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Author : Allan V. Kalueff, Laporte,Adam Michael Stewart Publisher : Humana Press Page : 376 pages File Size : 42,8 Mb Release : 2016-05-01 Category : Medical ISBN : 1493960024
Zebrafish Protocols for Neurobehavioral Research by Allan V. Kalueff, Laporte,Adam Michael Stewart Pdf
Zebrafish play an integral role in biomedical research, enabling scientists to examine physiological mechanisms and pathways relevant to human pathogenesis and its therapy. Written by experts, this volume sets out protocols for both larval and adult models.
Author : Allan V. Kalueff,Jonathan M. Cachat Publisher : Humana Press Page : 206 pages File Size : 48,9 Mb Release : 2011-04-06 Category : Medical ISBN : 1607619547
Zebrafish Neurobehavioral Protocols by Allan V. Kalueff,Jonathan M. Cachat Pdf
As a model organism, zebrafish (Danio rerio) offer an opportunity to perform steadfast scientific investigations in a robust and high-throughput manner. In Zebrafish Neurobehavioral Protocols, experts in the field provide a series of detailed behavioral protocols dealing with the major current research areas in the field of behavioral neuroscience. The chapters discuss the use and interpretation of video-aided quantification of zebrafish behaviors, describe novel assays commonly used to quantify emotionality, learning, memory, and social behaviors in zebrafish, and instruct how to quantify endocrine responses and correlate them with behavior. Written in the Neuromethods series format, the chapters provide authoritative reviews of many commonly used approaches in the field today. This "how to" book will be a useful practical guide for zebrafish researchers and will complement another related book from this series, Zebrafish Models in Neurobehavioral Research. Cutting-edge and timely, Zebrafish Neurobehavioral Protocols serves as an excellent compilation epitomizing the growing potential of zebrafish in modern scientific inquiry.
Author : Allan V. Kalueff,Jonathan M. Cachat Publisher : Humana Press Page : 296 pages File Size : 54,6 Mb Release : 2010-10-28 Category : Medical ISBN : 1607619210
Zebrafish Models in Neurobehavioral Research by Allan V. Kalueff,Jonathan M. Cachat Pdf
Animal models have traditionally played a crucial role in improving our understanding of brain pathogenesis. Zebrafish (Danio rerio) have generated considerable discoveries in the areas of genetics, embryology, endocrinology, and neuroscience. Zebrafish Models in Neurobehavioral Research emphasizes the growing importance of zebrafish in neurobehavioral research and portrays an extensive, thorough perspective on the emergence of zebrafish as robust and translational models. Written by leading international experts, the book covers major topics ranging from stress to learned recognition of environment, encompassing a wide spectrum of the utility of zebrafish within neurobiological disciplines. The chapters provide authoritative reviews of many zebrafish paradigms commonly used in the field today. This book will be a useful guide for zebrafish researchers, and will complement another related book from the popular Neuromethods series, Zebrafish Neurobehavioral Protocols. Comprehensive and up-to-date, Zebrafish Models in Neurobehavioral Research serves as an ideal resource for scientists new to the field as well as for established researchers seeking valuable insight into the growing utility of zebrafish in neuroscience.
Animal Models for the Study of Human Disease by Angela L. Shamchuk,Keith B. Tierney Pdf
Olfactory dysfunction, although caused by many factors including physical damage and genetic abnormalities, is an early stage symptom of several neurodegenerative diseases. Not only is the olfactory system subject to the specific histological abnormalities but patients also lose the capacities to detect, identify, and discriminate among odors. In addition to olfactory deficits, motor dysfunction is another prominent manifestation of these conditions. Recent studies have begun to create zebrafish (Danio rerio) models for neurodegenerative diseases. Despite successful execution, there remains a great deal of potential in testing the models using established methods of olfactory and motion assessment. This chapter discusses the current zebrafish models and suggests olfactory and motor endpoints for Parkinson's, Alzheimer's, Huntington's, multiple system atrophy, and amyotrophic lateral sclerosis.
Behavioral and Neural Genetics of Zebrafish by Robert T. Gerlai Pdf
Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions. Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field Describes behavioral, genetic and neural methods and concepts for use in adult and larval zebrafish Features examples of zebrafish models of human central nervous system disorders Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics
The rights and wrongs of zebrafish: Behavioral phenotyping of zebrafish by Allan V. Kalueff Pdf
Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans (~75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally). Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book “The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling” explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes. The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.
Personality in Nonhuman Animals by Jennifer Vonk,Alexander Weiss,Stan A. Kuczaj Pdf
This stimulating and comprehensive collection brings together multiple perspectives on the topic of personality in nonhuman animals—linking historical perspectives, theoretical approaches, methods, and cutting-edge discoveries. Experts from various fields describe their findings on species ranging from dogs, cats, chimpanzees, and dolphins to sharks, snakes, and other reptiles. Chapters not only discuss the evolution of personality, but also describe potential applications within the areas of animal-human interactions, animal ethics and welfare, conservation science, and other areas. A key focus is the role of genetics and the environment in determining animal behavior and personality, including related traits, such as creativity and boredom. These chapters present the study of personality in nonhumans as a means by which we can better understand medical and psychological issues specific to our own species as well. Chapters include: · Exploring factor space (and other adventures) with the Hominoid Personality Questionnaire · The quantitative and molecular genetics of individual differences in animal personality · Personality, temperament and individuality in reptile behavior · What do we want to know about personality in marine mammals? · Individual differences in nonhuman animals: examining boredom, curiosity, and creativity · The interplay between animal personality and foraging ecology Taking significant steps in advancing the study of animal personality, Personality in Nonhuman Animals will engage personality psychologists, comparative psychologists, and behavior ecologists as well as conservationists, zookeepers, livestock managers, and all those interested in the brain and behavior of animals.
