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Author : Jaap Goudsmit
Publisher : Oxford University Press on Demand
Page : 204 pages
File Size : 42,9 Mb
Release : 2004-08-12
Category : Medical
ISBN : 9780195130348
Addressing viral adaption as a general phenomenon, the author examines the heart of viral emergence as human behaviour alters viral ecosystems.
Author : Jaap Goudsmit M.D.
Publisher : Oxford University Press
Page : 208 pages
File Size : 48,8 Mb
Release : 2004-08-12
Category : Medical
ISBN : 0198029926
Despite vaccines and medicines, we have not succeeded in eradicating the most poisonous viruses in the world, like jaundice, measles, diarrhea, polio, and AIDS, not to mention newcomers like West Nile and SARS. Also, since September 11, it is no longer unthinkable that a terrorist would intentionally spread a virus among people or the food chain. In this book, Jaap Goudsmit argues that there is no such thing as life without viruses for many reasons; including the fact that many viruses spread without any visible signs, and can hide in animals; that there are too many different species of viruses and they multiply much faster than any animal or plant; and that infections strike especially in areas where life is difficult enough already, such as Africa and Asia. However, Goudsmit continues, if viruses hold onto life so stubbornly, perhaps they can be useful to other living beings. Do viruses offer people a better chance of survival in a hostile world? Do viruses make people fitter? Some viruses seem to play a role in the process whereby our genes adapt to the environment. What is it that makes viruses incredibly strong, and can we learn something from it? What is the secret of the enormous "fitness" of viruses? Will viruses spell the end of mankind or will man always be able to offer resistance? This book attempts to answer these and other questions.
Author : Esteban Domingo
Publisher : Academic Press
Page : 426 pages
File Size : 49,7 Mb
Release : 2019-11-06
Category : Science
ISBN : 9780128163320
Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. Features current views on key steps in the origin of life and origins of viruses Includes examples relating ancestral features of viruses with their current adaptive capacity Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read Considers quasispecies as a framework to understand virus adaptability and disease processes
Author : Lamei Chen
Publisher : Unknown
Page : 230 pages
File Size : 44,9 Mb
Release : 2005
Category : Electronic
ISBN : UCLA:L0091226613
Author : Jayajit Das,Ciriyam Jayaprakash
Publisher : CRC Press
Page : 355 pages
File Size : 47,7 Mb
Release : 2018-09-03
Category : Science
ISBN : 9781498717410
"Taken together, the body of information contained in this book provides readers with a bird’s-eye view of different aspects of exciting work at the convergence of disciplines that will ultimately lead to a future where we understand how immunity is regulated, and how we can harness this knowledge toward practical ends that reduce human suffering. I commend the editors for putting this volume together." –Arup K. Chakraborty, Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined. Readers from immunology, quantitative biology, and applied physics will benefit from the following: Fundamental principles of computational immunology and modern quantitative methods for studying immune response at the single molecule, cellular, organism, and population levels. An overview of basic concepts in modeling and data analysis. Coverage of topics where mechanistic modeling has contributed substantially to current understanding. Discussion of genetic diversity of the immune system, cell signaling in the immune system, immune response at the cell population scale, and ecology of host-pathogen interactions.
Author : Akio Adachi,Yasuyuki Miyazaki,Masako Nomaguchi,Mikako Fujita
Publisher : Frontiers Media SA
Page : 104 pages
File Size : 52,8 Mb
Release : 2024-05-31
Category : Electronic
ISBN : 9782889190249
Viruses are absolutely and strictly dependent on target host cells for their replication. However, they have their own unique strategies at each replication step from the entry into cells, transcription, translation, assembly of viral genome/proteins, and up to the release of progeny virions from cells. We virologists have to understand these complex biological interactions between viruses and host cells. Importantly, extensive studies based on bio-structural technology have revealed in succession the detailed and bottom line mechanisms of viral replication processes otherwise impossible. We now know the highly dynamic nature of viral genome/proteins, and are impressed by their ingeniously organized functionality in hostile host environments. For characterization of viruses as a unique genetic entity and pathogenic agent, it has been critical to investigate thoroughly the individual viral components and host factors involved in the virus replication cycle. Because many viral and cellular factors essential for viral replication and pathogenicity have been newly discovered through the efforts of virologists, the necessity of contribution to the progress of virology by the structural biology is now greatly increasing. To fully understand precise mechanisms underlying the functional interaction of viral and host molecules, needless to say, it is crucially required to have their structural information. We need to know molecular details of the nucleic acids, proteins, and interacting molecules. The information indispensable for understanding certain biological phenomena may only be provided by high-resolution three-dimensional structures. Of note, a number of anti-viral drugs have been generated based on the structural information. The interacting interfaces between virus and host components, which are important for viral replication, can be potent targets for anti-viral drugs. Their structural characterization would lead to designing rigid anti-viral drugs and/or vaccines. In this Research Topic, we wish to summarize and review what the structural biology has accomplished so far to resolve the important virological issues. We also wish to describe the perspective of the structural biology for the future virology. Finally, the presentation of ongoing original works is greatly encouraged.
