Two Faces Of Evil Cancer And Neurodegeneration

Author : Thomas Curran,Yves Christen
Publisher : Springer Science & Business Media
Page : 171 pages
File Size : 51,7 Mb
Release : 2010-12-16
Category : Medical
ISBN : 9783642166020

Get Book

Two Faces of Evil: Cancer and Neurodegeneration by Thomas Curran,Yves Christen Pdf

Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes

Author : Joseph Jebelli
Publisher : Little, Brown Spark
Page : 320 pages
File Size : 42,5 Mb
Release : 2017-10-31
Category : Health & Fitness
ISBN : 9780316398961

Get Book

In Pursuit of Memory by Joseph Jebelli Pdf

For readers of Atul Gawande, Siddhartha Mukherjee, and Henry Marsh, a riveting, gorgeously written biography of one of history's most fascinating and confounding diseases -- Alzheimer's -- from its discovery more than 100 years ago to today's race towards a cure. Alzheimer's is the great global epidemic of our time, affecting millions worldwide -- there are more than 5 million people diagnosed in the US alone. And as our population ages, scientists are working against the clock to find a cure. Neuroscientist Joseph Jebelli is among them. His beloved grandfather had Alzheimer's and now he's written the book he needed then -- a very human history of this frightening disease. But In Pursuit of Memory is also a thrilling scientific detective story that takes you behind the headlines. Jebelli's quest takes us from nineteenth-century Germany and post-war England, to the jungles of Papua New Guinea and the technological proving grounds of Japan; through America, India, China, Iceland, Sweden, and Colombia. Its heroes are scientists from around the world -- many of whom he's worked with -- and the brave patients and families who have changed the way that researchers think about the disease. This compelling insider's account shows vividly why Jebelli feels so hopeful about a cure, but also why our best defense in the meantime is to understand the disease. In Pursuit of Memory is a clever, moving, eye-opening guide to the threat one in three of us faces now.

Author : Mathias Jucker,Yves Christen
Publisher : Springer Science & Business Media
Page : 163 pages
File Size : 41,6 Mb
Release : 2013-03-27
Category : Medical
ISBN : 9783642354915

Get Book

Proteopathic Seeds and Neurodegenerative Diseases by Mathias Jucker,Yves Christen Pdf

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer’s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimer ́s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. ​

Author : R Ragaini
Publisher : World Scientific
Page : 540 pages
File Size : 40,5 Mb
Release : 2014-07-07
Category : Technology & Engineering
ISBN : 9789814623452

Get Book

International Seminars on Nuclear War and Planetary Emergencies 46th Session by R Ragaini Pdf

Proceedings of the 46th Session of the International Seminars on Nuclear War and Planetary Emergencies held in Erice, Sicily. This Seminar has again gathered, in 2013, over 100 scientists from 43 countries in an interdisciplinary effort that has been going on for the last 32 years, to examine and analyze planetary problems which had been followed up, all year long, by the World Federation of Scientists' Permanent Monitoring Panels. Contents:Why Science is Needed for the Culture of the Third MillenniumNuclear Power Safety and DevelopmentPollution and WaterClimate and the Limits of GeoengineeringMitigation of Megaterrorism and Hybrid ThreatsPollution Innovative Cleanup TechnologiesInformation Security Round TableEnergy — Key to the Evolution of CitiesEnergy as a Planetary EmergencyAids and Infectious DiseasesPMP Reports and ConclusionsConclusionsSeminar Participants Readership: Scientists in all fields, universities and institutes in all fields of science — politicians and decision makers — ministries of science, interior and security, foreign affairs — international organisations. Key Features:Freely-expressed scientific point of views on the most important contemporary and future emergencies facing humanityKeywords:Improvised Nuclear Devices;Preventing Nuclear Explosive Terrorism;Climate & Climate Economics Global Nuclear Energy Issues Outlook in Japan, China, Europe and USA;Global Food Production;Forest Dynamics;Water, Pollution & Terrorism;Brain Aging & Behavior;Frontiers In Fast Computing & Informatics;Sustainable Nuclear Energy Systems;Economics of Nuclear Power;Energy Sustainability in Cities;Information Security

