Welcome To The Genome

Author : Robert DeSalle,Michael Yudell
Publisher : John Wiley & Sons
Page : 280 pages
File Size : 55,6 Mb
Release : 2020-01-27
Category : Science
ISBN : 9781118750315

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Welcome to the Genome by Robert DeSalle,Michael Yudell Pdf

The popular introduction to the genomic revolution for non-scientists—the revised and updated new edition Welcome to the Genome is an accessible, up-to-date introduction to genomics—the interdisciplinary field of biology focused on the structure, function, evolution, mapping, and editing of an organism's complete set of DNA. Written for non-experts, this user-friendly book explains how genomes are sequenced and explores the discoveries and challenges of this revolutionary technology. Genomics is a mixture of many fields, including not only biology, engineering, computer science, and mathematics, but also social sciences and humanities. This unique guide addresses both the science of genomics and the ethical, moral, and social questions that rise from the technology. There have been many exciting developments in genomics since this book's first publication. Accordingly, the second edition of Welcome to the Genome offers substantial new and updated content to reflect recent major advances in genome-level sequencing and analysis, and demonstrates the vast increase in biological knowledge over the past decade. New sections cover next-generation technologies such as Illumina and PacBio sequencing, while expanded chapters discuss controversial ethical and philosophical issues raised by genomic technology, such as direct-to-consumer genetic testing. An essential resource for understanding the still-evolving genomic revolution, this book: Introduces non-scientists to basic molecular principles and illustrates how they are shaping the genomic revolution in medicine, biology, and conservation biology Explores a wide range of topics within the field such as genetic diversity, genome structure, genetic cloning, forensic genetics, and more Includes full-color illustrations and topical examples Presents material in an accessible, user-friendly style, requiring no expertise in genomics Discusses past discoveries, current research, and future possibilities in the field Sponsored by the American Museum of Natural History, Welcome to the Genome: A User's Guide to the Genetic Past, Present, and Future is a must-read book for anyone interested in the scientific foundation for understanding the development and evolutionary heritage of all life.

Author : Dr. Euan Angus Ashley
Publisher : Celadon Books
Page : 221 pages
File Size : 43,7 Mb
Release : 2021-02-23
Category : Science
ISBN : 9781250234971

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The Genome Odyssey by Dr. Euan Angus Ashley Pdf

In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease. Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000. For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human. In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures. He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome. These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.

Author : Veli Mäkinen,Djamal Belazzougui,Fabio Cunial,Alexandru I. Tomescu
Publisher : Cambridge University Press
Page : 470 pages
File Size : 50,5 Mb
Release : 2023-10-12
Category : Computers
ISBN : 9781009341219

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Genome-Scale Algorithm Design by Veli Mäkinen,Djamal Belazzougui,Fabio Cunial,Alexandru I. Tomescu Pdf

Guided by standard bioscience workflows in high-throughput sequencing analysis, this book for graduate students, researchers, and professionals in bioinformatics and computer science offers a unified presentation of genome-scale algorithms. This new edition covers the use of minimizers and other advanced data structures in pangenomics approaches.

Author : Barry Barnes,John Dupré
Publisher : University of Chicago Press
Page : 282 pages
File Size : 42,6 Mb
Release : 2009-05-15
Category : Science
ISBN : 9780226172965

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Genomes and What to Make of Them by Barry Barnes,John Dupré Pdf

The announcement in 2003 that the Human Genome Project had completed its map of the entire human genome was heralded as a stunning scientific breakthrough: our first full picture of the basic building blocks of human life. Since then, boasts about the benefits—and warnings of the dangers—of genomics have remained front-page news, with everyone agreeing that genomics has the potential to radically alter life as we know it. For the nonscientist, the claims and counterclaims are dizzying—what does it really mean to understand the genome? Barry Barnes and John Dupré offer an answer to that question and much more in Genomes and What to Make of Them, a clear and lively account of the genomic revolution and its promise. The book opens with a brief history of the science of genetics and genomics, from Mendel to Watson and Crick and all the way up to Craig Venter; from there the authors delve into the use of genomics in determining evolutionary paths—and what it can tell us, for example, about how far we really have come from our ape ancestors. Barnes and Dupré then consider both the power and risks of genetics, from the economic potential of plant genomes to overblown claims that certain human genes can be directly tied to such traits as intelligence or homosexuality. Ultimately, the authors argue, we are now living with a new knowledge as powerful in its way as nuclear physics, and the stark choices that face us—between biological warfare and gene therapy, a new eugenics or a new agricultural revolution—will demand the full engagement of both scientists and citizens. Written in straightforward language but without denying the complexity of the issues, Genomes and What to Make of Them is both an up-to-date primer and a blueprint for the future.

