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Author : Donald L. Trump,Candace S. Johnson Publisher : Springer Science & Business Media Page : 348 pages File Size : 40,5 Mb Release : 2010-12-09 Category : Medical ISBN : 9781441971883
Vitamin D and Cancer by Donald L. Trump,Candace S. Johnson Pdf
Substantial data indicate the broad importance of vitamin D-based signaling in normal human physiology and the broad effects of vitamin D deficiency. Vitamin D may play a role not only in the control of bone and mineral metabolism, but also appears to be involved in immune function, cardiovascular health, thrombosis and vasculogenesis and neuromuscular function. Considerable epidemiologic data demonstrate that low vitamin D serum levels occur very commonly in normal adult populations and that vitamin D deficiency is associated with an enhanced risk of cancer death from lung, prostate, head & neck, colorectal and other gastrointestinal cancers. In addition, preclinical data provide evidence that calcitriol and other active analogues of calcitriol have anti-proliferative, pro-differentiative, pro-apoptotic and anti-angiogenic activity in numerous in-vitro and in-vivo models. It is quite clear that, while it requires high exposure to calcitriol to induce these effects, such exposure can be readily achieved when high dose intermittent therapy is given.
Sunlight, Vitamin D and Skin Cancer by Jörg Reichrath Pdf
The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer. The pathophysiological, epidemiological and clinical aspects of hypercalcemia of malignancy are presented in this issue, with a focus on the recently discovered humoral factor responsible for the development of hypercalcemia. With a better understanding of the pathophysiology of this condition and the development of new potent drugs, capable of inhibiting bone resorption, especially bisphosphonates, the clinician will be more successful in correcting hypercalcemia in the great majority of patients.
Sunlight, Vitamin D, and Prostate Cancer Risk by P. J. Hyde Pdf
"Sunlight, Vitamin D, and Prostate Cancer Risk" P. J. Hyde This science-based book is the first to demonstrate that in prostate cancer, insufficient access to the sun's short wavelength ultraviolet-B irradiance, necessary for photosynthesis of vitamin D, increases the risk of progression. The author surveys five populations with steeply elevated mortality from prostate cancer: African-North Americans, Norwegians, Swedes, Swiss and Danes. He finds that insufficient exposure to UV-B and inadequate photosynthesis of vitamin D is common to them all. Based on data extracted from World Health Statistics Annuals published in hard copy by the World Health Organization (WHO) in the 1980s, graphs depicting age-specific rates of prostate cancer mortality in Western European countries show that the Swiss rates are anomalously high for the country's latitude and may even surpass the rates for Norway and Sweden. Age-standardized (world) statistics published on-line by the WHO's International Agency for Research into Cancer (IARC) in its Globocan 2000 Cancer Epidemiology Database list identical rates for Norway, Sweden and Switzerland. The age-specific and age-standardized rates of prostate cancer mortality reported for other northern alpine countries are normal for the latitudes. Their more extensive surface areas and dispersed populations, with the great majority of their citizens residing far from the Alps, are consistent with this. In a population survey conducted by Swiss scientists from two institutions, blood levels of calcidiol (25-hydroxyvitamin D), the body's major circulating reservoir of the vitamin, were measured in a large representative sample of adults in all age groups. Subjects older than 65 were found to be spending less than 30 minutes a day outdoors in the summer. This is significant, because the capacity of exposed skin to photosynthesize vitamin D declines with age. Moreover, its inverse correlation with the intensiveness of pigmentation means that African-North Americans in particular need to spend longer periods of time in direct sunlight than may be possible for a variety of reasons. The book contends that many aging individuals residing far from the Equator can achieve year-round sufficiency in vitamin D through relatively frequent, brief periods of exposure to sunlight, reinforced in winter by adequate supplementation. Published research indicating how many