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Vitamin D by David Feldman,J. Wesley Pike,Roger Bouillon,Edward Giovannucci,David Goltzman,Martin Hewison Pdf
Vitamin D: Volume 2: Health, Disease and Therapeutics, Fourth Edition, authoritatively covers the evidence for new roles for vitamin D, ranging from cardiovascular disease, to cancer, diabetes, inflammatory bowel disease, multiple sclerosis and renal disease. This collection represents a who’s who of vitamin D research and the coverage is appropriately broad, drawing in internal medicine, orthopedics, oncology and immunology. Clinical researchers will gain a strong understanding of the molecular basis for a particular area of focus. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin D Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articles Chapter authors include the most prominent and well-published names in the field Targets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis and vitamin D deficiency Presents a clinical focus on disorders, analogs, cancer, immunity, inflammation, disease and therapeutic applications
Vitamin D by David Feldman,J. Wesley Pike,Francis H. Glorieux Pdf
Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research. *Most comprehensive, up-to-date two-volume set on Vitamin D *New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more *Further sections on emerging uses for treatments of auto-immune diseases and diabetes *Over 600 illustrations and figures available on CD
Vitamin D is crucial to our health, yet most people are low in this vital vitamin - despite the vitamins they take, the foods they eat, the milk they drink or the sun exposure they receive. In Power of Vitamin D you will learn:?Çó Why we are facing a true Epidemic of Vitamin D deficiency.?Çó The crucial role Vitamin D can play in the Prevention as well as Treatment of various Cancers.?Çó How Vitamin D can help Prevent Diabetes, Coronary Heart Disease, Hypertension and Kidney Disease.?Çó How Vitamin D can Prevent as well as Treat Muscle Aches, Chronic Fatigue, Fibromyalgia, Bone Pains and Osteoporosis.?Çó The vital role of Vitamin D in the normal functioning of the Immune System.?Çó How Vitamin D can Prevent as well as Treat the Common Cold, Tuberculosis, Asthma, Thyroid Diseases, M.S., Lupus and Arthritis.?Çó The essential role of Vitamin D during Pregnancy for Mothers and Babies.?Çó Doctors frequently miss the Diagnosis of Vitamin D deficiency because they often order the wrong test.?Çó The right test to Diagnose Vitamin D deficiency.?Çó The best way to Prevent and Treat Vitamin D deficiency. ?Çó Vitamin D Toxicity and how to Prevent it. ?Çó Not just theoretical knowledge, but detailed, practical information from actual Case Studies.
Vitamin D by David Feldman,J. Wesley Pike,Roger Bouillon,Edward Giovannucci,David Goltzman,Martin Hewison Pdf
Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D. This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin D Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articles Targets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications
Author : Michael F. Holick Publisher : Springer Science & Business Media Page : 456 pages File Size : 47,7 Mb Release : 2013-03-09 Category : Medical ISBN : 9781475728613
The Nutrition and Health series of books has as an overriding mission to provide health professionals with texts that are considered essential because each includes: a synthesis of the state of the science; timely, in-depth reviews by the leading researchers in their respective fields; extensive, up-to-date fully annotated reference lists; a detailed index; relevant tables and figures; identification of paradigm shifts and the consequences; of information between chapters, but targeted, inter-chapter refer virtually no overlap rals, suggestions of areas for future research; and balanced, data-driven answers to patient questions that are based on the totality of evidence rather than the findings of any single study. The series volumes are not the outcome of a symposium. Rather, each editor has the potential to examine a chosen area with a broad perspective, both in subject matter as well as in the choice of chapter authors. The international perspective, especially with regard to public health initiatives, is emphasized where appropriate. The editors, whose training is both research and practice oriented, have the opportunity to develop a primary objective for their book, define the scope and focus, and then invite the leading authori ties from around the world to be part of their initiative. The authors are encouraged to provide an overview of the field, discuss their own research, and relate the research de findings to potential human health consequences.
