Genomes And What To Make Of Them

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Genomes and What to Make of Them

Barry Barnes,John Dupré
Genomes and What to Make of Them Book PDF

Author : Barry Barnes,John Dupré
Publisher : University of Chicago Press
Page : 282 pages
File Size : 42,5 Mb
Release : 2009-05-15
Category : Science
ISBN : 9780226172965

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Genomes and What to Make of Them by Barry Barnes,John Dupré Pdf

The announcement in 2003 that the Human Genome Project had completed its map of the entire human genome was heralded as a stunning scientific breakthrough: our first full picture of the basic building blocks of human life. Since then, boasts about the benefits—and warnings of the dangers—of genomics have remained front-page news, with everyone agreeing that genomics has the potential to radically alter life as we know it. For the nonscientist, the claims and counterclaims are dizzying—what does it really mean to understand the genome? Barry Barnes and John Dupré offer an answer to that question and much more in Genomes and What to Make of Them, a clear and lively account of the genomic revolution and its promise. The book opens with a brief history of the science of genetics and genomics, from Mendel to Watson and Crick and all the way up to Craig Venter; from there the authors delve into the use of genomics in determining evolutionary paths—and what it can tell us, for example, about how far we really have come from our ape ancestors. Barnes and Dupré then consider both the power and risks of genetics, from the economic potential of plant genomes to overblown claims that certain human genes can be directly tied to such traits as intelligence or homosexuality. Ultimately, the authors argue, we are now living with a new knowledge as powerful in its way as nuclear physics, and the stark choices that face us—between biological warfare and gene therapy, a new eugenics or a new agricultural revolution—will demand the full engagement of both scientists and citizens. Written in straightforward language but without denying the complexity of the issues, Genomes and What to Make of Them is both an up-to-date primer and a blueprint for the future.

Genomes and What to Make of Them

Barry Barnes,John Dupre
Genomes and What to Make of Them Book PDF

Author : Barry Barnes,John Dupre
Publisher : ReadHowYouWant.com
Page : 506 pages
File Size : 51,5 Mb
Release : 2011-02
Category : Science
ISBN : 9781459605930

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Genomes and What to Make of Them by Barry Barnes,John Dupre Pdf

The announcement in 2003 that the Human Genome Project had completed its map of the entire human genome was heralded as a stunning scientific breakthrough: our first full picture of the basic building blocks of human life. Since then, boasts about the benefits - and warnings of the dangers - of genomics have remained front-page news, with everyo...

Mapping and Sequencing the Human Genome

National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
Mapping and Sequencing the Human Genome Book PDF

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome
Publisher : National Academies Press
Page : 128 pages
File Size : 41,9 Mb
Release : 1988-01-01
Category : Science
ISBN : 9780309038409

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Mapping and Sequencing the Human Genome by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Mapping and Sequencing the Human Genome Pdf

There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Blossoms

Maxine F. Singer
Blossoms Book PDF

Author : Maxine F. Singer
Publisher : Oxford University Press
Page : 179 pages
File Size : 46,6 Mb
Release : 2018
Category : Science
ISBN : 9780198811138

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Blossoms by Maxine F. Singer Pdf

Flowers evolved to attract pollinators, so new generations of plant can form. But how do plants know when to bloom, and how do they construct their flowers? This book describes what we have learnt of the astonishing genetic and epigenetic processes behind the dazzling variety of flower shapes, colours, and scents.--

Heritable Human Genome Editing

The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Heritable Human Genome Editing Book PDF

Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Page : 239 pages
File Size : 47,9 Mb
Release : 2021-01-16
Category : Medical
ISBN : 9780309671132

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Heritable Human Genome Editing by The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing Pdf

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Welcome to the Genome

Rob DeSalle,Michael Yudell,American Museum of Natural History
Welcome to the Genome Book PDF

