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In 1983 Graham Hughes described a syndrome in which the blood has a tendency to clot. Hughes syndrome is at the root of diverse conditions such as stroke, leg vein thrombosis and recurrent abortion. Hughes Syndrome addresses the complete range of features produced by this common disorder, which is also known as antiphospholipid syndrome. The condition can affect any organ, and is treated using commonly available drugs including low-dose aspirin and warfarin. This timely book fulfils the need for a cross-disciplinary clinical textbook and contains contributions from the leading international authorities. Hughes Syndrome should be read by anyone who might have a clinical or scientific interest in this condition: rheumatologists, haematologists, obstetricians and neurologists.
Understanding Hughes Syndrome by Graham Hughes Pdf
Along with AIDS, antiphospholipid syndrome was the major medical discovery of the late 20th century, so for many it is still deemed a ‘new’ disease. The discovery of ‘sticky blood’ (commonly known as antiphospholipid syndrome or ‘Hughes Syndrome’) came out of years of observation of patients who had developed lupus. Many specialists in the 1970s were interested in the neurological aspects of lupus, and Dr Hughes, among others, spent a number of years studying the mechanisms of brain inflammation. In the mid 1970s, Hughes observed a number of young women with a form of viral paralysis, where interestingly many of them carried an antibody in their blood actually directed against ‘phospholipid’ – one of the components of brain and spinal cord. It quickly became apparent that individuals who had "anti-phospholipid antibodies" suffered from a tendency not only to develop brain and spinal cord symptoms, but also a tendency to develop both vein and artery thrombosis. As investigation continued it became apparent that these symptoms were not just confined to lupus patients, but occurred in others too, specifically those with severe migraines, with repeated strokes, with memory loss, and in women with recurrent miscarriage.
This second edition is a result from a worldwide surge of interest in antiphospholipid syndrome. This disease, also known as Hughes Syndrome, affects all organs of the body including the placenta, and therefore touches all areas of medicine.Many publications have shown that APS causes miscarriage, strokes, heart attacks and teenage epilepsy. This new edition will see many of the illustrations updated as well as an increase in the number of figures within the chapters, to help the reader understand and treat this disease. It aims to help patients with Hughes Syndrome and their families, as well as trainee doctors , GPs, nurses and midwives.
Hughes Syndrome: The Antiphospholipid Syndrome by Graham Hughes,Shirish Sangle Pdf
Hughes Syndrome: The Antiphospholipid Syndrome, A Guide for Students provides an in-depth analysis into the main effects of Hughes Syndrome. In 1983, Dr Graham Hughes, and his team in London, described a syndrome and subsequently developed simple blood tests to diagnose the condition. This syndrome is characterised by thrombosis (both in limbs and internal organs), headaches, memory loss, strokes and, in pregnant women, placental clotting and recurrent miscarriage. The syndrome, now known worldwide as Hughes Syndrome, or the Antiphospholipid Syndrome, is common - being responsible for example, for up to 1 in 5 cases of young stroke and more importantly, it is treatable. Hughes Syndrome: The Antiphospholipid Syndrome, A Guide for Students details the effects of Hughes Syndrome on the major organs, making it a valuable reference tool for students in training.
Positive Options for Antiphospholipid Syndrome (APS) by Triona Holden Pdf
This book contains information on an increasingly common autoimmune disorder. Also called "sticky blood" and Hughes Syndrome, APS makes one's blood clot too easily, creating high risk of stroke, thrombosis, and premature heart attack. It is also implicated in many other health problems including repeated miscarriages, neurological problems, eary dementia and migraines. It is often associated with lupus, and mimics the symptoms of other diseases, including MS. Symptoms include; migraines and headaches, recurrent miscarriage, memory loss, slurred speech, blood clots, poor circulation, muscle pain and cramps, blurred vision, extreme fatigue, epilepsy, strokes, thrombosis and a form of angina. Because of lack of knowledge of APS in the medical establishment, sufferers are often misdiagnosed with MS or other more life-threatening conditions. This book helps the reader identify the symptoms and provides important information on diagnosis and treatment of APS. It contains many moving stories, explaining how people eventually got a diagnosis, their symptoms, the impact of APS on their lives and whether or not treatment has worked. Written in collaboration with Dr. Graham Hughes, the major researcher of APS in the UK, this book provides a clearly written informative look at an important but little-known disease.
