Big Mechanisms In Systems Biology

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Big Mechanisms in Systems Biology

Bor-Sen Chen,Cheng-Wei Li
Big Mechanisms in Systems Biology Book PDF

Author : Bor-Sen Chen,Cheng-Wei Li
Publisher : Academic Press
Page : 878 pages
File Size : 49,6 Mb
Release : 2016-10-25
Category : Medical
ISBN : 9780128097076

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Big Mechanisms in Systems Biology by Bor-Sen Chen,Cheng-Wei Li Pdf

Big Mechanisms in Systems Biology: Big Data Mining, Network Modeling, and Genome-Wide Data Identification explains big mechanisms of systems biology by system identification and big data mining methods using models of biological systems. Systems biology is currently undergoing revolutionary changes in response to the integration of powerful technologies. Faced with a large volume of available literature, complicated mechanisms, small prior knowledge, few classes on the topics, and causal and mechanistic language, this is an ideal resource. This book addresses system immunity, regulation, infection, aging, evolution, and carcinogenesis, which are complicated biological systems with inconsistent findings in existing resources. These inconsistencies may reflect the underlying biology time-varying systems and signal transduction events that are often context-dependent, which raises a significant problem for mechanistic modeling since it is not clear which genes/proteins to include in models or experimental measurements. The book is a valuable resource for bioinformaticians and members of several areas of the biomedical field who are interested in an in-depth understanding on how to process and apply great amounts of biological data to improve research. Written in a didactic manner in order to explain how to investigate Big Mechanisms by big data mining and system identification Provides more than 140 diagrams to illustrate Big Mechanism in systems biology Presents worked examples in each chapter

Molecular Mechanisms of Autonomy in Biological Systems

Tara Karimi
Molecular Mechanisms of Autonomy in Biological Systems Book PDF

Author : Tara Karimi
Publisher : Springer
Page : 134 pages
File Size : 45,7 Mb
Release : 2018-07-28
Category : Science
ISBN : 9783319918242

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Molecular Mechanisms of Autonomy in Biological Systems by Tara Karimi Pdf

This book presents a novel molecular description for understanding the regulatory mechanisms behind the autonomy and self-organization in biological systems. Chapters focus on defining and explaining the regulatory molecular mechanisms behind different aspects of autonomy and self-organization in the sense of autonomous coding, data processing, structure (mass) formation and energy production in a biological system. Subsequent chapters discuss the cross-talk among mechanisms of energy, and mass and information, transformation in biological systems. Other chapters focus on applications regarding therapeutic approaches in regenerative medicine. Molecular Mechanisms of Autonomy in Biological Systems is an indispensable resource for scientists and researchers in regenerative medicine, stem cell biology, molecular biology, tissue engineering, developmental biology, biochemistry, biophysics, bioinformatics, as well as big data sciences, complexity and soft computing.

Computational Biology in Drug Discovery and Repurposing

Rajani Sharma,A. V. Senthil Kumar,Kunal Kumar
Computational Biology in Drug Discovery and Repurposing Book PDF

Author : Rajani Sharma,A. V. Senthil Kumar,Kunal Kumar
Publisher : CRC Press
Page : 478 pages
File Size : 50,6 Mb
Release : 2024-08-16
Category : Medical
ISBN : 9781000988703

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Computational Biology in Drug Discovery and Repurposing by Rajani Sharma,A. V. Senthil Kumar,Kunal Kumar Pdf

