Tuberculosis Pathogenesis Diagnosis And Treatment

Author : June Middleton
Publisher : American Medical Publishers
Page : 0 pages
File Size : 41,6 Mb
Release : 2023-09-26
Category : Health & Fitness
ISBN : 9798887405391

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Tuberculosis: Pathogenesis, Diagnosis and Treatment by June Middleton Pdf

Tuberculosis (TB) is a contagious disease that mainly causes damage to the lungs. This disease is caused by the Mycobacterium tuberculosis (Mtb) bacteria. It can be transmitted from an infected person to a healthy person, through tiny droplets released while sneezing and coughing. Some common symptoms of TB include coughing for more than three weeks, chest pain, or pain while coughing and breathing, fatigue, fever, and loss of appetite. Several conditions like diabetes, severe kidney disease, malnutrition, and HIV makes a person more prone to TB bacteria by reducing the capacity of immune system to work efficiently. Tuberculosis can cause death if left untreated. Furthermore, it is a leading cause of complications like spinal pain, swelling in the membranes covering the brain, heart disorders, and liver or kidney problems. Its diagnosis starts with a physical examination of lymph nodes for swelling. Other diagnostic methods include blood tests, imaging tests and sputum tests. DOT (directly observed therapy) is a predominant treatment of TB. This book includes some of the vital pieces of work being conducted across the world, on various topics related to tuberculosis. It will provide comprehensive knowledge to the readers on the pathogenesis, diagnosis and treatment of this disease.

Author : Dorothee Heemskerk,Maxine Caws,Ben Marais,Jeremy Farrar
Publisher : Springer
Page : 66 pages
File Size : 41,6 Mb
Release : 2015-07-17
Category : Medical
ISBN : 9783319191324

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Tuberculosis in Adults and Children by Dorothee Heemskerk,Maxine Caws,Ben Marais,Jeremy Farrar Pdf

This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Author : King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha
Publisher : World Bank Publications
Page : 506 pages
File Size : 53,5 Mb
Release : 2017-11-06
Category : Medical
ISBN : 9781464805257

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Disease Control Priorities, Third Edition (Volume 6) by King K. Holmes,Stefano Bertozzi,Barry R. Bloom,Prabhat Jha Pdf

Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.

Author : M. Monir Madkour
Publisher : Springer Science & Business Media
Page : 974 pages
File Size : 43,5 Mb
Release : 2003-11-18
Category : Medical
ISBN : 3540014411

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Tuberculosis by M. Monir Madkour Pdf

A comprehensive textbook on tuberculosis that covers all aspects of the disease: epidemiology, microbiology, diagnosis, treatment, control and prevention. The main part of the book comprises very detailed and richly illustrated clinical chapters. The copious images are the advantage of this book. Chapters on new methods and treatments and on animal tuberculosis are included. The material is based on a wealth of experience in tuberculosis as seen in endemic countries such as Saudi Arabia that enjoy free access to advanced investigative and therapeutic facilities. This coexistence of endemicity of the disease and state-of-the-art facilities is rare in poor and developing countries or in rich and developed nations. This multidisciplinary volume is ideal for all clinicians, laboratory and research workers, epidemiologists, university teachers and students, health care planners and international organizations involved in world health and infectious disease.

Author : Amit Singh,Divakar Sharma
Publisher : Frontiers Media SA
Page : 108 pages
File Size : 44,9 Mb
Release : 2024-01-30
Category : Medical
ISBN : 9782832543887

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Pathogenesis, Diagnostics, Treatments of Mycobacterium tuberculosis and Its co-Infection with HIV or SARS-CoV-2 by Amit Singh,Divakar Sharma Pdf

Mycobacterium tuberculosis is the major cause of tuberculosis (TB) across the globe. Around one-fourth of the world’s population is infected with TB asymptomatically. Longer regimen of anti-TB drugs (longer treatment leading to poor adherence to treatment), interrupted anti-TB drugs treatment (long regimen with incomplete anti-TB treatment), and ineffectiveness of the anti-TB drugs due to the re-emergence of latent TB infections are just a few mechanisms that play a major hindrance to achieving the end of the global TB epidemic by 2035 as WHO plans. The emergence of drug-resistant in Mycobacterium tuberculosis and co-infections with HIV as well as SARS-CoV-2 poses a serious threat to global health agencies. It was reported that the TB cases in India and other endemic countries are two to three times higher than in the last few years. Different mechanisms were acquired by the bacteria to become multidrug-resistant such as an alternation in the target site, drug efflux by overexpression of efflux pumps, inactivation of drugs by enzymes and biofilms. Mechanisms adopted by bacteria and longer anti-tuberculosis treatment regimens are the greatest threat in TB control programs especially in malnourished, immune-compromised, M. tuberculosis co-infection with HIV and SARS-CoV-2 individuals in developing countries. There is a great need for shorter anti-TB regimens and novel drugs with a different mode of action to encounter the emergence of drug resistance in Mycobacterium tuberculosis. Combinatorial drug treatments by anti-TB drugs along with the repurposed drugs are also the novel choice against this deadly TB. The current issue will focus on different mechanisms adopted by mycobacterium to develop multidrug-resistant mycobacteria and the impact of SARS-CoV-2 pandemics in TB treatment and management. Furthermore, the modern techniques used for the early diagnosis and management of M. tuberculosis and its co-infection with HIV and SARS-CoV-2 are the point of innovative interest that shows the potential development in technologies and applications for the management of these co-infections.