Hughes Syndrome: Highways and Byways by Graham Hughes,Munther A Khamashta Pdf
Hughes Syndrome: Highways and Byways is a handy and easy-to-read guide to the main features of Hughes syndrome. There has been worldwide interest in this 'new' syndrome (first described in 1983). A clotting tendency which can potentially affect any organ in the body, it is: * responsible for 1 in 5 recurrent miscarriages (now successfully treated with aspirin and heparin) * responsible for 1 in 5 young (under 45) strokes * a major cause of early heart attacks * responsible for 1 in 5 deep vein thromboses * an important cause of migraine. Hughes Syndrome: Highways and Byways is a valuable resource for professionals with an interest in the subject, as well as general practitioners and patients.
The description by Graham Hughes of the ?antiphospholipid syndrome? or Hughes Syndrome is one of the medical landmarks of the 20th century.There is something of a fashion in science to play down ?clinical? discoveries as being somehow less ground-breaking than ?basic? laboratory based observations.Here is a disease, a medical discovery, which should turn such fashions around. In a series of brilliant clinical observations, Dr Hughes, not only pieced together what is now clearly a common and important disease, but also, with his team, set up the blood tests and treatment guidelines, which are used world-wide.Kay Thackray describes the condition as a patient, providing a clear practical guide to living life.
Positive Options for Antiphospholipid Syndrome by Triona Holden Pdf
This book contains information on an increasingly common autoimmune disorder. Also called "sticky blood" and Hughes Syndrome, APS makes one's blood clot too easily, creating high risk of stroke, thrombosis, and premature heart attack. It is also implicated in many other health problems including repeated miscarriages, neurological problems, eary dementia and migraines. It is often associated with lupus, and mimics the symptoms of other diseases, including MS. Symptoms include; migraines and headaches, recurrent miscarriage, memory loss, slurred speech, blood clots, poor circulation, muscle pain and cramps, blurred vision, extreme fatigue, epilepsy, strokes, thrombosis and a form of angina. Because of lack of knowledge of APS in the medical establishment, sufferers are often misdiagnosed with MS or other more life-threatening conditions. This book helps the reader identify the symptoms and provides important information on diagnosis and treatment of APS. It contains many moving stories, explaining how people eventually got a diagnosis, their symptoms, the impact of APS on their lives and whether or not treatment has worked. Written in collaboration with Dr. Graham Hughes, the major researcher of APS in the UK, this book provides a clearly written informative look at an important but little-known disease.
The Antiphospholipid Syndrome by Ronald A. Asherson Pdf
Written by the foremost researchers in the field, this book gathers together in a single source the many important clinical associations of antiphospholipid antibodies. Antibody-related clotting mechanisms and their relationship to conditions such as recurrent strokes, chorea, multi infarct dementias, a variety of spinal syndromes, Addison's Disease, recurrent miscarriages, and many more are discussed in depth. The importance of these antibodies in 'Primary,' 'Secondary,' and 'Catastrophic' Antiphospholipid Syndrome is highlighted. Each chapter is devoted to a specific internal system and the clinical effects this syndrome has on that system. This authoritative book is an essential addition to medical libraries as well as an invaluable reference for general physicians, internists, rheumatologists, neurologists, cardiologists, nephrologists, endocrinologists, gastroenterologists, pulmonologists, dermatologists, and obstetricians.
Antiphospholipid Syndrome by Doruk Erkan,Silvia S. Pierangeli Pdf
The International Congress on Antiphospholipid Antibodies is held every three years to discuss the recent advances and future directions in Antiphospholipid Syndrome (APS). This volume collects the scientific highlights and new findings about APS that were generated from the most recent 13th Congress, held in Galveston, Texas in 2010. Chapters were written by an internationally-distinguished group of scientists from the point-of-view of multiple specialty areas. Each chapter was written in a uniform and systematic basis to present the latest evidence-based research, including the basic science of APS, task force reports from the Congress on controversial aspects of APS, and future directions of APS research. This book will appeal to all clinicians involved in the treatment and management of APS patients, to residents in a variety of medical subspecialties, and to research scientists interested in a better understanding of this complex and evolving disease.
