Vaccines Immunotherapy And New Antifungal Therapy Against Fungi Updates In The New Frontier

Author : Carlos P. Taborda,Joshua D. Nosanchuk
Publisher : Frontiers Media SA
Page : 185 pages
File Size : 55,8 Mb
Release : 2017-11-15
Category : Electronic
ISBN : 9782889453276

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Vaccines, Immunotherapy and New Antifungal Therapy Against Fungi: Updates in the New Frontier by Carlos P. Taborda,Joshua D. Nosanchuk Pdf

Invasive fungal diseases have increased many fold over the past 50 years. Current treatment regimens typically require prolonged administration of antifungal medications that can have significant toxicity. Moreover, our present potent antifungal armamentarium fails to eradicate fungal pathogens from certain compromised hosts. Additionally, invasive fungal diseases continue to have unacceptably high mortality rates. A growing body of work has focused on the utility of vaccines and/or immunotherapy as a powerful tool in combating mycoses, either for the active treatment, as an adjuvant, or in the prevention of specific fungal pathogens. Also, it is growing the interest over new drugs development as second choice for treatment when traditional chemotherapy fail. This Research Topic will detail the exciting progress in developing vaccines, immunotherapy and new drugs for fungi.

Author : Joshua D. Nosanchuk,Carlos P. Taborda
Publisher : Frontiers E-books
Page : 99 pages
File Size : 41,9 Mb
Release : 2024-06-26
Category : Electronic
ISBN : 9782889191161

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Vaccines and immunotherapy against fungi: the new frontier by Joshua D. Nosanchuk,Carlos P. Taborda Pdf

Invasive fungal diseases have increased many fold over the past 50 years. Current treatment regimens typically require prolonged administration of antifungal medications that can have significant toxicity. Moreover, our present potent antifungal armamentarium fails to eradicate fungal pathogens from certain compromised hosts. Additionally, invasive fungal diseases continue to have unacceptably high mortality rates. A growing body of work has focused on the utility of vaccines and/or immunotherapy as a powerful tool in combating mycoses, either for the active treatment, as an adjuvant, or in the prevention of specific fungal pathogens. This Research Topic will detail the exciting progress in developing vaccines and immunotherapy for fungi.

Author : Juan José Torrado Durán,Dolores R. Serrano,Javier Capilla
Publisher : MDPI
Page : 168 pages
File Size : 51,7 Mb
Release : 2020-07-01
Category : Science
ISBN : 9783039363063

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Antifungal and Antiparasitic Drug Delivery by Juan José Torrado Durán,Dolores R. Serrano,Javier Capilla Pdf

Fungal and parasitic diseases affect more than one billion people across the globe. This is one-sixth of the world´s population, mostly located in developing countries. The lack of effective and safe treatments, combined with inefficient diagnosis, leads to serious chronic illness or even death. There is a discrepancy between the rate of drug resistance and the development of new medicines. Formulation of antifungal and antiparasitic drugs adapted to different administration routes is challenging, bearing in mind the poor water solubility that limits their bioavailability and efficacy. There is an unmet clinical need to develop vaccines, novel formulations and drug delivery strategies that can improve the bioavailability and therapeutic effects by enhancing their dissolution, increasing their chemical potency, stabilizing the drug and targeting high concentrations of the drug to infection sites. This Special Issue includes ten research articles of antifungal and antiparasitic drug delivery systems.

Author : Andriy Sibirny
Publisher : Springer
Page : 568 pages
File Size : 43,7 Mb
Release : 2019-08-12
Category : Science
ISBN : 9783030211103

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Non-conventional Yeasts: from Basic Research to Application by Andriy Sibirny Pdf

This volume scopes several aspects of non-conventional yeast research prepared by the leading specialists in the field. An introduction on taxonomy and systematics enhances the reader’s knowledge on yeasts beyond established ones such as Saccharomyces cerevisiae. Biotechnological approaches that involve fungal utilization of unusual substrates, production of biofuels and useful chemicals as citric acid, glutathione or erythritol are discussed. Further, strategies for metabolic engineering based on knowledge on regulation of gene expression as well as sensing and signaling pathways are presented. The book targets researchers and advanced students working in Microbiology, Microbial Biotechnology and Biochemistry.

Author : James M. Ritter,Rod J. Flower,Graeme Henderson,Yoon Kong Loke,David MacEwan,Emma Robinson,James Fullerton
Publisher : Elsevier Health Sciences
Page : 1001 pages
File Size : 52,7 Mb
Release : 2023-05-13
Category : Medical
ISBN : 9780323873987

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Rang & Dale's Pharmacology E-Book by James M. Ritter,Rod J. Flower,Graeme Henderson,Yoon Kong Loke,David MacEwan,Emma Robinson,James Fullerton Pdf

