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THE NEW YORK TIMES BESTSELLER NOW A MAJOR FILM, STARRING STEVE CARELL AND BAFTA AND GOLDEN GLOBE NOMINATED TIMOTHEE CHALAMET ‘It was like being in a car with the gas pedal slammed down to the floor and nothing to do but hold on and pretend to have some semblance of control. But control was something I'd lost a long time ago.’ Nic Sheff was drunk for the first time at age 11. In the years that followed, he would regularly smoke pot, do cocaine and ecstasy, and develop addictions to crystal meth and heroin. Even so, he felt like he would always be able to quit and put his life together whenever he needed to. It took a violent relapse one summer to convince him otherwise. In a voice that is raw and honest, Nic spares no detail in telling us the compelling true story of his relapse and the road to recovery. He paints an extraordinary picture for us of a person at odds with his past, with his family, with his substances, and with himself. Tweak is a raw, harrowing, and ultimately hopeful tale of the road from relapse to recovery and complements his father’s parallel memoir, Beautiful Boy. Praise for Nic Sheff:- ‘Difficult to read and impossible to put down.’Chicago Tribune 'Nic Sheff's wrenching tale is told with electrifying honesty and insight.' Armistead Maupin
Patch & Tweak with Moog is the ultimate resource for Moog synthesizer enthusiasts and musicians of all skill levels interested in an immersive modular synthesis experience. Opening with a foreword from acclaimed film score composer Hans Zimmer, this hardcover book by Kim Bjørn features 200 pages full of synthesizer techniques, creative patch ideas, sound design tips, professional artist interviews, in-depth discussions with Moog engineers, and a glimpse into the company's remarkable history. The book's primary focus is Moog's well-loved line of semi-modular analog synthesizers: Mother-32, DFAM, Subharmonicon, Grandmother, and Matriarch. Patch & Tweak with Moog brings readers inside the creative minds of composers, producers, and performing artists like Suzanne Ciani, Trent Reznor, Lisa Bella Donna, Paris Strother, Hannes Bieger, Stranger Things composers Michael Stein and Kyle Dixon, and Moog synthesizer co-inventor Herb Deutsch in detailed interviews featuring patching tips and tricks for musicians of all skill levels.
Little Elephant and Mama Elephant are going for a walk. “Hold on to my tail,” says Mama. “If you want to ask me a question, tweak twice.” Tweak, tweak! “Mama, what is that?” Little Elephant is curious about the frog, the monkey, the songbird, the butterfly, and the crocodile—and especially about what a little elephant can do. Mama knows just how to answer, to help her cherished Little Elephant grow. Eve Bunting’s tender text and Sergio Ruzzier’s whimsical illustrations make this walk with Mama an excursion any little elephant would enjoy.
As the demands of work grow more intense, personal life can get shoved to the side. But resolving the job-versus-life conflict doesn't require the kind of big, disruptive, scary transformation that so many time-management "experts" recommend. In Tweak it, Cali Williams Yost proves that a comfortable work+life fit can be achieved through making small, consistent, everyday changes -- tweaks -- that, cumulatively, will optimize job performance and well-being. This engaging, practical book, filled with case studies of people who've tweaked their way to professional success and personal satisfaction, guides readers through an easy-to-implement program that can be tailored to suit any individual's life, both on off the job.
Improving teaching is the key to genuine and sustainable school improvement. Improvement involves persuading teachers to change and develop their practice but, as anyone who has ever tried will testify, this is far from easy. The focus of Tweak to Transform is what head teachers and school leaders can do to manage the change process and improve the quality of teaching in a school. Essentially, Tweak to Transform is a practical handbook that seeks to address three questions: - What do we know about change? - What do we know about learning? - What do we know about leading and managing the improvement process? While there is no single successful recipe for improving teaching in a school, this book attempts to establish some key principles. The result is a collection of thoughts, activities strategies and models that have been developed and successfully implemented in a wide range of schools.
