Metallothioneins In Biochemistry And Pathology

Author : Paolo Zatta
Publisher : World Scientific
Page : 335 pages
File Size : 49,5 Mb
Release : 2008
Category : Medical
ISBN : 9789812778932

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Metallothioneins in Biochemistry and Pathology by Paolo Zatta Pdf

Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer's and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.

Author : C. Klaasen
Publisher : Birkhäuser
Page : 641 pages
File Size : 47,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9783034888479

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Metallothionein IV by C. Klaasen Pdf

The Proceedings of the Fourth International Metallothionein Meeting (MT-97) feature the latest research on metallothionein. The book covers a broad range of topics which provide important information for both basic and clinical investigators. The selected 94 articles in this book are written by the leading scientists in the field around the world. This is an increasingly important, multi-disciplinary area of study that has benefitted from recent advances in concepts and methodologies from other fields.

Author : Astrid Sigel,Helmut Sigel,Roland K.O. Sigel
Publisher : Walter de Gruyter GmbH & Co KG
Page : 544 pages
File Size : 52,6 Mb
Release : 2015-07-24
Category : Science
ISBN : 9783110436273

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Metallothioneins and Related Chelators by Astrid Sigel,Helmut Sigel,Roland K.O. Sigel Pdf

These sulfur-rich chelators, being important in metal ion homeostasis, find increasing attention. MILS-5, written by 30 internationally recognized experts, focuses on this hot topic. The reader is supported by about 20 tables, more than 80 illustrations and nearly 2000 references. This book is an essential resource for scientists working in a wide range of disciplines from environmental toxicology and inorganic biochemistry all the way through to physiology and medicine.

Author : Anonim
Publisher : Unknown
Page : 756 pages
File Size : 47,6 Mb
Release : 1998
Category : Pharmacology
ISBN : NWU:35558004135402

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Research Communications in Molecular Pathology and Pharmacology by Anonim Pdf

Author : Anonim
Publisher : Elsevier
Page : 8639 pages
File Size : 54,7 Mb
Release : 2017-12-01
Category : Science
ISBN : 9780081006122

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Comprehensive Toxicology by Anonim Pdf

Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts

Author : Curtis D. Klaassen
Publisher : CRC Press
Page : 436 pages
File Size : 47,5 Mb
Release : 1991-08-27
Category : Medical
ISBN : 0849388325

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Metallothionein in Biology and Medicine by Curtis D. Klaassen Pdf

This book brings together work from leading researchers to present the most recent advances in research on metallothionein. This protein interests toxicologists because it is thought that metallothionein protects against metal toxicity and possibly against oxidative stress. It is of interest to pharmacologists because modification of metallothionein levels might have a role in cancer chemotherapy. Nutritionists have an interest in this protein because it appears to be a major storage protein for zinc. Biochemists and molecular biologists will be interested in the mechanisms of regulation of this protein because it is extremely inducible.

Author : Rudolfs K. Zalups,D. James Koropatnick
Publisher : CRC Press
Page : 608 pages
File Size : 47,7 Mb
Release : 2000-02-24
Category : Medical
ISBN : 0748407987

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Molecular Biology and Toxicology of Metals by Rudolfs K. Zalups,D. James Koropatnick Pdf

Molecular Biology and Toxicology of Metals provides a critical review and analysis of the current state of knowledge of metal ion transport and metabolism in prokaryotic and eukaryotic cellular systems. It covers the latest information on specific metals and the biological molecules with which metals interact. It also details mechanisms in the handling and toxicity of metals in specific organ systems, and the role of metals in cell signalling and gene transcription in target cells. This book is sure to prove a fertile meeting ground for the disciplines of molecular genetics and metal toxicology.

Author : Earl Frieden
Publisher : Springer Science & Business Media
Page : 433 pages
File Size : 53,5 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781468447750

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Biochemistry of the Essential Ultratrace Elements by Earl Frieden Pdf

The remarkable development of molecular biology has had its counterpart in an impressive growth of a segment of biology that might be described as atomic biology. The past several decades have witnessed an explosive growth in our knowledge of the many elements that are essential for life and maintenance of plants and animals. These essential elements include the bulk elements (hydro gen, carbon, nitrogen, oxygen, and sulfur), the macrominerals (sodium, potas sium, calcium, magnesium, chloride, and phosphorus), and the trace elements. This last group includes the ultra trace elements and iron, zinc, and copper. Only the ultratrace elements are featured in this book. Iron has attracted so much research that two volumes are devoted to this metal-The Biochemistry of Non-Heme Iron by A. Bezkoravainy, Plenum Press, 1980, and The Biochemistry of Heme Iron (in preparation). Copper and zinc are also represented by a separate volume in this series. The present volume begins with a discussion of essentiality as applied to the elements and a survey of the entire spectrum of possible required elements.