Author : Steven Monroe Lipkin,Jon Luoma
Publisher : Beacon Press
Page : 242 pages
File Size : 53,6 Mb
Release : 2017-05-16
Category : Science
ISBN : 9780807008775

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The Age of Genomes by Steven Monroe Lipkin,Jon Luoma Pdf

A leading geneticist explores what promises to be one of the most transformative advances in health and medicine in history Almost every week, another exciting headline appears about new advances in the field of genetics. Genetic testing is experiencing the kind of exponential growth once seen with the birth of the Internet, while the plummeting cost of DNA sequencing makes it increasingly accessible for individuals and families. Steven Lipkin and Jon Luoma posit that today’s genomics is like the last century’s nuclear physics: a powerful tool for good if used correctly, but potentially dangerous nonetheless. DNA testing is likely the most exciting advance in a long time for treating serious disease, but sequencing errors, complex biology, and problems properly interpreting genetic data can also cause life-threatening misdiagnoses of patients with debilitating and fatal genetic diseases. DNA testing can also lead to unnecessary procedures and significantly higher health-care costs. And just around the corner is the ability to cure genetic diseases using powerful gene-editing technologies that are already being used in human embryo research. Welcome to the Age of Genomes! The Age of Genomes immerses readers in true stories of patients on the frontier of genomic medicine and explores both the transformative potential and risks of genetic technology. It will inform anxious parents increasingly bombarded by offers of costly new prenatal testing products, and demonstrate how genetic technology, when deployed properly, can significantly improve the lives of patients who have devastating neurological diseases, cancer, and other maladies. Dr. Lipkin explains the science in depth, but in terms a layperson can follow.

Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Page : 239 pages
File Size : 45,5 Mb
Release : 2021-01-16
Category : Medical
ISBN : 9780309671132

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Heritable Human Genome Editing by The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing Pdf

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Author : Dalton Conley,Jason Fletcher
Publisher : Princeton University Press
Page : 294 pages
File Size : 54,7 Mb
Release : 2018-11-13
Category : Science
ISBN : 9780691183169

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The Genome Factor by Dalton Conley,Jason Fletcher Pdf

"For a century, social scientists have avoided genetics like the plague. But in the past decade, a small but intrepid group of economists, political scientists, and sociologists have harnessed the genomics revolution to paint a more complete picture of human social life than ever before. The Genome Factor describes the latest astonishing discoveries being made at the scientific frontier where genomics and the social sciences intersect. The Genome Factor reveals that there are real genetic differences by racial ancestry--but ones that don't conform to what we call black, white, or Latino. Genes explain a significant share of who gets ahead in society and who does not, but instead of giving rise to a genotocracy, genes often act as engines of mobility that counter social disadvantage. An increasing number of us are marrying partners with similar education levels as ourselves, but genetically speaking, humans are mixing it up more than ever before with respect to mating and reproduction. These are just a few of the many findings presented in this illuminating and entertaining book, which also tackles controversial topics such as genetically personalized education and the future of reproduction in a world where more and more of us are taking advantage of cheap genotyping services like 23andMe to find out what our genes may hold in store for ourselves and our children. The Genome Factor shows how genomics is transforming the social sciences--and how social scientists are integrating both nature and nurture into a unified, comprehensive understanding of human behavior at both the individual and society-wide levels."--

Author : Sandy B. Primrose,Richard Twyman
Publisher : Wiley-Blackwell
Page : 288 pages
File Size : 48,7 Mb
Release : 2002-12-30
Category : Science
ISBN : 1405101202

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Principles of Genome Analysis and Genomics by Sandy B. Primrose,Richard Twyman Pdf

Author : Jeremy W. Dale,Malcolm von Schantz
Publisher : Wiley
Page : 372 pages
File Size : 49,9 Mb
Release : 2002-10-08
Category : Science
ISBN : 0471497827

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From Genes to Genomes by Jeremy W. Dale,Malcolm von Schantz Pdf

Rapid advances in our understanding of genetics have required that new books contain topics such as the concept and theory of gene cloning, transgenics, genomics, and various other coverage of traditional and contemporary subjects. Although there is an abundance of textbooks that cover introductory genetics and advanced courses in genetics, there is a noticeable gap at the intermediate (second year) level. In the past gene structure, function and expression were taught at final year /postgraduate level, but the rapid advances in our understanding of genetics has encouraged courses to change considerably. Over recent years these topics have filtered down the curriculum and are currently taught as core topics at second year, with a corresponding change in textbook requirements. Where once second year students were restricted to learning about the concept and theory of gene cloning, now they routinely clone genes for themselves as part of their practical assignments. Genes to Genomics will fill the gap, cover much of the same ground as previous titles, but go further on contemporary topics like transgenics, sequence comparison and analysis of variation. * A concise, up to date textbook that provides a balanced coverage of traditional and contemporary topics taught within intermediate courses in molecular genetics * Jeremy Dale has a proven track record as the successful author of Molecular Genetics of Bacteria * Genes to Genomics will include a series of feature box-outs that will examine some of the topical issues related to the scientific concepts and examples explored within the text * A range of questions and exercises including worked examples and web-based practicals * An accompanying web site will allow the authors to keep their audience up to date in the areas that are prone to date most rapidly between successive editions of the textbook. It will also include the illustrations and images from the textbook, in addition to worked examples, answers to questions within the book, and links to related websites of key interest.