Author : Prashant Kesharwani
Publisher : Academic Press
Page : 284 pages
File Size : 54,5 Mb
Release : 2020-06-10
Category : Business & Economics
ISBN : 9780128226117

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Nanotechnology Based Approaches for Tuberculosis Treatment by Prashant Kesharwani Pdf

Nanotechnology Based Approaches for Tuberculosis Treatment discusses multiple nanotechnology-based approaches that may help overcome persisting limitations of conventional and traditional treatments. The book summarizes the types of nano drugs, their synthesis, formulation, characterization and applications, along with the most important administration routes. It also explores recent advances and achievements regarding therapeutic efficacy and provides possible future applications in this field. It will be a useful resource for investigators, pharmaceutical researchers, innovators and scientists working on technology advancements in the areas of targeted therapies, nano scale imaging systems, and diagnostic modalities in tuberculosis. Addresses the gap between nanomedicine late discovery and early development of tuberculosis therapeutics Explores tuberculosis nanomedicine standardization and characterization with newly developed treatment, diagnostic and treatment monitoring modalities Covers the field thoroughly, from the pathogenesis of tuberculosis and multi-drug resistant mycobacterium tuberculosis, to treatment approaches using nanotechnology and different nanocarriers

Author : Seyed Ehtesham Hasnain,Nasreen Z. Ehtesham,Sonam Grover
Publisher : Springer Nature
Page : 524 pages
File Size : 44,5 Mb
Release : 2019-11-30
Category : Medical
ISBN : 9789813294134

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Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions by Seyed Ehtesham Hasnain,Nasreen Z. Ehtesham,Sonam Grover Pdf

This book reviews recent advances in the molecular and infection biology, pathology, and molecular epidemiology of Mycobacterium tuberculosis, as well as the identification and validation of novel molecular drug targets for the treatment of this mycobacterial disease. Despite being completely curable, tuberculosis is still one of the leading global causes of death. M. tuberculosis, the causative organism – one of the smartest pathogens known – adopts highly intelligent strategies for survival and pathogenesis. Presenting a wealth of information on the molecular infection biology of M. tuberculosis, as well as nontuberculous mycobacteria (NTM), the book provides an overview of the functional role of the PE/PPE group of proteins, which is exclusive to the genus Mycobacteria, of host-pathogen interactions, and virulence. It also explores the pathogenesis of the infection, pathology, epidemiology, and diagnosis of NTM. Finally it discusses current and novel approaches in vaccine development against tuberculosis, including the role of nanotechnology. With state-of-the-art contributions from experts in the respective domains, this book is an informative resource for practitioners as well as medical postgraduate students and researchers.

Author : Mario C. Raviglione
Publisher : CRC Press
Page : 0 pages
File Size : 42,6 Mb
Release : 2009-11-18
Category : Medical
ISBN : 1420090216

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Tuberculosis by Mario C. Raviglione Pdf

Every second a new person is exposed to tuberculosis (TB). Each untreated TB-infected person will infect 10-15 people every year. Following the success of its predecessor, this new edition of Tuberculosis: The Essentials scrutinizes the new discoveries and observations of the key aspects of the disease. Recognized world experts provide a concise, state-of-the-art review of the 15 essential elements of TBsupply an international, current view of the epidemiology, pathophysiology, diagnosis, and treatment methodsdiscuss the emerging threat of XDR-TB and the HIV/AIDS factorassess advances in TB research such as new drugs and vaccinesreflect on the progress of the "Stop TB" strategy. See What’s New in the Fourth Edition: Updated chapters on epidemiology and pathogenesis provide new insights on TB infection and disease Updated chapters on diagnosis and treatment cover new tests and molecular detection methods Information on developing effective regiments and discussion of situations deserving specific precautions Coverage of adherence issues The book book is an essential guide for everybody working in the field of TB, from specialists to nurses and students, both from a clinical and public health perspective.

