A Molecular And Cellular View Of Protein Kinase Ck2

Author : Khalil Ahmed,E. Chambaz,Olaf-Georg Issinger
Publisher : Springer Science & Business Media
Page : 234 pages
File Size : 41,8 Mb
Release : 2012-09-18
Category : Science
ISBN : 9781441986245

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A Molecular and Cellular View of Protein Kinase CK2 by Khalil Ahmed,E. Chambaz,Olaf-Georg Issinger Pdf

It is now generally recognized that protein kinase signaling is involved in virtually every aspect of cell function, including growth and proliferation. The field of protein phosphorylation, including the enzymes involved in this post-translational modification, continues to advance at a fascinating pace. Since the first international meeting on this topic, held in Heidelberg in 1994, several new avenues of CK2 research have emerged despite persistent deficiencies in our understanding of the regulation of its activity. Among the significant new directions are studies related to the structure of the enzyme, especially its crystal structure, as well as an interesting aspect of CK2 function that involves its subunits as binding partners of several other proteins. In addition, new data have been gathered on the role of CK2 in transcription as well as in certain other cellular functions. To address these various aspects of the progress of CK2, a number of key scientists from different parts of the world came together at the second international meeting on `A Molecular and Cellular View of Protein Kinase CK2', held at Villard de Lans near Grenoble on September 24-26, 1997. The meeting was attended by nearly 50 participants and included 28 presentations, which provide a view of the latest progress on protein kinase CK2.

Author : O. G Issinger,Khalil Ahmed,E Chambaz
Publisher : Unknown
Page : 237 pages
File Size : 43,5 Mb
Release : 1999
Category : Electronic
ISBN : OCLC:246056296

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A Molecular and Cellular View of Protein Kinase CK2 by O. G Issinger,Khalil Ahmed,E Chambaz Pdf

Author : Lorenzo A. Pinna
Publisher : John Wiley & Sons
Page : 492 pages
File Size : 45,6 Mb
Release : 2013-01-14
Category : Science
ISBN : 9780470963036

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Protein Kinase CK2 by Lorenzo A. Pinna Pdf

Protein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its potential role in future therapeutics. Protein Kinase CK2 comprehensively brings together the varied work being done on this critical enzyme. Protein Kinase CK2 is logically divided into three sections. The first section reviews key molecular and structural aspects of the enzyme. The second section looks at functional aspects of CK2 and the diverse roles it plays in cellular development, function, and health. The final section focuses on CK2 and cancer, looking at the impacts of the kinase on neoplastic development and its rapidly developing role as a therapeutic agent. With contributions from the world’s leading experts in the field, Protein Kinase CK2 will serve as an invaluable guide to the expanding and vibrant body of research being performed on this enzyme. This will be an essential volume for anyone working in the fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics. Editor Lorenzo A. Pinna is Professor in the Department of Biomedical Sciences at the University of Padua, Padua, Italy. Also Published in the Wiley-IUBMB Series on Biochemistry and Molecular Biology: Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology Edited by Cesar G. Fraga ISBN: 978-0-470-28721-7

Author : Khalil Ahmed,J.E. Allende,Olaf-Georg Issinger,O. G. Issinger
Publisher : Springer Science & Business Media
Page : 200 pages
File Size : 49,8 Mb
Release : 2002-06-30
Category : Science
ISBN : 0792376668

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Protein Kinase CK2 — From Structure to Regulation by Khalil Ahmed,J.E. Allende,Olaf-Georg Issinger,O. G. Issinger Pdf

Signal Transduction through phosphorylation and dephosphorylation of proteins in the cell is now a well-recognized mechanism involved in countless physiological and pathological processes. Consequently, the enzymes, known as protein kinases, which catalyze the phosphorylation of proteins, are critical regulators of cellular events. One of these protein kinases is the protein kinase CK2 (also known as casein kinase 2) that has been implicated in multiple functions including control of cell growth and proliferation. CK2 is a protein serine/threonine kinase which is a highly conserved and ubiquitous protein kinase. It is localized in the cytoplasmic and nuclear compartments, which accords with its multiple functional activities in the cell. Pertinent to this is also the recognition that a large number of putative substrates for this kinase have been identified in various compartments of the cell. New evidence from several laboratories has further reinforced the involvement of CK2 in signal transduction related to many cellular functions, thus underscoring the significance of its functional role in normal and abnormal cell growth and proliferation. This volume provides an overview of the state of knowledge concerning this intriguing protein kinase. It brings together contributions from leading investigators engaged in research in this field. Key developments during the past three years pertain to the elaboration of the crystal structure and definition of novel functions of the kinase, such as its role as an inhibitor of apoptosis. Additionally, the shuttling of the kinase to various compartments in response to physiological and stress stimuli appears to be a key feature of the functional regulation of its activity in the cell.