Author : Rob DeSalle,Michael Yudell,American Museum of Natural History
Publisher : Wiley
Page : 240 pages
File Size : 52,7 Mb
Release : 2004-09-28
Category : Science
ISBN : 0471453315

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Welcome to the Genome by Rob DeSalle,Michael Yudell,American Museum of Natural History Pdf

A thrilling "user's guide" to the genomics era Welcome to the genome, the miraculous blueprint of your DNA, coiled tight as a spring in the nucleus of each cell of your body. If unwound, the DNA from just one cell, while only a molecule in width, would stretch six feet in length! The information stored in its double helix structure - three billion bits worth - could fill 142 Manhattan phone books. Yet far more amazing than these facts is the impact the study of genomics has had on so many areas of our lives. From the promise of personalized medicine and gene therapy to disputes over the safety of genetically modified (GM) foods, there is little doubt we are in the midst of the Genomic Revolution. Now how do we make sense of it all? Welcome to the Genome takes you right into the thick of today's most cutting-edge science and its far-reaching implications. Authors Rob DeSalle, who curated the highly successful Genomics Revolution exhibit at the American Museum of Natural History in New York, and Michael Yudell, Assistant Professor of Public Health at Drexel University, have written a book which clearly explains the ongoing saga of our attempts to understand the mystery of biology's Rosetta Stone and use its code to better our lives. This reader-friendly book employs an understandable style and eye-popping full-color illustrations to provide real insights into the complex science involved. It delves into the past discoveries that led to the sequencing of the human genome; it presents the challenges facing today's scientists and society and culture in general; and it considers the future possibilities of the developing genome era. Social issues, particularly questions of ethics, receive special attention, covering an important area too often overshadowed by science and technology. If the genome really is the book of life, then we have only just opened to the first of its many pages. Those who triumphantly claim DNA is destiny may have spoken too soon; it is far more likely today's discoveries will lead to insights yet to be imagined. A stirring and informative introduction to a scientific epic still unfolding, Welcome to the Genome is an essential guide for understanding - and participating in - the incredible explorations, discussions, and realizations of the Genomic Revolution.

The Genome Odyssey

Dr. Euan Angus Ashley
The Genome Odyssey Book PDF

Author : Dr. Euan Angus Ashley
Publisher : Celadon Books
Page : 221 pages
File Size : 40,6 Mb
Release : 2021-02-23
Category : Science
ISBN : 9781250234971

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The Genome Odyssey by Dr. Euan Angus Ashley Pdf

In The Genome Odyssey, Dr. Euan Ashley, Stanford professor of medicine and genetics, brings the breakthroughs of precision medicine to vivid life through the real diagnostic journeys of his patients and the tireless efforts of his fellow doctors and scientists as they hunt to prevent, predict, and beat disease. Since the Human Genome Project was completed in 2003, the price of genome sequencing has dropped at a staggering rate. It’s as if the price of a Ferrari went from $350,000 to a mere forty cents. Through breakthroughs made by Dr. Ashley’s team at Stanford and other dedicated groups around the world, analyzing the human genome has decreased from a heroic multibillion dollar effort to a single clinical test costing less than $1,000. For the first time we have within our grasp the ability to predict our genetic future, to diagnose and prevent disease before it begins, and to decode what it really means to be human. In The Genome Odyssey, Dr. Ashley details the medicine behind genome sequencing with clarity and accessibility. More than that, with passion for his subject and compassion for his patients, he introduces readers to the dynamic group of researchers and doctor detectives who hunt for answers, and to the pioneering patients who open up their lives to the medical community during their search for diagnoses and cures. He describes how he led the team that was the first to analyze and interpret a complete human genome, how they broke genome speed records to diagnose and treat a newborn baby girl whose heart stopped five times on the first day of her life, and how they found a boy with tumors growing inside his heart and traced the cause to a missing piece of his genome. These patients inspire Dr. Ashley and his team as they work to expand the boundaries of our medical capabilities and to envision a future where genome sequencing is available for all, where medicine can be tailored to treat specific diseases and to decode pathogens like viruses at the genomic level, and where our medical system as we know it has been completely revolutionized.

