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Author : Farhad Maleki,Renee Menezes,Sorin Draghici,Anthony Kusalik
Publisher : Frontiers Media SA
Page : 195 pages
File Size : 44,7 Mb
Release : 2022-08-01
Category : Science
ISBN : 9782889764235
Author : Carlos Fernandez-Lozano
Publisher : MDPI
Page : 314 pages
File Size : 50,7 Mb
Release : 2021-04-28
Category : Science
ISBN : 9783036509440
• Real-world problems can be high-dimensional, complex, and noisy • More data does not imply more information • Different approaches deal with the so-called curse of dimensionality to reduce irrelevant information • A process with multidimensional information is not necessarily easy to interpret nor process • In some real-world applications, the number of elements of a class is clearly lower than the other. The models tend to assume that the importance of the analysis belongs to the majority class and this is not usually the truth • The analysis of complex diseases such as cancer are focused on more-than-one dimensional omic data • The increasing amount of data thanks to the reduction of cost of the high-throughput experiments opens up a new era for integrative data-driven approaches • Entropy-based approaches are of interest to reduce the dimensionality of high-dimensional data
Author : Malik Yousef,Jens Allmer
Publisher : Unknown
Page : 333 pages
File Size : 54,8 Mb
Release : 2014
Category : RNA
ISBN : 1627037489
In miRNomics: MicroRNA Biology and Computational Analysis, expert researchers in the field present an overview of the current state of the art and aim to put the respective areas of research into a larger perspective. These include methods and techniques ranging from miRNA biogenesis, their biological function, computational analyses to their medical implications and applications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, miRNomics: MicroRNA Biology and Computational Analysis seeks to aid scientists in the further study into miRNA research and statistics.
Author : Sam Thiagalingam
Publisher : Cambridge University Press
Page : 597 pages
File Size : 49,9 Mb
Release : 2015-04-09
Category : Mathematics
ISBN : 9780521493390
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Review of the Department of Energy's Genomics: GTL Program
Publisher : National Academies Press
Page : 102 pages
File Size : 52,7 Mb
Release : 2006-04-19
Category : Science
ISBN : 9780309180719
The U.S. Department of Energy (DOE) promotes scientific and technological innovation to advance the national, economic, and energy security of the United States. Recognizing the potential of microorganisms to offer new energy alternatives and remediate environmental contamination, DOE initiated the Genomes to Life program, now called Genomics: GTL, in 2000. The program aims to develop a predictive understanding of microbial systems that can be used to engineer systems for bioenergy production and environmental remediation, and to understand carbon cycling and sequestration. This report provides an evaluation of the program and its infrastructure plan. Overall, the report finds that GTL's research has resulted in and promises to deliver many more scientific advancements that contribute to the achievement of DOE's goals. However, the DOE's current plan for building four independent facilities for protein production, molecular imaging, proteome analysis, and systems biology sequentially may not be the most cost-effective, efficient, and scientifically optimal way to provide this infrastructure. As an alternative, the report suggests constructing up to four institute-like facilities, each of which integrates the capabilities of all four of the originally planned facility types and focuses on one or two of DOE's mission goals. The alternative infrastructure plan could have an especially high ratio of scientific benefit to cost because the need for technology will be directly tied to the biology goals of the program.
Author : Bruce Alberts
Publisher : Unknown
Page : 0 pages
File Size : 53,7 Mb
Release : 2002
Category : Cytology
ISBN : 0815332181
Author : Hemant J. Purohit,Vipin Chandra Kalia,Ravi Prabhakar More
Publisher : Springer
Page : 300 pages
File Size : 51,7 Mb
Release : 2018-02-19
Category : Science
ISBN : 9789811074554
This book explains how the biological systems and their functions are driven by genetic information stored in the DNA, and their expression driven by different factors. The soft computing approach recognizes the different patterns in DNA sequence and try to assign the biological relevance with available information.The book also focuses on using the soft-computing approach to predict protein-protein interactions, gene expression and networks. The insights from these studies can be used in metagenomic data analysis and predicting artificial neural networks.
Author : Institute of Medicine,Board on Health Sciences Policy,Board on Health Care Services,Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Publisher : National Academies Press
Page : 354 pages
File Size : 50,9 Mb
Release : 2012-09-13
Category : Science
ISBN : 9780309224185
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Author : Mohammed J. Zaki,Jeffrey Xu Yu,B. Ravindran,Vikram Pudi
Publisher : Springer
Page : 520 pages
File Size : 50,9 Mb
Release : 2010-05-29
Category : Computers
ISBN : 9783642136726
This book constitutes the proceedings of the 14th Pacific-Asia Conference, PAKDD 2010, held in Hyderabad, India, in June 2010.
