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A New Look at the Mechanisms and Theory of Aging by Lev Salnikov Pdf
This work presents a novel theory of aging. Building on the traditional approach to the function of the genome in multicellular organisms, the author offers an alternative means to the understanding of the fundamental processes governing the function of the cells in the context of the organism as a whole. A distinction is drawn between the causes of aging and the processes that are associated with aging. Drawing on the published experimental data, the author presents his description of the mechanisms of aging. This text is aimed not only at the biologists working on the problem of aging, but also at a broader audience that may be interested in the problems of the biology of aging.
National Research Council,Commission on Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Future Directions for Cognitive Research on Aging
Author : National Research Council,Commission on Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Future Directions for Cognitive Research on Aging Publisher : National Academies Press Page : 285 pages File Size : 40,6 Mb Release : 2000-04-18 Category : Social Science ISBN : 9780309172196
The Aging Mind by National Research Council,Commission on Behavioral and Social Sciences and Education,Board on Behavioral, Cognitive, and Sensory Sciences,Committee on Future Directions for Cognitive Research on Aging Pdf
Possible new breakthroughs in understanding the aging mind that can be used to benefit older people are now emerging from research. This volume identifies the key scientific advances and the opportunities they bring. For example, science has learned that among older adults who do not suffer from Alzheimer's disease or other dementias, cognitive decline may depend less on loss of brain cells than on changes in the health of neurons and neural networks. Research on the processes that maintain neural health shows promise of revealing new ways to promote cognitive functioning in older people. Research is also showing how cognitive functioning depends on the conjunction of biology and culture. The ways older people adapt to changes in their nervous systems, and perhaps the changes themselves, are shaped by past life experiences, present living situations, changing motives, cultural expectations, and emerging technology, as well as by their physical health status and sensory-motor capabilities. Improved understanding of how physical and contextual factors interact can help explain why some cognitive functions are impaired in aging while others are spared and why cognitive capability is impaired in some older adults and spared in others. On the basis of these exciting findings, the report makes specific recommends that the U.S. government support three major new initiatives as the next steps for research.
Lifespan by David A. Sinclair,Matthew D. LaPlante Pdf
A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.” —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.
General system theory of aging. Special role of the immune system by V. Dontsov Pdf
The monograph examines the general methodological problems of the aging, main mechanisms, as well as consideration of the fundamental possibilities and directions of influence on this process. A special place is occupied by the use of system analysis, consideration of integrative systems, and the special role of the immune system, namely, that part of it, which is not responsible for immune phenomena proper, but regulates the interaction of proliferation of various cell populations in the body.
An Introduction to Biological Aging Theory by Theodore Goldsmith Pdf
Why do we age? The answer to this question is critical to our ability to prevent and treat highly age-related diseases such as cancer and heart disease that now cause the deaths of most people in the developed world. This short book provides an overview of biological aging theories including history, current status, major scientific controversies, and implications for the future of medicine. Major topics include: human mortality as a function of age, aging mechanisms and processes, the programmed vs. non-programmed aging controversy, empirical evidence on aging, and the feasibility of anti-aging and regenerative medicine. Evolution theory is essential to aging theories. Theorists have been struggling for 150 years to explain how aging, deterioration, and consequent death fit with Darwin’s survival of the fittest concept. This book explains how continuing genetics discoveries have produced changes in the way we think about evolution that in turn lead to new thinking about the nature of aging.
Contemporary Perspectives on Ageism by Liat Ayalon,Clemens Tesch-Römer Pdf
This open access book provides a comprehensive perspective on the concept of ageism, its origins, the manifestation and consequences of ageism, as well as ways to respond to and research ageism. The book represents a collaborative effort of researchers from over 20 countries and a variety of disciplines, including, psychology, sociology, gerontology, geriatrics, pharmacology, law, geography, design, engineering, policy and media studies. The contributors have collaborated to produce a truly stimulating and educating book on ageism which brings a clear overview of the state of the art in the field. The book serves as a catalyst to generate research, policy and public interest in the field of ageism and to reconstruct the image of old age and will be of interest to researchers and students in gerontology and geriatrics.
Human Aging by Calogero Caruso,Giuseppina Candore Pdf
Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging Offers the ability to access cross-sectional knowledge more easily Written by expert researchers in biogerontology who are actively involved in various fields within aging research
Aging and Decision Making by Thomas M. Hess,JoNell Strough,Corinna Löckenhoff Pdf
Decisions large and small play a fundamental role in shaping life course trajectories of health and well-being: decisions draw upon an individual's capacity for self-regulation and self-control, their ability to keep long-term goals in mind, and their willingness to place appropriate value on their future well-being. Aging and Decision Making addresses the specific cognitive and affective processes that account for age-related changes in decision making, targeting interventions to compensate for vulnerabilities and leverage strengths in the aging individual. This book focuses on four dominant approaches that characterize the current state of decision-making science and aging - neuroscience, behavioral mechanisms, competence models, and applied perspectives. Underscoring that choice is a ubiquitous component of everyday functioning, Aging and Decision Making examines the implications of how we invest our limited social, temporal, psychological, financial, and physical resources, and lays essential groundwork for the design of decision supportive interventions for adaptive aging that take into account individual capacities and context variables. Divided into four dominant approaches that characterize the current state of decision-making science and aging neuroscience Explores the impact of aging on the linkages between cortical structures/functions and the behavioral indices of decision-making Examines the themes associated with behavioral approaches that attempt integrations of methods, models, and theories of general decision-making with those derived from the study of aging Details the changes in underlying competencies in later life and the two prevailing themes that have emerged—one, the general individual differences perspective, and two, a more clinical focus
Malcolm L. Johnson,Vern L. Bengtson,Peter G. Coleman,Thomas B. L. Kirkwood
Author : Malcolm L. Johnson,Vern L. Bengtson,Peter G. Coleman,Thomas B. L. Kirkwood Publisher : Unknown Page : 784 pages File Size : 50,8 Mb Release : 2005-12 Category : Medical ISBN : STANFORD:36105120979930
Dynamic systems theory and embodiment in psychotherapy research. A new look at process and outcome by Sergio Salvatore,Wolfgang Tschacher,Omar Carlo Gioacchino Gelo,Sabine C Koch Pdf
In an attempt to cease from reducing the world and its (emergent) phenomena to linear modeling and analytic dissection, Dynamic Systems Theories (DST) and Embodiment theories and methods aim at accounting for the complex, dynamic, and non-linear phenomena that we constantly deal with in psychology. For instance, DST and Embodiment can enrich psychology’s understanding of the communicative process both in clinical and non-clinical settings. In psychotherapy, an important amount of research has shown that – next to other ingredients – the therapeutic relationship is the most important active factor contributing to psychotherapy outcome. These findings give communication a central role in the psychotherapy process. In the traditional view, the underlying model of understanding psychotherapy processes is that of a number of components summatively coming together enabling us to make a linear causal prediction. Yet, communication is inherently dynamic. A shift to viewing the communication process in psychotherapy as a field dynamic phenomenon helps us to take into account nonlinear phenomena, such as feedback processes within and between persons. We thus propose an embodied enactive dynamic systems view as a new theoretical and methodological perspective that can more realistically capture what happens among and between two persons in psychotherapy. This view reaches beyond the current narrow model of psychotherapy research. DST and Embodied Enactive Approaches can offer solutions to the loss of non-linear phenomena, the complex dynamics of reality, and the holistic level of analysis. DST and Embodied Enactive Approaches have developed not in a single discipline but in a joined movement based on various fields such as physics, biology, robotics, anthropology, philosophy, linguistics, neuroscience, and psychology, and have only recently entered clinical theorizing. The two new paradigms have already triggered a rethinking of the therapeutic exchange by recognizing the embodied nature of psychological and communicative phenomena. Their integration opens up a promising scenario in the field of psychotherapy research, developing new, profoundly transdisciplinary, theoretical concepts, methodologies, and standards of knowledge. The notion of field dynamics enables us to account for the role of the communicational context in the regulation of intra-psychological processes, while at the same time avoiding the pitfalls of an ontologization of the hierarchy of systemic organization. Moreover, the new approach implements methodological strategies that can transcend the conventional opposition between idiographic and nomothetic sciences.
National Research Council (U.S.). Committee on Chemical Toxicity and Aging,Robert N. Butler,Emil A. Pfitzer
Author : National Research Council (U.S.). Committee on Chemical Toxicity and Aging,Robert N. Butler,Emil A. Pfitzer Publisher : National Academies Page : 238 pages File Size : 42,5 Mb Release : 1987 Category : Family & Relationships ISBN : NAP:13240
Aging in Today's Environment by National Research Council (U.S.). Committee on Chemical Toxicity and Aging,Robert N. Butler,Emil A. Pfitzer Pdf
This report examines the relationships between aging and exposure to environmental agents (including natural and man-made agents, as well as life-style factors). Several relationships must be considered--the impact of intermittent or lifelong exposure to environmental agents on the rate of aging, the impact of lifelong exposure on health status when one reaches more advanced age, and the special response of the aged compared with that of the young when exposed to environmental agents.
Cognitive Neuroscience of Aging by Roberto Cabeza,Lars Nyberg,Denise C. Park Pdf
A rapidly growing body of research has consituted a new discipline that may be called cognitive neuroscience of aging. This book offers an introduction to the topic, useful to both professionals & students in cognitive neuroscience, cognitive psychology, neuroscience, neuropsychology & neurology.
Over a half-century of research has documented the fact that people of different ages perform at different levels on a variety of tests of cognitive functioning, and yet there are still no comprehensive theories to account for these phenomena. A Theory of Cognitive Aging is intended to begin intellectual discussion in this area by identifying major issues of controversy, and proposing a particular theoretical interpretation based on the notion that the rate of processing information slows down with increased age. Although still quite preliminary, the theoretical perspective is demonstrated to provide a plausible account for age-related differences in functioning on measures of memory, spatial ability and reasoning. The book has four aims: - To advocate a more explicitly theoretical approach to research in the area of cognitive aging. - To outline three important dimensions along which it is argued that any theory of cognitive aging phenomena must take a position. - To evaluate empirical evidence relevant to specific positions along those dimensions. - To summarize the major concepts of the current theory, and to describe its application to selected findings in the research literature.
As our society ages, the topic of cognitive aging is becoming increasingly important. This volume provides an accessible overview of how the cognitive system changes as a function of normal aging. Building on the successful first edition, this volume provide an even more comprehensive coverage of the major issues affecting memory, attention, language, speech and other aspects of cognitive functioning. The essential chapters from the first edition have been thoroughly revised and updated and new chapters have been introduced which draw in neuroscience studies and more applied topics. In addition, contributors were encouraged to ensure their chapters are accessible to students studying the topic for the first time. This therefore makes the volume appealing as a textbook on senior undergraduate and graduate courses.
Big Mechanisms in Systems Biology by Bor-Sen Chen,Cheng-Wei Li Pdf
Big Mechanisms in Systems Biology: Big Data Mining, Network Modeling, and Genome-Wide Data Identification explains big mechanisms of systems biology by system identification and big data mining methods using models of biological systems. Systems biology is currently undergoing revolutionary changes in response to the integration of powerful technologies. Faced with a large volume of available literature, complicated mechanisms, small prior knowledge, few classes on the topics, and causal and mechanistic language, this is an ideal resource. This book addresses system immunity, regulation, infection, aging, evolution, and carcinogenesis, which are complicated biological systems with inconsistent findings in existing resources. These inconsistencies may reflect the underlying biology time-varying systems and signal transduction events that are often context-dependent, which raises a significant problem for mechanistic modeling since it is not clear which genes/proteins to include in models or experimental measurements. The book is a valuable resource for bioinformaticians and members of several areas of the biomedical field who are interested in an in-depth understanding on how to process and apply great amounts of biological data to improve research. Written in a didactic manner in order to explain how to investigate Big Mechanisms by big data mining and system identification Provides more than 140 diagrams to illustrate Big Mechanism in systems biology Presents worked examples in each chapter