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Author : Claude Nicolau
Publisher : Unknown
Page : 440 pages
File Size : 47,7 Mb
Release : 1978
Category : Medical
ISBN : UOM:39015000290968
Author : Jan Ponten
Publisher : Springer Science & Business Media
Page : 256 pages
File Size : 49,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783709182581
A. Definitions of Transformation in vitro When normal tissues or organs are explanted to conditions favoring the growth of cells as individual units ("cell culture"), the original cell population undergoes a large variety of modifications. Only a minority of the cells will thrive and multiply and within a rather short period of time, the complex composition of the original explant is replaced by a much simplified one of only a few recogniz ably different cell types. With most organs fibroblast-like cells survive longest and outgrow other types. This is then a stable state of affairs for many gener ations. This treatise will not discuss whether this simplification and stabilization represents selection of certain pre-existing cell types or a modification of cells into only a few recognizably different categories; for an excellent review see HARRIS. (1964). Table 1. Terminology Employed to Describe Transformations in vitro Type of transformation Essential features Irregular growth Lack of contact inhibition of cell membrane movement ("ruffled membranes") between juxtaposed cells Unrestrained growth Deficient inhibition of the cell cycle (mitosis) in a crowded culture Infinite growth Capacity of cells to undergo an infinite number of di visions (formation of established cell lines) Cells may depart from this typical behavior in numerous ways involving for instance cellular morphology, immunology, chromosomes or metabolism. Such changes have, sometimes rather vaguely, been called "transformations". This is unprecise and the term "transformation" will here be used exclusively to indicate disturbances in cell growth related to neoplasia.
Author : Stacey B. Day,Robert A. Good
Publisher : Academic Press
Page : 625 pages
File Size : 46,9 Mb
Release : 2014-06-28
Category : Medical
ISBN : 9781483267494
Membranes and Viruses in Immunopathology covers the proceedings of the 1972 symposium by the same title, held at the University of Minnesota Medical School, sponsored by the Bell Museum of Pathology. This book is composed of 40 chapters that highlight the significant advances in fundamental experiments of membrane structure chemistry. Considerable chapters explore the diagnosis and analysis of slow and oncogenic virus infections, as well as the role of immunobiologic processes in the pathogenesis, prevention, and treatment of disease. The remaining chapters contain research works on the detailed mechanisms that may contribute to cancer induction and dissemination. This book will prove useful to immunopathologists and practicing physicians.
Author : Paul Welberry Kent
Publisher : Elsevier Publishing Company
Page : 252 pages
File Size : 40,8 Mb
Release : 1973
Category : Science
ISBN : UOM:39015000871106
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 46,6 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Roger J. A. Grand
Publisher : Gulf Professional Publishing
Page : 540 pages
File Size : 46,8 Mb
Release : 2001-04-20
Category : Medical
ISBN : 0444504966
Viruses are the agent responsible for perhaps up to one million cases of cancer worldwide each year. Significantly, the study of viruses has also provided important clues to the causes and development of the most common human cancers. This volume presents an account of those viruses which have been directly associated with common human malignancies such as human papillomavirus (HPV), cervical carcinoma, Epstein-Barr virus (EBV) and Burkitt's lymphoma. In addition, the biology and biochemistry of those viruses which have been shown to be capable of transforming cells in culture are described in detail. Thus adenovirus are discussed, as are the other small DNA tumour viruses - Simian virus 40 (SV40) and polyoma virus. Consideration has also been given to human T-cell leukaemia virus (HTLV), hepatitis B virus (HBV) and human herpes virus 8 (HHV8), amongst others. General themes such as the host's immune response to viral infection, virally-induced apoptosis and the use of viruses as a delivery system in gene therapy have been discussed. Individual chapters have been written by an international group of experts in their own field of research.
Author : George Poste,Garth L. Nicolson
Publisher : Elsevier
Page : 772 pages
File Size : 53,7 Mb
Release : 2013-10-22
Category : Science
ISBN : 9781483164014
Cell Surface Reviews, Volume 3: Dynamic Aspects of Cell Surface Organization reviews the progress in the study of the dynamic nature of membrane organization. The book is comprised of 14 chapters that discuss the various areas of concerns relating to membrane dynamics. The coverage of the text includes techniques and methods employed in the analysis and manipulation of the various aspects of cell membranes, such as freeze-fracture techniques; manipulation of the lipid composition of cultured animal cells; and somatic genetic analysis. The book also talks about some of the traits and behaviors of membrane dynamics including shedding of tumor cell surface antigens; dynamics of antibody binding and complement interactions at the cell surface; and structure and function of surface immunoglobulin of lymphocytes. The text will be of great use to microbiologists, biochemists, and other researchers whose work requires a good understanding of the various aspects of cells.