Curiosity Guides: The Human Genome

John Quackenbush
Curiosity Guides The Human Genome Book PDF

Author : John Quackenbush
Publisher : Charlesbridge
Page : 189 pages
File Size : 49,6 Mb
Release : 2011-02-01
Category : Science
ISBN : 9781607343561

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Curiosity Guides: The Human Genome by John Quackenbush Pdf

The DNA sequence that comprises the human genome--the genetic blueprint found in each of our cells--is undoubtedly the greatest code ever to be broken. Completed at the dawn of a new millennium, the feat electrified both the scientific community and the general public with its tantalizing promise of new and better treatments for countless diseases, including Alzheimer's, cancer, diabetes, and Parkinson's. Yet what is arguably the most important discovery of our time has also opened a Pandora's box of questions about who we are as humans and how the unique information stored in our genomes can and might be used, making it all the more important for everyone to understand the new science of genomics. In the CURIOSITY GUIDE TO THE HUMAN GENOME, Dr. John Quackenbush, a renowned scientist and professor, conducts a fascinating tour of the history and science behind the Human Genome Project and the technologies that are revolutionizing the practice of medicine today. With a clear and engaging narrative style, he demystifies the fundamental principles of genetics and molecular biology, including the astounding ways in which genes function, alone or together with other genes and the environment, to either sustain life or trigger disease. In addition, Dr. Quackenbush goes beyond medicine to examine how DNA-sequencing technology is changing how we think of ourselves as a species by providing new insights about our earliest ancestors and reconfirming our inextricable link to all life on earth. Finally, he explores the legal and ethical questions surrounding such controversial topics as stem cell research, prenatal testing, forensics, and cloning, making this volume of the Curiosity Guides series an indispensable resource for navigating our brave new genomic world.

Rebel Cell

Kat Arney
Rebel Cell Book PDF

Author : Kat Arney
Publisher : BenBella Books
Page : 256 pages
File Size : 44,6 Mb
Release : 2020-10-20
Category : Medical
ISBN : 9781950665518

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Rebel Cell by Kat Arney Pdf

Why do we get cancer? Is it our modern diets and unhealthy habits? Chemicals in the environment? An unwelcome genetic inheritance? Or is it just bad luck? The answer is all of these and none of them. We get cancer because we can't avoid it—it's a bug in the system of life itself. Cancer exists in nearly every animal and has afflicted humans as long as our species has walked the earth. In Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal, Kat Arney reveals the secrets of our most formidable medical enemy, most notably the fact that it isn't so much a foreign invader as a double agent: cancer is hardwired into the fundamental processes of life. New evidence shows that this disease is the result of the same evolutionary changes that allowed us to thrive. Evolution helped us outsmart our environment, and it helps cancer outsmart its environment as well—alas, that environment is us. Explaining why "everything we know about cancer is wrong," Arney, a geneticist and award-winning science writer, guides readers with her trademark wit and clarity through the latest research into the cellular mavericks that rebel against the rigid biological "society" of the body and make a leap towards anarchy. We need to be a lot smarter to defeat such a wily foe—smarter even than Darwin himself. In this new world, where we know that every cancer is unique and can evolve its way out of trouble, the old models of treatment have reached their limits. But we are starting to decipher cancer's secret evolutionary playbook, mapping the landscapes in which these rogue cells survive, thrive, or die, and using this knowledge to predict and confound cancer's next move. Rebel Cell is a story about life and death, hope and hubris, nature and nurture. It's about a new way of thinking about what this disease really is and the role it plays in human life. Above all, it's a story about where cancer came from, where it's going, and how we can stop it.