Author : Anonim
Publisher : Unknown
Page : 1228 pages
File Size : 49,8 Mb
Release : 1987
Category : Medicine
ISBN : OSU:32436011073374

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Cumulated Index Medicus by Anonim Pdf

Author : Gregory Becker,Manickam Sugumaran,Edwin L. Cooper
Publisher : Springer Science & Business Media
Page : 380 pages
File Size : 52,8 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461512912

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Phylogenetic Perspectives on the Vertebrate Immune System by Gregory Becker,Manickam Sugumaran,Edwin L. Cooper Pdf

This book contains the proceedings of the first meeting on invertebrate immunity ever sponsored as a summer research conference by the Federation of American Societies for Experimental Biology (FASEB). The conference was held in Copper Mountain, CO from July 11-16, 1999. It was a an extension of a New York Academy of Sciences meeting entitled "Primordial Immunity: Foundations for the Vertebrate Immune System" held on May 2-5,1993 at the Marine Biological Laboratories in Woods Hole, MA. The proceedings of that meeting were published in The Annals of the New York Academy of Sciences (volume 712). At that meeting all the attendes agreed that this type of conference (a relatively small focused gathering) allowed for participation by investigators at all levels of their careers. We further agreed that we should search for a forum that would allow this meeting to continue. The FASEB Summer Research Conference was an excellent vehicle for this type of meeting. Furthermore, this year's participants decided to continue this meeting as a regularly scheduled FASEB sponsored event. This was a unique conference in the sense that it focused upon mechanisms of development and defense in protostome and deuterostome invertebrates and lower vertebrates. There was a strong emphasis on evolutionary cell biology, phylogenetic inferences and the evolution of recognition and regulatory systems.

Author : Anonim
Publisher : Unknown
Page : 366 pages
File Size : 54,8 Mb
Release : 1993
Category : Environmental health
ISBN : MSU:31293010778417

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Environmental Health Perspectives by Anonim Pdf

Author : Anonim
Publisher : Unknown
Page : 372 pages
File Size : 52,9 Mb
Release : 1994
Category : Carcinogenicity testing
ISBN : IND:30000143548760

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Molecular Mechanisms of Metal Toxicity and Carcinogenicity by Anonim Pdf

Author : Christopher Ari Shaw
Publisher : Routledge
Page : 389 pages
File Size : 51,5 Mb
Release : 2018-10-08
Category : Medical
ISBN : 9781351444620

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Glutathione In The Nervous System by Christopher Ari Shaw Pdf

The goal of this text is to focus readers attention on three major areas; the origin and localization of GSH in the nervous system; the multiple effects of GSH on neural health activity; and the potential for alterations on GSH status to lead to neurological damage of the type observed in amyotrophic lateral sclerosis, Parkinson's disease and other neurological disorders. The text also touches upon the additional roles of the antoxidant GSH, including possible neurotransmitter action, redox modulation of ionotropic receptor function, and neuroprotection against exicitoxic actions of glutamate.

Author : Terence P. Boyle
Publisher : ASTM International
Page : 222 pages
File Size : 44,7 Mb
Release : 1987
Category : Aquatic ecology
ISBN : 9780803109391

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New Approaches to Monitoring Aquatic Eco-systems by Terence P. Boyle Pdf

Author : Robert A. Goyer,M. George Cherian
Publisher : Springer Science & Business Media
Page : 480 pages
File Size : 45,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642791628

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Toxicology of Metals by Robert A. Goyer,M. George Cherian Pdf

An insight into new advances of current interest in metal toxicology, such as mechanisms important in risk-assessment for human health. The book also has chapters on emerging conceptual problems including resistance to metal toxicity effects on gene expression, alongside principles regarding drug-chelation of metals, the potential use of prophyrins as indicators of metal exposure and toxicity. The toxicology of specific metals of major public health concern are discussed in depth, such as mercury, aluminum, arsenic, chromium, and cadmium. Of interest to basic scientists as well as public health administrators.