Author : Bryan Cullen
Publisher : Oxford University Press
Page : 220 pages
File Size : 49,6 Mb
Release : 1993
Category : Gene Expression Regulation.
ISBN : 0199633827
The first book to specifically cover the molecular biology of retroviruses - of immense importance since the high profile of HIV. International contributors provide detailed reviews of the latest knowledge. An excellent text for both medical and non-medical researchers, it also serves as an illuminating introduction for scientists active in other areas.
Author : Erik Lycke,Erling Norrby
Publisher : Butterworth-Heinemann
Page : 384 pages
File Size : 47,9 Mb
Release : 2014-06-28
Category : Medical
ISBN : 9781483191942
Textbook of Medical Virology presents a critical review of general principles in the field of medical virology. It discusses the description and molecular structures of virus. It addresses the morphology and classifications of viruses. It also demonstrates the principal aspects of virus particle structure. Some of the topics covered in the book are the symmetrical arrangements of viruses; introduction to different families of animal viruses; biochemistry of virus particles; the immunological properties and biological activities of viral gene products; description of enzymatic activities of viruses; and haemagglutination, cell fusion, and haemolysis of viruses. The description and characteristics of viral antigens are covered. The identification and propagation of viruses in tissue and cell cultures are discussed. An in-depth analysis of the principles of virus replication is provided. A study of the morphogenesis of virions is also presented. A chapter is devoted to virus-induced changes of cell structures and functions. The book can provide useful information to virologists, microbiologists, students, and researchers.
Author : Anonim
Publisher : Unknown
Page : 1254 pages
File Size : 42,7 Mb
Release : 1984
Category : Oncogenic viruses
ISBN : UOM:39015013229722
Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Page : 2008 pages
File Size : 50,6 Mb
Release : 2017-03-10
Category : Medical
ISBN : 9781119000846
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author : M. A. Epstein,B. G. Achong
Publisher : Springer Science & Business Media
Page : 467 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642672361
The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.
Author : Anonim
Publisher : Elsevier
Page : 610 pages
File Size : 41,9 Mb
Release : 2003-10-02
Category : Science
ISBN : 9780080493770
Virus Structure covers the full spectrum of modern structural virology. Its goal is to describe the means for defining moderate to high resolution structures and the basic principles that have emerged from these studies. Among the topics covered are Hybrid Vigor, Structural Folds of Viral Proteins, Virus Particle Dynamics, Viral Gemone Organization, Enveloped Viruses and Large Viruses. Covers viral assembly using heterologous expression systems and cell extracts Discusses molecular mechanisms in bacteriophage T7 procapsid assembly, maturation and DNA containment Includes information on structural studies on antibody/virus complexes
Author : Ivan Cameron
Publisher : Elsevier
Page : 452 pages
File Size : 52,6 Mb
Release : 1981-01-01
Category : Science
ISBN : 9780323162968
The Transformed Cell deals with many of the differences that may exist between transformed cells and their normal counterparts. Topics covered range from malignancy and the cell surface to cell cycle regulation in normal and transformed cells; phenotypic expression of malignant transformation and its relationship to energy metabolism; and virus-induced transformation. The involvement of cyclic nucleotides in transformation is also discussed, together with intracellular pH and growth control in eukaryotic cells. This book is comprised of 12 chapters and begins with a brief description of terminology and basic concepts relating to cancer cells, as well as some comments on tumorigenicity and cell transformation. The next two chapters explore the evidence for and against the possible correlation of in vivo tumorigenicity to in vitro changes in the cytoskeletal system; anchorage-dependent growth; plasminogen activator production; agglutinability by lectins; and cell surface and plasma membrane properties. The regulation of cell proliferation and the relationships between ion movement and energy metabolism in normal and transformed cells are then examined, along with the transformation of normal cells by infection with new genetic material from tumor viruses. The remaining chapters focus on selected cellular properties that have been purported to differ between the normal and transformed cell, with particular reference to cyclic nucleotides; polyamine metabolism; cell viscosity; mobility of cellular water; intracellular pH; and element concentration. This monograph will be of interest to biologists and medical practitioners devoted to understanding cancer cell biology and cancer therapy.
Author : National Institutes of Health (U.S.). Division of Research Grants
Publisher : Unknown
Page : 1212 pages
File Size : 41,8 Mb
Release : 1975
Category : Medicine
ISBN : UOM:39015072175394
