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Author : Yvon Lapierre,Barry Jones
Publisher : Unknown
Page : 76 pages
File Size : 52,5 Mb
Release : 1992
Category : Antipsychotic drugs
ISBN : UOM:39015025261655
Author : Peter Manu,Robert J. Flanagan,Kathlyn J. Ronaldson
Publisher : Academic Press
Page : 394 pages
File Size : 50,8 Mb
Release : 2016-08-16
Category : Medical
ISBN : 9780128033906
Life-Threatening Effects of Antipsychotic Drugs describes in detail more than 20 life-threatening effects associated with antipsychotics, presents the best available data on their incidence and case fatality, and gives comprehensive advice on diagnosis, management and preventive strategies. In addition, the book discusses the benefit of antipsychotic medication in a range of therapeutic indications, and demonstrates the gain in life-expectancy associated with clozapine use in severe mental illness despite its serious, potentially life-threatening adverse effects. Covers cardiovascular, neurological, muscular, hematological, gastrointestinal, autonomic and metabolic effects Gives advice on risk factors, confounding diagnoses and measures to minimise seriousness Discusses clozapine rechallenge after each of its serious adverse reactions Makes suggestions for optimum management of somatic disease in those with severe mental illness, to improve life-expectancy Includes data on post-mortem considerations
Author : H. Elkis,H.Y. Meltzer
Publisher : Karger Medical and Scientific Publishers
Page : 210 pages
File Size : 47,8 Mb
Release : 2010-07-29
Category : Medical
ISBN : 9783805595124
The psychotic symptoms of up to 30% of schizophrenic patients do not respond adequately to treatment with antipsychotic drugs, other than clozapine. These refractory patients are generally among the most disabled of all people with schizophrenia and require special assessment and treatment. This volume presents the latest research and recommendations on the definition, causes and therapy of treatment-resistant schizophrenia (TRS). Methods for identification and optimal management of TRS are reviewed. Clozapine and other atypical antipsychotic drugs which are the primary treatment for TRS, as well as non-pharmacologic treatments such as transcranial magnetic stimulation, cognitive behavior therapy and ECT are discussed in depth. Potential causative factors and identifying features such as genetic factors, poor premorbid functioning, longer duration of untreated psychosis, and biological measures such as structural and functional brain abnormalities are also reviewed in depth in the present volume.
Author : Felice Iasevoli,Vincenzo De Luca,Frederick Charles Nucifora
Publisher : Frontiers Media SA
Page : 130 pages
File Size : 42,6 Mb
Release : 2020-01-13
Category : Electronic
ISBN : 9782889633319
Author : Peter F. Buckley,Fiona Gaughran
Publisher : Springer Science & Business Media
Page : 230 pages
File Size : 50,5 Mb
Release : 2014-03-18
Category : Medical
ISBN : 9783642452574
Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care. In this book, leading experts from Europe, Australia and the Americas provide a timely appraisal of treatments for the most severely ill schizophrenia patients. This clinically focused book is informed by the latest research on the neurobiology and treatment of schizophrenia. It is comprehensive in scope, covering current treatment options, various add-on approaches, and a range of psychosocial treatments. The contributors are respected experts who have combined their clinical experience with cutting-edge research to provide readers with authoritative information on fundamental aspects of clinical care for schizophrenia.
Author : Jonathan M. Meyer,Stephen M. Stahl
Publisher : Cambridge University Press
Page : 331 pages
File Size : 53,9 Mb
Release : 2019-05-16
Category : Medical
ISBN : 9781108447461
A practical Handbook that provides clinically-focussed approaches and guidelines on the effective management of clozapine treated patients.