Author : Linda C. Burkly,Timothy S. Zheng,John Silke Publisher : Frontiers Media SA Page : 203 pages File Size : 51,9 Mb Release : 2016-01-21 Category : Electronic book ISBN : 9782889197002
Regulation of Tissue Responses: The TWEAK/Fn14 Pathway and other TNF/ TNFR Superfamily Members that Activate Noncanonical NFkB Signaling by Linda C. Burkly,Timothy S. Zheng,John Silke Pdf
The immune system mediates tissue responses under both physiological and pathological conditions, impacting the inflammatory, fibrogenic and regenerative components. In addition to various leukocyte subsets, it is now recognized that epithelial, endothelial and other non-hematopoietic tissue cell types actively contribute to the interplay shaping tissue responses. Further understanding the molecular pathways and mechanisms mediating these tissue responses is of great interest. In the past decade, TNF-like weak inducer of apoptosis (TWEAK) and its receptor, FGF-inducible molecule-14 (Fn14), members of the TNF/TNFR superfamily, have emerged as a prominent molecular axis regulating tissue responses. Generally leukocyte-derived, TWEAK signals through Fn14 which is highly induced in injured and diseased tissues on the surface of parenchymal, stromal and progenitor cells, thereby orchestrating a host of tissue-shaping responses, including inflammation, angiogenesis, cell proliferation or death, and the regulation of progenitor cells. Compelling preclinical results indicate that whereas transient TWEAK/Fn14 activation promotes productive tissue responses after acute injury, excessive or persistent TWEAK/Fn14 activation drives pathological tissue responses, leading to progressive damage and degeneration in target organs of injury, autoimmune and inflammatory diseases and cancer. Given that the highly inducible pattern of Fn14 expression is well conserved between mouse and man, the role of TWEAK/Fn14 in human disease is an area of intense investigation. Recent findings have also begun to shed light on how the TWEAK/Fn14 pathway fits into the immune network, interplaying with other well-established pathways, including TNFa, IL-17, IL-13 and TGFb, in regulating tissue responses. The noncanonical nuclear factor kB (NF?B) pathway plays a role in immunity and disease pathologies and appears to be activated by only a subset of TNF/ TNFR superfamily members. Of the various signaling pathways downstream of TWEAK/Fn14, particular attention has been placed on the noncanonical NF?B pathway given that given that TWEAK induces acute activation of canonical NF?B but prolonged activation of noncanonical pathway. Thus dovetailing of the TWEAK/Fn14 axis with noncanonical NF?B pathway activation may be a key mechanism underlying tissue responses. Also of great interest is a deeper understanding of where, when and how tissue responses are regulated by other TNF/ TNFR superfamily members that can signal through noncanonical NF?B. This Research Topic issue will cover: 1. TWEAK/Fn14 pathway biology, role in tissue responses, injury, and disease pathogenesis 2. Role of noncanonical NFkB signaling cascade in tissue responses 3. Translational studies of relevance of TWEAK/Fn14 and noncanonical NFkB in human disease 4. Other TNF superfamily members’ signaling through noncanonical NFkB in the regulation of tissue responses 5. Reviews and Perspectives on the above
Tweak It and Freak It A Killer Guide to Making Windows Run Your Way Hundreds of millions of people use Windows every day, and it’s a safe bet that some of them would not describe themselves as happy campers. Regardless of skill level, most people have something they dislike about Windows, and they often have a whole laundry list of Windows gripes. “Why can’t Windows do this rather than that?” “Why does Windows do X instead of Y?” “Wouldn’t it be great if Windows could do Z?” Most people think Windows is set in stone, but it isn’t! Strip off that veneer and a whole world comes into view, one that’s hackable, moddable, tweakable, customizable, and personalizable. This book shows you the tools and technologies that anyone can use to hack almost every aspect of Windows, from startup to shutdown, from the interface to the Internet, from security to scripting. • Speed up your tired PC with a fistful of easy-to-do, but oh so powerful tweaks! • Tired of looking at the same old Windows day in and day out? So are we! That’s why we show you how to give Windows a makeover! • Want to be more productive at work or home? This book is full of productivity tweaks that not only make Windows more fun to use, but also save you tons of time. • Create custom backup routines that safeguard your precious data. • Tighten the security of your PC and your network to stop would-be thieves in their tracks. • Dual-boot Windows XP and Vista on the same machine, or dare we say it, run MacOS on your PC! We won’t tell. Paul McFedries is a passionate computer tinkerer and Windows expert. He is the author of more than 60 computer books that have sold more than 3 million copies worldwide. His recent titles include the Sams Publishing books Windows Vista Unleashed, Second Edition, and Windows Home Server Unleashed, and the Que Publishing books Build It. Fix It. Own It. : Networking with Windows Vista, Formulas and Functions with Microsoft Excel 2007, Tricks of the Microsoft Office 2007 Gurus, and Microsoft Access 2007 Forms, Reports, and Queries. Paul is also the proprietor of Word Spy (www.wordspy.com), a website devoted to tracking new words and phrases as they enter the English language. CATEGORY: Windows Operating System COVERS: Windows Vista and XP USER LEVEL: Beginning-Intermediate
As the demands of work grow more intense, personal life can get shoved to the side. But resolving the job-versus-life conflict doesn't require the kind of big, disruptive, scary transformation that so many time-management "experts" recommend. In Tweak it, Cali Williams Yost proves that a comfortable work+life fit can be achieved through making small, consistent, everyday changes -- tweaks -- that, cumulatively, will optimize job performance and well-being. This engaging, practical book, filled with case studies of people who've tweaked their way to professional success and personal satisfaction, guides readers through an easy-to-implement program that can be tailored to suit any individual's life, both on off the job.
