Biomarkers Of The Tumor Microenvironment

Author : Lars A. Akslen,Randolph S. Watnick
Publisher : Springer
Page : 534 pages
File Size : 54,8 Mb
Release : 2017-08-02
Category : Medical
ISBN : 9783319391472

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Biomarkers of the Tumor Microenvironment by Lars A. Akslen,Randolph S. Watnick Pdf

This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.

Author : Lars A. Akslen,Randolph S. Watnick
Publisher : Springer Nature
Page : 596 pages
File Size : 44,8 Mb
Release : 2022-07-12
Category : Medical
ISBN : 9783030989507

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Biomarkers of the Tumor Microenvironment by Lars A. Akslen,Randolph S. Watnick Pdf

This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Methodological advancements and practical applications, in terms of how biomarkers are studied and increasingly included in clinical trials and therapy protocols, are described and discussed. Biomarkers of the Tumor Microenvironment is an educational resource for students and members of the cancer research community as a whole, especially for those using morphology analysis techniques and models focusing on the cross-talk between different cell types in tumors. The textbook provides a comprehensive overview of the microenvironment in various contexts from the perspectives of experienced and accomplished cancer researchers and clinicians.

Author : Zhenyu Jia,Kexin Xu,Farah Rahmatpanah
Publisher : Frontiers Media SA
Page : 316 pages
File Size : 47,7 Mb
Release : 2022-01-19
Category : Medical
ISBN : 9782889740987

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Therapeutic Opportunities and Innovative Biomarkers in Tumor Microenvironment by Zhenyu Jia,Kexin Xu,Farah Rahmatpanah Pdf

Author : Peter P. Lee,Francesco M. Marincola
Publisher : Springer Nature
Page : 326 pages
File Size : 45,5 Mb
Release : 2020-03-25
Category : Medical
ISBN : 9783030388621

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Tumor Microenvironment by Peter P. Lee,Francesco M. Marincola Pdf

This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.

Author : Jacinta Serpa
Publisher : Springer Nature
Page : 430 pages
File Size : 54,6 Mb
Release : 2020-03-04
Category : Medical
ISBN : 9783030340254

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Tumor Microenvironment by Jacinta Serpa Pdf

The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.

Author : Zhouxiao Li,Hongyong Cao,Wei Xu
Publisher : Frontiers Media SA
Page : 693 pages
File Size : 49,9 Mb
Release : 2024-01-15
Category : Science
ISBN : 9782832537336

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The role of the tumor microenvironment (TME) and relevant novel biomarkers in oncogenesis by Zhouxiao Li,Hongyong Cao,Wei Xu Pdf

Author : Debabrata Banerjee,Raj K. Tiwari
Publisher : Springer Nature
Page : 171 pages
File Size : 52,7 Mb
Release : 2021-12-09
Category : Medical
ISBN : 9783030832827

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Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions by Debabrata Banerjee,Raj K. Tiwari Pdf

Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor micronenvironment’s various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.

Author : Magdalena Thurin,Alessandra Cesano,Francesco M. Marincola
Publisher : Humana
Page : 0 pages
File Size : 45,8 Mb
Release : 2019-09-10
Category : Medical
ISBN : 1493997726

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Biomarkers for Immunotherapy of Cancer by Magdalena Thurin,Alessandra Cesano,Francesco M. Marincola Pdf

This book provides the immune oncology (IO) community with a deeper understanding of the scope of the biomarker methods to potentially improve the outcome from immunotherapy. The editors secured the input from experts in the field dedicated to translating scientific research from bench to bedside was submitted. The book provides not only details about the technical, standardization and interpretation aspects of the methods but also introduces the reader to the background information and scientific justification for selected biomarkers and assays. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Author : Na Luo,José Alexandre Ferreira,Hongming Miao
Publisher : Frontiers Media SA
Page : 231 pages
File Size : 46,8 Mb
Release : 2023-04-26
Category : Science
ISBN : 9782832521540

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Volume II: Tumor Microenvironment in Cancer Hallmarks and Therapeutics by Na Luo,José Alexandre Ferreira,Hongming Miao Pdf

Author : Susan Costantini Alfredo Budillon,Alfredo Budillon
Publisher : MDPI
Page : 294 pages
File Size : 46,7 Mb
Release : 2021-02-12
Category : Medical
ISBN : 9783039439775