Author : D.J. Rowlands
Publisher : Gulf Professional Publishing
Page : 176 pages
File Size : 53,8 Mb
Release : 2003-01-24
Category : Science
ISBN : 0444513027
"Foot-and-Mouth Disease Virus (FMDV), the cause of these dramatic consequences, is one of the smallest animal viruses, yet is often quoted as being the most infectious agent known. This book, for the first time, presents the story of FMDV as written by world experts on the virus. Initial chapters describe the structure of the virus and what is known of the molecular mechanisms that enable it to replicate faster than any other known animal virus. Anti-FMD vaccines are made in vast quantities and can be extremely effective for disease control. However, the ability of the virus to change rapidly is a constant headache for vaccine manufacturers. Both vaccine production and virus evolution are reviewed comprehensively. In addition to vaccination, disease control requires accurate and sensitive diagnostic procedures and effective hygiene measures. Modern molecular epidemiology and the measures available for infection control are described in further chapters." "Finally, the role of wildlife in the spread and maintenance of FMD is discussed."--BOOK JACKET.
Author : Anonim
Publisher : ScholarlyEditions
Page : 574 pages
File Size : 48,9 Mb
Release : 2012-01-09
Category : Medical
ISBN : 9781464922220
Viral Sexually Transmitted Diseases: Advances in Research and Treatment: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Viral Sexually Transmitted Diseases in a concise format. The editors have built Viral Sexually Transmitted Diseases: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Viral Sexually Transmitted Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Viral Sexually Transmitted Diseases: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Douglas L. Mayers,Jack D. Sobel,Marc Ouellette,Keith S. Kaye,Dror Marchaim
Publisher : Springer
Page : 773 pages
File Size : 50,7 Mb
Release : 2017-06-19
Category : Medical
ISBN : 9783319467184
The two volumes included in Antimicrobial Drug Resistance, Second Edition is an updated, comprehensive and multidisciplinary reference covering the area of antimicrobial drug resistance in bacteria, fungi, viruses, and parasites from basic science, clinical, and epidemiological perspectives. This newly revised compendium reviews the most current research and development on drug resistance while still providing the information in the accessible format of the first edition. The first volume, Antimicrobial Drug Resistance: Mechanisms of Drug Resistance, is dedicated to the biological basis of drug resistance and effective avenues for drug development. With the emergence of more drug-resistant organisms, the approach to dealing with the drug resistance problem must include the research of different aspects of the mechanisms of bacterial resistance and the dissemination of resistance genes as well as research utilizing new genomic information. These approaches will permit the design of novel strategies to develop new antibiotics and preserve the effectiveness of those currently available. The second volume, Antimicrobial Drug Resistance: Clinical and Epidemiological Aspects, is devoted to the clinical aspects of drug resistance. Although there is evidence that restricted use of a specific antibiotic can be followed by a decrease in drug resistance to that agent, drug resistance control is not easily achieved. Thus, the infectious diseases physician requires input from the clinical microbiologist, antimicrobial stewardship personnel, and infection control specialist to make informed choices for the effective management of various strains of drug-resistant pathogens in individual patients. This 2-volume set is an important reference for students in microbiology, infectious diseases physicians, medical students, basic scientists, drug development researchers, microbiologists, epidemiologists, and public health practitioners.