international units of the vitamin may be needed daily is also discussed. There is a detailed description of the mechanism whereby minute quantities of a powerful steroid hormone (calcitriol) metabolized from calcidiol, bind to the hormone's receptors (VDR) within the nuclei of the cells. By a signalling procedure involving "cross talk" between the hormone and the VDR, and resulting changes in the transcription of genes within the nuclei, proliferation of malignant cells can be inhibited. Besides prostate cancer, several other common cancers are reported to be associated with deficiencies of vitamin D. "Recommended reading for anyone interested in lowering their risk of prostate cancer"---Christopher Morash, MD, FRCSC, Chief of Urosurgical Oncology, Ottawa Regional Cancer Centre, Ottawa, Ontario. ISBN: 1-4010-8258-0 (paperback) and 1-4010-8259-9 (hardback). Surface: Xlibris Corporation at International Plaza II, Suite 340, Philadelphia, PA, U.S.A. 19113 Web: http://www.xlibris.com/bookstore/bookdisplay.asp'bookid=17092 Email: [email protected] Price (paperback): U
Drug Resistance in Cancer Cells by Kapil Mehta,Zahid H. Siddik Pdf
It was estimated that in 2008, 1,437,180 patients would receive a new cancer diagnosisand 565,650individualswould die of cancer (Jemal et al. 2008).Since the vast majority of patients dying of cancer will have had anticancer therapy, both c- ventional chemotherapy and novel targeted therapy, it can be concluded that these patients are dying with drug resistant cancer. The term multidrug resistance is also apt – in that these patients die after having undergone multiple rounds of different and structurally unrelated cancer therapies. However, for some, the concept of m- tidrug resistance is a worn out idea, stemming from disappointment with the drug resistancereversalstrategiesthatwerecarriedoutinthe1990susingpumpinhibitors to block drug resistance mediated by P-glycoprotein, product of the MDR-1 gene. However, if one takes the larger de?nition – multidrug resistance as simultaneous resistance to multiple structurally unrelated anticancer therapies – its existence c- not be denied. The purpose of this book is to explore new concepts related to drug resistance in cancer, including resistance to the new molecularly targeted agents. Perhaps new terminology is needed for resistance that occurs following therapy with the targeted agents: Novel Targeted Agent Resistance (NTR). Alternatively, we can return to the original de?nition of multidrug resistance as simply the res- tance to multipleagents that occurs in the course of normalcancer progression.This resistance is likely to be mediated by many factors.
Author : Michael F. Holick Publisher : Springer Science & Business Media Page : 456 pages File Size : 53,9 Mb Release : 2013-03-09 Category : Medical ISBN : 9781475728613
The Nutrition and Health series of books has as an overriding mission to provide health professionals with texts that are considered essential because each includes: a synthesis of the state of the science; timely, in-depth reviews by the leading researchers in their respective fields; extensive, up-to-date fully annotated reference lists; a detailed index; relevant tables and figures; identification of paradigm shifts and the consequences; of information between chapters, but targeted, inter-chapter refer virtually no overlap rals, suggestions of areas for future research; and balanced, data-driven answers to patient questions that are based on the totality of evidence rather than the findings of any single study. The series volumes are not the outcome of a symposium. Rather, each editor has the potential to examine a chosen area with a broad perspective, both in subject matter as well as in the choice of chapter authors. The international perspective, especially with regard to public health initiatives, is emphasized where appropriate. The editors, whose training is both research and practice oriented, have the opportunity to develop a primary objective for their book, define the scope and focus, and then invite the leading authori ties from around the world to be part of their initiative. The authors are encouraged to provide an overview of the field, discuss their own research, and relate the research de findings to potential human health consequences.
Natural Products for Cancer Chemoprevention by John M. Pezzuto,Ole Vang Pdf
This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research.