Author : Davide Maria Ferraris,Riccardo Miggiano,Menico Rizzi
Publisher : Unknown
Page : 128 pages
File Size : 45,5 Mb
Release : 2020
Category : Electronic
ISBN : 3039366599

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Mycobacterium Tuberculosis Pathogenesis, Infection Prevention and Treatment by Davide Maria Ferraris,Riccardo Miggiano,Menico Rizzi Pdf

Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB) and it represents a persistent public health threat for a number of complex biological and sociological reasons. According to the most recent Global Tuberculosis Report (2019) edited by the World Health Organization (WHO), TB is considered the ninth cause of death worldwide and the leading cause of mortality by a single infectious agent, with the highest rate of infections and death toll rate mostly concentrated in developing and low-income countries. We present here the editorial section to the Special Issue entitled “Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment” that includes 7 research articles and a review. The scientific contributions included in the Special Issue mainly focus on the characterization of MTB strains emerging in TB endemic countries as well as on multiple mechanisms adopted by the bacteria to resist and to adapt to antitubercular therapies.

Author : Mehmet Turgut,Ali Akhaddar,Ahmet T. Turgut,Ravindra K. Garg
Publisher : Springer
Page : 633 pages
File Size : 45,9 Mb
Release : 2017-06-13
Category : Medical
ISBN : 9783319507125

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Tuberculosis of the Central Nervous System by Mehmet Turgut,Ali Akhaddar,Ahmet T. Turgut,Ravindra K. Garg Pdf

Written and edited by leading international authorities in the field, this book provides an in-depth review of knowledge of tuberculosis of the central nervous system, with emphasis on clinical, diagnostics, and therapeutic features. Tuberculosis, one of the most lethal diseases in human history, still poses a serious threat in the world together with economic and social problems, although a great progress in the fight against this infectious disease in the last century. It covers the full range of tuberculosis of central nervous system and the chapters are organized into six sections: (1) the cranial; (2) the spinal; and (3) the peripheral portions of the nervous system; followed by (4) a section on the laboratory studies in tuberculosis; (5) a section on medical and surgical therapy; and (6) further insights into tuberculosis. This comprehensive reference book will be an ideal source for neurosurgeons, neurologists and specialists upon infectious diseases seeking both basic and more sophisticated information and surgical procedures relating to the complications associated with tuberculosis involving the spine, brain and peripheral nerves.

Author : Digambar Behera
Publisher : JP Medical Ltd
Page : 216 pages
File Size : 48,6 Mb
Release : 2018-07-31
Category : Medical
ISBN : 9789386322012

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Clinic Consult Pulmonology: Tuberculosis by Digambar Behera Pdf

This book is a practical guide to the diagnosis and management of tuberculosis. Presented in a step by step approach, the text provides the latest information in the specialty, guiding clinicians through the history of the disease, its epidemiology, pathogenesis and pathology, to clinical presentation, imaging, diagnosis, and treatment options. The book is enhanced by illustrations and figures, and provides a clear understanding of the management of the disease from a global perspective and the challenges associated with tuberculosis care. Key points Practical guide to diagnosis and management of tuberculosis Presented in a step by step approach, providing latest information in the field Includes illustrations and figures to assist learning Provides clear understanding of challenges associated with tuberculosis care

Author : Barry R. Bloom
Publisher : Unknown
Page : 664 pages
File Size : 48,7 Mb
Release : 1994
Category : Medical
ISBN : UOM:39015035754277

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Tuberculosis by Barry R. Bloom Pdf

The authors discuss fundamental questions about the biology, genetics, mechanisms of pathogenicity, mechanisms of resistance, and drug development strategies that are likely to provide important new knowledge about TB and new interventions to prevent and treat this disease.

Author : World Health Organization
Publisher : World Health Organization
Page : 277 pages
File Size : 42,5 Mb
Release : 2018-11-20
Category : Medical
ISBN : 9789241565646

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Global Tuberculosis Report 2018 by World Health Organization Pdf

WHO has published a global TB report every year since 1997. The main aim of the report is to provide a comprehensive and up-to-date assessment of the TB epidemic and of progress in prevention diagnosis and treatment of the disease at global regional and country levels. This is done in the context of recommended global TB strategies and targets endorsed by WHO?s Member States and broader development goals set by the United Nations (UN). The 2018 edition of the global TB report was released on 18 September in the lead up to the first-ever UN High Level Meeting on TB on 26 September 2018.

Author : Arnold Carl Klebs
Publisher : Unknown
Page : 990 pages
File Size : 43,6 Mb
Release : 1909
Category : Diagnosis, Radioscopic
ISBN : UCAL:B3219994

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Tuberculosis; a Treatise by American Authors on Its Etiology, Pathology, Frequency, Semeiology, Diagnosis, Prognosis, Prevention and Treatment by Arnold Carl Klebs Pdf

Author : Onya Opota,Emmanuelle Cambau,Delia Goletti,Jesica Mazza-Stalder,Miguel Viveiros,Miguel Santin
Publisher : Frontiers Media SA
Page : 196 pages
File Size : 43,7 Mb
Release : 2021-12-31
Category : Science
ISBN : 9782889719044

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Tuberculosis and Non-Tuberculous Mycobacteria Infections: Control, Diagnosis and Treatment by Onya Opota,Emmanuelle Cambau,Delia Goletti,Jesica Mazza-Stalder,Miguel Viveiros,Miguel Santin Pdf