Vitamin D in Clinical Medicine by A. Giustina,J.P. Bilezikian Pdf
Vitamin D deficiency is prevalent today not only among the elderly but pervasively throughout all ages of life.This is due, in part, to systemic diseases that affect vitamin D metabolism, to changes in lifestyle, such as insufficient exposure to sunlight, and to increased use of sunscreen. Apart from the obvious effects of vitamin D deficiency on skeletal metabolism, the problem is assuming even greater significance because observational and interventional studies have linked vitamin D deficiency to cardiovascular disease, cancer, and diabetes. This book addresses a variety of important issues that have emerged from this fast-moving area of clinical medicine. The topics include assays of vitamin D and its binding protein, effects on aging and associated complications, primary and secondary states of altered parathyroid hormone secretion, vitamin D in the growing years of children and adolescents, nutritional requirements, and vitamin D as it relates to systemic disorders such as diabetes mellitus. Vitamin D in Clinical Medicine aims to offer new insights, in an evidence-based way, on important issues related to vitamin D. It is written for general practitioners and internists, as well as for endocrinologists, nutritionists, pulmonologists, cardiologists, and oncologists.
A global survey of drawing today featuring over 100 contemporary artists Vitamin D offers a fresh and pioneering overview of the current state and underlying significance of drawing as an artistic medium. It highlights the originality and innovation with which contemporary artists in the genre - from across the world and in a vast variety of contexts - experiment with a diversity of styles and statements. Vitamin D features the work of 109 contemporary artists, selected by some of the world's foremost critics and curators for their unique outlook. It is in itself an artistic compilation of the endless possibilities that drawing offers an artist from any background. This book is a captivating composition of examples of the evolution of drawing in the twenty-first century. It reveals the energy of contemporary drawing, in a subtle presentation of the richness and versatility of the medium. With several pages dedicated to images of each artist's work and a deeply analytical parallel text, Vitamin D is at once a detailed reference book for art world aficianados and an absorbing introduction for newcomers to the scene. Highly informative and aesthetically stimulating, this book is an essential work in its own right, through its exposition of just how fundamental an artistic medium drawing continues to be.
Citing the role of Vitamin D deficiency in chronic health conditions, a program for implementing safe moderate quantities of sunlight into a lifestyle also provides anecdotes and case studies that have demonstrated effective treatments.
Extraskeletal Effects of Vitamin D by Emilia Pauline Liao Pdf
While the skeletal effects of vitamin D are well-documented, the role and importance of vitamin D outside of bone health has not been well-established. Vitamin D receptors are located in nearly every tissue of the body, and low levels of vitamin D are associated with a range of various diseases. This book provides an in-depth examination of these extraskeletal effects of vitamin D and the associations between vitamin D deficiency and various disease states. Beginning with a review of the biochemistry and physiology of vitamin D, subsequent chapters investigate its relationship to autoimmune and infectious diseases, various forms of cancer, endocrine issues such as diabetes, obesity and reproductive function, cardiovascular disease and muscle weakness. Concluding chapters discuss the role of vitamin D in neurological disorders, including Alzheimer's Disease, and cognitive function. Focusing on extraskeletal effects only across a range of conditions, Extraskeletal Effects of Vitamin D will be an important resource for clinical endocrinologists and primary care physicians.
Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes
Author : Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes Publisher : National Academies Press Page : 449 pages File Size : 51,6 Mb Release : 1999-10-17 Category : Medical ISBN : 9780309064033
Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride by Institute of Medicine,Food and Nutrition Board,Standing Committee on the Scientific Evaluation of Dietary Reference Intakes Pdf
Since 1941, Recommended Dietary Allowances (RDAs) has been recognized as the most authoritative source of information on nutrient levels for healthy people. Since publication of the 10th edition in 1989, there has been rising awareness of the impact of nutrition on chronic disease. In light of new research findings and a growing public focus on nutrition and health, the expert panel responsible for formulation RDAs reviewed and expanded its approachâ€"the result: Dietary Reference Intakes. This new series of references greatly extends the scope and application of previous nutrient guidelines. For each nutrient the book presents what is known about how the nutrient functions in the human body, what the best method is to determine its requirements, which factors (caffeine or exercise, for example) may affect how it works, and how the nutrient may be related to chronic disease. The first volume of Dietary Reference Intakes includes calcium, phosphorus, magnesium, vitamin D, and fluoride. The second book in the series presents information about thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Based on analysis of nutrient metabolism in humans and data on intakes in the U.S. population, the committee recommends intakes for each age groupâ€"from the first days of life through childhood, sexual maturity, midlife, and the later years. Recommendations for pregnancy and lactation also are made, and the book identifies when intake of a nutrient may be too much. Representing a new paradigm for the nutrition community, Dietary Reference Intakes encompasses: Estimated Average Requirements (EARs). These are used to set Recommended Dietary Allowances. Recommended Dietary Allowances (RDAs). Intakes that meet the RDA are likely to meet the nutrient requirement of nearly all individuals in a life-stage and gender group. Adequate Intakes (AIs). These are used instead of RDAs when an EAR cannot be calculated. Both the RDA and the AI may be used as goals for individual intake. Tolerable Upper Intake Levels (ULs). Intakes below the UL are unlikely to pose risks of adverse health effects in healthy people. This new framework encompasses both essential nutrients and other food components thought to pay a role in health, such as dietary fiber. It incorporates functional endpoints and examines the relationship between dose and response in determining adequacy and the hazards of excess intake for each nutrient.
Vitamin D: The Calcium Homeostatic Steroid Hormone provides a continuing coordinated group of edited critiques of the dynamic state of the science and art of nutrition. The most recent basic advances will be reviewed within the broad framework of the scientific knowledge of food and nutrition, including its application to man, individually and societally. The volumes, authored singly or by invited contributors, will appeal to serious scholars concerned with pure or applied nutrition. This volume comprises 13 chapters, with the first discussing the progress of vitamin D-cholecalciferol from vitamin to steroid hormone. Succeeding chapters then discuss the biological and chemical assay of vitamin D, its metabolites, and analogs; metabolism of vitamin D; and the tissue and subcellular localization of vitamin D and its metabolites. Other chapters cover binding proteins and receptors for vitamin D and its metabolites; interrelationships between vitamin D and other hormones; intestinal effects of vitamin D; vitamin D actions in the kidney; vitamin D actions on bone; and vitamin D and its clinical relationships. This book will be of interest to practitioners in the fields of chemistry, nutrition, and medicine.
Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. Focusing on areas not extensively covered in other comparable books, Vitamin D: Oxidative Stress, Immunity, and Aging highlights the most recent research findings on the impact of this nutrient in oxidative stress, immunity, and aging. A state-of-the-art compilation of essential information, this book explores: Vitamin D and its genomic and nongenomic effects, the role of therapeutic analogs in treating disease, and the production of vitamin D by the body The role vitamin D plays in modulating oxidative stress—with emphasis on cancer, stress-mediated diseases, photo-protection of the skin, and energy metabolism Beneficial effects of vitamin D in regulating the immune response and its importance in protecting against autoimmune, infectious, and inflammatory diseases The role vitamin D plays in the regulation of the aging process—including aspects of oxidative stress, senescence, and mortality, as well as its role in protection against cardiovascular disease and nervous system disorders This book represents an important contribution toward understanding the mechanisms by which vitamin D promotes health, increasing awareness of the importance that vitamin D plays during development, at birth, and throughout the aging process. It is a valuable reference for researchers in academia, nutrition, medicine, and industry.
Author : Donald L. Trump,Candace S. Johnson Publisher : Springer Science & Business Media Page : 348 pages File Size : 53,9 Mb Release : 2010-12-09 Category : Medical ISBN : 9781441971883
Vitamin D and Cancer by Donald L. Trump,Candace S. Johnson Pdf
Substantial data indicate the broad importance of vitamin D-based signaling in normal human physiology and the broad effects of vitamin D deficiency. Vitamin D may play a role not only in the control of bone and mineral metabolism, but also appears to be involved in immune function, cardiovascular health, thrombosis and vasculogenesis and neuromuscular function. Considerable epidemiologic data demonstrate that low vitamin D serum levels occur very commonly in normal adult populations and that vitamin D deficiency is associated with an enhanced risk of cancer death from lung, prostate, head & neck, colorectal and other gastrointestinal cancers. In addition, preclinical data provide evidence that calcitriol and other active analogues of calcitriol have anti-proliferative, pro-differentiative, pro-apoptotic and anti-angiogenic activity in numerous in-vitro and in-vivo models. It is quite clear that, while it requires high exposure to calcitriol to induce these effects, such exposure can be readily achieved when high dose intermittent therapy is given.
