Inflammatory Processes

Author : D. Neil Granger,Elena Senchenkova
Publisher : Morgan & Claypool Publishers
Page : 99 pages
File Size : 48,9 Mb
Release : 2010
Category : Medical
ISBN : 9781615041657

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Inflammation and the Microcirculation by D. Neil Granger,Elena Senchenkova Pdf

The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References

Author : L. Gordon Letts,Douglas W. Morgan
Publisher : Springer
Page : 146 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783034884686

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Inflammatory Processes: by L. Gordon Letts,Douglas W. Morgan Pdf

In November 1998 many of the key leaders of new drug discovery for inflammatory diseases gathered at Hershey, Pennsylvania for the 9th International Conference of the Inflammation Research Association. The Conference was held over a five day period and provided a stimulating environment for the open exchange of important advances in basic inflammation research as well as new drug discovery and development. This book encompasses some of the highlights of several presentations made at the Conference. It contains some of the latest and important developments in the field of inflammation research. Topics include the status of eotaxin and chemokines in asthma and allergy, signal transduction and regulation of diverse mediators such as the JNK group of MAP kinases, TNF and IL-1 signaling of NF-kB as well as regulators of AP-1, macrophage metalloproteinases, lymphotoxin and further insights into the role of MCP-1 in disease. Also discussed are drug targets in rheumatoid and osteoarthritis, fibrotic diseases,...

Author : Charles N. Serhan,Peter A. Ward,Derek W. Gilroy
Publisher : Cambridge University Press
Page : 489 pages
File Size : 49,8 Mb
Release : 2010-04-26
Category : Medical
ISBN : 9780521887298

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Fundamentals of Inflammation by Charles N. Serhan,Peter A. Ward,Derek W. Gilroy Pdf

The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion.

Author : Benjamin W. Zweifach,Lester Grant,Robert T. McCluskey
Publisher : Academic Press
Page : 670 pages
File Size : 55,9 Mb
Release : 2014-05-12
Category : Health & Fitness
ISBN : 9781483220796

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The Inflammatory Process by Benjamin W. Zweifach,Lester Grant,Robert T. McCluskey Pdf

The Inflammatory Process, Second Edition is an account of the inflammatory process and covers topics ranging from cell surface phenomena and connective tissue to the role of the formed elements of the blood in inflammatory states, particularly in the light of the rapidly burgeoning literature on platelet physiology. The life history and functional capacities of leukocytes are also examined, along with chemotaxis, phagocytosis, and the mechanisms responsible for tissue damage in inflammation. Comprised of 10 chapters, this volume begins with an overview of the experimental approach to the study of inflammation, followed by a discussion on the biochemistry of the mammalian plasma membrane. The reader is then introduced to cell injury; chemotaxis; phagocytosis; and lysosomal mechanisms in the inflammatory process. Subsequent chapters deal with the inflammatory process at the cellular level, paying particular attention to neutrophil leukocytes; the metabolism and physiology of mononuclear phagocytes; the role of platelets in inflammatory reactions; and structural and biochemical characteristics of mast cells. This book will be of interest to practitioners in fields ranging from biochemistry to pathology, bacteriology, physiology, and immunology.

Author : Adriano Rossi,Deborah A. Sawatzky
Publisher : Springer Science & Business Media
Page : 240 pages
File Size : 51,8 Mb
Release : 2008-03-17
Category : Medical
ISBN : 9783764375065

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The Resolution of Inflammation by Adriano Rossi,Deborah A. Sawatzky Pdf

This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 46,8 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : Anonim
Publisher : Unknown
Page : 931 pages
File Size : 55,6 Mb
Release : 1969
Category : Electronic
ISBN : 0127834508

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The Inflammatory Process by Anonim Pdf

Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 44,5 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181

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Molecular Biology of The Cell by Bruce Alberts Pdf

