Acute Leukemias Iv

Author : T. Büchner,W. Hiddemann,B. Wörmann,G. Schellong,J. Ritter
Publisher : Springer Science & Business Media
Page : 803 pages
File Size : 53,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642783500

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Acute Leukemias IV by T. Büchner,W. Hiddemann,B. Wörmann,G. Schellong,J. Ritter Pdf

The rates of acute leukemia cure have gradually improved over the last decade. Clinical study results reflect the impact of chemotherapy intensity and duration, the role of prolonged maintenance, intensified consolidation or very early intensification. Further progress has also been achieved in bone marrow trans plantation, and recent prospective studies and meta-analyses have contributed comparisons of the high antileukemic efficacy of bone marrow transplantation to that of improved chemotherapy. This allows a more successful combining of the two forms of treatment. New prognostic factors have emerged from both cytogenetic and molecular genetic research. Thus, the Philadelphia chromosome translocation and the bcr/abl gene rearrangement have proven to be the dominating risk factor in acute lymphoblastic leukemia. Since the frequency increases with age, differences in prognosis between children and adults can be explained. Evaluation of molecular and immunologic leukemia cell markers has provided a better understanding of residual leukemia in clinical remission, as a prognostic factor and in monitoring the effectiveness of the antileukemic strategy. Recent work on leukemic cell biology has resulted in novel therapeutic approaches such as terminal differentiation by all-trans-retinoic acid, modulation of chemotherapy by hematopoietic growth factors such as GM-CSF and enhancement of immunologic control by cytokines such as interleukin 2. New antimicrobial drugs and the application of mostly empiric anti-infectious strategies have helped reducing the therapeutic risk. Thus, a number of recent achievements have provided us with new options in the management of patients with acute leukemias.

Author : Hillard M. Lazarus,Mary J. Laughlin
Publisher : Springer Science & Business Media
Page : 881 pages
File Size : 40,6 Mb
Release : 2010-03-02
Category : Medical
ISBN : 9781597454780

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Allogeneic Stem Cell Transplantation by Hillard M. Lazarus,Mary J. Laughlin Pdf

Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Author : Ajay Vora
Publisher : Springer
Page : 342 pages
File Size : 49,8 Mb
Release : 2017-04-21
Category : Medical
ISBN : 9783319397085

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Childhood Acute Lymphoblastic Leukemia by Ajay Vora Pdf

This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Author : Wolfgang Hiddemann
Publisher : Springer
Page : 92 pages
File Size : 41,5 Mb
Release : 2016-11-14
Category : Medical
ISBN : 9783319267722

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Handbook of Acute Leukemia by Wolfgang Hiddemann Pdf

This book provides an overview of the key developments in both acute lymphocytic leukemia and acute myeloid leukemia with a comprehensive guide to the epidemiology, pathogenesis, etiology, clinical manifestations, classification, diagnosis, and staging as well as the most recent developments in the therapeutic landscape for acute leukemia. The Handbook of Acute Leukemia offers readers a key resource into the future outlook for patients with leukemia and is edited and authored by internationally renowned experts in the field. Leukemia is cancer of the white blood cells and acute leukemia means the condition progresses rapidly and aggressively, requiring immediate treatment. Acute leukemia is classified according to the type of white blood cells that are affected: either lymphocytes and myeloid cells.

Author : R. Neth,R. C. Gallo,T. Graf,K. Mannweiler,K. Winkler
Publisher : Springer Science & Business Media
Page : 574 pages
File Size : 47,8 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642679841

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Modern Trends in Human Leukemia IV by R. Neth,R. C. Gallo,T. Graf,K. Mannweiler,K. Winkler Pdf

Organized on behalf of the Deutsche Gesellschaft für Hämatologie und Onkologie. Wilsede, June 21-23, 1982

Author : Pier Paolo Piccaluga
Publisher : BoD – Books on Demand
Page : 324 pages
File Size : 53,8 Mb
Release : 2021-03-24
Category : Medical
ISBN : 9781838811686

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Acute Leukemias by Pier Paolo Piccaluga Pdf

Written by expert research teams, this book describes different aspects of both acute myeloid and acute lymphocytic leukemia, specifically their pathobiology, classification/diagnosis, and treatment. Chapters highlight current research as well as the gold standards for diagnosis and treatment of these diseases, examining recent advances in personalized approaches to acute leukemia.

Author : Ching-Hon Pui
Publisher : Springer Science & Business Media
Page : 562 pages
File Size : 51,9 Mb
Release : 2002-11-14
Category : Medical
ISBN : 9781592593071

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Treatment of Acute Leukemias by Ching-Hon Pui Pdf

In Treatment of Acute Leukemias, international experts not only review the state-of-the-art in managing children and adults with acute leukemia, but also debate the pros and cons of current controversial and problematic issues. The book summarizes the best diagnostic and treatment practices for acute leukemias in children, adolescents, and adults. Among the therapies discussed are methotrexate, asparaginase, antipurines, epipodophyllotoxins, hematopoietic stem cell transplantation, hematopoietic growth factors, and immunotherapy.