Sixteen-year-old Gordie Jessup is a good kid but he's living a nightmare. His eighteen-year-old brother Chase's two-year addiction to crystal meth has left their family emotionally and financially drained. And just when Gordie thinks he can no longer stand the manipulating, the lying and the stealing, things get even worse. Chase is arrested for aggravated assault, released on bail and sent home to his family. But his dealers are after him and Chase appeals to Gordie for help. Gordie, disgusted with his brother and fully aware that it's a gamble, risks everything he has in the hope of bringing his family some peace.
In his follow-up to his bestselling memoir Tweak: Growing Up On Methamphetamines, Nic Sheff reveals a brutally honest account of a young person's struggles with relapse and rehab. In his bestselling memoir Tweak, Nic Sheff took readers on an emotionally gripping roller-coaster ride through his days as an addict. In this powerful follow-up about his continued efforts to stay clean, Nic writes candidly about eye-opening stays at rehab centers, devastating relapses, and hard-won realizations about what it means to be a young person living with addiction. By candidly revealing his own failures and small personal triumphs, Nic inspires readers to maintain hope and to remember that they are not alone in their battles. A group reading guide is included. Nic Sheff's Tweak, We All Fall Down, and his father's memoir about him (Beautiful Boy) are the basis of the film Beautiful Boy starring Steve Carell and Timothée Chalamet.
Acres of Windows 8 tweaks from a Microsoft MVP and creator of Tweaks.com! From a Microsoft MVP, who is also the savvy creator of Tweaks.com, comes this ultimate collection of Windows 8 workarounds. Steve Sinchak takes you way beyond default system settings, deep under the hood of Windows 8, down to the hidden gems that let you customize your Windows 8 system like you wouldn't believe. From helping you customize the appearance to setting up home networking, sharing media, and squeezing every ounce of performance out of the OS, this book delivers. Get ready to rock and roll with Windows 8! Uncovers hidden gems to help you get the most out of Windows 8 Bypasses the default system settings to show you how to customize the login and start screens, unlock hidden settings, supercharge your network speed, get rid of features you hate, and more Provides over 400 pages of workarounds and tweaks, including many high-level ones for you hotshot techies who really love to reshape an OS and make it your own Offers expert guidance and insight from author Steve Sinchak, a Microsoft MVP and creator of Tweaks.com Start tweaking and make Windows 8 your own with Windows 8 Tweaks.
The definitive guide to unlocking the hidden potential of the Windows 7 OS Written by bestselling author and the creator of tweaks.com Steve Sinchak, this unique guide provides you with the ultimate collection of hidden gems that will enable you to get the most out of Windows 7. Packed with more than 400 pages of insider tips, the book delves beneath the surface to reveal little-known ways to tweak, modify, and customize Windows 7 so you can get every ounce of performance from your operating system. Regardless of your experience with tweaking your system, you'll find fascinating and fun tips and tricks for getting under the hood of Windows 7 that will allow you to optimize its appearance, speed, usability, and security. Bestselling author and creator of tweaks.com shows you how to tweak, modify, customize, and take complete control of the new Windows 7 operating system Unlocks hidden gems for optimizing the appearance, speed, usability, and security of the Windows 7 OS Shows you how to customize boot and login screens, supercharge your network and online speed, get rid of features that drive you nuts, fine tune your User Account Protection, and more So roll up your sleeves and take off your gloves so you can take total control over your Windows 7 OS!
Tweaked: A Crystal Meth Memoir by Patrick Moore Pdf
This candid memoir of addiction and recovery shares an intimate chronicle of life from Midwestern childhood to NYC's drug-fueled underground. Patrick Moore's account of life as a crystal meth addict combines heartbreaking honesty with rare insight and surprising humor. It chronicles a twenty-year trip stretching from Moore's lonely childhood in Iowa to the day he sits, naked, in a Los Angeles rental, hallucinating about psycho-robbers while talking to a possum he's sure is God. Along the way, there are acid trips at the V.F.W., Dexetrim study halls, teeth-grinding nights of dancing and anonymous sex in New York City's hottest eighties clubs. He takes pictures of Andy Warhol, loses friends and lovers, and navigates a Byzantine underworld of cookers, users, club kids, dealers, and colorful characters as intense as the drug itself. Through Patrick's vivid retelling, you'll meet Lee, the glamorous bad boy with a taste for danger; Tony, the tweaker who likes to remove his eyebrows; Ding-Dong, the Depends-wearing, nearly blind housemate; Hisako, the artist and squatter with a fondness for hot plate cooking; "Mother" Judy, the tough, butch rehab counselor who takes no prisoners, and countless others on the road from crystal meth hell to eventual sobriety.
