Advances In Alzheimer S Research

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Advances in Alzheimer's Research

Debomoy K. Lahiri

Author : Debomoy K. Lahiri
Publisher : Bentham Science Publishers
Page : 463 pages
File Size : 48,6 Mb
Release : 2014-09-29
Category : Medical
ISBN : 9781608058525

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Advances in Alzheimer's Research by Debomoy K. Lahiri Pdf

Alzheimer’s disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is global – afflicting over 36 million people worldwide, with the number growing in an unabated and frightening manner. The goal of the series Advances in Alzheimer’s Research , with Volumes 1 and 2, is to provide an integrated approach to AD from basic and clinical research and to highlight the valuable information in order to unravel the origin, pathogenesis and prevention of AD. The aim of this book is to both capture and discuss improvements toward the diagnosis and potential treatment of AD by both established and novel strategies. This book series, including the Volume 2, provides an important mechanism to bring under the same roof a variety of scientific interests and expertise to specifically focus on AD and related dementias. The fullest attempt has been made to disseminate the most current knowledge on recent advances in potential therapy of AD.

Recent Advances in Alzheimer Research

Ahmad Salehi,Michael Rafii ,Cristy Phillips

Author : Ahmad Salehi,Michael Rafii ,Cristy Phillips
Publisher : Bentham Science Publishers
Page : 322 pages
File Size : 55,6 Mb
Release : 2015-11-11
Category : Medical
ISBN : 9781681081380

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Recent Advances in Alzheimer Research by Ahmad Salehi,Michael Rafii ,Cristy Phillips Pdf

Recent Advances in Alzheimer Disease Research is a book series focusing on contemporary research on Alzheimer’s disease epidemiology, pathophysiology, diagnosis and therapy. The series features reviews by experts in neuroscience and aims to provide current information in the field to both researchers and clinicians. Down syndrome is a chromosomal disorder affecting more than 5.8 million individuals worldwide. Down syndrome can be viewed as a complex multi-system disorder as it manifests into significant physical, psychological, and cognitive abnormalities in affected persons. With aging, most adults with Down syndrome develop the clinical and neuropathological hallmarks of Alzheimer's disease. Unfortunately, no extant treatments have proven beneficial for cognitive dysfunction for either Down syndrome or Alzheimer’s disease. An incomplete understanding of the common pathogenic mechanisms that link these two disorders has limited researchers’ progress to this end. Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a novel attempt to fill this void, by summarizing the work of world-renowned scientists in the field of Alzheimer’s disease and Down syndrome, and thus providing an unprecedented opportunity to attract attention to Down syndrome as a tool for understanding the common molecular mechanisms that underlie Alzheimer’s disease and to develop new therapies for similar neurodegenerative disorders of the brain. The book covers the fundamental pathophysiology and molecular mechanisms behind the incidence of Alzheimer’s disease in Down syndrome affected individuals as well other key topics such as diagnosis and management, in vivo brain imaging studies, and progressive neurodegeneration of the monoaminergic system. The book concludes with a review of recent clinical trials of drugs designed to mitigate cognitive dysfunction in aging adults with Down syndrome and establishes a scientific warrant for the increased testing of candidate pharmacotherapies. Common Pathogenic Mechanisms between Down syndrome and Alzheimer's Disease: Steps toward Therapy is a useful reference clinicians involved in treating Down syndrome patients as well as for neuroscience researchers seeking to understand the influence of a specific case of aneuploidy on Alzheimer’s disease incidence and its progression at the molecular level.

Advances in Alzheimer's Research

Debomoy K. Lahiri

Author : Debomoy K. Lahiri
Publisher : Bentham Science Publishers
Page : 342 pages
File Size : 53,5 Mb
Release : 2013-11-05
Category : Medical
ISBN : 9781608054954

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Advances in Alzheimer's Research by Debomoy K. Lahiri Pdf

Alzheimer’s disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is globally afflicting an estimated 36 million people and this number is growing in an unabated and frightening manner. Advances in Alzheimer Research, provides researchers with an integrated approach to AD academic literature ranging from basic to advanced clinical research. The series highlights the latest information in order to unravel the origin, pathogenesis and prevention of AD. The purpose of this book series is, therefore, to capture and discuss both, improvements towards the diagnosis and potential treatment of AD by established and novel strategies. This first volume of the series provides an important mechanism to bring individuals having a variety of scientific interests and expertise under one roof to specifically focus on AD and related dementias. This volume presents articles on beta amyloid protein targets as well as research on secretase enzyme systems among other topics that deal with AD therapy.