Rang and Dale’s Pharmacology is internationally acknowledged as the core textbook for students of pharmacology, and has provided accessible, up-to-date information on drugs and their mechanism of action for more than 30 years. Now in its tenth edition, it has been updated to include important new drugs such as gene therapies, personalised medicines and the new wave of RNA drugs. However it has not lost any of the elements that have contributed to its popularity, such as color coding and illustrations, making it reader-friendly while comprehensively covering the depth of detail required. This essential book is recommended as the first-choice undergraduate text for science and medical students and junior doctors and will also be useful for students in other professional disciplines such as pharmacy, veterinary medicine and nursing. Comprehensive information on drug mechanisms, basic physiology and biochemistry, and underlying pathophysiology of disease – suitable for students from many disciplines Clear figures to aid understanding, including data figures as well as mechanistic diagrams, Key points box summaries, clinical boxes and colour-coded chapters help to master difficult concepts Emphasis on therapeutic drugs to help apply theory to practice Over 150 questions and 12 clinical cases to test your knowledge New chapters on drugs and the eye and the pharmacological management of headache Revised information on biopharmaceuticals (including RNA drugs), antivirals (including Covid-19 therapies) as well as general principles of antimicrobial therapy. A completely revised and updated chapter on lifestyle drugs Recent advances in oxygen sensing and response to reduced oxygen tension Expanded chapters on dementia and analgesic drugs

Author : James M. Ritter,Rod J. Flower,Graeme Henderson,Yoon Kong Loke,David MacEwan,Emma Robinson,James Fullerton
Publisher : Elsevier Health Sciences
Page : 1001 pages
File Size : 49,5 Mb
Release : 2023-05-13
Category : Medical
ISBN : 9780323873987

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Rang & Dale's Pharmacology E-Book by James M. Ritter,Rod J. Flower,Graeme Henderson,Yoon Kong Loke,David MacEwan,Emma Robinson,James Fullerton Pdf

Rang and Dale’s Pharmacology is internationally acknowledged as the core textbook for students of pharmacology, and has provided accessible, up-to-date information on drugs and their mechanism of action for more than 30 years. Now in its tenth edition, it has been updated to include important new drugs such as gene therapies, personalised medicines and the new wave of RNA drugs. However it has not lost any of the elements that have contributed to its popularity, such as color coding and illustrations, making it reader-friendly while comprehensively covering the depth of detail required. This essential book is recommended as the first-choice undergraduate text for science and medical students and junior doctors and will also be useful for students in other professional disciplines such as pharmacy, veterinary medicine and nursing. Comprehensive information on drug mechanisms, basic physiology and biochemistry, and underlying pathophysiology of disease – suitable for students from many disciplines Clear figures to aid understanding, including data figures as well as mechanistic diagrams, Key points box summaries, clinical boxes and colour-coded chapters help to master difficult concepts Emphasis on therapeutic drugs to help apply theory to practice Over 150 questions and 12 clinical cases to test your knowledge New chapters on drugs and the eye and the pharmacological management of headache Revised information on biopharmaceuticals (including RNA drugs), antivirals (including Covid-19 therapies) as well as general principles of antimicrobial therapy. A completely revised and updated chapter on lifestyle drugs Recent advances in oxygen sensing and response to reduced oxygen tension Expanded chapters on dementia and analgesic drugs

Author : Fausto Almeida,Joshua D. Nosanchuk,Gustavo Alexis Niño-Vega
Publisher : Frontiers Media SA
Page : 167 pages
File Size : 43,8 Mb
Release : 2020-11-19
Category : Science
ISBN : 9782889661329

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The Fungal Cell Wall by Fausto Almeida,Joshua D. Nosanchuk,Gustavo Alexis Niño-Vega Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Jagdish Chander
Publisher : JP Medical Ltd
Page : 958 pages
File Size : 47,8 Mb
Release : 2017-11-30
Category : Medical
ISBN : 9789386261830

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Textbook of Medical Mycology by Jagdish Chander Pdf

Medical mycology refers to the study of fungi that produce disease in humans and other animals, and of the diseases they produce, their ecology, and their epidemiology. This new edition has been fully revised to provide microbiologists with the latest information on fungal infections, covering the entire spectrum of different types of infection, and therapeutic modalities. Beginning with a general overview explaining morphology, taxonomy, and diagnosis, the following sections cover the different categories of fungal infection including superficial cutaneous mycoses, subcutaneous mycoses, systemic mycoses and opportunistic mycoses. A complete section is dedicated to pseudofungal infections. The highly illustrated text concludes with a detailed appendices section and each chapter features key references for further reading. Key points Fully revised, fourth edition providing latest information on the diagnosis and management of fungal infections Covers the entire spectrum of mycoses Highly illustrated with clinical photographs and figures Previous edition (9788188039780) published in 2009

Author : Mahmoud Ghannoum,John R. Perfect
Publisher : CRC Press
Page : 484 pages
File Size : 41,6 Mb
Release : 2016-04-19
Category : Medical
ISBN : 9780849387869

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Antifungal Therapy by Mahmoud Ghannoum,John R. Perfect Pdf

A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a c

Author : Anonim
Publisher : Unknown
Page : 2164 pages
File Size : 48,6 Mb
Release : 2004
Category : Medicine
ISBN : MINN:31951P00992546G

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Index Medicus by Anonim Pdf

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Author : Chaminda Jayampath Seneviratne,Edvaldo Antonio Ribeiro Rosa
Publisher : Frontiers Media SA
Page : 138 pages
File Size : 50,6 Mb
Release : 2016-09-13
Category : Microbiology
ISBN : 9782889199501