Author : Richard A. Kaslow,Lawrence R. Stanberry,James W. Le Duc
Publisher : Springer
Page : 1215 pages
File Size : 41,9 Mb
Release : 2014-09-27
Category : Medical
ISBN : 9781489974488
Striking changes have occurred in the world since the publication of the last edition of Viral Infections of Humans. The global population is rapidly approaching 8 billion; climate change is leading to the introduction of new hosts, vectors and virus diseases heretofore never seen in many parts of the world; technological advances have revolutionized the ability to recognize and characterize viruses new and old; vaccines are altering the epidemiological landscape of the diseases they target, in some cases raising the hope of their eradication and remarkably powerful computational tools are enabling not only detection of outbreaks of disease much sooner than in the past but also, through complex mathematical modeling, more accurate prediction of their potential impact. The new Fifth Edition of Viral Infections of Humans captures the both the excitement and frustration of the dynamic struggle between humankind and the viruses that continue to cause immense suffering. It presents the latest concepts, methods and technologies in epidemiology, detection, investigation, modeling and intervention. Updated and entirely new chapters by dozens of experts across the field provide analytic summaries of current knowledge of viruses and prions causing acute syndromes, chronic illnesses and/or malignancies. In sum, this ambitiously expanded volume offers a uniquely comprehensive perspective on viruses in humans, from agents of classic diseases (e.g., hepatitis, measles, polio, rabies and yellow fever), to those with greatest pandemic impact (e.g., influenza and human immunodeficiency virus), to those discovered relatively recently (e.g., henipavirus, metapneumovirus and norovirus). The new Fifth Edition of Viral Infections of Humans is an invaluable reference for students, fellows and established professionals in the fields of microbiology, public health and infectious disease epidemiology, medicine and health policy.
Author : Christon J. Hurst
Publisher : Academic Press
Page : 639 pages
File Size : 40,9 Mb
Release : 2000-05-02
Category : Science
ISBN : 0080543561
Viral Ecology defines and explains the ecology of viruses by examining their interactions with their hosting species, including the types of transmission cycles that have evolved, encompassing principal and alternate hosts, vehicles, and vectors. It examines virology from an organismal biology approach, focusing on the concept that viral infections represent areas of overlap in the ecology of viruses, their hosts, and their vectors. The relationship between viruses and their hosting species The concept that viral interactions with their hosts represents a highly evolved aspect of organismal biology The types of transmission cycles which exist for viruses, including their hosts, vectors, and vehicles The concept that viral infections represent areas of overlap in the ecology of the viruses, their hosts, and their vectors
Author : Anonim
Publisher : Academic Press
Page : 168 pages
File Size : 46,9 Mb
Release : 2010-11-26
Category : Science
ISBN : 0123850355
Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. The impact factor for 2008 is 4.886, placing it 4th in the highly competitive category of virology. * Contributions from leading authorities * Informs and updates on all the latest developments in the field
Author : Hiromitsu Moriyama,Jiatao Xie,Ioly Kotta-Loizou,Kook-Hyung Kim
Publisher : Frontiers Media SA
Page : 207 pages
File Size : 49,9 Mb
Release : 2022-01-18
Category : Science
ISBN : 9782889740680
Author : Covadonga Alonso,Josep Quer
Publisher : Frontiers Media SA
Page : 110 pages
File Size : 55,9 Mb
Release : 2024-02-06
Category : Science
ISBN : 9782832544242
About this Research Topic Submission closed. Guidelines Recently, our society has experimented that Virology is a changing panorama with a large impact on health, economy, and society. In the post-pandemic times, preparedness for existing and new threats has become a key factor focusing the work of clinical virologists and researchers. This Research Topic is focused on the knowledge and recent experience in viral diseases in the Iberian Peninsula geographical area, neighboring countries - due to climate change - and worldwide - given the ease of communications and the globalization of our societies. For research focussed on plant virology, please see the twinned Research Topic in Frontiers in Microbiology.
Author : Luis Enjuanes,Stuart G. Siddel,Willy Spaan
Publisher : Springer Science & Business Media
Page : 776 pages
File Size : 52,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461553311
Proceedings of the VIIth International Symposium held in Segovia, Spain, May 10-15, 1997