Virus Escape From Immunosurveillance

Author : M. Saveria Campo
Publisher : Elsevier Science & Technology
Page : 0 pages
File Size : 54,7 Mb
Release : 2002
Category : Antigen-antibody reactions
ISBN : 0444511296

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Virus Escape from Immunosurveillance by M. Saveria Campo Pdf

Viruses must be able to overcome the host immune response to replicate themselves and produce infectious progeny. Although eventually the host immune response succeeds in eliminating viruses and virus-infected cells, viruses have evolved a variety of mechanisms to escape immuno surveillance and survive in a hostile environment. In addition to rapid antigenic variation (HIV), latent infection (herpesvirus) or modality of life cycle (papillomaviruses), these mechanisms include the production of viral proteins which actively fight the host immune response. The reviews in this book, written by authors of international renown, deal with the immuno modulators and inhibitors encoded by a variety of viruses, from the poxviruses, which are very well known in this respect, to the papillomaviruses, whose evasion from the host immune response has just begun being elucidated. In addition to being scientifically stimulating, the reviews, by highlighting the countermeasures operated by viruses to fight the host immune response, point the way to new potential anti-viral strategies.

Author : Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter
Publisher : Garland Science
Page : 128 pages
File Size : 42,6 Mb
Release : 2010-06-22
Category : Medical
ISBN : 0815344570

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Janeway's Immunobiology by Kenneth Murphy,Paul Travers,Mark Walport,Peter Walter Pdf

The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Author : R. Ahmed,Irvin Chen
Publisher : Wiley-Blackwell
Page : 754 pages
File Size : 46,9 Mb
Release : 1999
Category : Medical
ISBN : UOM:39015041993448

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Persistent Viral Infections by R. Ahmed,Irvin Chen Pdf

Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.

Author : Macfarlane Burnet
Publisher : Elsevier
Page : 289 pages
File Size : 53,6 Mb
Release : 2014-05-17
Category : Medical
ISBN : 9781483159225

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Immunological Surveillance by Macfarlane Burnet Pdf

Immunological Surveillance

Author : A. L. Notkins,M. B. A. Oldstone
Publisher : Springer Science & Business Media
Page : 418 pages
File Size : 52,9 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461252504

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Concepts in Viral Pathogenesis by A. L. Notkins,M. B. A. Oldstone Pdf

The current proliferation of scientific information makes it difficult for even the most diligent reader to keep up with the latest developments in his/her own field, let alone other areas of interest. Review articles are one solution, but they too have become so voluminous and detailed that they often defeat the purpose for which they were intended. We have attempted to ease this problem by using a different format. In this volume on Concepts in Viral Pathogenesis, we have assembled a series of mini-reviews/editorials, 1,000 to 2,000 words in length. Each is a pithy distil lation of the state-of-the-art with emphasis on current thinking and unifying concepts rather than a compendium of the literature. The 53 articles, all written by active workers in their respective fields, are organized systemati cally so that the book will provide busy investigators, teachers and students of up-to-date information in a very brief and easily read a conceptual core able form. In addition, the authors have attempted to identify unresolved problems and point to future directions.

Author : Richard T. Smith
Publisher : Elsevier
Page : 553 pages
File Size : 52,6 Mb
Release : 2012-12-02
Category : Nature
ISBN : 9780323146265

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Immune Surveillance by Richard T. Smith Pdf

Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology.

Author : Covadonga Alonso
Publisher : Springer Science & Business Media
Page : 342 pages
File Size : 55,5 Mb
Release : 2013-04-18
Category : Science
ISBN : 9783540742647

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Viruses and Apoptosis by Covadonga Alonso Pdf

Using different viral models, molecular pathways regulated by viral genes and their role in the pathogenesis of infection are analyzed. The book also offers an update of known signaling pathways in apoptosis and their role in normal and infected cells. Special emphasis is given to molecular pathways underlying viral transformation and oncogenesis and how research in this area is opening opportunities in cancer therapy.

Author : Suraj Gupte
Publisher : Elsevier Health Sciences
Page : 151 pages
File Size : 51,8 Mb
Release : 2012-06-07
Category : Medical
ISBN : 9788131232569

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Influenza Complete Spectrum - I - ECAB by Suraj Gupte Pdf

The Elsevier’s project, Influenza: Complete Spectrum–I, under the aegis of ECAB Clinical Update, aims at a comprehensive, well-illustrated and state-of the-art survey of salient aspects of the age-old infectious disease, influenza, which is notorious for causing seasonal epidemics and, rarely, pandemics. A hallmark of influenza viruses is their ability to cause global worldwide epidemics affecting a great number of individuals, or pandemics. Pandemic episodes are solely attributed to influenza A viruses and they occur every 10–50 years. Today, it is clear that influenza cannot be eradicated, at least in the foreseeable future. We are therefore, condemned to live with it though with better preparedness and endeavor to cope with its onslaught. The book, Influenza: Complete Spectrum–I, deals with the fundamentals and allied matters concerning influenza.

Author : Erle S. Robertson
Publisher : Springer Science & Business Media
Page : 869 pages
File Size : 46,7 Mb
Release : 2012-02-14
Category : Medical
ISBN : 9781461400165

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Cancer Associated Viruses by Erle S. Robertson Pdf

The acknowledgment that viruses are potent biological factors in driving many cancers have seen a dramatic upsurge in recent years in large part to the success of the human papilloma virus vaccine against invasive cervical carcinomas and followed by the awarding of the noble prize in medicine in 2008 to Dr. Harald zurHausen who identified the link between papilloma virus and cervical cancers. Over the last few years there have been some volumes addressing different aspects of viruses and cancers and to some extent focusing on the DNA viruses, more specifically the human DNA viruses. This proposed volume will attempt to review and address the major gaps in current knowledge in DNA viruses as well as RNA viruses bringing a historical perspective of where studies began to a more recent molecular approach and vaccine successes in tumor viruses. We will also cover other known oncogenic viruses associated cancers in other mammals in addition to humans.