Maria L. Bertolaccini,Oier Ateka-Barrutia,Munther A Khamashta
Author : Maria L. Bertolaccini,Oier Ateka-Barrutia,Munther A Khamashta Publisher : Springer Science & Business Media Page : 98 pages File Size : 42,8 Mb Release : 2010-01-18 Category : Medical ISBN : 9781846287350
Antiphospholipid Syndrome Handbook by Maria L. Bertolaccini,Oier Ateka-Barrutia,Munther A Khamashta Pdf
This book discusses the major clinical features of the antiphospholipid syndrome. It provides a quick, practical and reader-friendly reference for the different problems that might be encountered in clinical practice. Treatment is a major concern in an area where evidence-based medicine is sparse and there are chapters dedicated to diagnosis from a laboratory point of view. Further chapters focus on subjects including pregnancy management, arterial thrombosis and prognosis. Due to the multi-disciplinary nature of this disease, the primary readership groups are general and internal medicine physicians and sub-specialties, including rheumatologists, hematologists, cardiovascular physicians, and obstetricians, among others.
Antiphospholipid Antibody Syndrome by Pier Luigi Meroni Pdf
This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss/complications are explained. The main clinical manifestations, classification criteria and diagnostic tools are identified, and close attention is paid to the nature of the involvement of various organs or organ systems in APS. Specific chapters describe the treatment of the different symptoms, therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome.
Antiphospholipid Syndrome in Systemic Autoimmune Diseases by Ricard Cervera,Gerard Espinosa,Munther Khamashta Pdf
Antiphospholipid Syndrome in Systemic Autoimmune Diseases, Second Edition provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations in both the thrombotic and non-thrombotic manifestations of this important disease. Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy, and memory loss, and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, and from psychiatry to orthopedics. Brings the reader up-to-date and allows easy access to individual topics in one place Written by a respected panel of distinguished physicians/scientists actively involved in the field of Antiphospholipid Syndrome Includes box summaries at the end of each chapter that highlight important topics Gives up-to-date, basic knowledge and a modern approach to diagnosis and therapy Provides a comprehensive review of this major disease Includes information on treatment options available
Sticky Blood Explained: Hughes Syndrome by Kay Thackray Pdf
Hughes Syndrome is now recognised as a major 'new' disease. It has been described by colleague Dr Josep Font of Barcelona, as, "one of the two new diseases (with AIDS) of the 20th century." The messages are simple. Blood clots can cause untold damage. The tendency to 'sticky blood' found in Hughes Syndrome can be diagnosed by simple blood tests. The use of medicines, some as simple as aspirin, can protect against the clotting tendency. Kay Thackray here provides just the sort of clear guidance patients with Hughes Syndrome need. Coming from a patient, and coming straight from the heart, I believe that the lessons provided by this book are beyond value. - Munther A Khamashta MD FRCP Consultant Physician, Lupus Unit ST THOMAS' HOSPITAL, LONDON
Antiphospholipid Syndrome by Doruk Erkan,Michael D. Lockshin Pdf
This new edition is a comprehensive and updated resource on antiphospholipid syndrome (APS), which is an autoimmune disorder. In APS, the body recognizes certain normal components of blood and/or cell membranes as foreign substances and produces antibodies (antiphospholipid antibodies) against them. APS is associated with recurrent clotting events (thrombosis) including premature stroke, repeated miscarriages, phlebitis, venous thrombosis, and pulmonary thromboembolism. It is also associated with low platelet or blood elements that prevent bleeding. Recently, however, even more disease states have been linked with APS, including premature heart attack, various cardiac valvular abnormalities, skin lesions, kidney disease, abnormal involuntary movement/chorea, diseases that mimic multiple sclerosis, and vascular diseases of the eye that can lead to visual loss and blindness. The International Congress on Antiphospholipid Antibodies, held every 3 years, is the venue where representatives from different disciplines gather to discuss the recent advances in APS. The conference intends to cover basic aspects of APS, such as pathogenesis, origins, genetics, intracellular and molecular events, the role of infections, as well as traditional and non-traditional clinical manifestations associated with antiphospholipid antibodies. The 15th Congress took place in September 2016. A novel aspect of the Congress was that multiple teams, chaired by Scientific Planning Committee members, used evidence-based literature reviews and expert discussions to answer specific pre-defined APS-related questions. These teams included points of view from experts in rheumatology, hematology, cardiovascular medicine, obstetrics, neurology, and immunology. The Scientific Planning Committee members also chaired the congress sessions and supervised completion of the reports that are the bases of the chapters of this book. In addition, there are two chapters included specifically written for APS patients. Much like the previous volume, dedicated to the 13th International Congress on Antiphospholipid Antibodies (April 2010), this up-to-date and comprehensive work gathers invaluable insights from a multidisciplinary team of world-renowned experts and represents the authoritative resource on causes, symptoms, diagnosis, and treatment of APS.