Alzheimer's Disease: Pathological and Clinical Findings

Blas Gil-Extremera

Author : Blas Gil-Extremera
Publisher : Bentham Science Publishers
Page : 191 pages
File Size : 55,7 Mb
Release : 2019-04-03
Category : Medical
ISBN : 9789811405129

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Alzheimer's Disease: Pathological and Clinical Findings by Blas Gil-Extremera Pdf

Alzheimer's disease is the most frequent cause of dementia that slowly and progressively causes cognitive impairment and profoundly alters the daily activities of the patients. Approximately, ten percent of all persons over the age of seventy experience significant memory loss, and in more than half of the cases, the cause is Alzheimer's disease. This reference book is an update on the most relevant pathological and clinical findings of this neurological disorder. Chapters cover the basic hypothesis of Alzheimer’s disease, pathological features of the disease in the brain, Alzheimer’s disease diagnosis and therapy. Information provided in the book is focused on research in developed countries. The book offers students of medicine and nursing as well as medical practitioners and specialists (internists, neurologists, gerontologists, and psychiatrists), the necessary information to understand the pathological and clinical aspects of the disease in depth, with the goal of improving medical outcomes in the care of their patients.

Advances in Research and Treatment for Alzheimer's Disease

Samuel Barrack

Author : Samuel Barrack
Publisher : iMedPub
Page : 117 pages
File Size : 47,5 Mb
Release : 2012-01-30
Category : Medical
ISBN : 9781475095425

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Advances in Research and Treatment for Alzheimer's Disease by Samuel Barrack Pdf

Alzheimer's disease (AD), is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death. The cause and progression of Alzheimer's disease are not well understood. Research indicates that the disease is associated with plaques and tangles in the brain. Current treatments only help with the symptoms of the disease. There are no available treatments that stop or reverse the progression of the disease. As of 2012, more than 1000 clinical trials have been or are being conducted to find ways to treat the disease, but it is unknown if any of the tested treatments will work. Because AD cannot be cured and is degenerative, the sufferer relies on others for assistance. The role of the main caregiver is often taken by the spouse or a close relative. Alzheimer's disease is known for placing a great burden on caregivers; the pressures can be wide-ranging, involving social, psychological, physical, and economic elements of the caregiver's life. In developed countries, AD is one of the most costly diseases to society. Research is the only hope to present and future patients and families suffering from this devastating disorder. This book compiles some of the most interesting articles on Alzheimer's disease published by PLoS journals lately: from epidemiology and prevention to management and treatment.

Current State of Alzheimer's Disease Research and Therapeutics

Elias K. Michaelis,Mary Lou Michaelis

Author : Elias K. Michaelis,Mary Lou Michaelis
Publisher : Academic Press
Page : 400 pages
File Size : 52,7 Mb
Release : 2012-08-02
Category : Medical
ISBN : 9780123948168

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Current State of Alzheimer's Disease Research and Therapeutics by Elias K. Michaelis,Mary Lou Michaelis Pdf

"Providing a cross-section of current research, treatments and potential clinical developments, this volume of Advances in Pharmacology is an essential resource for biologists, pharmacologists and those engaged with Alzheimer's research."--P. [4] of cover.

Advances in Alzheimer Research

Debomoy K. Lahiri,Atta-ur-Rahman,M. Iqbal Choudhary,Allen B. Reitz

Author : Debomoy K. Lahiri,Atta-ur-Rahman,M. Iqbal Choudhary,Allen B. Reitz
Publisher : Unknown
Page : 128 pages
File Size : 44,8 Mb
Release : 2013-11-05
Category : Medical
ISBN : 1608057143

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Advances in Alzheimer Research by Debomoy K. Lahiri,Atta-ur-Rahman,M. Iqbal Choudhary,Allen B. Reitz Pdf

"Alzheimer's disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is globally afflicting an estimated 36 million people and this number is growing in an unabated and frightening manner. Advances in Alz"

Alzheimer’s Disease Research

Christian Behl

Author : Christian Behl
Publisher : Springer Nature
Page : 661 pages
File Size : 40,9 Mb
Release : 2023-08-14
Category : Medical
ISBN : 9783031315701

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Alzheimer’s Disease Research by Christian Behl Pdf

This book highlights the key phases and central findings of Alzheimer’s Disease research since the introduction of the label ‘Alzheimer’s Disease’ in 1910. The author, Christian Behl, puts dementia research in the context of the respective zeitgeist and summarizes the paths that have led to the currently available Alzheimer’s drugs. As the reader is taken through the major developments in Alzheimer's Disease research, particularly over the past thirty years, Behl poses critical questions: Why are the exact causes of Alzheimer's Disease still in the dark, despite all the immense, worldwide research efforts in academia as well as in the pharmaceutical industry? Why has the majority of an entire research field kept focusing on a single hypothesis that establishes the deposition of the amyloid beta peptide in the brain as the key trigger of Alzheimer's pathology, even though this concept has still not been convincingly proven in the clinics? Are there other hypotheses that might explain the pathogenesis of this complex brain disease, and if so, why were these perspectives not adequately followed? In this book, Behl tries to answer these questions. Starting with the historical background, the author illustrates the long and arduous research journey, its numerous setbacks, and the many alternative explanations for the disease, which have started gaining increasing attention and acceptance in the Alzheimer’s research community only more recently. With his deep dive into the history and progression of this research, including the most recent developments, Behl explains why he believes that it is high time to promote a paradigm shift in Alzheimer’s Disease research. The book is written for all researchers in the fields of neurobiology and neurodegeneration, as well as other biomedical fields, who would like to gain a broad and beyond the surface insight into (the key developments of) one of the most promoted research fields of our time. With its extensive literature references and over 100 illustrations, the book is also attractive for students and interested lay persons. Elaborating on all the different aspects and research approaches of this research field, the author aims to convince the reader that the underlying causes of Alzheimer’s Disease may be much more complex than previously thought and that this must be considered for future research directions. While he hopes that the Alzheimer’s research community is finally ready to shed its ‘amyloid-straitjacket’ that has hampered progress for too long, he is also convinced that a much-needed paradigm shift can guide future Alzheimer’s Disease research and provide a new and broader perspective on this age-dependent brain disease.

Alzheimer's Disease Drug Development

Jeffrey Cummings,Jefferson Kinney,Howard Fillit

Author : Jeffrey Cummings,Jefferson Kinney,Howard Fillit
Publisher : Cambridge University Press
Page : 575 pages
File Size : 43,7 Mb
Release : 2022-03-31
Category : Business & Economics
ISBN : 9781108838665

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Alzheimer's Disease Drug Development by Jeffrey Cummings,Jefferson Kinney,Howard Fillit Pdf

Provides a definitive overview of the complex ecosystem facilitating Alzheimer's Disease drug research and development. Demonstrates a drug's journey from in the lab, clinical trial testing, regulatory review, and marketing by pharmaceutical companies. Details the use of artificial intelligence, clinical trial management, and financing models.

Research Progress in Alzheimer's Disease and Dementia

Miao-Kun Sun

Author : Miao-Kun Sun
Publisher : Nova Publishers
Page : 452 pages
File Size : 47,7 Mb
Release : 2007
Category : Alzheimer's disease
ISBN : 1600219608

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Research Progress in Alzheimer's Disease and Dementia by Miao-Kun Sun Pdf

Alzheimer's disease (AD), the most common form of neurodegenerative disorder in the elderly, is characterised pathologically by extracellular amyloid plaques and intracellular neurofibrillary tangles, pathophysiologically by synaptic dysfunction, and clinically by a progressive decline in cognition. Currently, AD has no cure and its prevalence is predicted to triple by 2050 with the rapid increase in the ageing population, unless more effective treatments are developed. Since the publication of the second book volume, the rapid progress in the research fields of AD and dementia continues through the intensive efforts of research scientists worldwide. This third book volume contains 15 chapters, bringing together a presentation of research frontiers in current AD/dementia research. The topics include molecular genetics of AD, gene expression abnormalities in AD progression, presenilins, taupathy in AD, single -induced(neuron gene expression abnormalities in AD, intracellular A neurodegeneration, roles of lipoprotein receptors in AD onset and progression, cholesterol and tau hyperphosphorylation, AD diagnostics and therapeutic strategies, in vivo visualisation of amyloid-like structures, cathepsin B, antiamyloidogenesis and neuroprotection, environmental enrichment, Fragile X mental retardation gene and dementia, category learning in Parkinson's disease, cerebrovascular disease and dementia, and dementia and hypertension. These chapters cover current advances in our understanding of the pathogenic mechanisms underlying AD and dementia, in the diagnosis of early AD and dementia, and in the development of therapeutic agents that target memory-relevant AD pathogenesis. The book will be highly valuable to students and scientists worldwide who are interested in the scientific research progress in AD and dementia.

