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Update on Hepatitis C by Martina Smolic,Aleksandar Vcev,George Wu Pdf
In the past few years, remarkable progress has been made in our understanding of HCV biology, pathogenesis of infection, and structure-function relationships. This has led to quantum advances in clinical efficacy and tolerability. Yet, in spite of this amazing progress, there remain obstacles to widespread successful treatment. These issues include biological failures even with direct-acting agents, lack of options for individual with organ failures, drug-drug interactions, access to medications either due to lack of availability or affordability, and psychiatric and social issues. These problems are likely to remain in the future. Therefore, this book has been created by distinguished faculties from around the world to address the progress in our understanding of HCV infection and to review new treatment options, limitations, and accessibility of new therapeutic options.
National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on a National Strategy for the Elimination of Hepatitis B and C
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on a National Strategy for the Elimination of Hepatitis B and C Publisher : National Academies Press Page : 187 pages File Size : 52,5 Mb Release : 2016-06-01 Category : Medical ISBN : 9780309438025
Eliminating the Public Health Problem of Hepatitis B and C in the United States by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on a National Strategy for the Elimination of Hepatitis B and C Pdf
Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the first of two, examines the feasibility of hepatitis B and C elimination in the United States and identifies critical success factors. The phase two report will outline a strategy for meeting the elimination goals discussed in this report.
Hepatitis C in Renal Disease, Hemodialysis, and Transplantation by J. M. Morales,Beatriz Domínguez-Gil Pdf
A timely update on HCV infection and the kidney Hepatitis C virus (HCV) infection is a major health problem worldwide, with currently over 150 million HCV-infected people on the five continents. Although there have been important advances in the diagnosis, prevention and therapy, the infection remains an important health problem in most countries. HCV infection is considered a systemic disease: Not only does it affect the liver, it can induce autoimmune, dermatological and renal disease. Moreover, soon after the discovery of HCV as the major cause of non-A non-B hepatitis, HCV infection was recognized as an important cause and consequence of chronic kidney disease. The publication at hand is an update on the most important topics concerning HCV infection, renal disease and problems with dialysis in the general population as well as in renal transplant patients. Also included is a chapter on the emerging problem of renal complications associated with HCV virus in patients with HIV infection. Containing contributions from a panel of internationally acclaimed experts, this publication is a timely update on HCV infection and the kidney.
Author : World Health Organization Publisher : World Health Organization Page : 0 pages File Size : 45,8 Mb Release : 2017 Category : Medical ISBN : 924154998X
Guidelines on Hepatitis B and C Testing by World Health Organization Pdf
Testing and diagnosis of hepatitis B (HBV) and C (HCV) infection is the gateway for access to both prevention and treatment services, and is a crucial component of an effective response to the hepatitis epidemic. Early identification of persons with chronic HBV or HCV infection enables them to receive the necessary care and treatment to prevent or delay progression of liver disease. Testing also provides an opportunity to link people to interventions to reduce transmission, through counselling on risk behaviors and provision of prevention commodities (such as sterile needles and syringes) and hepatitis B vaccination. These are the first WHO guidelines on testing for chronic HBV and HCV infection and complement published guidance by WHO on the prevention, care and treatment of chronic hepatitis C and hepatitis B infection. These guidelines outline the public health approach to strengthening and expanding current testing practices for HBV and HCV, and are intended for use across age groups and populations.
Advances in Treatment of Hepatitis C and B by Naglaa Allam Pdf
As in many areas of medicine, treatment of viral hepatitis has seen an acceleration of change driven by new therapies and evolving technology. Thanks to the direct-acting antiviral agents (DAAs), the era of HCV eradication and cure has begun. As regards to hepatitis B therapy, potent antiviral drugs for suppression of viral replication are available, new research activities to enhance eradication are visible, and these may influence clinical practice in the coming years. This book covers the latest advances in hepatitis C and hepatitis B therapeutics as well as the emerging and investigational treatment strategies. "Advances in Treatment of Hepatitis C and Hepatitis B" book is an up-to-date source of information for physicians, residents, and advanced medical students seeking a broader understanding of treatment of viral hepatitis. The authors of the chapters come from many eminent centers around the world and are experts in their respective fields.