Author : Bart A. Ellenbroek,Alexander R. Cools
Publisher : Birkhäuser
Page : 239 pages
File Size : 52,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034884488
The introduction of chlorpromazine in 1953, and haloperidol in 1958, into clinical practice dramatically altered the therapy of schizophrenic patients. Although representing by no means a cure for this severe psychiatric ill ness, it allowed, for the first time, to adequately control the severe hallu cinations and delusional beliefs which prevent these patients from leading a more or less independent life. Indeed these antipsychotics (and the many congeners that were to follow) significantly reduced the number ofchronic schizophrenic inpatients in psychiatric clinics all over the world. However soon after their introduction it became clear that, like all other available drugs, antipsychotics were by no means miracle drugs. In fact, two major problems appeared. First, the antipsychotics had very little effect on the so-called negative or defect symptoms, like social isolation, apathy and anhedonia, and secondly virtually all antipsychotics produced a number of side-effects, of which the neurological (often called extra pyramidal) side-effects were the most troublesome. Especially the tardive dyskinesia, which occurred in about 15 to 20% of the patients after pro longed treatment, represented a major problem in the treatment of schizo phrenic patients.
Author : Oliver Howes
Publisher : Oxford University Press
Page : 240 pages
File Size : 40,8 Mb
Release : 2018-09-13
Category : Medical
ISBN : 9780192563910
Treatment resistant schizophrenia (TRS) is common, affecting approximately a third of patients diagnosed. Despite the prevalence of TRS, the best approach to practical management is often unclear to clinicians and patients. Treatment Response and Resistance in Schizophrenia offers a practical, clinically focused guide to TRS and the real-world challenges faced by those impacted. Over 14 chapters this resource covers the principles and practice of TRS, from the definition, epidemiology, and clinical assessment, to the pharmacological, physical, and psychological management of treatment resistance. All chapters have been written by internationally leading experts in the field to ensure busy clinicians have high-quality, applicable content that is rooted in real clinical experiences. A chapter of case studies is included to link real-life scenarios to each of the instructive chapters, illustrating approaches to practical management and application. Part of the Oxford Psychiatry Library, this useful pocket book is an invaluable resource and quick reference for psychiatrists, psychiatry trainees, and other mental health practitioners, as well as clinical psychologists, primary care physicians, and specialist nurses.
Author : Mirko Manchia,Bernardo Carpiniello
Publisher : Frontiers Media SA
Page : 177 pages
File Size : 55,8 Mb
Release : 2020-08-27
Category : Electronic
ISBN : 9782889639625
Author : Michael Cummings,Stephen Stahl
Publisher : Cambridge University Press
Page : 545 pages
File Size : 47,5 Mb
Release : 2021-07-22
Category : Medical
ISBN : 9781108965682
An essential handbook providing practical guidance and medication advice on the effective management and treatment of psychotic disorders.
Author : D.E. Casey,T.N. Chase,A.V. Christensen,J. Gerlach
Publisher : Springer Science & Business Media
Page : 230 pages
File Size : 52,7 Mb
Release : 2013-03-12
Category : Medical
ISBN : 9783642701405
Papers Presented at an International Symposium, Held in 1984 at Kollekolle, Denmark
Author : Richard S. E. Keefe,Joseph P. McEvoy
Publisher : American Psychiatric Pub
Page : 216 pages
File Size : 53,9 Mb
Release : 2008-11-01
Category : Medical
ISBN : 9781585627974
For the first time in a single volume, distinguished experts address the complex issues -- issues rarely confronted in empirical studies of patients with schizophrenia -- and controversial research surrounding the assessment of negative symptoms and cognitive deficits in patients with schizophrenia. Despite recent advances in our understanding of schizophrenia, still notably absent is consensus in assessing negative symptom treatment response. What is the most effective assessment method -- given the varying methodologies and contradictory results to date? What constitutes an adequate response? Which medication -- none is specifically indicated and licensed for negative symptom treatment -- yields the best results? What are the indications for use of this medication? Which instrument best measures negative symptom treatment response (eight rating scales are analyzed here)? Reaching consensus among clinicians and researchers alike is even more difficult because assessment is often thwarted by extrapyramidal side effects of