Advances In Tumor Immunology And Immunotherapy

Author : Joseph D. Rosenblatt,Eckhard R. Podack,Glen N. Barber,Augusto Ochoa
Publisher : Springer Science & Business Media
Page : 371 pages
File Size : 41,9 Mb
Release : 2013-10-25
Category : Medical
ISBN : 9781461488095

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Advances in Tumor Immunology and Immunotherapy by Joseph D. Rosenblatt,Eckhard R. Podack,Glen N. Barber,Augusto Ochoa Pdf

Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumor immunity and tumor evasion. In addition to emerging understanding of tumor evasion, new immune targets such as CTLA4 blockade, NK stimulatory receptors, manipulation of the antigen processing and presentation, cytokine and costimulatory responses all provide new possibilities for enhancing anti-tumor immunity even in tumors previously felt to be resistant to immune attack. Several of these strategies have already been realized in the clinic. The volume will explore evolving paradigms in antigen presentation, dendritic cell biology, the innate response and immunosuppressive mechanisms, and emerging strategies for manipulation of the immune system for therapeutic benefit that have realized success in neuroblastoma, leukemia, melanoma, lung cancer, and allogeneic transplantation. Early successes as well as failures will be highlighted to provide a snapshot of the state of clinical immunotherapy with an eye to future possibilities such as combination therapies, adoptive T-cell transfer, and the retargeting of immune cells via T-cell receptor engineering.

Author : Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS
Publisher : Springer Publishing Company
Page : 1339 pages
File Size : 54,7 Mb
Release : 2021-08-25
Category : Medical
ISBN : 9780826137432

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Cancer Immunotherapy Principles and Practice, Second Edition by Lisa H. Butterfield, PhD,Howard L. Kaufman, MD, FACS,Francesco M. Marincola, MD, FACS Pdf

Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer. The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field. Key Features: Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field Covers the basic principles and science behind cancer immunotherapy and tumor immunology Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs

Author : Kōkichi Kikuchi,Noriyuki Satō,Benoît van den Eynde
Publisher : Unknown
Page : 232 pages
File Size : 40,6 Mb
Release : 1999-09
Category : Cancer
ISBN : UOM:39015058268619

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Recent Advances of Human Tumor Immunology and Immunotherapy by Kōkichi Kikuchi,Noriyuki Satō,Benoît van den Eynde Pdf

Author : Rasha Abu-Eid,John E. Janik
Publisher : Frontiers Media SA
Page : 64 pages
File Size : 42,6 Mb
Release : 2019-06-19
Category : Electronic
ISBN : 9782889458394

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Advances in Head and Neck Cancer Immunology and Immunotherapy by Rasha Abu-Eid,John E. Janik Pdf

Understanding the immunology of different cancers has led to great advances in developing cancer immunotherapies which are successfully used in generating effective anti-tumour immune responses. Head and neck cancers are no exception and various immunotherapies are now under study for the treatment of this diverse group of diseases. The articles in in this eBook provide a range of topics that highlight some of the latest advances in head and neck cancer immunology and immunotherapy. The authors of these articles provide their unique insight and expertise and suggest future directions for translational clinical research.

Author : P. K. Ray
Publisher : Springer Science & Business Media
Page : 301 pages
File Size : 55,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461395584

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Advances in Immunity and Cancer Therapy by P. K. Ray Pdf

The rapid and continuous upsurge of interesting data in the subject of tumor immunology necessitates the publication of an annual series to furnish the updated materials to the students, researchers, and clinicians in this rapidly advancing field. Concepts and methodologies are ever changing. Also, current research in tumor immunology promises to offer breakthroughs in the future. Important is the need to communicate to the right people the exact role of immunodiagnostic methods and immunological intervention in cancer preven tion and treatment. The role of immunotherapy in combination with conven tional modalities of treatment needs to be understood in its proper perspective. Oncogene, interferon, lymphokines, monoclonal antibodies, natural killer cells, platelet-mediated cytotoxicity of antibody-coated target cells, suppressor cells, platelet-derived factors, plasma-blocking factors, control of suppressor cell func tion, abrogation of plasma-blocking factors, and so forth, are some of the areas that are continually advancing. Progress in these areas will have implication in cancer therapy. Further, it is already understood that if immunocompetence of the host can be maintained at a reasonably good level, there exists the potential to increase the therapeutic indexes of conventional modalities of treatment. This series will attempt to present updated information in all these areas based on con tributed and solicited articles.

Author : Robert C. Rees
Publisher : Oxford University Press, USA
Page : 469 pages
File Size : 51,9 Mb
Release : 2014
Category : Medical
ISBN : 9780199676866

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Tumor Immunology and Immunotherapy by Robert C. Rees Pdf

A comprehensive account of cancer immunity and immunotherapy, examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines. It provides insight into how these problems may be overcome as viewed by leaders in the field.

Author : A. G. Dalgleish,M. J. Browning
Publisher : Cambridge University Press
Page : 382 pages
File Size : 50,6 Mb
Release : 1996-06-13
Category : Medical
ISBN : 0521472377

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Tumor Immunology by A. G. Dalgleish,M. J. Browning Pdf

This 1996 volume reviewed advances in the field of human tumour immunology for an audience of clinicians and researchers.

Author : Nima Rezaei
Publisher : Springer Nature
Page : 600 pages
File Size : 52,9 Mb
Release : 2020-12-12
Category : Medical
ISBN : 9783030579494

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Cancer Immunology by Nima Rezaei Pdf

This book explains the immunology of organ-specific malignancies and discusses novel immunotherapy strategies for their treatment. Since the first, very successful edition of the book was published in 2015, a number of entirely new chapters have been included. The range of cancers considered has accordingly been extended, with coverage of the latest immunotherapy approaches for cancers in different organs. In addition, the original chapters have been updated to document the latest advances in immunotherapy for pediatric solid tumors, hematologic malignancies, gastrointestinal tumors, bone tumors, central nervous tumors, lung cancer, genitourinary tract tumors, and breast cancer, among others. The book is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Other volumes in the series address the translational medicine context and bench to bedside immunotherapy. Cancer Immunology: Cancer Immunotherapy for Organ-Specific Tumors will be of special value to clinical immunologists, hematologists, and oncologists.