This new book takes an in-depth look at the emerging and prospective field of computational biology and bioinformatics, which possesses the ability to analyze large accumulated biological data collected from sequence analysis of proteins and genes and cell population with an aim to make new predictions pertaining to drug discovery and new biology. The book explains the basic methodology associated with a bioinformatics and computational approach in drug designing. It then goes on to cover the implementation of computational programming, bioinformatics, pharmacophore modeling, biotechnological techniques, and pharmaceutical chemistry in designing drugs. The major advantage of intervention of computer language or programming is to cut down the number of steps and costs in the field of drug designing, reducing the repeating steps and saving time in screening the potent component for drug or vaccine designing. The book describes algorithms used for drug designing and the use of machine learning and AI in drug delivery and disease diagnosis, which are valuable in clinical decision-making. The implementation of robotics in different diseases like stroke, cancer, COVID-19, etc. is also addressed. Topics include machine learning, AI, databases in drug design, molecular docking, bioinformatics tools, target-based drug design, and immunoinformatics, chemoinformatics, and nanoinformatics in drug design. Drug repurposing in drug design in general as well as for specific diseases, including cancer, Alzheimer’s disease, tuberculosis, COVID-19, etc., is also addressed in depth.

An Introduction to Systems Biology

Uri Alon
An Introduction to Systems Biology Book PDF

Author : Uri Alon
Publisher : CRC Press
Page : 324 pages
File Size : 41,5 Mb
Release : 2006-07-07
Category : Mathematics
ISBN : 9781584886426

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An Introduction to Systems Biology by Uri Alon Pdf

Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.

Advances in Systems Biology

Igor I. Goryanin,Andrew B. Goryachev
Advances in Systems Biology Book PDF

Author : Igor I. Goryanin,Andrew B. Goryachev
Publisher : Springer Science & Business Media
Page : 679 pages
File Size : 53,9 Mb
Release : 2011-12-08
Category : Science
ISBN : 9781441972095

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Advances in Systems Biology by Igor I. Goryanin,Andrew B. Goryachev Pdf

The International Society for Systems Biology (ISSB) is a society aimed at advancing world-wide systems biology research by providing a forum for scientific discussions and various academic services. The ISSB helps coordinate researchers to form alliances for meeting the unique needs of multidisciplinary and international systems biology research. The annual International Conference on Systems Biology (ICSB) serves as the main meeting for the society and is one of the largest academic and commercial gatherings under the broad heading of ‘Systems Biology’.

Evolutionary Systems Biology

Orkun S. Soyer
Evolutionary Systems Biology Book PDF

Author : Orkun S. Soyer
Publisher : Springer Science & Business Media
Page : 459 pages
File Size : 47,8 Mb
Release : 2012-07-23
Category : Science
ISBN : 9781461435679

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Evolutionary Systems Biology by Orkun S. Soyer Pdf

The book aims to introduce the reader to the emerging field of Evolutionary Systems Biology, which approaches classical systems biology questions within an evolutionary framework. An evolutionary approach might allow understanding the significance of observed diversity, uncover “evolutionary design principles” and extend predictions made in model organisms to others. In addition, evolutionary systems biology can generate new insights into the adaptive landscape by combining molecular systems biology models and evolutionary simulations. This insight can enable the development of more detailed mechanistic evolutionary hypotheses.

Case Studies in Systems Biology

Pavel Kraikivski
Case Studies in Systems Biology Book PDF

Author : Pavel Kraikivski
Publisher : Springer Nature
Page : 310 pages
File Size : 46,5 Mb
Release : 2021-10-06
Category : Science
ISBN : 9783030677428

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Case Studies in Systems Biology by Pavel Kraikivski Pdf

This book provides case studies that can be used in Systems Biology related classes. Each case study has the same structure which answers the following questions: What is the biological problem and why is it interesting? What are the relevant details with regard to cell physiology and molecular mechanisms? How are the details put together into a mathematical model? How is the model analyzed and simulated? What are the results of the model? How do they compare to the known facts of the cell physiology? Does the model make predictions? What can be done to extend the model? The book presents a summary of results and references to more relevant sources. The volume contains the classic collection of topics and studies that are well established yet novel in the systems biology field.

Systems Biology

Dimitrios Vlachakis
Systems Biology Book PDF

Author : Dimitrios Vlachakis
Publisher : BoD – Books on Demand
Page : 108 pages
File Size : 46,7 Mb
Release : 2019-06-19
Category : Technology & Engineering
ISBN : 9781838808037

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Systems Biology by Dimitrios Vlachakis Pdf

Systems biology is the inevitable outcome of long years of knowledge acquisition and data accumulation. The aim of systems biology is to integrate in a seamless way all existing knowledge in interconnected disciplines, stretching from modern biomedical research to physics, chemistry, and mathematics. The main integration tool of such complex biomedical systems is via computational and mathematical modeling. In this direction, a series of state-of-the-art computer science techniques are used, namely, data mining and fusion, machine learning, and deep learning all under the prism of big data. All in all, systems biology is at the arrowhead of modern and state-of-the-art biomedical research by attempting to address key biological questions describing holistically complex biological systems.

Systems Biology

Lilia Alberghina,Hans V. Westerhoff
Systems Biology Book PDF

Author : Lilia Alberghina,Hans V. Westerhoff
Publisher : Springer Science & Business Media
Page : 432 pages
File Size : 54,9 Mb
Release : 2007-10-04
Category : Computers
ISBN : 3540742697

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Systems Biology by Lilia Alberghina,Hans V. Westerhoff Pdf

For life to be understood and disease to become manageable, the wealth of postgenomic data now needs to be made dynamic. This development requires systems biology, integrating computational models for cells and organisms in health and disease; quantitative experiments (high-throughput, genome-wide, living cell, in silico); and new concepts and principles concerning interactions. This book defines the new field of systems biology and discusses the most efficient experimental and computational strategies. The benefits for industry, such as the new network-based drug-target design validation, and testing, are also presented.

A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems

Vishwesh V. Kulkarni,Guy-Bart Stan,Karthik Raman
A Systems Theoretic Approach to Systems and Synthetic Biology II Analysis and Design of Cellular Systems Book PDF

Author : Vishwesh V. Kulkarni,Guy-Bart Stan,Karthik Raman
Publisher : Springer
Page : 298 pages
File Size : 46,7 Mb
Release : 2014-07-03
Category : Medical
ISBN : 9789401790475

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A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems by Vishwesh V. Kulkarni,Guy-Bart Stan,Karthik Raman Pdf

The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems. More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Volume II contains chapters contributed by leading researchers in the field of systems and synthetic biology that concern modeling physiological processes and bottom-up constructions of scalable biological systems. The modeling problems include characterisation and synthesis of memory, understanding how homoeostasis is maintained in the face of shocks and relatively gradual perturbations, understanding the functioning and robustness of biological clocks such as those at the core of circadian rhythms, and understanding how the cell cycles can be regulated, among others. Some of the bottom-up construction problems investigated in Volume II are as follows: How should biomacromolecules, platforms, and scalable architectures be chosen and synthesised in order to build programmable de novo biological systems? What are the types of constrained optimisation problems encountered in this process and how can these be solved efficiently? As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.

Systems Biology

Leszek Konieczny,Irena Roterman-Konieczna,Paweł Spólnik
Systems Biology Book PDF

Author : Leszek Konieczny,Irena Roterman-Konieczna,Paweł Spólnik
Publisher : Springer Nature
Page : 269 pages
File Size : 53,8 Mb
Release : 2023-06-08
Category : Science
ISBN : 9783031315572

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Systems Biology by Leszek Konieczny,Irena Roterman-Konieczna,Paweł Spólnik Pdf

This open-access textbook is an excellent introduction to systems biology, which has developed rapidly in recent years. It discusses the processes in living organisms in an integrated way, enabling the reader to understand the fundamental principles and cause-effect relationships in biology and biochemistry. The authors have chosen an original but at the same time clear way of presenting the topics, repeatedly drawing comparisons and models from the macroscopic world and making the reader aware of the unity of the laws of physics, chemistry and biology. The fully updated 2nd edition also contains information that has only become available as a result of the increase in knowledge in recent years. This includes information on tumorigenesis, where significant progress has been made due to the explosive development of genetic knowledge as well as bioengineering with a highly effective technique adopted from the solutions of the bacterial world, such as CRISPR/CAS. This richly illustrated book is essential for postgraduate students and scientists of the following disciplines: biology, biotechnology, medicine, bioinformatics, robotics and automation, biocybernetics, and biomedical engineering. It is also an exciting read for anyone interested in biology.

Understanding the Dynamics of Biological Systems

Werner Dubitzky,Jennifer Southgate,Hendrik Fuß
Understanding the Dynamics of Biological Systems Book PDF

Author : Werner Dubitzky,Jennifer Southgate,Hendrik Fuß
Publisher : Springer Science & Business Media
Page : 249 pages
File Size : 40,7 Mb
Release : 2011-01-07
Category : Science
ISBN : 9781441979643

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Understanding the Dynamics of Biological Systems by Werner Dubitzky,Jennifer Southgate,Hendrik Fuß Pdf

This book is intended as a communication platform to bridge the cultural, conceptual, and technological gap among the key systems biology disciplines of biology, mathematics, and information technology. To support this goal, contributors were asked to adopts an approach that appeals to audiences from different backgrounds.

Systems Biology

P. Bringmann,E. Butcher,G. Parry,B. Weiss
Systems Biology Book PDF

Author : P. Bringmann,E. Butcher,G. Parry,B. Weiss
Publisher : Springer Science & Business Media
Page : 184 pages
File Size : 43,5 Mb
Release : 2007-05-26
Category : Medical
ISBN : 9783540313397

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Systems Biology by P. Bringmann,E. Butcher,G. Parry,B. Weiss Pdf

This volume features contributions from participants of an ESRF Workshop on "Systems Biology" held in Berkeley, USA, in November 2005. Significant progress has been made in developing technologies that enable systems interrogations at a molecular level. Recent successes and challenges of applying systems level measurements to the different steps of drug discovery and development in the pharmaceutical industry are summarized.

Systems Biology

A.K. Konopka
Systems Biology Book PDF

Author : A.K. Konopka
Publisher : CRC Press
Page : 258 pages
File Size : 55,7 Mb
Release : 2006-11-20
Category : Science
ISBN : 9781420015126

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Systems Biology by A.K. Konopka Pdf

With extraordinary clarity,the Systems Biology: Principles, Methods, and Concepts focuses on the technical practical aspects of modeling complex or organic general systems. It also provides in-depth coverage of modeling biochemical, thermodynamic, engineering, and ecological systems. Among other methods and concepts based in logic, computer

Systems Cancer Biology

Bor-Sen Chen
Systems Cancer Biology Book PDF

Author : Bor-Sen Chen
Publisher : Cambridge Scholars Publishing
Page : 632 pages
File Size : 45,9 Mb
Release : 2021-07-13
Category : Medical
ISBN : 9781527572348

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Systems Cancer Biology by Bor-Sen Chen Pdf

Cancer is a complex and heterogeneous (systematic) disease that exhibits high levels of robustness against various therapeutic interventions. Due to the complex, heterogeneous, and evolving nature of cancer, it is essential for a system-oriented view to be adopted in order to understand the pathogenic mechanism of cancer which will eventually lead to the drug discovery and treatment of patients. This book not only provides new insights from system modeling and large scale experimental data, but also will allow the reader to perceive the systematic characteristics of cancer under some micro-environments. Based on the systems biology method and genome-wide high throughput data, the book presents the PPI network, gene regulatory network and epigenetic network as an integrated genetic and epigenetic cellular network of lung cancer, bladder cancer, thyroid cancer, colorectal cancer, and liver cancer to investigate their core signaling pathways of the carcinogenesis process to identify their corresponding significant carcinogenic biomarkers as drug targets for systems drug discovery and design. Consequently, the book presents the design of a multiple-molecule drug that can target these biomarkers for the therapeutic treatment of cancer with fewer side effects.