Tumor Immunology And Immunotherapy

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Cancer Immunology and Immunotherapy

Mansoor M. Amiji,Lara Scheherazade Milane
Cancer Immunology and Immunotherapy Book PDF

Author : Mansoor M. Amiji,Lara Scheherazade Milane
Publisher : Academic Press
Page : 550 pages
File Size : 42,6 Mb
Release : 2021-08-18
Category : Business & Economics
ISBN : 9780128236376

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Cancer Immunology and Immunotherapy by Mansoor M. Amiji,Lara Scheherazade Milane Pdf

Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO

Tumor Immunology and Immunotherapy

Robert C. Rees
Tumor Immunology and Immunotherapy Book PDF

Author : Robert C. Rees
Publisher : Oxford University Press, USA
Page : 469 pages
File Size : 40,7 Mb
Release : 2014
Category : Medical
ISBN : 9780199676866

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Tumor Immunology and Immunotherapy by Robert C. Rees Pdf

A comprehensive account of cancer immunity and immunotherapy, examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines. It provides insight into how these problems may be overcome as viewed by leaders in the field.

Cancer Immunology and Immunotherapy

Glenn Dranoff
Cancer Immunology and Immunotherapy Book PDF

Author : Glenn Dranoff
Publisher : Springer Science & Business Media
Page : 306 pages
File Size : 45,8 Mb
Release : 2011-04-11
Category : Medical
ISBN : 9783642141362

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Cancer Immunology and Immunotherapy by Glenn Dranoff Pdf

The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

Tumor Immunology and Immunotherapy - Integrated Methods Part B

Anonim
Tumor Immunology and Immunotherapy Integrated Methods Part B Book PDF

Author : Anonim
Publisher : Academic Press
Page : 404 pages
File Size : 53,8 Mb
Release : 2020-04-01
Category : Science
ISBN : 9780128206676

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Tumor Immunology and Immunotherapy - Integrated Methods Part B by Anonim Pdf

Tumor Immunology and Immunotherapy - Integrated Methods Part B, Volume 636 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this update include Quantification methods of Transforming Growth Factor beta (TGF??) activity in the setting of cancer immunotherapy, Decoding cancer cell death-driven immune cell recruitment: An in vivo method for site-of-vaccination analyses, Tracking and interrogating tissue-resident and recruited microglia in brain tumors, Metabolomics and lipidomics of the tumor microenvironment, Monitoring abscopal responses to radiation in mice, and much more. Provides an array of authors who are authorities in the field Presents comprehensiveness coverage of the topics Includes a broad level of detail and in-depth coverage

Tumor Immunology and Immunotherapy - Integrated Methods Part B

Anonim
Tumor Immunology and Immunotherapy Integrated Methods Part B Book PDF

Author : Anonim
Publisher : Academic Press
Page : 406 pages
File Size : 44,8 Mb
Release : 2020-03-15
Category : Science
ISBN : 9780128206683

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Tumor Immunology and Immunotherapy - Integrated Methods Part B by Anonim Pdf

Tumor Immunology and Immunotherapy - Integrated Methods Part B, Volume 636 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this update include Quantification methods of Transforming Growth Factor beta (TGF?ß) activity in the setting of cancer immunotherapy, Decoding cancer cell death-driven immune cell recruitment: An in vivo method for site-of-vaccination analyses, Tracking and interrogating tissue-resident and recruited microglia in brain tumors, Metabolomics and lipidomics of the tumor microenvironment, Monitoring abscopal responses to radiation in mice, and much more. Provides an array of authors who are authorities in the field Presents comprehensiveness coverage of the topics Includes a broad level of detail and in-depth coverage

Advances in Tumor Immunology and Immunotherapy

Joseph D. Rosenblatt,Eckhard R. Podack,Glen N. Barber,Augusto Ochoa
Advances in Tumor Immunology and Immunotherapy Book PDF

Author : Joseph D. Rosenblatt,Eckhard R. Podack,Glen N. Barber,Augusto Ochoa
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 55,9 Mb
Release : 2013-10-25
Category : Medical
ISBN : 9781461488095

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Advances in Tumor Immunology and Immunotherapy by Joseph D. Rosenblatt,Eckhard R. Podack,Glen N. Barber,Augusto Ochoa Pdf

Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion. In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.

Cancer Immunology

Nima Rezaei
Cancer Immunology Book PDF

Author : Nima Rezaei
Publisher : Springer Nature
Page : 600 pages
File Size : 42,5 Mb
Release : 2020-12-12
Category : Medical
ISBN : 9783030579494

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Cancer Immunology by Nima Rezaei Pdf

This book explains the immunology of organ-specific malignancies and discusses novel immunotherapy strategies for their treatment. Since the first, very successful edition of the book was published in 2015, a number of entirely new chapters have been included. The range of cancers considered has accordingly been extended, with coverage of the latest immunotherapy approaches for cancers in different organs. In addition, the original chapters have been updated to document the latest advances in immunotherapy for pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, bone tumors, central nervous tumors, lung cancer, genitourinary tract tumors, and breast cancer, among others. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and bench to bedside immunotherapy. Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors will be of special value to clinical immunologists, hematologists, and oncologists.