Author : Laurence Zitvogel,Guido Kroemer
Publisher : Springer
Page : 724 pages
File Size : 40,6 Mb
Release : 2017-12-13
Category : Medical
ISBN : 9783319624310

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Oncoimmunology by Laurence Zitvogel,Guido Kroemer Pdf

In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.

Author : Sandra P. D'Angelo,Seth M. Pollack
Publisher : Springer
Page : 152 pages
File Size : 55,5 Mb
Release : 2018-11-27
Category : Medical
ISBN : 9783319935300

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Immunotherapy of Sarcoma by Sandra P. D'Angelo,Seth M. Pollack Pdf

This book describes recent progress in the development of immunotherapies for advanced sarcoma, paying special attention to the potential role of manipulations of the sarcoma tumor immune microenvironment in improving patient outcomes. Readers will find a thorough overview of the state of the art in tumor immunology and immunotherapy as they relate to sarcoma. Among the topics addressed are advances in vaccine therapy; cytokine therapies; natural killer cells; the development of adoptive T cell strategies; and the scope for use of checkpoint inhibitors in patients with sarcoma, mirroring the tremendous breakthroughs made in other malignancies. Detailed information is provided on laboratory and clinical research, with analysis of outcomes of recent trials and identification of key challenges. There is every reason to believe that more effective and less toxic therapies for metastatic sarcoma can be attained by deepening our understanding of cancer immunology and building on the advances in immunotherapy for other solid tumors. In this context, Immunotherapy of Sarcoma will be of high interest for all medical oncologists responsible for the treatment of sarcoma patients.

Author : Anonim
Publisher : Academic Press
Page : 392 pages
File Size : 47,9 Mb
Release : 2015-07-29
Category : Medical
ISBN : 9780128025543

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Immunotherapy of Cancer by Anonim Pdf

Immunotherapy of Cancer provides information on cancer research related to inflammation and immunity, containing outstanding reviews by experts in the field. It is suitable for researchers and students who have an interest in cancer immunobiology. Provides information on cancer research, including outstanding and original reviews Covers the current progress and emerging concepts in cancer inflammation, immunology, and immunotherapy Suitable for researchers and students studying, and interested in, the field of immunotherapy for cancer Ideal for those studying cancer inflammation, tumor immunology, cancer immunotherapy, dendritic cell, antigen presentation, immune checkpoint, myeloid-derived suppressor cells, macrophages, and tumor environments

Author : Howard L. Kaufman,Jedd D. Wolchok
Publisher : Springer Science & Business Media
Page : 502 pages
File Size : 51,6 Mb
Release : 2007-10-22
Category : Medical
ISBN : 9781402060861

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General Principles of Tumor Immunotherapy by Howard L. Kaufman,Jedd D. Wolchok Pdf

This book brings together the world’s leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated.

Author : Hilal Arnouk
Publisher : BoD – Books on Demand
Page : 232 pages
File Size : 51,5 Mb
Release : 2012-02-03
Category : Medical
ISBN : 9789533079981

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Advancements in Tumor Immunotherapy and Cancer Vaccines by Hilal Arnouk Pdf

Harnessing the potential of the human body's own immune system to attack malignant tumor cells has been the goal of many scientific investigators in recent years, with advances in cancer biology and immunology enabling cancer immunotherapy to become a reality. World-class bench and clinical researchers have joined forces to collaborate and review current developments and trends in cancer immunology for the purposes of this book, and the result is a promising review of contemporary clinical treatments. In each chapter the authors present the scientific basis behind such therapeutic approaches, including cancer vaccines with special focus on prostate cancer, melanoma and novel approaches utilizing both innate and adaptive immune responses.

Author : Glenn Dranoff
Publisher : Springer Science & Business Media
Page : 306 pages
File Size : 40,9 Mb
Release : 2011-04-11
Category : Medical
ISBN : 9783642141362

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Cancer Immunology and Immunotherapy by Glenn Dranoff Pdf

The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

Author : P. K. Ray
Publisher : Springer Science & Business Media
Page : 320 pages
File Size : 51,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781461250685

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Advances in Immunity and Cancer Therapy by P. K. Ray Pdf

The rapid and continuous upsurge of interesting data in the subject of tumor immunology necessitates the publication of an annual series to furnish the updated materials to the students, researchers, and clinicians in this rapidly advancing field. Concepts and methodologies are ever changing. Also, current research in tumor immunology promises to offer breakthroughs in the future. Important is the need to communicate to the right people the exact role of immunodiagnostic methods and immunolog ical intervention in cancer prevention and treatment. The role of immuno therapy in combination with conventional modalities of treatment needs in its proper perspective. Oncogene, interferon, lympho to be understood kines, monoclonal antibodies, natural killer cells, platelet-mediated cyto toxicity of antibody-coated target cells, suppressor cells, platelet-derived factors, plasma-blocking factors, control of suppressor cell function, ab rogation of plasma-blocking factors, etc. , are some of the areas that are continually advancing. Progress in these areas will have implication in cancer therapy. Further, it is already understood that if immunocompe tence of the host can be maintained at a reasonably good level, there exists the potential to increase the therapeutic indexes of conventional modalities of treatment. This series will attempt to present updated infor mation in all these areas based on contributed and solicited articles. P. K.