Recent Advances in Cannabinoid Research by Willard James Costain,Robert Brad Laprairie Pdf
Scientific interest in cannabinoid research is currently experiencing a significant increase because of changing attitudes toward Cannabis and the evolving awareness of its pharmaceutical benefits. Coincidently, numerous jurisdictions are moving toward legalizing Cannabis and Cannabis-derived products, which reflects a larger global movement to understand Cannabis and its bioactive chemicals for their potential biomedical uses, harms, and economic value. Research activities are surging to fill important knowledge gaps in the field of cannabinoids as they continue to be identified. The purpose of this book is to summarize some leading areas of research in the cannabinoid field where knowledge gaps are actively being addressed. The research described herein spans basic biological and clinical research.
Biology of Stress in Fish by Carl B. Schreck,Lluis Tort,Anthony P. Farrell,Colin J. Brauner Pdf
Biology of Stress in Fish: Fish Physiology provides a general understanding on the topic of stress biology, including most of the recent advances in the field. The book starts with a general discussion of stress, providing answers to issues such as its definition, the nature of the physiological stress response, and the factors that affect the stress response. It also considers the biotic and abiotic factors that cause variation in the stress response, how the stress response is generated and controlled, its effect on physiological and organismic function and performance, and applied assessment of stress, animal welfare, and stress as related to model species. Provides the definitive reference on stress in fish as written by world-renowned experts in the field Includes the most recent advances and up-to-date thinking about the causes of stress in fish, their implications, and how to minimize the negative effects Considers the biotic and abiotic factors that cause variation in the stress response
Ayurvedic Herbal Preparations in Neurological Disorders by Murali Muralidhara,Padmanabhan S. Rajini Pdf
Ayurvedic Herbal Preparations in Neurological Disorders provides a comprehensive and mechanistic understanding of the therapeutic potential of many ayurvedic herbal preparations in disease management. Examining research data for evidence-based ayurvedic approaches, this volume begins with a focused introduction to major ayurvedic plants, discussing various mechanisms underlying their neuromodulatory potential in preclinical and clinical settings. Major subsets of ayurvedic plants are discussed, including Bacopa monnieri, Centella asiatica, Withania somnifera, and others. This volume outlines the importance of integrative approaches along with existing treatments in the intervention/management of Alzheimer’s disease, Parkinson’s disease, depressive mood disorders, epilepsy, schizophrenia, and more. More than a mere compilation of studies, this volume identifies relevant gaps for future research avenues and encourages interdisciplinary collaboration and sharing of knowledge to together identify the most efficacious ayurvedic approaches. Highlighting recent developments (e.g., Ayurgenomics, Ayurahar) and other pertinent research for neuroprotection, this book is crucial for anyone researching or working in the field of neurological disorder treatment and prevention. Provides a focused introduction to major Ayurvedic plants and their therapeutic potential in the management of neurodegenerative diseases Discusses various mechanisms underlying the neuromodulatory potential of several ayurvedic herbal preparations in preclinical and clinical settings Examines major subsets of ayurvedic plants (e.g., Bacopa monnieri, Centella asiatica, Withaniasomnifera, and others) and potential of several other plants in various neurological disorders Outlines the importance of integrative approaches along with existing treatments in the intervention/management of depressive mood disorders, epilepsy, schizophrenia, and more Highlights recent developments (e.g., Ayurgenomics, Ayurahar) and other pertinent research for neuroprotection
Neuropharmacological, Neurobiological and Behavioral Mechanisms of Learning and Memory by Alfredo Meneses,Antonella Gasbarri,Assunta Pompili Pdf
Among the more dynamic topics in science are Neuropharmacological, Neurobiological and Behavioral Mechanisms of Learning and Memory. In this eBook the reader will find fresh reviews and research papers illustrating diverse approaches, which will be seminal in the future.
Robot Fish by Ruxu Du,Zheng Li,Kamal Youcef-Toumi,Pablo Valdivia y Alvarado Pdf
This book provides a comprehensive coverage on robot fish including design, modeling and optimization, control, autonomous control and applications. It gathers contributions by the leading researchers in the area. Readers will find the book very useful for designing and building robot fish, not only in theory but also in practice. Moreover, the book discusses various important issues for future research and development, including design methodology, control methodology, and autonomous control strategy. This book is intended for researchers and graduate students in the fields of robotics, ocean engineering and related areas.
Animal Models for the Study of Human Disease by P. Michael Conn Pdf
Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases
Nanotoxicology and Nanosafety 2.0 by Ying-Jan Wang Pdf
With the rapid development of nanotechnology, nanomaterials have been widely applied in many industrial sectors, including medicine, consumer products, and electronics. While such technology has brought benefits and convenience to our daily lives, it may also potentially threaten human health. In some cases, nanomaterials present unexpected risks to both humans and the environment. Assessments of the potential hazards associated with nanotechnology have been emerging, but substantial challenges remain, because the large number of different nanomaterials cannot be effectively evaluated in a timely manner. The development of a good strategy for a nanomaterials hazard assessment not only promotes the more widespread adoption of non-rodent or 3Rs principles, but also makes nanotoxicology testing more ethical, relevant, and cost- and time-efficient. A thorough understanding of the mechanisms by which nanomaterials perturb biological systems is critical for a more comprehensive elucidation of their nanotoxicity, and this will also facilitate the development of prevention and intervention policies against adverse outcomes induced by them. We hope that the articles included in this eBook can provide updated knowledge on nanotoxicology and nanosafety, from the point of view of both toxicology and ecotoxicology.