Author : Matthias Dehmer,Subhash C. Basak
Publisher : John Wiley & Sons
Page : 269 pages
File Size : 49,7 Mb
Release : 2012-06-26
Category : Mathematics
ISBN : 9781118346983
Explore the multidisciplinary nature of complex networks through machine learning techniques Statistical and Machine Learning Approaches for Network Analysis provides an accessible framework for structurally analyzing graphs by bringing together known and novel approaches on graph classes and graph measures for classification. By providing different approaches based on experimental data, the book uniquely sets itself apart from the current literature by exploring the application of machine learning techniques to various types of complex networks. Comprised of chapters written by internationally renowned researchers in the field of interdisciplinary network theory, the book presents current and classical methods to analyze networks statistically. Methods from machine learning, data mining, and information theory are strongly emphasized throughout. Real data sets are used to showcase the discussed methods and topics, which include: A survey of computational approaches to reconstruct and partition biological networks An introduction to complex networks—measures, statistical properties, and models Modeling for evolving biological networks The structure of an evolving random bipartite graph Density-based enumeration in structured data Hyponym extraction employing a weighted graph kernel Statistical and Machine Learning Approaches for Network Analysis is an excellent supplemental text for graduate-level, cross-disciplinary courses in applied discrete mathematics, bioinformatics, pattern recognition, and computer science. The book is also a valuable reference for researchers and practitioners in the fields of applied discrete mathematics, machine learning, data mining, and biostatistics.
Author : Vijai Singh
Publisher : Springer Nature
Page : 365 pages
File Size : 53,6 Mb
Release : 2024-06-17
Category : Electronic
ISBN : 9789819984015
Author : Sajal Chakraborti
Publisher : Elsevier
Page : 2974 pages
File Size : 46,7 Mb
Release : 2023-08-01
Category : Science
ISBN : 9780323956888
Phospholipases in Physiology and Pathology presents a comprehensive overview on the physiology and pathology of phospholipases. This seven-volume set considers the biochemical and molecular mechanisms of normal and abnormal cell function upon dysregulation of phospholipases in different diseases. Volumes cover signal transduction mechanisms, implications in cancer, infectious diseases, neural diseases, cardiovascular diseases and other diseases, implications in inflammation, apoptosis, gene expression and non-coding RNAs, the role of natural and synthetic compounds, and stem cell therapies, nanotechnology-based therapies, and more. Together, these volumes give researchers critical insight on the mechanistic and therapeutic aspects of phospholipases. Discusses the biochemical and molecular mechanisms of normal and abnormal cell function in different disease processes Covers a wide range of basic and translational research appropriate for scientists engaged in studying the regulation of phospholipases from interdisciplinary perspectives Features state-of-the-art chapter contributions from international leaders in the field
Author : Israel Tojal Da Silva,Joel Correa Da Rosa,Liang Zhao,Rodrigo Drummond,Jianjiong Gao
Publisher : Frontiers Media SA
Page : 149 pages
File Size : 45,8 Mb
Release : 2022-09-21
Category : Science
ISBN : 9782832500200
Author : A. Fazel Famili
Publisher : Springer Science & Business Media
Page : 534 pages
File Size : 46,8 Mb
Release : 2005-08-30
Category : Business & Economics
ISBN : 9783540287957
This book constitutes the refereed proceedings of the 6th International Conference on Intelligent Data Analysis, IDA 2005, held in Madrid, Spain in September 2005. The 46 revised papers presented together with two tutorials and two invited talks were carefully reviewed and selected from 184 submissions. All current aspects of this interdisciplinary field are addressed; the areas covered include statistics, machine learning, data mining, classification and pattern recognition, clustering, applications, modeling, and interactive dynamic data visualization.
Author : Lars A. Akslen,Randolph S. Watnick
Publisher : Springer Nature
Page : 596 pages
File Size : 55,7 Mb
Release : 2022-07-12
Category : Medical
ISBN : 9783030989507
This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Methodological advancements and practical applications, in terms of how biomarkers are studied and increasingly included in clinical trials and therapy protocols, are described and discussed. Biomarkers of the Tumor Microenvironment is an educational resource for students and members of the cancer research community as a whole, especially for those using morphology analysis techniques and models focusing on the cross-talk between different cell types in tumors. The textbook provides a comprehensive overview of the microenvironment in various contexts from the perspectives of experienced and accomplished cancer researchers and clinicians.