Author : John C. Sanford
Publisher : Ivan Press
Page : 232 pages
File Size : 41,5 Mb
Release : 2005
Category : Science
ISBN : PSU:000058517666

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Genetic Entropy & the Mystery of the Genome by John C. Sanford Pdf

Dr. John Sanford, a retired Cornell Professor, shows in Genetic Entropy and the Mystery of the Genome that the Primary Axiom is false. The Primary Axiom is the foundational evolutionary premise - that life is merely the result of mutations and natural selection. In addition to showing compelling theoretical evidence that whole genomes can not evolve upward, Dr. Sanford presents strong evidence that higher genomes must in fact degenerate over time. This book strongly refutes the Darwinian concept that man is just the result of a random and pointless natural process.

Author : John Collins
Publisher : Unknown
Page : 427 pages
File Size : 42,6 Mb
Release : 1991
Category : Gene mapping
ISBN : 3778520547

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Genome Analysis by John Collins Pdf

Author : Barry Barnes,John Dupré
Publisher : University of Chicago Press
Page : 281 pages
File Size : 52,7 Mb
Release : 2008-12-01
Category : Science
ISBN : 0226172953

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Genomes and What to Make of Them by Barry Barnes,John Dupré Pdf

The announcement in 2003 that the Human Genome Project had completed its map of the entire human genome was heralded as a stunning scientific breakthrough: our first full picture of the basic building blocks of human life. Since then, boasts about the benefits—and warnings of the dangers—of genomics have remained front-page news, with everyone agreeing that genomics has the potential to radically alter life as we know it. For the nonscientist, the claims and counterclaims are dizzying—what does it really mean to understand the genome? Barry Barnes and John Dupré offer an answer to that question and much more in Genomes and What to Make of Them, a clear and lively account of the genomic revolution and its promise. The book opens with a brief history of the science of genetics and genomics, from Mendel to Watson and Crick and all the way up to Craig Venter; from there the authors delve into the use of genomics in determining evolutionary paths—and what it can tell us, for example, about how far we really have come from our ape ancestors. Barnes and Dupré then consider both the power and risks of genetics, from the economic potential of plant genomes to overblown claims that certain human genes can be directly tied to such traits as intelligence or homosexuality. Ultimately, the authors argue, we are now living with a new knowledge as powerful in its way as nuclear physics, and the stark choices that face us—between biological warfare and gene therapy, a new eugenics or a new agricultural revolution—will demand the full engagement of both scientists and citizens. Written in straightforward language but without denying the complexity of the issues, Genomes and What to Make of Them is both an up-to-date primer and a blueprint for the future.

Author : John C. Avise
Publisher : Oxford University Press on Demand
Page : 237 pages
File Size : 45,9 Mb
Release : 2010-02-12
Category : Science
ISBN : 9780195393439

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Inside the Human Genome by John C. Avise Pdf

How do you explain flaw in a world engineered by God? Avise extends this age-old question to the most basic aspect of humanity's physical evidence-- our genes-- and provides the evolutionary answers.

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Review of the Department of Energy's Genomics: GTL Program
Publisher : National Academies Press
Page : 102 pages
File Size : 53,7 Mb
Release : 2006-04-19
Category : Science
ISBN : 9780309180719

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Review of the Department of Energy's Genomics: GTL Program by National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Review of the Department of Energy's Genomics: GTL Program Pdf

The U.S. Department of Energy (DOE) promotes scientific and technological innovation to advance the national, economic, and energy security of the United States. Recognizing the potential of microorganisms to offer new energy alternatives and remediate environmental contamination, DOE initiated the Genomes to Life program, now called Genomics: GTL, in 2000. The program aims to develop a predictive understanding of microbial systems that can be used to engineer systems for bioenergy production and environmental remediation, and to understand carbon cycling and sequestration. This report provides an evaluation of the program and its infrastructure plan. Overall, the report finds that GTL's research has resulted in and promises to deliver many more scientific advancements that contribute to the achievement of DOE's goals. However, the DOE's current plan for building four independent facilities for protein production, molecular imaging, proteome analysis, and systems biology sequentially may not be the most cost-effective, efficient, and scientifically optimal way to provide this infrastructure. As an alternative, the report suggests constructing up to four institute-like facilities, each of which integrates the capabilities of all four of the originally planned facility types and focuses on one or two of DOE's mission goals. The alternative infrastructure plan could have an especially high ratio of scientific benefit to cost because the need for technology will be directly tied to the biology goals of the program.

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences
Publisher : National Academies Press
Page : 201 pages
File Size : 52,6 Mb
Release : 2020-12-18
Category : Science
ISBN : 9780309676731

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Next Steps for Functional Genomics by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences Pdf

One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.