Author : Nicolaus Kröger,Mohamad Mohty,Carlo Dufour
Publisher : Unknown
Page : 688 pages
File Size : 55,9 Mb
Release : 2020-10-08
Category : Medical
ISBN : 1013273672

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The EBMT Handbook by Nicolaus Kröger,Mohamad Mohty,Carlo Dufour Pdf

This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Author : Justin Loke,Ankit J. Kansagra
Publisher : Karger Medical and Scientific Publishers
Page : 138 pages
File Size : 50,7 Mb
Release : 2022-02-22
Category : Medical
ISBN : 9783318069969

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Fast Facts: Leukemia by Justin Loke,Ankit J. Kansagra Pdf

Leukemia is a hematologic malignancy arising from hematopoietic stem cells (HSCs) in the bone marrow. Starting with a detailed description of hematopoiesis and what goes wrong in leukemia, this concise guide covers all aspects of the four most common subtypes of the disease. Although the incidence and prevalence of leukemia are rising worldwide, survival rates are also increasing. However, both the effects of the disease and the adverse effects of treatment remain complex challenges. Yet, as our understanding of the molecular landscape increases, therapeutic options are becoming more personalized. This revised and updated second edition of 'Fast Facts: Leukemia' addresses the causes and risk factors for each subtype of leukemia, the initial and confirmatory diagnostic tests, and the latest treatment options. Designed as a comprehensive primer for physician assistants, nurse practitioners, primary care providers, oncology nurses, hematology/ oncology trainees and pharmacists, this resource will help the non-specialist and those in training to identify leukemia early and provide a thorough understanding of the pathology and genetic basis of the disease, treatment options, and effective approaches to emergency and supportive care. Table of Contents: • Understanding blood and its components • What is leukemia? • Epidemiology, etiology and risk factors • Diagnosis • Staging and general management • Supportive care • Emergencies in leukemia

Author : Anonim
Publisher : Unknown
Page : 194 pages
File Size : 52,8 Mb
Release : 1999
Category : Cancer
ISBN : PURD:32754069237919

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Cancer Incidence and Survival Among Children and Adolescents by Anonim Pdf

Author : Barbara J. Bain,Estella Matutes
Publisher : Clinical Pub
Page : 0 pages
File Size : 45,9 Mb
Release : 2010
Category : Blood
ISBN : 1846920558

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Myeloid Malignancies by Barbara J. Bain,Estella Matutes Pdf

Aimed at meeting the needs for haematologists and clinical chemists for a reference, this atlas offers a visual presentation of myeloproliferative neoplasms and myeloid leukaemia. It surveys individual disease, covering the clinical presentation, haematological and pathological features, immunophenotyping and cytogenetic and genetic abnormalities.

Author : Eelco F.M. Wijdicks
Publisher : Oxford University Press
Page : 688 pages
File Size : 49,9 Mb
Release : 2014-04-28
Category : Medical
ISBN : 9780199331239

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The Comatose Patient by Eelco F.M. Wijdicks Pdf

The Comatose Patient, Second Edition, is a critical historical overview of the concepts of consciousness and unconsciousness, covering all aspects of coma within 100 detailed case vignettes. This comprehensive text includes principles of neurologic examination of comatose patients as well as instruction of the FOUR Score coma scale, and also discusses landmark legal cases and ethical problems. As the Chair of Division of Critical Care Neurology at Mayo Clinic, Dr. Wijdicks uses his extensive knowledge to discuss a new practical multistep approach to the diagnosis of the comatose patient. Additionally, this edition includes extensive coverage of the interpretation of neuroimaging and its role in daily practice and decision making, as well as management in the emergency room and ICU. Dr. Wijdicks details long-term supportive care and an appropriate approach to communication with family members about end-of-life decision making. In addition, video clips on neurologic examination and neurologic manifestations seen in comatose patients can be found here: http://oxfordmedicine.com/comatosepatient2e. All video recordings from the first edition have been reformatted and remastered for optimal use, and several more video clips of patients have also been included.

Author : S.H. Faderl,H.M. Kantarjian
Publisher : Springer Science & Business Media
Page : 294 pages
File Size : 43,9 Mb
Release : 2007-11-21
Category : Medical
ISBN : 9783540723042

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Hematologic Malignancies: Acute Leukemias by S.H. Faderl,H.M. Kantarjian Pdf

Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. This hugely important new book describes the current knowledge of acute leukemia biology and discusses new classification systems that have arisen as a result of emerging insights into pathogenesis. Estey, Faderl and Kantarjian, who all work at the respected Anderson Cancer Center in Houston, Texas, USA, examine in detail advances in the treatment of particular types of acute leukemia. Their book also covers the management of acute leukemia in general as well as the development of new therapies. This book will be extremely useful to clinicians.

Author : Margarita Guenova,Gueorgui Balatzenko
Publisher : BoD – Books on Demand
Page : 366 pages
File Size : 48,5 Mb
Release : 2015-11-11
Category : Medical
ISBN : 9789535122029

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Leukemias by Margarita Guenova,Gueorgui Balatzenko Pdf

Hematology has constantly been advancing in parallel with technological developments that have expanded our understanding of the phenotypic, genetic, and molecular complexity and extreme clinical and biological heterogeneity of leukemias. This in turn allowed for developing more effective and less toxic alternative therapeutic approaches directed against critical molecular pathways in leukemic cells. The continuous and rather extensive influx of new information regarding the key features and underlying mechanisms as well as treatment options of leukemias requires frequent updating of this topic. The primary objective of this book is to provide the specialists involved in the clinical management and experimental research of acute and chronic leukemias with comprehensive and concise information on some important theoretical and practical developments in the biology, clinical assessment, and treatment of patients with leukemias; on specific clinical scenarios such as pregnancy or age; as well as on some molecular and pathogenetic mechanisms and their respective translation into novel therapies.

Author : Anna Porwit,Marie Christine Béné
Publisher : Cambridge University Press
Page : 247 pages
File Size : 51,5 Mb
Release : 2018-01-25
Category : Medical
ISBN : 9781107503830

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Multiparameter Flow Cytometry in the Diagnosis of Hematologic Malignancies by Anna Porwit,Marie Christine Béné Pdf

This practical manual offers an active understanding of how to implement flow-cytometry when facing complex, haematological diseases.