Accelerating access to hepatitis C diagnostics and treatment by Anonim Pdf
WHO approved more hepatitis direct-acting antivirals (DAAs) for the treatment of infection with the hepatitis C virus (HCV) by 2020 which helped low- and middle-income countries increase the number of registered treatments, reduce prices of a full treatment under US$100 – update is as low as $60 for three months, and strive towards hepatitis C elimination. For the first time, this year’s report includes information on hepatitis C diagnostics. With a focus on selected countries with diverse HCV epidemics, the report provides updates on the various dimensions of access to HCV diagnostics and pharmaceutical products, including product pricing, the regulatory environment and patent status, which together shape the national hepatitis response in different settings. It highlights key areas for action by ministries of health and other government decision-makers, pharmaceutical manufacturers and technical partners. Globally, at the end of 2017, only 5 million – or 7% – of the 71 (62–79) million people chronically infected with HCV had cumulatively received treatment with DAAs. As countries continue to tackle the disease burden and service disruptions caused by the COVID-19 pandemic, it is critical to ensure that the recent momentum and gains in the response to hepatitis C are not lost. Against this backdrop, this report is a strong reminder to continue to invest in building resilient and sustainable health systems that are focused on universal health coverage.
Author : World Health Organization Publisher : World Health Organization Page : 140 pages File Size : 51,7 Mb Release : 2016-04-30 Category : Medical ISBN : 9789241549615
Guidelines for the Screening Care and Treatment of Persons with Chronic Hepatitis C Infection Updated Version April 2016 by World Health Organization Pdf
The field of HCV therapeutics continues to evolve rapidly and since the World Health Organization (WHO) issued its first Guidelines for the screening care and treatment of persons with hepatitis C infection in 2014 several new medicines have been approved by at least one stringent regulatory authority. These medicines called direct-acting antivirals (DAAs) are transforming the treatment of HCV enabling regimens that can be administered orally are of shorter duration (as short as eight weeks) result in cure rates higher than 90% and are associated with fewer serious adverse events than the previous interfere on containing regimens. WHO is updating its hepatitis C treatment guidelines to provide recommendations for the use of these new medicines. The objectives of these WHO guidelines are to provide updated evidence-based recommendations for the treatment of persons with hepatitis C infection using where possible all DAA-only combinations. The guidelines also provide recommendations on the preferred regimens based on a patient?s HCV genotype and clinical history and assess the appropriateness of continued use of certain medicines. This document also includes existing recommendations on screening for HCV infection and care of persons infected with HCV that were first issued in 2014. The key audience for these guidelines are policy-makers in low- and middle-income countries who formulate country-specific treatment guidelines and who plan infectious disease treatment programmes and services in addition to those people responsible for delivering treatment. The guidelines are appropriate for all countries including high-income countries.
The New Hepatitis C by Nancy Reau,Donald M. Jensen Pdf
Fueled in part by the opioid epidemic, the number of reported hepatitis C virus infections tripled in the United States between 2010 and 2015. As new infections continue to mount, new therapies have produced seismic changes in how HCV is treated clinically, leaving a gap between the most current clinical guidance and the ongoing demands of patient care. The New Hepatitis C is a current and essential review of HCV's epidemiology, diagnosis, and clinical approaches -- a clinician's guidebook for navigating everything from screening to treatment. Acute and chronic HCV are addressed, as are important new treatment options for HCV, management of side effects, and a convenient summary of clinical trials on the treatment of chronic hepatitis C. Updated to detail the standards of care that will define the next decade of HCV management, this evidence-based volume is an essential clinical reference for to any practitioner in gastroenterology, hepatology, infectious disease, transplant, or internal medicine.
Howard C. Thomas,Stanley M. Lemon,Arie J. Zuckerman
Author : Howard C. Thomas,Stanley M. Lemon,Arie J. Zuckerman Publisher : John Wiley & Sons Page : 915 pages File Size : 41,9 Mb Release : 2008-04-15 Category : Medical ISBN : 9781405143882
Viral Hepatitis by Howard C. Thomas,Stanley M. Lemon,Arie J. Zuckerman Pdf
There has been an explosion of both the incidence and medicalknowledge of viral hepatitis over the last two decades. Not only isthe incidence of infection and disease increasing, but newhepatitis viruses have been discovered, as well as the launch ofnew pharmaceutical products. Previously published by Churchill Livingstone, ViralHepatitis by Zuckerman & Thomas was the first comprehensivebook on hepatitis and is recognized as the standardreference text in this field. The new third edition, now published by Blackwell Publishing,addresses the recent advances in diagnosis and treatment withentirely revised and current topics. It covers the entire spectrumof viral hepatitis and has something of interest for everyspecialist. Viral Hepatitis presents the latest thinking from theleading international researchers and clinicians working in thisfield and the Editors are joined by a North American co-Editor forthis edition - Professor Stanley Lemon of the University of Texas,Galveston, TX, USA. This book offers an ideal reference for all healthcareprofessionals involved in the research and patient care of thisdisease.