Tumor Immunology and Immunotherapy - Integrated Methods Part A

Anonim
Tumor Immunology and Immunotherapy Integrated Methods Part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 344 pages
File Size : 53,5 Mb
Release : 2020-02-28
Category : Science
ISBN : 9780128188750

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Tumor Immunology and Immunotherapy - Integrated Methods Part A by Anonim Pdf

Tumor Immunology and Immunotherapy Integrated Methods - Part A, Volume 635 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Specific chapters to this release include Deconvolution of the immunological contexture of mouse tumors with multiplexed immunohistochemistry, High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers, Multiplex assay by IHC for melanoma tumor microenvironment evaluation, Characterization of the tumor immune microenvironment by multispectral image analysis of multiplex immunofluorescence images, Phenotyping of immune cells in situ using multispectral imaging quantification, and much more. Authored by leaders in the field of enzymology Provides a comprehensiveness level of discussion on the field Presents a highly specialized group of topics that delve deep into new updates and future prospects

Tumor Immunology

A. G. Dalgleish,M. J. Browning
Tumor Immunology Book PDF

Author : A. G. Dalgleish,M. J. Browning
Publisher : Cambridge University Press
Page : 382 pages
File Size : 54,8 Mb
Release : 1996-06-13
Category : Medical
ISBN : 0521472377

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Tumor Immunology by A. G. Dalgleish,M. J. Browning Pdf

This 1996 volume reviewed advances in the field of human tumour immunology for an audience of clinicians and researchers.

Cancer Immunotherapy Principles and Practice, Second Edition

Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS
Cancer Immunotherapy Principles and Practice Second Edition Book PDF

Author : Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS
Publisher : Springer Publishing Company
Page : 1339 pages
File Size : 50,7 Mb
Release : 2021-08-25
Category : Medical
ISBN : 9780826137432

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Cancer Immunotherapy Principles and Practice, Second Edition by Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS Pdf

Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer. The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field. Key Features: Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field Covers the basic principles and science behind cancer immunotherapy and tumor immunology Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs

Tumor Immunology and Immunotherapy – Molecular Methods

Anonim
Tumor Immunology and Immunotherapy Molecular Methods Book PDF

Author : Anonim
Publisher : Academic Press
Page : 554 pages
File Size : 53,7 Mb
Release : 2019-11-13
Category : Science
ISBN : 9780128186725

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Tumor Immunology and Immunotherapy – Molecular Methods by Anonim Pdf

Tumor Immunology and Immunotherapy – Molecular Methods, Volume 629, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this release include Droplet digital PCR for measuring circulating tumor-derived DNA, Detection and quantification of cytosolic DNA, Methods to detect endogenous dsRNA induction and recognition, Quantification of eIF2alpha phosphorylation during immunogenic cell death, Assessment of annexin A1 release during immunogenic cell death, Luciferase-assisted detection of extracellular ATP in the course of ICD, The P2X7 receptor: structure and function, and much more. Contains the authority of authors who are leaders in their field Provides a comprehensive source on new methods and research in enzymology

Tumor Immunology and Immunotherapy - Cellular Methods Part B

Anonim
Tumor Immunology and Immunotherapy Cellular Methods Part B Book PDF

Author : Anonim
Publisher : Academic Press
Page : 588 pages
File Size : 43,5 Mb
Release : 2020-01-29
Category : Science
ISBN : 9780128186763

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Tumor Immunology and Immunotherapy - Cellular Methods Part B by Anonim Pdf

Tumor Immunology and Immunotherapy – Cellular Methods Part B, Volume 632, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Topics covered include Quantitation of calreticulin exposure associated with immunogenic cell death, Side-by-side comparisons of flow cytometry and immunohistochemistry for detection of calreticulin exposure in the course of immunogenic cell death, Quantitative determination of phagocytosis by bone marrow-derived dendritic cells via imaging flow cytometry, Cytofluorometric assessment of dendritic cell-mediated uptake of cancer cell apoptotic bodies, Methods to assess DC-dependent priming of T cell responses by dying cells, and more. Contains content written by authorities in the field Provides a comprehensive view on the topics covered Includes a high level of detail

Tumor Immunology and Immunotherapy – Cellular Methods Part A

Anonim
Tumor Immunology and Immunotherapy Cellular Methods Part A Book PDF

Author : Anonim
Publisher : Academic Press
Page : 554 pages
File Size : 47,5 Mb
Release : 2020-01-14
Category : Science
ISBN : 9780128186749

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Tumor Immunology and Immunotherapy – Cellular Methods Part A by Anonim Pdf

Tumor Immunology and Immunotherapy – Cellular Methods Part A, Volume 631, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New chapters include Detection of intracellular cytokine production by T cells with flow cytometry, High-throughput identification of human antigen-specific CD8+ and CD4+ T cells using soluble pMHC multimers, In vitro assays for effector T cell functions and activity of immunostimulatory antibodies, Ex vivo energetic profiling of tumor cells and T cells from mouse models and human samples, A cytofluorimetric assay to evaluate T cell polyfunctionality, and much more. Contains the authority of authors who are leaders in their field Provides a comprehensive source on new methods and research in enzymology

Tumor Immunology and Cancer Therapy

R. H. Goldfarb
Tumor Immunology and Cancer Therapy Book PDF

Author : R. H. Goldfarb
Publisher : CRC Press
Page : 346 pages
File Size : 41,9 Mb
Release : 2020-07-24
Category : Medical
ISBN : 9781000148305

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Tumor Immunology and Cancer Therapy by R. H. Goldfarb Pdf

Based on a Tumor Immunology Symposium held in Pittsburgh, this work provides comprehensive coverage of the most important aspects of tumor immunology. It reveals novel approaches to the immunotherapy of cancer and presents complex issues in an accessible manner.

General Principles of Tumor Immunotherapy

Howard L. Kaufman,Jedd D. Wolchok
General Principles of Tumor Immunotherapy Book PDF

Author : Howard L. Kaufman,Jedd D. Wolchok
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 42,8 Mb
Release : 2007-10-12
Category : Medical
ISBN : 9781402060878

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General Principles of Tumor Immunotherapy by Howard L. Kaufman,Jedd D. Wolchok Pdf

This book brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated.