Vitamin D Binding Protein Total And Free Vitamin D Levels In Different Physiological And Pathophysiological Conditions

Author : Daniel David Bikle,Zhongjian Xie,Xiangbing Wang
Publisher : Frontiers Media SA
Page : 86 pages
File Size : 43,9 Mb
Release : 2020-03-04
Category : Electronic
ISBN : 9782889635788

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Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions by Daniel David Bikle,Zhongjian Xie,Xiangbing Wang Pdf

There is a high prevalence of vitamin D deficiency worldwide, but how to define vitamin D deficiency is controversial. Currently, the plasma concentration of total 25-hydroxyvitamin D [25(OH)D] is considered an indicator of vitamin D status. The free hormone hypothesis states that protein-bound hormones are inactive while unbound hormones are free to influence biological activity. The majority of circulating 25(OH)D and 1,25(OH)2D is tightly bound to vitamin D binding protein (DBP), 10 -15% is bound to albumin, and less than 1% of circulating vitamin D exists in an unbound form. While DBP is relatively stable in most healthy populations, recent studies have shown that there are gene polymorphisms associated with race and ethnicity that could alter DBP levels and binding affinity. Furthermore, in some clinical situations total 25(OH)D levels are altered, and knowing whether DBP is also altered may have implications for diagnosis and treatment. In this Research Topic, we provide a collection of comprehensive research on vitamin D and DBP metabolism among different ethnic population and patients with different diseases.

Author : Masood Umer,Haroon Ur Rashid
Publisher : Cambridge Scholars Publishing
Page : 440 pages
File Size : 49,5 Mb
Release : 2024-04-18
Category : Medical
ISBN : 9781036402761

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Orthopaedic Innovations in Developing Countries by Masood Umer,Haroon Ur Rashid Pdf

This book focuses on improving orthopaedic surgery in low and middle-income countries (LMIC). Over the last 35 years, orthopaedic surgeons have made multiple innovations locally in Pakistan that have never come to the surface. Many surgeons in our world work in a resource-constrained setting and have to use frugal innovations to work their way out. These are the ground realities of working in a LMIC, which will be shared globally through this book. Starting from seeing patients in the clinic and to the operating room, very high standards have been set in Pakistan for others to follow and replicate within their own resources. This book will be a narrative of how these innovations were achieved and the way forward considering the resource constraints that are present in low-middle-income countries compared to Western countries.

Author : Michael D Waters,Alok Dhawan,Tim Marrs,Diana Anderson,Stafford Warren,Claude L Hughes
Publisher : Royal Society of Chemistry
Page : 595 pages
File Size : 55,6 Mb
Release : 2022-04-27
Category : Medical
ISBN : 9781839163654

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The Coronavirus Pandemic and the Future by Michael D Waters,Alok Dhawan,Tim Marrs,Diana Anderson,Stafford Warren,Claude L Hughes Pdf

This first volume chronicles the early stages of the outbreak and world-wide spread of SARS-Cov-2 (COVID-19) and delineates the role of several disciplines in therapeutic and control measures. Documenting the epidemiologic response from China, the clinical evaluation, pathology and intial therapeutics that were available during the first 6 months and onwards of the outbreak, this book records how the response to the pandemic was mounted and how various branches of science and research combined to rapidly expand our understanding of the disease.

Author : Rachel Nadif
Publisher : Academic Press
Page : 264 pages
File Size : 52,9 Mb
Release : 2022-09-08
Category : Science
ISBN : 9780323854207

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Asthma in the 21st Century by Rachel Nadif Pdf

Asthma in the 21st Century: New Research Advances provides an overview on asthma, with discussions on its heterogeneity, risk factors and their interrelations, and e-health in an aging world based on current research knowledge. The book covers heterogeneity of the disease beyond severe asthma, new risk factors, new diagnoses with climate change, a focus on chemical exposures at home, e-health and links with aging, and notable advances in key areas such as diet and microbiota, the genetics of asthma, and the asthma versus COPD debate. Worldwide, the total number of asthma sufferers is estimated to be ~270 million with an additional 100 million expected to develop asthma by 2025, and asthma is the most common chronic disease among children. There are a number of clinical books available on asthma, but none with much discussion on current scientific findings and new disease understanding. Yet, the concept of asthma has evolved quickly in the past 5–10 years, with many clinicians struggling to keep up with new scientific findings. Offers an overall view of asthma and addresses notable advances in key areas such as diet and the microbiota, the genetics of asthma, and asthma-COPD overlap syndrome Covers hot topics such as heterogeneity of asthma beyond severe asthma, new risk factors, more common complications with climate change, a focus on chemical exposures at home, e-health, and links with frailty in an aging world Provides a deep understanding of a multifactorial, complex, and heterogeneous chronic inflammatory disease known as asthma

Author : Abid Hussain Banday
Publisher : Bentham Science Publishers
Page : 330 pages
File Size : 55,6 Mb
Release : 2023-07-18
Category : Science
ISBN : 9789815049343

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Steroids and their Medicinal Potential by Abid Hussain Banday Pdf

Steroids are an important class of biomolecules with diverse roles and functions. Besides being important as structural and signaling molecules, these molecules hold promise against numerous disorders, including cardiovascular conditions, cancer, inflammation, and autoimmune disorders. Many investigations have demonstrated that steroidal frameworks may provide lipid solubility, receptor selectivity, or membrane binding properties to non-steroidal pharmacophores. However, the therapeutic use of steroids can be dangerous when they're used incorrectly. Additionally, misconceptions about steroids among athletes or recreational users can lead to steroid abuse and poor health outcomes. Steroids and their MedicinalPotential discusses the classification, distribution, biosynthesis, chemical synthesis, and semi-synthesis of different steroids. The medicinal potential of each class is exhaustively discussed in different chapters. The latest advances and developments in steroid-based drug discovery are also discussed thoroughly. The book aims to address general questions and concerns about steroids, providing readers with a useful resource on the subject. Key Features -Provides comprehensive coverage on all aspects of steroids including steroid chemistry, biochemistry, medicinal potential, drug discovery, and advances in target-binding interactions of steroid-based drugs -Includes chapters dedicated to anabolic steroids and their abuse -Designed as an accessible source of information for understanding steroidal drugs with structured chapters-Includes references for advanced readers.

Author : Darshan Malik,Nandita Narayanasamy,V A Pratyusha,Jayita Thakur,Nimisha Sinha
Publisher : Springer Nature
Page : 687 pages
File Size : 48,6 Mb
Release : 2023-11-30
Category : Science
ISBN : 9789811941504

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Textbook of Nutritional Biochemistry by Darshan Malik,Nandita Narayanasamy,V A Pratyusha,Jayita Thakur,Nimisha Sinha Pdf

This textbook for undergraduate students aims at providing an in-depth understanding of the relationship between diet, nutrients, health, diseases, and drug treatment. The book presents a comprehensive but detailed view of the field of Nutritional Biochemistry; balancing the historical with contemporary findings, the descriptive with the experimental, structure with function as well as the mechanistic and the clinical aspects of any particular nutrient. Though the major emphasis of the book is on Nutritional Biochemistry, the book also attempts to provide an insight into other related and relevant areas. Amongst the topics that are covered are: nutraceuticals, food, and nutrient interactions; the newly emerging field of the human microbiome, its interdependence on diet and human health as well as the public health concerns which is a looming burden of non-communicable diseases. Each chapter begins with an insight into the history of discovery and structure of the nutrient, its absorption, and metabolism, physiological functions, ending with diseases associated with nutrient deficiency/toxicity along with a clinical perspective. Apart from this, the book emphasizes the biochemical basis of physiological responses and correlates the same with symptoms identifying the pathophysiology. This textbook caters to students of undergraduate courses like Biochemistry, Biomedical Sciences, Biological Sciences, Life Sciences, Home Science; Nutrition and Dietetics, Clinical Nutrition and Dietetics, and Nursing. ​

Author : Peng An,Aimin Yang,Jinhui Li,Yongting Luo
Publisher : Frontiers Media SA
Page : 285 pages
File Size : 55,5 Mb
Release : 2024-03-25
Category : Medical
ISBN : 9782832546710

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Micronutrients and Metabolic Diseases by Peng An,Aimin Yang,Jinhui Li,Yongting Luo Pdf

Author : Federico Baronio,Fátima Baptista
Publisher : Frontiers Media SA
Page : 126 pages
File Size : 51,5 Mb
Release : 2023-01-13
Category : Medical
ISBN : 9782832511459

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Bone health and development in children and adolescents by Federico Baronio,Fátima Baptista Pdf

Author : Bernadette P. Marriott,Diane F. Birt,Virginia A. Stalling,Allison A. Yates
Publisher : Academic Press
Page : 680 pages
File Size : 42,6 Mb
Release : 2020-07-21
Category : Technology & Engineering
ISBN : 9780128198421

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Present Knowledge in Nutrition by Bernadette P. Marriott,Diane F. Birt,Virginia A. Stalling,Allison A. Yates Pdf

Present Knowledge in Nutrition: Basic Nutrition and Metabolism, Eleventh Edition, provides an accessible, referenced source on the most current information in the broad field of nutrition. Now broken into two volumes and updated to reflect scientific advancements since the publication of the last edition, the book includes expanded coverage on basic nutrition, metabolism and clinical and applied topics. This volume provides coverage of macronutrients, vitamins, minerals and other dietary components and concludes with new approaches in nutrition science that apply to many, if not all, of the nutrients and dietary components presented throughout the reference. Advanced undergraduate, graduate and postgraduate students in nutrition, public health, medicine and related fields will find this resource useful. In addition, professionals in academia and medicine, including clinicians, dietitians, physicians, health professionals, academics and industrial and government researchers will find the content extremely useful. The book was produced in cooperation with the International Life Sciences Institute (https://ilsi.org/). Provides an accessible source of the most current, reliable and comprehensive information in the broad field of nutrition Features new chapters on topics of emerging importance, including the microbiome, eating disorders, nutrition in extreme environments, and the role of nutrition and cognition in mental status Covers topics of clinical relevance, including the role of nutrition in cancer support, ICU nutrition, supporting patients with burns, and wasting, deconditioning and hypermetabolic conditions

Author : Susu M. Zughaier,Erik Lubberts,Abdulbari Bener
Publisher : Frontiers Media SA
Page : 177 pages
File Size : 48,6 Mb
Release : 2020-12-16
Category : Medical
ISBN : 9782889661749

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Immune-Modulatory Effects of Vitamin D by Susu M. Zughaier,Erik Lubberts,Abdulbari Bener Pdf

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Author : Airu Chia,Ling-Wei Chen,Jun Shi Lai,Shan Xuan Lim
Publisher : Frontiers Media SA
Page : 102 pages
File Size : 41,7 Mb
Release : 2023-12-05
Category : Medical
ISBN : 9782832538449

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Maternal Dietary and Lifestyle Patterns with Pregnancy, Birth, and Child Health Outcomes by Airu Chia,Ling-Wei Chen,Jun Shi Lai,Shan Xuan Lim Pdf

To date, limited evidence suggests that maternal preconception and pregnancy dietary patterns are associated with reduced risks of adverse maternal and child health outcomes such as gestational diabetes mellitus and preterm birth. However, there are insufficient studies examining preconception and pregnancy dietary patterns on birth weight outcomes such as gestational-age birth weight for any conclusion to be made. Additionally, there is a relative paucity of studies investigating preconception, postpartum, and beyond postpartum dietary patterns. Recent research has advanced from examining each modifiable lifestyle factor singly (e.g. diet, physical activity, smoking) towards a holistic approach of examining multiple lifestyle factors using composite healthy lifestyle scores. Two large-scale mother-offspring cohorts in Ireland and the United States have shown that adherence to a healthy lifestyle during pregnancy and beyond pregnancy is associated with reduced risks of adverse offspring birth outcomes and childhood obesity. These findings are consistent with data obtained from cross-sectional studies based in China and Tanzania.

Author : Andrea Giustina,Alberto Angeli,Ernesto Canalis
Publisher : Karger Medical and Scientific Publishers
Page : 213 pages
File Size : 53,8 Mb
Release : 2002
Category : Medical
ISBN : 9783805572965

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Glucocorticoid-induced Osteoporosis by Andrea Giustina,Alberto Angeli,Ernesto Canalis Pdf

Osteoporosis is one of the most clinically relevant disabling chronic disease encountered in clinical practice. A common cause of osteoporosis is glucocorticoid excess, as glucocorticoids may increase bone resorption, inhibit bone formation, have indirect actions on bone by decreasing intestinal calcium absorption and induce hypercalciuria. This book presents a comprehensive overview of the effects of glucocorticoids on bone metabolism and structure and on the diagnosis and treatment of glucocorticoid-induced osteoporosis. It aims at providing updated information on the pathogenesis, diagnosis and treatment of this often dramatic complication of glucocorticoid excess. Being one of the few publications completely devoted to glucocorticoid-induced osteoporosis it will heighten the awareness of specialists who prescribe glucocorticoids of the clinical relevance of this treatment complication. 'Glucocorticoid-Induced Osteoporosis' is addressed to clinical experts as well as to general practitioners who will both benefit from the comprehensive and integrative view of the management of patients exposed to glucocorticoids.

Author : Simon Spedding
Publisher : MDPI
Page : 307 pages
File Size : 53,9 Mb
Release : 2019-02-21
Category : Biology (General)
ISBN : 9783038975861

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Vitamin D and Human Health by Simon Spedding Pdf

This book is a printed edition of the Special Issue "Vitamin D and Human Health" that was published in Nutrients

Author : Shaul Massry
Publisher : Springer Science & Business Media
Page : 611 pages
File Size : 48,9 Mb
Release : 2013-11-21
Category : Medical
ISBN : 9781461342175

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Phosphate Metabolism by Shaul Massry Pdf

We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.

Author : A. W. Norman,K. Schaefer,D. v. Herrath,H.-G. Grigoleit,J. W. Coburn,H. F. De Luca,E. B. Mawer,T. Suda
Publisher : Walter de Gruyter GmbH & Co KG
Page : 1348 pages
File Size : 52,5 Mb
Release : 2020-10-26
Category : Medical
ISBN : 9783112330029

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Vitamin D. Basic Research and its Clinical Application by A. W. Norman,K. Schaefer,D. v. Herrath,H.-G. Grigoleit,J. W. Coburn,H. F. De Luca,E. B. Mawer,T. Suda Pdf

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