Treatment Refractory Schizophrenia

Author : Peter F. Buckley,Fiona Gaughran
Publisher : Springer Science & Business Media
Page : 230 pages
File Size : 53,7 Mb
Release : 2014-03-18
Category : Medical
ISBN : 9783642452574

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Treatment–Refractory Schizophrenia by Peter F. Buckley,Fiona Gaughran Pdf

Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care. In this book, leading experts from Europe, Australia and the Americas provide a timely appraisal of treatments for the most severely ill schizophrenia patients. This clinically focused book is informed by the latest research on the neurobiology and treatment of schizophrenia. It is comprehensive in scope, covering current treatment options, various add-on approaches, and a range of psychosocial treatments. The contributors are respected experts who have combined their clinical experience with cutting-edge research to provide readers with authoritative information on fundamental aspects of clinical care for schizophrenia.

Author : Peter Manu,Robert J. Flanagan,Kathlyn J. Ronaldson
Publisher : Academic Press
Page : 394 pages
File Size : 49,5 Mb
Release : 2016-08-16
Category : Medical
ISBN : 9780128033906

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Life-Threatening Effects of Antipsychotic Drugs by Peter Manu,Robert J. Flanagan,Kathlyn J. Ronaldson Pdf

Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their incidence and case fatality, and gives comprehensive advice on diagnosis, management and preventive strategies. In addition, the book discusses the benefit of antipsychotic medication in a range of therapeutic indications, and demonstrates the gain in life-expectancy associated with clozapine use in severe mental illness despite its serious, potentially life-threatening adverse effects. Covers cardiovascular, neurological, muscular, hematological, gastrointestinal, autonomic and metabolic effects Gives advice on risk factors, confounding diagnoses and measures to minimise seriousness Discusses clozapine rechallenge after each of its serious adverse reactions Makes suggestions for optimum management of somatic disease in those with severe mental illness, to improve life-expectancy Includes data on post-mortem considerations

Author : H. Elkis,H.Y. Meltzer
Publisher : Karger Medical and Scientific Publishers
Page : 210 pages
File Size : 55,9 Mb
Release : 2010-07-29
Category : Medical
ISBN : 9783805595124

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Therapy-Resistant Schizophrenia by H. Elkis,H.Y. Meltzer Pdf

The psychotic symptoms of up to 30% of schizophrenic patients do not respond adequately to treatment with antipsychotic drugs, other than clozapine. These refractory patients are generally among the most disabled of all people with schizophrenia and require special assessment and treatment. This volume presents the latest research and recommendations on the definition, causes and therapy of treatment-resistant schizophrenia (TRS). Methods for identification and optimal management of TRS are reviewed. Clozapine and other atypical antipsychotic drugs which are the primary treatment for TRS, as well as non-pharmacologic treatments such as transcranial magnetic stimulation, cognitive behavior therapy and ECT are discussed in depth. Potential causative factors and identifying features such as genetic factors, poor premorbid functioning, longer duration of untreated psychosis, and biological measures such as structural and functional brain abnormalities are also reviewed in depth in the present volume.

Author : Peter F. Buckley,Fiona Gaughran
Publisher : Unknown
Page : 240 pages
File Size : 48,5 Mb
Release : 2014-04-30
Category : Electronic
ISBN : 3642452582

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Treatment-Refractory Schizophrenia by Peter F. Buckley,Fiona Gaughran Pdf

Author : Felice Iasevoli,Vincenzo De Luca,Frederick Charles Nucifora
Publisher : Frontiers Media SA
Page : 130 pages
File Size : 48,9 Mb
Release : 2020-01-13
Category : Electronic
ISBN : 9782889633319

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Neurobiology, Clinical Course, and Therapeutic Approaches of Treatment Resistant Schizophrenia: Toward an Integrated View by Felice Iasevoli,Vincenzo De Luca,Frederick Charles Nucifora Pdf

Author : Leslie Citrome
Publisher : Springer Science & Business Media
Page : 66 pages
File Size : 51,5 Mb
Release : 2013-11-29
Category : Medical
ISBN : 9781908517883

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Handbook of Treatment-resistant Schizophrenia by Leslie Citrome Pdf

Handbook of Treatment-resistant Schizophrenia is a concise review of treatment-resistant schizophrenia’s definition, measurement tools, adherence issues, substance abuse, optimal dosing, clinician–patient relationships, and current management approaches. The book was originally commissioned with the intention of creating a comprehensive text focusing on treatment-resistant schizophrenia and its management. The book explores many aspects of the background and practice- and research-based evidence for treating this complex subset of schizophrenia, including psychopharmacological, somatic, and nonpharmacological treatment approaches. While exploring the various therapies for treatment-resistant schizophrenia, Dr Citrome also emphasizes the importance of building strong and trusting relationships between patients and their clinicians so the clinician can best manage their patient’s adherence and overall treatment.

Author : World Health Organization
Publisher : World Health Organization
Page : 80 pages
File Size : 51,7 Mb
Release : 2009
Category : Medical
ISBN : 9789241547697

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Pharmacological Treatment of Mental Disorders in Primary Health Care by World Health Organization Pdf

This manual attempts to provide simple, adequate and evidence-based information to health care professionals in primary health care especially in low- and middle-income countries to be able to provide pharmacological treatment to persons with mental disorders. The manual contains basic principles of prescribing followed by chapters on medicines used in psychotic disorders; depressive disorders; bipolar disorders; generalized anxiety and sleep disorders; obsessive compulsive disorders and panic attacks; and alcohol and opioid dependence. The annexes provide information on evidence retrieval, assessment and synthesis and the peer view process.

Author : Oliver Freudenreich
Publisher : Springer Nature
Page : 479 pages
File Size : 44,9 Mb
Release : 2019-12-04
Category : Medical
ISBN : 9783030294502

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Psychotic Disorders by Oliver Freudenreich Pdf

This book provides clear and concise guidance for clinicians when they encounter a patient with psychosis, starting with the medical work-up to arrive at a diagnosis and ending with the comprehensive care for patients with established schizophrenia. It covers the optimal use of medications (emphasizing safe use) but also addresses other treatment approaches (psychological treatments, rehabilitation) and the larger societal context of care, including how to work effectively in complex systems. It uniquely condenses the literature into teaching points without simplifying too much, effectively serving as a learning tool for trainees and professionals. For this second edition, the book was extensively updated and its content expanded, with new figures as well. Each chapter begins with an initial summary and includes Tips and Key Points in text boxes. Each chapter also includes links to external websites and additional readings. The book contains clinical and practical wisdom for clinicians who are treating real patients at the front lines, setting it apart from all other texts. Psychotic Disorders is an excellent resource for medical students, early career professionals such as trainees and fellows, and related clinicians seeking additional training and resources, including those in psychiatry, psychology, neurology, and all others.

Author : Katherine J. Aitchison,Robin M. Murray,Patrick J. Power,Eva M. Tsapakis
Publisher : CRC Press
Page : 152 pages
File Size : 45,9 Mb
Release : 2022-03-26
Category : Medical
ISBN : 9780429524141

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First Episode Psychosis by Katherine J. Aitchison,Robin M. Murray,Patrick J. Power,Eva M. Tsapakis Pdf

The new edition of this popular handbook has been thoroughly updated to include the latest data concerning treatment of first-episode patients. Drawing from their experience, the authors discuss the presentation and assessment of the first psychotic episode and review the appropriate use of antipsychotic agents and psychosocial approaches in effective management. This is an authoritative text written by a team of highly respected authors for psychiatrists, neurologists, primary care practitioners and health care professional working in psychiatry. Drawing from their experience, the presentation and assessment of the first psychotic episode are discussed, details regarding antipsychotic drugs and their appropriate use are reviewed and psychosocial approaches are examined. The resulting book offers a concise and valuable guide to those wishing to review the latest proposals for the treatment of first-episode psychosis supported by up-to-date references, in a single publication.

Author : Patrick D. McGorry,Henry J. Jackson
Publisher : Cambridge University Press
Page : 527 pages
File Size : 49,6 Mb
Release : 1999-07-28
Category : Psychology
ISBN : 9781139429146

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The Recognition and Management of Early Psychosis by Patrick D. McGorry,Henry J. Jackson Pdf

The treatment of early psychosis has been bedevilled by an entrenched pessimism, stemming from the asylum era and the Kraepelinian model of schizophrenia. More recently, however, there has been a surge of interest in preventively oriented treatment of patients showing the first signs of psychotic illness, with the realization that these illnesses are frequently highly responsive to early treatment. This is the first text to focus on the potential of early detection of psychosis, and the practicalities of treatment. Based on the pioneering experience and research of a now well-established prevention and intervention centre, and with contributions from international authorities, the book outlines a framework for intervention, reviews the evidence available to guide clinical practice, and describes models of treatment. Incorporating many personal narratives and case histories, it is strong on theory, sensitive on practical issues, and will challenge, inform and guide clinicians.

Author : American Psychiatric Association
Publisher : American Psychiatric Publishing
Page : 164 pages
File Size : 53,7 Mb
Release : 1997
Category : Schizophrenia
ISBN : 0890423091

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Practice Guideline for the Treatment of Patients with Schizophrenia by American Psychiatric Association Pdf

The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians.

Author : Yvon Lapierre,Barry Jones
Publisher : Unknown
Page : 76 pages
File Size : 52,8 Mb
Release : 1992
Category : Antipsychotic drugs
ISBN : UOM:39015025261655

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Clozapine in Treatment-resistant Schizophrenia by Yvon Lapierre,Barry Jones Pdf

Author : Bart A. Ellenbroek,Alexander R. Cools
Publisher : Birkhäuser
Page : 239 pages
File Size : 42,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034884488

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Atypical Antipsychotics by Bart A. Ellenbroek,Alexander R. Cools Pdf

The introduction of chlorpromazine in 1953, and haloperidol in 1958, into clinical practice dramatically altered the therapy of schizophrenic patients. Although representing by no means a cure for this severe psychiatric ill ness, it allowed, for the first time, to adequately control the severe hallu cinations and delusional beliefs which prevent these patients from leading a more or less independent life. Indeed these antipsychotics (and the many congeners that were to follow) significantly reduced the number ofchronic schizophrenic inpatients in psychiatric clinics all over the world. However soon after their introduction it became clear that, like all other available drugs, antipsychotics were by no means miracle drugs. In fact, two major problems appeared. First, the antipsychotics had very little effect on the so-called negative or defect symptoms, like social isolation, apathy and anhedonia, and secondly virtually all antipsychotics produced a number of side-effects, of which the neurological (often called extra pyramidal) side-effects were the most troublesome. Especially the tardive dyskinesia, which occurred in about 15 to 20% of the patients after pro longed treatment, represented a major problem in the treatment of schizo phrenic patients.

Author : Jonathan M. Meyer,Stephen M. Stahl
Publisher : Cambridge University Press
Page : 331 pages
File Size : 40,5 Mb
Release : 2019-05-16
Category : Medical
ISBN : 9781108447461

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The Clozapine Handbook by Jonathan M. Meyer,Stephen M. Stahl Pdf

A practical Handbook that provides clinically-focussed approaches and guidelines on the effective management of clozapine treated patients.

Author : Robin M. Murray,Peter B. Jones,Ezra Susser,Jim Van Os,Mary Cannon
Publisher : Cambridge University Press
Page : 474 pages
File Size : 50,6 Mb
Release : 2002-11-28
Category : Medical
ISBN : 9781139439480

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The Epidemiology of Schizophrenia by Robin M. Murray,Peter B. Jones,Ezra Susser,Jim Van Os,Mary Cannon Pdf

An international team of leading researchers and clinicians here provide a comprehensive, epidemiological overview of this multi-faceted and still perplexing disorder, and address some of the key questions it raises. How important in the genetic contribution to schizophrenia? Do pregnancy and birth complications increase the risk for schizophrenia? Is the incidence of schizophrenia changing? Why is the rate higher among immigrants and in those born in cities? Controversial issues such as the validity of discrete or dimensional classifications of schizophrenia and the continuum between psychosis and 'normality' are explored in depth, and separate chapters are devoted to topics of particular relevance to schizophrenia such as suicide, violence and substance abuse. Finally, new prospects for treatment and prevention are considered. Drawing together the findings from social, genetic, developmental and classical epidemiology of schizophrenia, this text will prove an invaluable resource for clinicians and researchers.