Institute of Medicine,Board on Population Health and Public Health Practice,Committee on the Prevention and Control of Viral Hepatitis Infections
Author : Institute of Medicine,Board on Population Health and Public Health Practice,Committee on the Prevention and Control of Viral Hepatitis Infections Publisher : National Academies Press Page : 252 pages File Size : 42,6 Mb Release : 2010-05-23 Category : Medical ISBN : 9780309146289
Hepatitis and Liver Cancer by Institute of Medicine,Board on Population Health and Public Health Practice,Committee on the Prevention and Control of Viral Hepatitis Infections Pdf
The global epidemic of hepatitis B and C is a serious public health problem. Hepatitis B and C are the major causes of chronic liver disease and liver cancer in the world. In the next 10 years, 150,000 people in the United States will die from liver disease or liver cancer associated with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections. Today, between 800,000 and 1.4 million people in the United States have chronic hepatitis B and between 2.7 and 3.9 million have chronic hepatitis C. People most at risk for hepatitis B and C often are the least likely to have access to medical services. Reducing the rates of illness and death associated with these diseases will require greater awareness and knowledge among health care workers, improved identification of at-risk people, and improved access to medical care. Hepatitis B is a vaccine-preventable disease. Although federal public health officials recommend that all newborns, children, and at-risk adults receive the vaccine, about 46,000 new acute cases of the HBV infection emerge each year, including 1,000 in infants who acquire the infection during birth from their HBV-positive mothers. Unfortunately, there is no vaccine for hepatitis C, which is transmitted by direct exposure to infectious blood. Hepatitis and Liver Cancer identifies missed opportunities related to the prevention and control of HBV and HCV infections. The book presents ways to reduce the numbers of new HBV and HCV infections and the morbidity and mortality related to chronic viral hepatitis. It identifies priorities for research, policy, and action geared toward federal, state, and local public health officials, stakeholder, and advocacy groups and professional organizations.
Prevention of Progression in Chronic Liver Disease by N. Hiyashi,M.P. Manns,Marianne Manns,Nariyuki Hayashi Pdf
In several liver diseases, the underlying cause cannot always be eliminated, i.e. the progression of liver disease cannot be prevented. This is particularly true for non-responders to the treatment of chronic hepatitis C (HCV). It is relevant for more than 40% of patients with HCV genotype 1 and up to 20% of patients with genotype 2 or 3. Several approaches are now underway to prevent or ameliorate mechanisms of disease progression. In Asia, and particularly in Japan, Glycyrrhizine-SNMC has been widely used for this purpose. At present, SNMC is under clinical evaluation in Europe. This book, the proceedings of the Falk Workshop on 'Prevention of Progression in Chronic Liver Disease - An Update on SNMC (Stronger Neo-Minophagen C)' (Part IV of the XII Falk Liver Week, in honour of Hans Popper's 100th birthday) held in Freiburg, Germany, on 22 October 2003, is devoted to the understanding of basic mechanisms of fibrogenesis, the state of the art of non-invasive markers of disease progression that may substitute liver biopsy in the future, and of other predictive parameters indicating disease progression, in particular the development of hepatocellular carcinoma. All these problems are particularly relevant for chronic hepatitis C. A better characterization of so-called non-responders for the treatments available is crucial for the development of new strategies preventing or postponing disease progression. Such strategies should influence fibrogenesis and, thus, cirrhosis formation as well as the development of life threatening complications of liver cirrhosis, including hepatocellular carcinoma. In this volume, the available information on SNMC as an approach to prevent progression of chronic liver disease is discussed by several internationally renowned authors who report on the mechanisms of liver fibrogenesis and fibrolysis, on non-invasive markers of disease progression, and on hepatocellular carcinoma as one of the major complications of liver cirrhosis nowadays. Finally, experts from Japan report on their knowledge and experience concerning the drug SNMC/Glycyrrhizine in the prevention of cirrhosis and HCC, and first study results from Europe are presented.
Living with Hepatitis C, Fifth Edition by Gregory T. Everson Pdf
The Most Trusted Resource and Reference for Millions of Americans Living with Hepatitis C was the first book to explain in everyday language the causes of this disease, its major and minor symptoms, and all of the latest treatments available. Researchers have continued to make dramatic strides in helping the millions of Americans who suffer from Hepatitis C since the book's first publication, and each new edition has kept up with the most recent findings. The latest revised Living With Hepatitis C, Fifth Edition includes cutting-edge information on: * New treatments including pegylated and consensus interferons * Living-donor transplants * Co-infections with Hepatitis B and HIV/AIDS * Promising new clinical trials of protease and polymerase inhibitors * New maintenance therapies, an expanded and updated resource section, ways to avoid infection, and much more Living with Hepatitis C, Fifth Edition is still the "gold standard" resource and reference for those who must endure this disease. It offers guidance and answers for those infected by the virus--and for their spouses, families, and friends.