Author : Robert Fitridge,M. M. Thompson
Publisher : University of Adelaide Press
Page : 589 pages
File Size : 48,5 Mb
Release : 2011
Category : Medical
ISBN : 9781922064004

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Mechanisms of Vascular Disease by Robert Fitridge,M. M. Thompson Pdf

New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Author : Gian Marco Ghiggeri,Stephen McAdoo,Laura Piera Obici,Augusto Vaglio,Marco Gattorno
Publisher : Frontiers Media SA
Page : 169 pages
File Size : 46,7 Mb
Release : 2023-01-27
Category : Medical
ISBN : 9782832511862

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The kidney in auto-immune and auto-inflammatory processes: Definitions, mechanisms, and biomarkers by Gian Marco Ghiggeri,Stephen McAdoo,Laura Piera Obici,Augusto Vaglio,Marco Gattorno Pdf

Author : Danièle Noël,Paula Barbim Donate,Fausto Almeida,Yann Lamarre,Karina Pino-Lagos
Publisher : Frontiers Media SA
Page : 209 pages
File Size : 40,9 Mb
Release : 2022-02-25
Category : Medical
ISBN : 9782889745265

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Extracellular Vesicles as Immunomodulatory Mediators in Inflammatory Processes by Danièle Noël,Paula Barbim Donate,Fausto Almeida,Yann Lamarre,Karina Pino-Lagos Pdf

Author : Ivan Zanoni,Charlotte Odendall
Publisher : Frontiers Media SA
Page : 120 pages
File Size : 49,5 Mb
Release : 2020-01-14
Category : Electronic
ISBN : 9782889633050

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Interferon-λs: New Regulators of Inflammatory Processes by Ivan Zanoni,Charlotte Odendall Pdf

Author : Z. Kmiec
Publisher : Springer Science & Business Media
Page : 154 pages
File Size : 52,8 Mb
Release : 2013-06-29
Category : Science
ISBN : 9783642565533

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Cooperation of Liver Cells in Health and Disease by Z. Kmiec Pdf

It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Author : J. Whicher,S.W. Evans
Publisher : Springer Science & Business Media
Page : 316 pages
File Size : 52,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401129961

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Biochemistry of Inflammation by J. Whicher,S.W. Evans Pdf

Our understanding of inflammation has increased rapidly in recent years, due in large part to the impact of molecular biology and gene identification and cloning. This book brings together ideas from a number of different biochemical disciplines which are frequently not integrated. The first chapter gives a visual overview of the subject; the remaining chapters are organized into three themes: the affector molecules, the regulatory components and the processes of inflammation itself. This book is essential reading for the busy physician or pathologist who wants to be up-to-date with the latest developments in immunology as they affect the diagnosis and treatment of many conditions.

Author : Anonim
Publisher : Birkhäuser
Page : 0 pages
File Size : 50,7 Mb
Release : 2016-09-15
Category : Medical
ISBN : 3764385308

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Encyclopedia of Inflammatory Diseases by Anonim Pdf

Inflammation has become one of the most exciting and rewarding areas of medical research. Recent years have seen a revolution in our understanding of how blood and tissue cells interact and of the intracellular mechanisms controlling their activation. This has revealed the underlying inflammatory pathology of many diseases and provided multiple new targets for anti-inflammatory and immunomodulatory therapy. The Encyclopedia of Inflammatory Diseases will cover the following areas: Inflammatory Processes and Cells Inflammatory Diseases Mediators of Inflammation Pharmacology of Inflammation Since inflammatory diseases and their therapy cover a broad range of scientific and medical fields, the encyclopedia will be co-edited by four international experts, a clinician and three researchers from the disciplines of immunology, biochemistry, and pharmacology, in this way providing students, basic and clinical scientists and practitioners in academia, hospitals and industry with valuable interlinked information. This living project will serve as a reliable and comprehensive data pool for everybody working in inflammation research. Owing to its dynamic nature, it will grow with time and future editions, becoming an indispensible source of information for academia, clinical practitioners and industry.