Author : Anonim
Publisher : Elsevier
Page : 534 pages
File Size : 54,6 Mb
Release : 2019-09-22
Category : Medical
ISBN : 9780444641519

Get Book

Neurocognitive Development: Normative Development by Anonim Pdf

This is one of a two-volume work on neurocognitive development, focusing separately on normative and non-normative development. The normative volume focuses on neurology, biology, genetics, and psychology of normative cognitive development. It covers the development of intellectual abilities, visual perception, motor function, language, memory, attention, executive function, social cognition, learning abilities, and affect and behavior. The book identifies when and how these functions develop, the genetics and neurophysiology of their operation, and their evaluation and assessment in clinical practice. This book will serve as a comprehensive reference to researchers in cognitive development in neuroscience, psychology, and medicine, as well as to clinicians and allied health professionals focused on developmental disabilities (child neurologists, pediatric neuropsychologists, child psychiatrists, speech and language therapists, and occupational therapists.) Summarizes research on normative neurocognitive development Includes intellectual abilities, language, memory, attention, motor function, and more Discusses genetics and environmental influences on development Provides interdisciplinary information of use to both researchers and clinicians

Author : Colin R Martin,Victor R Preedy
Publisher : Academic Press
Page : 1866 pages
File Size : 40,6 Mb
Release : 2020-12-23
Category : Medical
ISBN : 9780128160442

Get Book

The Neuroscience of Dementia by Colin R Martin,Victor R Preedy Pdf

The Neuroscience of Dementia brings together different fields of dementia research into a single book, covering a wide range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, molecular biology, and more. This foundational, comprehensive book compiles the latest understanding on all forms of dementia and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers comprehensive coverage of a broad range of topics related to dementia Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about dementia

Author : Colin R Martin,Victor R Preedy
Publisher : Academic Press
Page : 954 pages
File Size : 44,7 Mb
Release : 2020-08-11
Category : Medical
ISBN : 9780128158692

Get Book

Genetics, Neurology, Behavior, and Diet in Dementia by Colin R Martin,Victor R Preedy Pdf

Genetics, Neurology, Behavior, and Diet in Dementia: The Neuroscience of Dementia, Volume 2 consolidates different fields of dementia research into a single book, covering a range of subjects, including Alzheimer’s disease, Lewy body dementia, mixed dementia, vascular dementia, physical activity, risk factors, mortality, biomarkers, SPECT, CT, MRI, questionnaires, nutrition, sleep, delirium, hearing loss, agitation, aggression, delusions, anxiety, depression, hallucinations, psychosis, senile plaques, tau and amyloid-beta, neuroinflammation, and molecular biology. This foundational, comprehensive book assembles the latest understanding on all dementias and their common features in a single source. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers comprehensive coverage of a broad range of topics related to dementia Serves as a foundational collection for neuroscientists and neurologists on the biology of dementia and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Provides unique sections on specific subareas, intellectual components, and knowledge-based niches that will help readers navigate key areas for research and further clinical recommendations Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about dementia

Author : Crawford M. Thomas
Publisher : Routledge
Page : 177 pages
File Size : 42,8 Mb
Release : 2021-11-22
Category : Psychology
ISBN : 9780429581564