Who We Are and How We Got Here

David Reich
Who We Are and How We Got Here Book PDF

Author : David Reich
Publisher : Oxford University Press
Page : 320 pages
File Size : 48,5 Mb
Release : 2018-03-29
Category : Science
ISBN : 9780192554383

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Who We Are and How We Got Here by David Reich Pdf

The past few years have witnessed a revolution in our ability to obtain DNA from ancient humans. This important new data has added to our knowledge from archaeology and anthropology, helped resolve long-existing controversies, challenged long-held views, and thrown up remarkable surprises. The emerging picture is one of many waves of ancient human migrations, so that all populations living today are mixes of ancient ones, and often carry a genetic component from archaic humans. David Reich, whose team has been at the forefront of these discoveries, explains what genetics is telling us about ourselves and our complex and often surprising ancestry. Gone are old ideas of any kind of racial âpurity.' Instead, we are finding a rich variety of mixtures. Reich describes the cutting-edge findings from the past few years, and also considers the sensitivities involved in tracing ancestry, with science sometimes jostling with politics and tradition. He brings an important wider message: that we should recognize that every one of us is the result of a long history of migration and intermixing of ancient peoples, which we carry as ghosts in our DNA. What will we discover next?

Genes , Genomes ,Genetics and Chromosomes

Logan Aguilar
Genes Genomes Genetics and Chromosomes Book PDF

Author : Logan Aguilar
Publisher : Scientific e-Resources
Page : 312 pages
File Size : 50,8 Mb
Release : 2019-09-03
Category : Electronic
ISBN : 9781839473517

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Genes , Genomes ,Genetics and Chromosomes by Logan Aguilar Pdf

A genome is an organism's complete set of DNA, including all of its genes. Each genome contains all of the information needed to build and maintain that organism. In humans, a copy of the entire genome-more than three billion DNA base pairs-is contained in all cells that have a nucleus. Developmental Genetics studies how the genes regulate developmental changes in behavior and influence scientific approaches in several fields. It highlights the interdisciplinary approach of developmental genetics with new revolutionary technologies and details how these advances have accelerated our understanding of the molecular genetic processes that regulates development. Chromosomes come in matching sets of two (or pairs) and there are hundreds-sometimes thousands-of genes in just one chromosome. The chromosomes and genes are made of DNA, which is short for deoxyribonucleic. Genes, Genomes, and Genomics, with chapters written by internationally renowned experts, provide an enormous reservoir of new information in the various theoretical and applied aspects of unravelling the secrets hidden in the genes of plants, animals and microorganisms. A gene is the basic physical and functional unit of heredity. Genes, which are made up of DNA, act as instructions to make molecules called proteins. In humans, genes vary in size from a few hundred DNA bases to more than two million bases. Moreover, the book presents a thorough overview of a wide array of methodologies from classical genetics to modern genomics technologies.

Neanderthal Man

Svante Pääbo
Neanderthal Man Book PDF

Author : Svante Pääbo
Publisher : Basic Books
Page : 290 pages
File Size : 55,8 Mb
Release : 2014-02-11
Category : Science
ISBN : 9780465080687

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Neanderthal Man by Svante Pääbo Pdf

A preeminent geneticist, winner of the 2022 Nobel Prize in medicine, hunts the Neanderthal and Denisovan genomes to answer the biggest question of them all: how did our ancestors become human? Neanderthal Man tells the riveting personal and scientific story of the quest to use ancient DNA to unlock the secrets of human evolution. Beginning with the study of DNA in Egyptian mummies in the early 1980s and culminating in the sequencing of the Neanderthal genome in 2010, Neanderthal Man describes the events, intrigues, failures, and triumphs of these scientifically rich years through the lens of the pioneer and inventor of the field of ancient DNA, Svante Pääbo. We learn that Neanderthal genes offer a unique window into the lives of our ancient relatives and may hold the key to unlocking the mysteries of where language came from as well as why humans survived while Neanderthals went extinct. Pääbo redrew our family tree and permanently changed the way we think about who we are and how we got here. For readers of Richard Dawkins, David Reich, and Hope Jahren, Neanderthal Man is the must-read account of how he did it.