The miraculous results of extremely high doses of the sunshine hormone vitamin D3 : my experiment with huge doses of D3, from 25,000 to 50,000 to 100,000 IU, a day over a 1 year period by Jeff T. Bowles Pdf
This updated edition has a fascinating new look at diabetes as an evolved defense to freezing damage in winter gone out of control- Don''t miss it! 144+ Pages of Fact-Packed Science Based Information-But FUN to read- Upon realizing that taking 4,000 IU of Vitamin D3 a day was not enough for me, I decided to embark on a "dangerous" experiment that directly contradicted everything MD''s had told me for years: "DON''T TAKE TOO MUCH VITAMIN D IT IS DANGEROUS!" I started taking 20,000 IU a day-50X times the recommended dose of 400 IU a day. After about 4 months upped the dose to 50,000 IU a day or 150X the old recommended "safe" dose I then boosted it to 100,000 IU a day or 300 x TIMES the old maximum safe dose! What happened over these last 10 months? Did I die? get sick? No! Just the opposite!! High dose Vitamin D3 therapy over the last year- CURED ALL MY CHRONIC CONDITIONS- SOME THAT I''D HAD FOR 20+ YEARS! A painful snapping hip syndrome which I had been suffering from for 23 years and no Dr could help me-It is now 100% gone. No pain and NO SNAPPING!! Yellow fungus infected toenails (under the nail)- I tried everything over 20 years and nothing worked-10 months of high dose Vitamin D3 and they are clear as a bell! 100% cured. A knobby bone spur on my elbow that made me look like Popeye the sailor man-It has now 100% dissolved and my elbow is back to the way it used to be 20 years ago. Painful , clicking, popping, stiff Arthritic shoulders that prevented me from even throwing a ball from home plate past the infield. A condition I''ve had for 15 years. Gone. No more popping snapping or clicking and I can throw the ball twice as far . A ganglion cyst that persisted on my wrist for over 5 years has shrunk from the size of half a golf ball to the size of a pea and now it is rock hard ,painless, and shrinking. A small subcutaneous cyst on my face that had not gone away for 20 years -now gone! AND-Without even trying my weight has dropped by 25 pounds from 204 to 179. This book tells you detailed results of my experiment, dangers to avoid, and also discusses a simple and elegant new theory that suggests how High Dose Vitamin D3 therapy Should help PREVENT OR CURE all the epidemics of disease and health issues that have been plaguing us since the 1980''s when Doctors started warning us to stay out of the sun and always use sunscreen. This has created the huge epidemics we see today of Obesity, Autism, Asthma, and many others! When your Vitamin D3 levels are low, your body gets you to prepare for winter by overeating, slowing you down to conserve energy, and even making you depressed to keep you housebound. Interestingly it is this same drop in Vitamin D3 levels that signals a bear to start hibernating! If your body expects famine-like conditions caused by winter to be likely- it will conserve your critical resources for the future. This leads to what I call the Incomplete Repair Syndrome which in turn causes most of the diseases humans face other than spontaneous gene mutations that cause syndromes and diseases caused exclusively by aging. High D3 can be used to prevent or treat a huge number of diseases MS, asthma, 17 kinds of cancer, lupus, arthritis, heart disease, obesity, depression, Parkinsons+many more... This IS the better mousetrap! Most MD''s get just a basic 4 years in Med School, then work to earn not learn. I''ve researched diseases and aging for 20+ years, with a 10 year stint where I spent 12 hrs/day everyday in the Northwestern Med School''s library just reviewing clinical and scientific studies! I''ve had 3 major papers published; the publishing journal has 5 Nobel Prizes between the editors. And described my papers as extremely exciting and of major importance