Get Book

Sleep and Brain Injury by Crawford M. Thomas Pdf

This ground-breaking book binds together a contemporary understanding of sleep and brain injury, pairing empirical understanding through clinical practice with extensive up-to-date research, to provide a deeply considered approach to these overlapping topics. Firstly, the author discusses the neuroanatomy and architecture of sleep, including the need for sleep, definitions of good sleep, and what can go wrong with sleep. The focus then moves to the neuroanatomical damage and dysfunction from brain injury, and the resultant functional effects. The author then adroitly fuses the two streams of coverage together, focusing on the neurobiological, neurochemical, and functional aspects of both sleep and brain injury to offer new insights as to how they interrelate. The book then looks towards the applied aspects of treatment and rehabilitation, bringing further thoughts of how, because of this new understanding, we can potentially offer novel treatments for brain injury recovery and sleep problems. In this final practical part, four sleep foundations are given, necessary to optimize the three most common sleep problems and their treatments after brain injury. This new approach highlights how sleep can affect the specific functional effects of brain injury and how brain injury can exacerbate some of the specific functional effects of sleep problems, thus having the potential to transform the field of neurorehabilitation. It is essential reading for professionals working with brain injury and postgraduate students in clinical neuropsychology.

Author : L. Calderón-Garcidueñas
Publisher : IOS Press
Page : 616 pages
File Size : 50,9 Mb
Release : 2021-05-03
Category : Medical
ISBN : 9781643681597

Get Book

Alzheimer's Disease and Air Pollution by L. Calderón-Garcidueñas Pdf

Most people think of Alzheimer’s disease as a condition which predominately affects elderly people, but an increasing amount of evidence indicates that in populations exposed to high concentration of air pollutants, Alzheimer’s disease development and progression can be identified in pediatric and young adulthood ages. Cognitive, olfactory, gait, equilibrium and auditory alterations are seen early, thus the concept of decades-long asymptomatic period prior to clinical cognitive impairment does not apply to the millions of people exposed day in and day out to polluted environments. This book Alzheimer's Disease and Air Pollution – The Development and Progression of a Fatal Disease from Childhood and the Opportunities for Early Prevention is a compilation of work by researchers intent on revealing the links between air pollution and neurodegeneration. The book is divided into 6 sections. It includes a section describing the ways in which air pollution from traffic and tobacco smoke can damage the brain; epidemiological studies establishing a strong link between dementia and particulate matter and ozone; papers explaining the properties of pollution; and works describing the intricate pathways which transform normal neurons into ghost tangles surrounded by a devastated brain. Air pollution is complex; different pollutants, different sizes and shapes and different portals of entry, play different roles, but their capacity to damage neural tissue is abundantly illustrated in this book, which highlights the need for preventive measures to protect the millions of people currently exposed to air pollutants, and the need to ameliorate their harmful effects.

Author : John M. Barry
Publisher : Penguin
Page : 580 pages
File Size : 42,5 Mb
Release : 2005-10-04
Category : History
ISBN : 0143036491

Get Book

The Great Influenza by John M. Barry Pdf

#1 New York Times bestseller “Barry will teach you almost everything you need to know about one of the deadliest outbreaks in human history.”—Bill Gates "Monumental... an authoritative and disturbing morality tale."—Chicago Tribune The strongest weapon against pandemic is the truth. Read why in the definitive account of the 1918 Flu Epidemic. Magisterial in its breadth of perspective and depth of research, The Great Influenza provides us with a precise and sobering model as we confront the epidemics looming on our own horizon. As Barry concludes, "The final lesson of 1918, a simple one yet one most difficult to execute, is that...those in authority must retain the public's trust. The way to do that is to distort nothing, to put the best face on nothing, to try to manipulate no one. Lincoln said that first, and best. A leader must make whatever horror exists concrete. Only then will people be able to break it apart." At the height of World War I, history’s most lethal influenza virus erupted in an army camp in Kansas, moved east with American troops, then exploded, killing as many as 100 million people worldwide. It killed more people in twenty-four months than AIDS killed in twenty-four years, more in a year than the Black Death killed in a century. But this was not the Middle Ages, and 1918 marked the first collision of science and epidemic disease.

Author : Ismail Laher
Publisher : Springer
Page : 0 pages
File Size : 47,7 Mb
Release : 2014-06-16
Category : Medical
ISBN : 3642300170

Get Book

Systems Biology of Free Radicals and Antioxidants by Ismail Laher Pdf

The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.