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New Prognostic and Predictive Markers in Cancer Progression by Susan Costantini Alfredo Budillon,Alfredo Budillon Pdf

Biomarkers are of critical medical importance for oncologists, allowing them to predict and detect disease and to determine the best course of action for cancer patient care. Prognostic markers are used to evaluate a patient’s outcome and cancer recurrence probability after initial interventions such as surgery or drug treatments and, hence, to select follow-up and further treatment strategies. On the other hand, predictive markers are increasingly being used to evaluate the probability of benefit from clinical intervention(s), driving personalized medicine. Evolving technologies and the increasing availability of “multiomics” data are leading to the selection of numerous potential biomarkers, based on DNA, RNA, miRNA, protein, and metabolic alterations within cancer cells or tumor microenvironment, that may be combined with clinical and pathological data to greatly improve the prediction of both cancer progression and therapeutic treatment responses. However, in recent years, few biomarkers have progressed from discovery to become validated tools to be used in clinical practice. This Special Issue comprises eight review articles and five original studies on novel potential prognostic and predictive markers for different cancer types.

Author : Guohui Sun,Wei Zhang,Jianhua Wa,Chengwei He
Publisher : Frontiers Media SA
Page : 165 pages
File Size : 52,5 Mb
Release : 2024-03-18
Category : Science
ISBN : 9782832546291

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New Progress in Cancer Biomarkers and Therapy by Guohui Sun,Wei Zhang,Jianhua Wa,Chengwei He Pdf

As we know, cancer is an important disease threatening human health. According to the latest statistics in “Global Cancer Statistics 2020”, cancer is expected to overtake cardiovascular disease as the leading cause of premature death in most countries this century. That sounds pretty terrible, but it is believed that this situation should be better along with the advances in tumor biology. There is no doubt that biomarkers have very significant clinical implications, which can be used for early diagnosis, monitoring progress, and predicting the prognosis of cancer.

Author : Gagan Deep
Publisher : Unknown
Page : 258 pages
File Size : 51,9 Mb
Release : 2022
Category : Cancer
ISBN : 1071618962

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Cancer Biomarkers by Gagan Deep Pdf

This detailed volume explores numerous methods used in basic science laboratories to characterize cancer-related biomarkers, vital for better managing cancer burden, including cancer risk assessment, cancer diagnosis, determining cancer progression, and therapeutic response. From a radiography method to an examination of single-cell RNA-seq and computational analysis tools in cancer research, this book delves into many techniques that could provide valuable molecular information about the tumor and its microenvironment components. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cancer Biomarkers: Methods and Protocols offers researchers multiple helpful ways to study cancer-associated molecular biomarkers.

Author : Ming Jun Zheng,Marina Pinheiro,Mingming Deng
Publisher : Frontiers Media SA
Page : 342 pages
File Size : 50,9 Mb
Release : 2024-01-08
Category : Science
ISBN : 9782832542569

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Systematic identification of novel diagnostic and prognostic tumor biomarkers based on multi-omics data analysis of solid tumors by Ming Jun Zheng,Marina Pinheiro,Mingming Deng Pdf

Author : Jorge Morales-Montor,Karen Elizabeth Nava-Castro,Mariana Segovia
Publisher : Frontiers Media SA
Page : 398 pages
File Size : 49,6 Mb
Release : 2023-01-10
Category : Medical
ISBN : 9782832511152

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Exploring the breast tumor microenvironment: Association to metastasis, novel risk factors and novel treatments and immunotherapies by Jorge Morales-Montor,Karen Elizabeth Nava-Castro,Mariana Segovia Pdf

Author : Josie Ursini-Siegel
Publisher : Springer Nature
Page : 417 pages
File Size : 46,9 Mb
Release : 2023-01-01
Category : Medical
ISBN : 9781071629147

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The Tumor Microenvironment by Josie Ursini-Siegel Pdf

This second edition provides update and new chapters detailing core and emerging in vitro and in vivo protocols. Chapters guide readers through cellular and molecular biology approaches, in vivo genetic approaches, various “omics”-based strategies, therapeutic strategies, and advanced techniques in the fields of tissue engineering and nanotechnology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, The Tumor Microenvironment: Methods and Protocols, Second Edition is a valuable resource for both novice and expert scientists in this developing field.