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Antifungal Drug Discovery: New Theories and New Therapies by Chaminda Jayampath Seneviratne,Edvaldo Antonio Ribeiro Rosa Pdf

Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

Author : Simon Wong,Gemma Arsequell
Publisher : Springer Science & Business Media
Page : 336 pages
File Size : 43,8 Mb
Release : 2003-10-31
Category : Medical
ISBN : 0306478447

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Immunobiology of Carbohydrates by Simon Wong,Gemma Arsequell Pdf

This book is unique in providing pertinent information on the various established roles carbohydrate play in the immune system and how the innate and adaptive immune systems respond to this type of microbial antigens. The editors selected only topics that have established basic and clinical relevance to this field. The topics from basic research are organised like a textbook, in order to guide the readers through complex sets of events that lead to clearance of or to immune responses toward carbohydrate antigens. The book is clear, concise and contains fully annotated summaries of the key basic and practical information on carbohydrate immunology from current literature. These topics are written by investigators from various disciplines (chemistry, medicine, biochemistry, glycobiology and immunology), creating a fine balance in the point of views presented in the book. It explores the challenges and rewards of understanding the importance of carbohydrates and glycoconjugates in health and disease, applying new knowledge from carbohydrate immunology in improving or developing novel sugar-based therapeutics, and vaccines and medicines. This book is most suitable for glycobiologists and immunologists, but many researchers whose interests, background and expertise are in any of the fifteen topics presented in this book will also find it appealing. It is also a valuable resource for postgraduate students, clinicians or anyone else who is curious about the role of carbohydrates in immunology, and would like to see the topics combined under one cover and in relation to each other.

Author : René Roy
Publisher : ACS Symposium
Page : 0 pages
File Size : 51,6 Mb
Release : 2008
Category : Science
ISBN : 0841239835

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Carbohydrate-based Vaccines by René Roy Pdf

This book is the first of its kind entirely dedicated to carbohydrate vaccines written by renowned scientists with expertise in carbohydrate chemistry and immunochemistry. It covers the synthesis of carbohydrate antigens related to bacteria and parasites such as: Heamophilus influenza, Streptococcus pnemoniae, Shigella flexneri, Candida albicans, Mycobacterium tuberculosis, and Chlamydia. The first three chapters are of wide interest as they cover fundamental concerns in new vaccine developments. The first one presents the immune system and how carbohydrate antigens are processed before protective antibodies are produced. It also illustrates antigen presentation in the context of major histocompatibility complexes (MHCs). The second chapter describes regulatory issues when carbohydrate vaccines are involved while the third one discuss several techniques used in conjugation chemistry and the implication of certain chemical linkages that may induce unexpected anti-linker antibodies. This section will be particularly appealing for those involved in drug-conjugate design, pro-drug developments, and drug vectorization. The book concludes with one chapter that illustrates the principle through which peptide antigens can functionally mimic carbohydrate epitopes, thus, unraveling the potential for peptide surrogates as replacement for complex carbohydrate structures. This book is unique in that it covers all aspects related to carbohydrate vaccines including the success story with the first semi-synthetic bacterial polysaccharide vaccine against Heamophilus influenza type b responsible for pneumonia and meningitis, liable for more than 600,000 infant deaths worldwide in developing countries. The book also presents regulatory issues and will thus be vital for government agencies approving candidate vaccines. It widely covers synthetic methodologies for the attachment of carbohydrate antigens to peptides and immunogenic protein carriers. Vaccines against bacterial antigens, cancer, and parasites are also discussed by worldwide experts in this field in details. No other book contains such a wide panel of different expertise. It will also be useful to students and researchers involved with the immunology of forreings antigens and how the under appreciated carbohydrate antigens are processed by the immune system.

Author : Yanmei Li,Zhongping Tan
Publisher : Frontiers Media SA
Page : 219 pages
File Size : 53,6 Mb
Release : 2020-11-18
Category : Science
ISBN : 9782889661206

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Latest Advances in Glycoengineering by Yanmei Li,Zhongping Tan Pdf

Glycans have long been known to be one of the most abundant biological molecules in living organisms. They can function as energy compounds, form structural cell wall/matrix polymers, or exist as oligomers that are attached on proteins, lipids and natural products to influence their properties and function. Because of their important biological roles, glycans have great potential for applications in the development of new drugs, materials, food additives and many other products. However, it is often difficult to directly obtain glycans from natural sources with ideal properties for these applications. Thus, modification of glycan structures for desired properties has emerged as an active area of research. This research area is generally called glycoengineering.

Author : Clarisa Beatriz Palatnik-de-Sousa,Irene da Silva Soares,Daniela Santoro Rosa
Publisher : Frontiers Media SA
Page : 284 pages
File Size : 54,8 Mb
Release : 2018-07-12
Category : Antigens
ISBN : 9782889455225

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Epitope Discovery and Synthetic Vaccine Design by Clarisa Beatriz Palatnik-de-Sousa,Irene da Silva Soares,Daniela Santoro Rosa Pdf