medications, similarities to depressive symptoms, and secondary effects of psychotic experiences. In addition to clarifying these pressing issues, Negative Symptom and Cognitive Deficit Treatment Response in Schizophrenia also discusses The importance of measuring the experience of emotion versus the more traditional objectively measured symptoms in patients with schizophrenia, and how deficits in emotional experience may resist treatment -- even in treatment-responsive patients. The family as an often overlooked source of information about negative symptom improvement or worsening, and the impact of negative symptoms on patients' relatives. How treatment affects social functioning and subjective experience of "quality of life," and the importance of neurocognitive dysfunction in the social deficits of schizophrenia, which often persist despite significant amelioration of other symptoms. Specific guidelines for assessing neurocognitive treatment response. Cognitive enhancement is a major factor in improving the quality of patients' lives. The latest research on the neurobiology of negative symptoms, including the role of various neurotransmitter systems and brain regions in mediating negative symptom pathology. Also discussed is single vs. multiple pathophysiological processes and single treatment modality vs. distinct treatments for different aspects of negative symptoms. How to distinguish "pure" negative symptoms from deficit symptoms (i.e., those that persist for at least 1 year and are not secondary to factors such as depression, medication side effects, anxiety, delusions, and hallucinations), and which treatment is indicated for each. Highlighted by patient vignettes, this in-depth guide will be welcomed by all clinicians who treat patients with schizophrenia and want to know and document whether their interventions ameliorate negative symptoms and cognitive dysfunction, and by all researchers who study schizophrenia, particularly those interested in clinical issues and treatment studies.
Author : Kuppuswami Shivakumar,Shabbir Amanullah
Publisher : Springer
Page : 236 pages
File Size : 45,9 Mb
Release : 2018-05-25
Category : Medical
ISBN : 9783319703114
This book provides the readers with a series of complex cases that are organized by psychiatric disorder. Written by experts in the field, the cases offer insight on how to navigate care in delicate situations while considering preexisting medical conditions. Topics cover pharmacological concerns in women who are pregnant or nursing, working with dementia patients suffering from HIV, assessing and treating ADHD in special populations, monitoring medication use in patience recovering from Substance Use Disorder, and working with patients suffering from personality disorders. Each chapter offers guidance through the maze of classifications, clinical features, diagnosis and various complex interventions. The book also covers new information on the advances in research and management aspects. Complex Clinical Conundrums in Psychiatry is a valuable resource for psychiatrists, psychologists, family physicians, geriatricians, counselors, social workers, nurses, and all medical professionals working with complex psychiatric patients.
Author : Yong-Ku Kim
Publisher : Springer
Page : 416 pages
File Size : 54,7 Mb
Release : 2018-10-29
Category : Medical
ISBN : 9789811043581
This book reviews all the important aspects of treatment-resistant psychiatric disorders, covering issues such as definitions, clinical aspects, neurobiological correlates, treatment options, and predictors of treatment response. The book is divided into three sections, the first of which examines the most recent thinking on treatment resistance in psychiatry, including definition and epidemiology, paradigm shift in the study of the subjects, individual susceptibility and resilience, abnormal structural or functional connectivity, and insights from animal models. The second section then discusses treatment resistance in each of the major psychiatric disorders, with particular focus on the responsible clinical and biological factors and the available management strategies. Finally, more detailed information is presented on diverse pharmacological and non-pharmacological therapeutic interventions. The book, written by leading experts from across the world, will be of value to all who seek a better understanding of the clinical-neurobiological underpinnings and the development of management for treatment resistance in psychiatric disorders.
Author : American Psychiatric Association
Publisher : American Psychiatric Publishing
Page : 164 pages
File Size : 49,8 Mb
Release : 1997
Category : Schizophrenia
ISBN : 0890423091
The American Psychiatric Association (APA) is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians.