Acute Leukemias Ix

Author : Wolfgang Hiddemann,T. Haferlach,Thomas Büchner,J. Ritter,M. Unterhalt
Publisher : Springer Science & Business Media
Page : 606 pages
File Size : 48,9 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642593581

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Acute Leukemias IX by Wolfgang Hiddemann,T. Haferlach,Thomas Büchner,J. Ritter,M. Unterhalt Pdf

Acute Leukemias IX provides an extended and thorough overview of recent developments in cell biology and experimental therapy for acute leukemias. Following the tradition of the Acute Leukemias series since 1987, this book bridges the gap between basic research and clinical studies and emphasizes that both aspects are equally necessary to achieve improvements, not only in understanding the disease but also in providing better therapy. As a forum for world-wide activities in the field of acute leukemias the volume contains invaluable contributions that provide the reader with new, previously unpublished information.

Author : Rolf Neth,Elena Frolova,Robert C. Gallo,Melvyn F. Greaves,Boris V. Afanasiev,Elena Elstner
Publisher : Springer Science & Business Media
Page : 696 pages
File Size : 49,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642768293

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Modern Trends in Human Leukemia IX by Rolf Neth,Elena Frolova,Robert C. Gallo,Melvyn F. Greaves,Boris V. Afanasiev,Elena Elstner Pdf

This volume provides a comprehensive account of the most recent trends in human leukemia, as presented at the Ninth Wilsede Meeting. The internationally renowned contributors deal with all different aspects of these diseases: As well as discussing important clinical aspects of leukemia, new information on the biological basis of leukemia gained using the methods of molecular genetics, cell and molecular biology, virology, and immunology is covered. The book shows both the complexity of leukemia research, as well as the value of basic scientific research in furthering clinical medicine and therapy.

Author : S.H. Faderl,H.M. Kantarjian
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 43,5 Mb
Release : 2007-11-21
Category : Medical
ISBN : 9783540723042

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Hematologic Malignancies: Acute Leukemias by S.H. Faderl,H.M. Kantarjian Pdf

Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. This hugely important new book describes the current knowledge of acute leukemia biology and discusses new classification systems that have arisen as a result of emerging insights into pathogenesis. Estey, Faderl and Kantarjian, who all work at the respected Anderson Cancer Center in Houston, Texas, USA, examine in detail advances in the treatment of particular types of acute leukemia. Their book also covers the management of acute leukemia in general as well as the development of new therapies. This book will be extremely useful to clinicians.

Author : B. Löwenberg,A. Hagenbeek
Publisher : Springer Science & Business Media
Page : 398 pages
File Size : 52,7 Mb
Release : 2013-11-11
Category : Medical
ISBN : 9789400956704

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Minimal Residual Disease in Acute Leukemia by B. Löwenberg,A. Hagenbeek Pdf

The objective of the treatment of acute leukemia involves the eradication of all neoplastic cells, including the last one. Ideally, treatment should be controlled by monitoring cell kill. If the last cells could be discovered and their biological properties be determined, the qualitative and quantitative effects of treatment should be directly evaluable. This should ultimately permit a calculated tumor cell reduction thereby avoiding overtreatment and excessive toxicity and thus providing a basis for individualized antileukemic treatment. In recent years several new developments have contributed to the selective discovery of minimal numbers of leukemic cells which are hidden among the normal cells in the marrow cavities. These methods are the first steps to the realization of the therapeutic goals indicated above. They include the production and ap plication of monoclonal antibodies against differentiation antigens on the cell sur face, the use of pulse cytophotometry - and cell sorter techniques, the employment of cytogenetics, the development of culture techniques for selective growth of precursor cells and several others. These methodologies offer prospects for refined diagnosis and, as far as the elimination of leukemic cells is concerned, the further development of autologous bone marrow transplantation. Eliminating tumor cells from autologous grafts requires the detailed knowledge of the cellular inter relationships within the neoplasm so that the neoplastic cells responsible for tumor propagation are specifically removed. Recognition and characterization of the clonogenic cells of the neoplasm should then lead to determining their sensitivity to the therapeutic agents which are clinically applied.

Author : Anonim
Publisher : Unknown
Page : 928 pages
File Size : 50,8 Mb
Release : 1980
Category : Medicine
ISBN : OSU:32436001304078

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Cumulated Index Medicus by Anonim Pdf

Author : Stefan Faderl,Hagop Kantarjian
Publisher : John Wiley & Sons
Page : 456 pages
File Size : 51,5 Mb
Release : 2011-09-14
Category : Medical
ISBN : 9781444347814

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Leukemias by Stefan Faderl,Hagop Kantarjian Pdf

Edited by experts from one of the world’s largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials. Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agents Leukemias: Principles and Practice of Therapy Includes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory disease Incorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area

Author : Ching-Hon Pui
Publisher : Springer Science & Business Media
Page : 562 pages
File Size : 47,7 Mb
Release : 2002-11-14
Category : Medical
ISBN : 9781592593071

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Treatment of Acute Leukemias by Ching-Hon Pui Pdf

In Treatment of Acute Leukemias, international experts not only review the state-of-the-art in managing children and adults with acute leukemia, but also debate the pros and cons of current controversial and problematic issues. The book summarizes the best diagnostic and treatment practices for acute leukemias in children, adolescents, and adults. Among the therapies discussed are methotrexate, asparaginase, antipurines, epipodophyllotoxins, hematopoietic stem cell transplantation, hematopoietic growth factors, and immunotherapy.

Author : Anonim
Publisher : Unknown
Page : 1416 pages
File Size : 40,7 Mb
Release : 1974
Category : Epidemiology
ISBN : UIUC:30112113403197

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Current Bibliography of Epidemiology by Anonim Pdf

Monthly, with annual cumulations. Comprehensive, current index to periodical medical literature intended for use of practitioners, investigators, and other workers in community medicine who are concerned with the etiology, prevention, and control of disease. Citations are derived from MEDLARS tapes for Index medicus of corresponding date. Arrangement by 2 sections, i.e., Selected subject headings, and Diseases, organisms, vaccines. No author index.

Author : Inès B. Moreau
Publisher : Nova Publishers
Page : 302 pages
File Size : 46,5 Mb
Release : 2008
Category : Medical
ISBN : 1604560819

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Chronic Lymphocytic Leukemia by Inès B. Moreau Pdf

This book presents recent and important research on Chronic lymphocytic leukemia (or "chronic lymphoid leukemia"), known for short as CLL, which is a type of leukemia in which too many lymphocytes are produced. Although the malignant lymphocytes in CLL may look normal and mature, they are not and these cells may not cope effectively with infection. CLL is the most common form of leukemia in adults. Men are twice as likely to develop CLL as women. However, the key risk factor is age; over 75% of new cases are diagnosed in patients over age 50.

Author : Anonim
Publisher : Unknown
Page : 2452 pages
File Size : 42,9 Mb
Release : 2004
Category : Medicine
ISBN : MINN:31951P00992553J

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Index Medicus by Anonim Pdf

Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Author : Wolf-Dieter Ludwig,Eckhard Thiel
Publisher : Springer Science & Business Media
Page : 407 pages
File Size : 47,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642848957

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Recent Advances in Cell Biology of Acute Leukemia by Wolf-Dieter Ludwig,Eckhard Thiel Pdf

The development of new techniques such as immuno phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo somal breakpoints using molecular techniques can now pinpoint many genomic sites essential for normal develop ment and maturation of hematopoietic cells but functionally disrupted in leukemic cells. The main goal of the international workshop that we held in Berlin with a select group of scientists and clinicians involved in leukemia research was to describe the state of the art and new developments in the immunologic, cytogenetic, and molecular characterization of acute leukemias and to discuss the clinical importance of cell biological features. After introductory survey lectures dealing with the immunological and molecular-biological characteristics of normal vs. malignant lymphatic and myeloid progenitor cells, the workshop centered on con tributions characterizing the immunophenotype and both numerical and structural chromosomal abnormalities in acute leukemias.

Author : Wojciech Gorczyca
Publisher : CRC Press
Page : 922 pages
File Size : 46,9 Mb
Release : 2014-03-21
Category : Medical
ISBN : 9781482212211

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Atlas of Differential Diagnosis in Neoplastic Hematopathology, Third Edition by Wojciech Gorczyca Pdf

Management of tumor patients now relies on new individualized approaches to treatment, requiring extensive knowledge of the molecular makeup of tumors. Updated and expanded, the third edition of Atlas of Differential Diagnosis in Neoplastic Hematopathology examines not only the differential diagnosis but also the detailed morphologic, immunophenotypic, and especially genetic characteristics of the majority of hematolymphoid malignancies. Featuring a new structure and including new chapters, the third edition updates all content and presents considerable expansion on many topics, including: Metaphase cytogenetic and FISH Flow cytometry (overview and detailed analysis of specific tumors) Acute myeloid leukemia and new classification schemes MDS, AML, and B- and T-cell lymphoproliferations Abnormal patterns in the lymph node and bone marrow with detail differential diagnosis based on histologic features and cellular composition Detailed differential diagnosis based on the expression of broad list of antigenic markers (flow cytometry and immunohistochemistry) Extranodal lymphomas Diagnosis of MDS and myeloproliferative neoplasm and their differential diagnosis based on the morphologic, flow cytometric, and chromosomal features The book also provides expanded differential diagnosis of the most common as well as most difficult and rare entities, including morphologic, immunophenotypic, and karyotypic/molecular features. This edition includes updated algorithms for most common diagnoses as well as several new algorithms. The majority of figures have been revised and are in full color.

Author : Rafael M. Romero
Publisher : Nova Publishers
Page : 206 pages
File Size : 47,6 Mb
Release : 2004
Category : Leukemia
ISBN : 1594540934

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Focus on Leukemia Research by Rafael M. Romero Pdf

This new book brings together leading research from around the globe. Leukaemia is cancer that begins in blood cells. In people with leukaemia, the bone marrow produces abnormal white blood cells. The abnormal cells are leukaemia cells. At first, leukaemia cells function almost normally. In time, they may crowd out normal white blood cells, red blood cells, and platelets. The scope of the book includes the four common types of leukaemia: chronic lymphocytic leukaemia (chronic lymphoblastic leukaemia, CLL) - most often affecting people over age 55; chronic myeloid leukaemia (chronic myelogenous leukaemia, CML) - affects mainly adults; acute lymphocytic leukaemia (acute lymphoblastic leukaemia, ALL) - the most common type of leukaemia in young children; and acute myeloid leukaemia (acute myelogenous leukaemia, AML) - which occurs in both adults and children. New advances in diagnosis, pathogenesis and therapy are also presented.

Author : Thomas Büchner,W. Hiddemann,B. Wörmann,G. Schellong,J. Ritter
Publisher : Springer
Page : 848 pages
File Size : 53,5 Mb
Release : 1994-02-24
Category : Medical
ISBN : 3540569510

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Acute Leukemias IV by Thomas Büchner,W. Hiddemann,B. Wörmann,G. Schellong,J. Ritter Pdf

The rates of acute leukemia cure have gradually improved over the last decade. Clinical study results reflect the impact of chemotherapy intensity and duration, the role of prolonged maintenance, intensified consolidation or very early intensification. Further progress has also been achieved in bone marrow trans plantation, and recent prospective studies and meta-analyses have contributed comparisons of the high antileukemic efficacy of bone marrow transplantation to that of improved chemotherapy. This allows a more successful combining of the two forms of treatment. New prognostic factors have emerged from both cytogenetic and molecular genetic research. Thus, the Philadelphia chromosome translocation and the bcr/abl gene rearrangement have proven to be the dominating risk factor in acute lymphoblastic leukemia. Since the frequency increases with age, differences in prognosis between children and adults can be explained. Evaluation of molecular and immunologic leukemia cell markers has provided a better understanding of residual leukemia in clinical remission, as a prognostic factor and in monitoring the effectiveness of the antileukemic strategy. Recent work on leukemic cell biology has resulted in novel therapeutic approaches such as terminal differentiation by all-trans-retinoic acid, modulation of chemotherapy by hematopoietic growth factors such as GM-CSF and enhancement of immunologic control by cytokines such as interleukin 2. New antimicrobial drugs and the application of mostly empiric anti-infectious strategies have helped reducing the therapeutic risk. Thus, a number of recent achievements have provided us with new options in the management of patients with acute leukemias.

Author : Thomas Büchner,Wolfgang Hiddemann,Bernhard Wörmann,Günter Schellong,Jörg Ritter,Ursula Creutzig
Publisher : Springer Science & Business Media
Page : 1005 pages
File Size : 45,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642603778

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Acute Leukemias VI by Thomas Büchner,Wolfgang Hiddemann,Bernhard Wörmann,Günter Schellong,Jörg Ritter,Ursula Creutzig Pdf

For 10 years the book series Acute Leukemias has been providing updates on the rapid progress being made internationally concerning this group of diseases. The fifth volume mainly addressed experimental approaches, but the present issue presents both therapeutic and prognostic aspects of the most recent results from major multicenter clinical trials. Additional chapters report new trends in leukemia cell biology,the monitoring of minimal residual disease, and secondary leukemias, as well as new antileukemic drugs, antimicrobial strategies, and the use of cytokines. The combined efforts against acute leukemias described in this book explain the recent improvements in the outcome of patients suffering from acute leukemias.