Author : Lorenzo A. Pinna
Publisher : John Wiley & Sons
Page : 492 pages
File Size : 44,5 Mb
Release : 2012-10-16
Category : Science
ISBN : 9781118482346

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Protein Kinase CK2 by Lorenzo A. Pinna Pdf

Protein kinases play a critical role in cellular processes that impact overall organismal health and function. Of the kinases that collectively make up the Human Kinome, CK2 has garnered special attention because of its significant role in the generation of the human phosphoproteome. The role CK2 plays in the development of cancer and other disease has also made it of significant interest for its potential role in future therapeutics. Protein Kinase CK2 comprehensively brings together the varied work being done on this critical enzyme. Protein Kinase CK2 is logically divided into three sections. The first section reviews key molecular and structural aspects of the enzyme. The second section looks at functional aspects of CK2 and the diverse roles it plays in cellular development, function, and health. The final section focuses on CK2 and cancer, looking at the impacts of the kinase on neoplastic development and its rapidly developing role as a therapeutic agent. With contributions from the world’s leading experts in the field, Protein Kinase CK2 will serve as an invaluable guide to the expanding and vibrant body of research being performed on this enzyme. This will be an essential volume for anyone working in the fields of biochemistry, protein science, signal transduction, metabolic regulation, and cancer biology and therapeutics. Editor Lorenzo A. Pinna is Professor in the Department of Biomedical Sciences at the University of Padua, Padua, Italy. Also Published in the Wiley-IUBMB Series on Biochemistry and Molecular Biology: Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology Edited by Cesar G. Fraga ISBN: 978-0-470-28721-7

Author : Joachim Jose,Marc Le Borgne,Lorenzo A. Pinna,Mathias Montenarh
Publisher : MDPI
Page : 321 pages
File Size : 44,7 Mb
Release : 2017-05-22
Category : Electronic
ISBN : 9783038424123

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An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2 by Joachim Jose,Marc Le Borgne,Lorenzo A. Pinna,Mathias Montenarh Pdf

This book is a printed edition of the Special Issue "An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2" that was published in Pharmaceuticals

Author : Khalil Ahmed,Olaf-Georg Issinger,Ryszard Szyszka
Publisher : Springer
Page : 386 pages
File Size : 45,6 Mb
Release : 2015-03-03
Category : Medical
ISBN : 9783319145440

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Protein Kinase CK2 Cellular Function in Normal and Disease States by Khalil Ahmed,Olaf-Georg Issinger,Ryszard Szyszka Pdf

Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in all cancers examined. While CK2 levels are known to be high in proliferating normal cells, CK2 has also been found to be a potent suppressor of apoptosis and is a link to the cancer cell phenotype, which is characterized by deregulation of both cell proliferation and cell death. Indeed, it would appear that CK2 impacts many of the hallmarks of cancer and it has now gained considerable attention as a potential target for cancer therapy. Protein Kinase CK2 and Cellular Function in Normal and Disease States increases knowledge of the role of CK2 in the development of cellular dysfunction and emphasizes that this protein may serve as a target of drug development for improved cancer therapy. In addition, it is a handy tool that provides cancer researchers, graduate students, and all scientists involved in CK2 research with one main source for the latest advances in CK2 research. ​

Author : David Figurski
Publisher : IntechOpen
Page : 0 pages
File Size : 42,8 Mb
Release : 2013-02-05
Category : Medical
ISBN : 9535109944

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Genetic Manipulation of DNA and Protein by David Figurski Pdf

This diverse collection of research articles is united by the enormous power of modern molecular genetics. Every author accomplished two objectives: (1) making the field and the research described accessible to a large audience and (2) explaining fully the genetic tools and approaches that were used in the research. One fact stands out - the importance of a genetic approach to addressing a problem. I encourage you to read several chapters. You will feel the excitement of the scientists, and you will learn about an area of research with which you may not be familiar. Perhaps most importantly, you will understand the genetic approaches; and you will appreciate their importance to the research.

Author : Friedrich Marks
Publisher : John Wiley & Sons
Page : 404 pages
File Size : 52,7 Mb
Release : 2008-09-26
Category : Science
ISBN : 9783527615025

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Protein Phosphorylation by Friedrich Marks Pdf

Protein phosphorylation is a key mechanism in cellular signaling. This volume presents a state-of-the-art survey of one of the most rapidly developing fields of biochemical research. Written by leading experts, it presents the latest results for some of the most important cellular pathways. Color plates illustrate structural or functional relationships, numerous references provide links to the original literature.