Author : Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi
Publisher : Cambridge University Press
Page : 1325 pages
File Size : 54,8 Mb
Release : 2007-08-16
Category : Medical
ISBN : 9781139461641

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Human Herpesviruses by Ann Arvin,Gabriella Campadelli-Fiume,Edward Mocarski,Patrick S. Moore,Bernard Roizman,Richard Whitley,Koichi Yamanishi Pdf

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Author : Roger J. A. Grand
Publisher : Gulf Professional Publishing
Page : 540 pages
File Size : 53,6 Mb
Release : 2001-04-20
Category : Medical
ISBN : 0444504966

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Viruses, Cell Transformation, and Cancer by Roger J. A. Grand Pdf

Viruses are the agent responsible for perhaps up to one million cases of cancer worldwide each year. Significantly, the study of viruses has also provided important clues to the causes and development of the most common human cancers. This volume presents an account of those viruses which have been directly associated with common human malignancies such as human papillomavirus (HPV), cervical carcinoma, Epstein-Barr virus (EBV) and Burkitt's lymphoma. In addition, the biology and biochemistry of those viruses which have been shown to be capable of transforming cells in culture are described in detail. Thus adenovirus are discussed, as are the other small DNA tumour viruses - Simian virus 40 (SV40) and polyoma virus. Consideration has also been given to human T-cell leukaemia virus (HTLV), hepatitis B virus (HBV) and human herpes virus 8 (HHV8), amongst others. General themes such as the host's immune response to viral infection, virally-induced apoptosis and the use of viruses as a delivery system in gene therapy have been discussed. Individual chapters have been written by an international group of experts in their own field of research.

Author : Bin Su,Kai Deng,Christiane Moog,R. Brad Jones
Publisher : Frontiers Media SA
Page : 437 pages
File Size : 54,7 Mb
Release : 2022-04-06
Category : Medical
ISBN : 9782889749034

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Immune Evasion Mechanisms by RNA Viruses by Bin Su,Kai Deng,Christiane Moog,R. Brad Jones Pdf

Author : Neal Nathanson
Publisher : Elsevier
Page : 280 pages
File Size : 55,5 Mb
Release : 2007-04-04
Category : Medical
ISBN : 0080471056

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Viral Pathogenesis and Immunity by Neal Nathanson Pdf

Based on the highly successful reference work Viral Pathogenesis published in 1997, this concise, economical version can be used both as an introductory text or for self-education by medical students and biologists alike. This latest edition provides a completely revised overview of the subject with new chapters on innate immunity, emerging viral diseases, and antiviral therapy in a format that is easy to understand without continually referring to additional information. Used by the author in his graduate classes at the University of Pennsylvania, it sets forth the essential principles and discusses the details of how the immune system responds to viral invasion including the treatment and prevention of infection. Illustrated by pertinent examples it is one of the only books devoted exclusively to this topic. * Offers almost a 20% expansion over the first edition * Focuses specifically on viral pathogenesis unlike other texts where only a few chapters are devoted to the topic * Neal Nathanson is one of the primary authorities in the field and has authored chapters on viral pathogenesis in two of the most well known virology and microbiology titles Field's Virology and Topley and Wilson's Microbiology * Now in four color throughout!

Author : Beverly A. Teicher
Publisher : Springer Science & Business Media
Page : 611 pages
File Size : 42,9 Mb
Release : 2007-11-09
Category : Medical
ISBN : 9781597450355

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Cancer Drug Resistance by Beverly A. Teicher Pdf

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Author : Michael G. Katze,Marcus J. Korth,G. Lynn Law,Neal Nathanson
Publisher : Academic Press
Page : 366 pages
File Size : 40,9 Mb
Release : 2015-12-30
Category : Science
ISBN : 9780128011744

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Viral Pathogenesis by Michael G. Katze,Marcus J. Korth,G. Lynn Law,Neal Nathanson Pdf

Viral Pathogenesis: From Basics to Systems Biology, Third Edition, has been thoroughly updated to cover topical advances in the evolving field of viral pathogenesis, while also providing the requisite classic foundational information for which it is recognized. The book provides key coverage of the newfound ability to profile molecular events on a system-wide scale, which has led to a deeper understanding of virus-host interactions, host signaling and molecular-interaction networks, and the role of host genetics in determining disease outcome. In addition, the content has been augmented with short chapters on seminal breakthroughs and profiles of their progenitors, as well as short commentaries on important or controversial issues in the field. Thus, the reader will be given a view of virology research with perspectives on issues such as biomedical ethics, public health policy, and human health. In summary, the third edition will give the student a sense of the exciting new perspectives on viral pathogenesis that have been provided by recent developments in genomics, computation, modeling, and systems biology. Covers all aspects of viral infection, including viral entry, replication, and release, as well as innate and adaptive immunity and viral pathogenesis Provides a fresh perspective on the approaches used to understand how viruses cause disease Features molecular profiling techniques, whole genome sequencing, and innovative computational methods Highlights the use of contemporary approaches and the insights they provide to the field