Author : R.C. Cutler,L. Packer,J. Bertram,A. Mori
Publisher : Birkhäuser
Page : 393 pages
File Size : 48,7 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783034873376

Get Book

Oxidative Stress and Aging by R.C. Cutler,L. Packer,J. Bertram,A. Mori Pdf

Oxidative stress and aging Over the past several years there has been an extraordinarily rapid growth in our knowledge of free radical chemistry and its possible involvement in both normal essential biology and age related disease and dysfunction. Much of this growth in the traditionally separate sciences of chemistry and molecular gerontology occurred independently, with little interaction or communi cation between the scientists working in these two fields. In view of the growing maturity of the two fields and the potential importance of advancing our knowledge in the area of oxidative stress and aging, we perceived a critical need to organize an international conference the "First Inter national Conference on Oxidative Stress and Aging" in Hawaii in 1994 to bring together the world's leading scientists in the fields of reactive oxygen species and molecular gerontology. The objective of this conference was to provide a unique opportunity for scholars working in these two related and rapidly growing fields to participate in the exchange, integration, and synthesis of new concepts and ideas, to engage in constructive criticism and to initiate new collaborative research projects. The conference focused on the molecular and cellular aspects of aging as related to oxidative stress. It was one of the largest and most comprehensive international conferences held in molecular gerontology. At this conference a call was made for submission of papers to be used in the publication of a book covering the major contributions of the meeting.

Author : Drue H. Barrett,Leonard W. Ortmann,Angus Dawson,Carla Saenz,Andreas Reis,Gail Bolan
Publisher : Springer
Page : 0 pages
File Size : 43,6 Mb
Release : 2016-04-20
Category : Medical
ISBN : 3319238469

Get Book

Public Health Ethics: Cases Spanning the Globe by Drue H. Barrett,Leonard W. Ortmann,Angus Dawson,Carla Saenz,Andreas Reis,Gail Bolan Pdf

This Open Access book highlights the ethical issues and dilemmas that arise in the practice of public health. It is also a tool to support instruction, debate, and dialogue regarding public health ethics. Although the practice of public health has always included consideration of ethical issues, the field of public health ethics as a discipline is a relatively new and emerging area. There are few practical training resources for public health practitioners, especially resources which include discussion of realistic cases which are likely to arise in the practice of public health. This work discusses these issues on a case to case basis and helps create awareness and understanding of the ethics of public health care. The main audience for the casebook is public health practitioners, including front-line workers, field epidemiology trainers and trainees, managers, planners, and decision makers who have an interest in learning about how to integrate ethical analysis into their day to day public health practice. The casebook is also useful to schools of public health and public health students as well as to academic ethicists who can use the book to teach public health ethics and distinguish it from clinical and research ethics.

Author : Nadia M. Hamdy,Aditi Banerjee,Divya P. Kumar
Publisher : Frontiers Media SA
Page : 134 pages
File Size : 42,8 Mb
Release : 2023-06-08
Category : Medical
ISBN : 9782832525630

Get Book

Women in Gastrointestinal Cancers, volume II: 2022 by Nadia M. Hamdy,Aditi Banerjee,Divya P. Kumar Pdf

Author : Robert Bugh
Publisher : Tyndale House Publishers, Inc.
Page : 209 pages
File Size : 49,7 Mb
Release : 2011-10-12
Category : Religion
ISBN : 9781414366876

Get Book

When the Bottom Drops Out by Robert Bugh Pdf

Nobody is immune to disappointment. Unfortunately, at some point all of us will face that horrific moment when the bottom completely drops out of out of our life, leaving us broken, devastated, and desperately searching for God’s grace. Pastor and theologian Robert Bugh has experienced unthinkable pain and disappointment firsthand, having lost both his wife and his best friend to cancer within a year and a half of each other. Though devastating, Bugh’s tragedy also brought him into a stronger, deeper relationship with God. When the Bottom Drops Out chronicles Rob’s journey from loss to restoration and shows readers how to find and hold tightly to Christ through even the most painful episodes of life. Bugh’s story is proof positive that while pain and disappointment are an unavoidable part of life, God is nonetheless faithful, holding us close at all times and in all circumstances.