Author : Kivie Moldave
Publisher : Elsevier
Page : 315 pages
File Size : 53,6 Mb
Release : 2003-10-01
Category : Science
ISBN : 0080522688

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Progress in Nucleic Acid Research and Molecular Biology by Kivie Moldave Pdf

Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume. * Provides a forum for discussion of new discoveries, approaches and ideas in molecular biology * Includes contributions from the leaders in the field * Has abundant references

Author : Lalit M. Pandey,Raghvendra Gupta,Rajkumar P. Thummer,Rajiv Kumar Kar
Publisher : Springer Nature
Page : 431 pages
File Size : 50,5 Mb
Release : 2023-08-28
Category : Technology & Engineering
ISBN : 9789819940561

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Healthcare Research and Related Technologies by Lalit M. Pandey,Raghvendra Gupta,Rajkumar P. Thummer,Rajiv Kumar Kar Pdf

This book presents select proceedings of the North East Research Conclave (NERC 2022). The book mainly covers research related to healthcare and related technologies. It includes broad bioengineering applications divided into four parts, namely, biomaterials and tissue engineering, biomedical science and engineering, drug delivery and therapeutics and cell and molecular biology. The book encompasses the latest research and advancements in the field of healthcare and related technologies. This book also describes a few studies based on computer simulations in bioengineering. In addition, the fundamental and basic aspects are also discussed for the better understanding of readers. The book can be a valuable reference for beginners, researchers and professionals interested in the field of healthcare and related technologies.

Author : R. Alvarez-Gonzalez
Publisher : Springer Science & Business Media
Page : 156 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781441987402

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ADP-Ribosylation Reactions by R. Alvarez-Gonzalez Pdf

This special issue of Molecular and Cellular Biochemistry contains twenty-two selected research papers and reviews from a total of one hundred and ten presentations given at the 12th International Symposium on ADP-ribosylation Reactions: From Bacterial Pathogenesis to Cancer, held in Cancun, Mexico, May 10-14, 1997. The Symposium was hosted by the Sociedad Mexicana de Bioquimica and was sponsored by the University of North Texas Health Science Center, Fort Worth, TX, USA. This volume provides a state-of-the-art source of information for basic scientists and clinicians who are interested in the molecular, biochemical, and cellular aspects of protein-(ADP-ribose) transfer reactions in human health and disease.

Author : Dipak K. Das
Publisher : Springer Science & Business Media
Page : 177 pages
File Size : 55,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461550976

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Stress Adaptation, Prophylaxis and Treatment by Dipak K. Das Pdf

Stress reaction is likely to play a crucial role in a variety of degenerative diseases including cancer and cardiovascular diseases. The process of stress adaptation may appear to be simple, but in reality this is a very complex process and we are only beginning to understand the mechanism of adaptation. In January, 1998, scientists from around the world assembled to discuss the potential applicability of the concept of stress adaptation in the clinical arena. This volume contains original research papers presented on this subject during the conference Stress Adaptation, Prophylaxis and Treatment held in Calcutta, India, and serves as an up-to-date source of information for scientists, as well as clinicians interested in applying the concept of stress adaptation to the cure of diseases.

Author : Shoichi Imai,Makoto Endo,Iwao Ohtsuki
Publisher : Springer Science & Business Media
Page : 201 pages
File Size : 52,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461555438

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Muscle Physiology and Biochemistry by Shoichi Imai,Makoto Endo,Iwao Ohtsuki Pdf

The papers in this volume were contributed by close friends, co-workers and pupils of Professor Setsuro Ebashi. They are dedicated to him to commemorate his great and pioneering contribution to the advancement of muscle physiology and biochemistry, which, in time, exerted a great influence on the whole field of life science. We believe that this issue reveals the present state of research on muscle and/or calcium that was opened up by Professor Ebashi.

Author : Heinz Rupp,Bernhard Maisch
Publisher : Springer Science & Business Media
Page : 227 pages
File Size : 48,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461543510

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Control of Gene Expression by Catecholamines and the Renin-Angiotensin System by Heinz Rupp,Bernhard Maisch Pdf

The special issue of Molecular and Cellular Biochemistry focuses on `Control of Gene Expression by Catecholamines and the Renin-Angiotensin System' in health and disease. In recent years, great progress has been made in the understanding of catecholamine and angiotensin II modulated gene expression. There is also increasing evidence that catecholamine and angiotensin II induced cellular injury not solely arises from classical pathways but also from a perturbed gene expression. Taking into account that catecholamines and angiotensin II are vital for a balanced gene expression of many cells, the intriguing possibility arises that various disease are initiated or aggravated by such an imbalance. Catecholamine and angiotensin II influences can be in excess arising from, for example, hypercaloric food intake or psychosocial stress. During early progression of heart failure, sympathetic activity and angiotensin II influences also become increased. Due to beta-adrenergic receptor downregulation, depressed catecholamine influences are expected in the final stage of heart failure. An imbalanced influence of catecholamines and angiotensin II on gene expression leads to disordered molecular structures of the cell and an impaired cell function. This focused issue is organized into chapters concentrating on catecholamines, angiotensin II, and the interaction between catecholamines and angiotensin II. Basic biochemical processes are covered in detail and the potential of these pathways for explaining chronic diseases associated with excess catecholamine and angiotensin II influences should become apparent. It is hoped that this focussed issue triggers novel research into the development of drugs that are targeted at diseases characterized by an imbalanced gene expression involving catecholamines and angiotensin II.