Adam and the Genome

Scot McKnight,Dennis R. Venema
Adam and the Genome Book PDF

Author : Scot McKnight,Dennis R. Venema
Publisher : Brazos Press
Page : 240 pages
File Size : 52,8 Mb
Release : 2017-01-31
Category : Religion
ISBN : 9781493406746

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Adam and the Genome by Scot McKnight,Dennis R. Venema Pdf

Genomic science indicates that humans descend not from an individual pair but from a large population. What does this mean for the basic claim of many Christians: that humans descend from Adam and Eve? Leading evangelical geneticist Dennis Venema and popular New Testament scholar Scot McKnight combine their expertise to offer informed guidance and answers to questions pertaining to evolution, genomic science, and the historical Adam. Some of the questions they explore include: - Is there credible evidence for evolution? - Do we descend from a population or are we the offspring of Adam and Eve? - Does taking the Bible seriously mean rejecting recent genomic science? - How do Genesis's creation stories reflect their ancient Near Eastern context, and how did Judaism understand the Adam and Eve of Genesis? - Doesn't Paul's use of Adam in the New Testament prove that Adam was a historical individual? The authors address up-to-date genomics data with expert commentary from both genetic and theological perspectives, showing that genome research and Scripture are not irreconcilable. Foreword by Tremper Longman III and afterword by Daniel Harrell.

Genes and Genomes

R.S. Verma
Genes and Genomes Book PDF

Author : R.S. Verma
Publisher : Elsevier
Page : 509 pages
File Size : 44,6 Mb
Release : 1998-06-03
Category : Science
ISBN : 0080526152

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Genes and Genomes by R.S. Verma Pdf

The laws of inheritance were considered quite superficial until 1903, when the chromosome theory of heredity was established by Sutton and Boveri. The discovery of the double helix and the genetic code led to our understanding of gene structure and function. For the past quarter of a century, remarkable progress has been made in the characterization of the human genome in order to search for coherent views of genes. The unit of inheritance termed factor or gene, once upon a time thought to be a trivial an imaginary entity, is now perceived clearly as the precise unit of inheritance that has continually deluged us with amazement by its complex identity and behaviour, sometimes bypassing the university of Mendel's law. The aim of the fifth volume, entitled Genes and Genomes, is to cover the topics ranging from the structure of DNA itself to the structure of the complete genome, along with everything in between, encompassing 12 chapters. These chapters relate much of the information accumulated on the role of DNA in the organization of genes and genomes per se. Several distinguished scientists, all pre-eminent authorities in each field to share their expertise. Obviously, since the historical report on the double helix configuration in 1953, voluminous reports on the meteoric advances in genetics have been accumulated, and to cover every account in a single volume format would be a Herculean task. Therefore, only a few topics are chosen, which are of great interest to molecular geneticists. This volume is intended for advanced graduate students who would wish to keep abreast with the most recent trends in genome biology.

The Human Genome Sourcebook

Tara Acharya,Neeraja Sankaran
The Human Genome Sourcebook Book PDF

Author : Tara Acharya,Neeraja Sankaran
Publisher : Greenwood
Page : 0 pages
File Size : 45,5 Mb
Release : 2005-06-30
Category : Science
ISBN : 9781573565295

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The Human Genome Sourcebook by Tara Acharya,Neeraja Sankaran Pdf

This is not another book about the Human Genome Project. It is, however, about the human genome: the genes that make it up, what the genes do when they are acting properly, and what happens when these genes are damaged. Designed for today's reader who demands quick answers to a wide range of questions, this book is intended to offer the nonspecialist a first-stop, but fairly detailed, guide to the genome. The information it provides is given context: namely, the basic scientific principles of genome research, the new knowledge unearthed or created by this research, and the social and ethical implications of this knowledge.