top researchers in the field, this volume provides bothan up-to-date review of the complex "life" of an mRNA molecule andan introduction to current work on the diversity of mechanisms ofpost-transcriptional reactions. Topics covered include: * RNA structure * Mammalian RNA editing * RNA export from the nucleus * The fundamentals of translation initiation * Control of mRNA decay in plants * mRNA metabolism and cancer * Control of mRNA stability during herpes simplex virus infection * Regulation of mRNA expression in HIV-1 and other complexretroviruses * Nucleases * RNA localization A timely contribution to the understanding of genetic regulatorymechanisms, mRNA Metabolism and Post-Transcriptional GeneRegulation provides a basis from which potential therapeuticstrategies may be developed. This book will be of vital interest tocell and molecular biologists at all levels, from graduate studentsto senior investigators, clinical researchers, and professionals inthe pharmaceutical and biotechnology industries.