Cancer-Leading Proteases by Satya Prakash Gupta Pdf
Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers. In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases. Explains the role of proteases in the biology of cancer Discusses how proteases can be used as potential drug targets or as diagnostic and prognostic biomarkers Covers a wide range of cancers and provides detailed discussions on protease examples
Vitamin D Analogs in Cancer Prevention and Therapy by J. Reichrath,M. Friedrich,W. Tilgen Pdf
A comprehensive, highly readable overview of the topics discussed at the First International Symposium on "Vitamin D Analogs in Cancer Prevention and Therapy" held in Homburg/Saar, Germany in May 2002. Leading researchers discuss our present knowledge of the vitamin D system in cancer. Topics range from the newest findings in molecular biology, epidemiology, synthesis and metabolism of vitamin D to new concepts for the use of vitamin D analogs in cancer prophylaxis and treatment. The book provides essential up-to-date information for every researcher or clinician interested in the biology of vitamin D or cancer.
Vitamin D by David Feldman,J. Wesley Pike,Francis H. Glorieux Pdf
Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research. *Most comprehensive, up-to-date two-volume set on Vitamin D *New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more *Further sections on emerging uses for treatments of auto-immune diseases and diabetes *Over 600 illustrations and figures available on CD
Author : Donald L. Trump,Candace S. Johnson Publisher : Springer Page : 342 pages File Size : 42,9 Mb Release : 2010-12-10 Category : Medical ISBN : 1441971874
Vitamin D and Cancer by Donald L. Trump,Candace S. Johnson Pdf
Substantial data indicate the broad importance of vitamin D-based signaling in normal human physiology and the broad effects of vitamin D deficiency. Vitamin D may play a role not only in the control of bone and mineral metabolism, but also appears to be involved in immune function, cardiovascular health, thrombosis and vasculogenesis and neuromuscular function. Considerable epidemiologic data demonstrate that low vitamin D serum levels occur very commonly in normal adult populations and that vitamin D deficiency is associated with an enhanced risk of cancer death from lung, prostate, head & neck, colorectal and other gastrointestinal cancers. In addition, preclinical data provide evidence that calcitriol and other active analogues of calcitriol have anti-proliferative, pro-differentiative, pro-apoptotic and anti-angiogenic activity in numerous in-vitro and in-vivo models. It is quite clear that, while it requires high exposure to calcitriol to induce these effects, such exposure can be readily achieved when high dose intermittent therapy is given.
Vitamin D by David Feldman,J. Wesley Pike,Roger Bouillon,Edward Giovannucci,David Goltzman,Martin Hewison Pdf
Vitamin D: Volume 2: Health, Disease and Therapeutics, Fourth Edition, authoritatively covers the evidence for new roles for vitamin D, ranging from cardiovascular disease, to cancer, diabetes, inflammatory bowel disease, multiple sclerosis and renal disease. This collection represents a who’s who of vitamin D research and the coverage is appropriately broad, drawing in internal medicine, orthopedics, oncology and immunology. Clinical researchers will gain a strong understanding of the molecular basis for a particular area of focus. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin D Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articles Chapter authors include the most prominent and well-published names in the field Targets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis and vitamin D deficiency Presents a clinical focus on disorders, analogs, cancer, immunity, inflammation, disease and therapeutic applications
Calcium, Vitamin D, and Prevention of Colon Cancer by Martin Lipkin Pdf
These proceedings were published as a result of a workshop sponsored by the Chemoprevention Branch of the National Cancer Institute. The workshop covered a range of topics including calcium and vitamin D in human nutrition; epidemiologic relationships betweencalcium, vitamin D, and colon cancer; the biology of calium and vitamin D at the tissue and cellular level; and enimal and human studies investigating the potential for prevention of colon cancer with calcium and vitamin D.
Assessment Scales in Depression and Anxiety - CORPORATE by Raymond W. Lam,Erin E. Michalaak,Richard P. Swinson Pdf
There are a number of books recently published on assessment scales for depression and anxiety. However, these books are generally more detailed than clinicians require, are specific to one or other condition, or involve specialty populations such as children or geriatrics. To meet the needs of clinicians treating patients with depressive and anxiety disorders, this volume aims to bring together empirically validated assessment scales. In a concise and user-friendly format, Assessment Scales in Depression and Anxiety illustrates the assessment scales used in clinical trials and research studies; shows how to select an assessment scale and to decide which scale to use for a particular clinical situation; and provides sample assessment scales for clinicians to use in their practice.