Alzheimer's Disease

Khalid Iqbal,Sangram S. Sisodia,Bengt Winblad

Author : Khalid Iqbal,Sangram S. Sisodia,Bengt Winblad
Publisher : John Wiley & Sons
Page : 888 pages
File Size : 42,8 Mb
Release : 2003-01-24
Category : Medical
ISBN : 9780470851746

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Alzheimer's Disease by Khalid Iqbal,Sangram S. Sisodia,Bengt Winblad Pdf

Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.

Alzheimer's Disease

George Perry,Jesús Avila,Xiongwei Zhu,Mark A. Smith,Aaron Sorensen

Author : George Perry,Jesús Avila,Xiongwei Zhu,Mark A. Smith,Aaron Sorensen
Publisher : IOS Press
Page : 486 pages
File Size : 43,6 Mb
Release : 2013
Category : Medical
ISBN : 9781614991533

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Alzheimer's Disease by George Perry,Jesús Avila,Xiongwei Zhu,Mark A. Smith,Aaron Sorensen Pdf

This volume is a companion to the highly successful book published in association with the Journal of Alzheimer's Disease (JAD) on the centennial of Alzheimer's discovery: "Alzheimer's Disease: A Century of Scientific and Clinical Research". Instead of looking back, this collection, "Alzheimer's Disease: Advances for a New Century", will look forward. Using scientometric analysis the most promising developments since the Alzheimer Centennial in 2006 have been substantiated. While prior trends and advances in genetics, amyloid-β, tau, neuropathology, and oxidative stress continue as active areas, emergent areas impacting the transition from normal cognition to Alzheimer's disease such as diagnostic imaging, biomarkers, metabolism, and lifestyle (areas conceived only a few years ago) now dominate the debate.Invited contributors have summarized their landmark publications identified by our analysis and have put them into perspective, explaining the impetus behind the work, the contribution of the results to the field, and who played a role in the work.

Advances in Dementia Research and Treatment: 2013 Edition

Anonim

Author : Anonim
Publisher : ScholarlyEditions
Page : 169 pages
File Size : 50,9 Mb
Release : 2013-06-21
Category : Medical
ISBN : 9781481670173

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Advances in Dementia Research and Treatment: 2013 Edition by Anonim Pdf

Advances in Dementia Research and Treatment: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Advances in Dementia Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Dementia Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Advances in Dementia Research

Kurt A. Jellinger,Reinhold Schmidt,Manfred Windisch

Author : Kurt A. Jellinger,Reinhold Schmidt,Manfred Windisch
Publisher : Springer Science & Business Media
Page : 489 pages
File Size : 53,7 Mb
Release : 2013-03-07
Category : Medical
ISBN : 9783709167816

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Advances in Dementia Research by Kurt A. Jellinger,Reinhold Schmidt,Manfred Windisch Pdf

Dementia is a major health problem that becomes increasingly common with advancing age. Despite recent progress in neurobiology and molecular genetics, the aetiology and pathogenesis of most dementia disorders are still poorly understood, and early exact diagnosis as a prerequisite of effective treatment needs to be improved. The present volume includes the contributions of renowned experts in the field of neurodegeneration presented at the International Symposium "Ageing and Dementia 1999”, September 24–26, 1999 at Graz. It focusses on genetics, epidemiology, new neuroimaging techniques, and the role of vascular, immunological and other mechanisms including oxidative stress and estrogens in the development of neurodegeneration and dementia. Recent developments in diagnosis and therapy of Alzheimer disease and related disorders are reviewed and future therapeutic approaches are discussed. Thus, this volume provides a timely overview of most recent developments in dementia research and treatment strategies of dementia disorders.

A New Era in Alzheimer's Research

Sandeep Kumar Singh,Ricardo Maccioni

Author : Sandeep Kumar Singh,Ricardo Maccioni
Publisher : Elsevier
Page : 0 pages
File Size : 52,9 Mb
Release : 2024-11-11
Category : Medical
ISBN : 9780443155390

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A New Era in Alzheimer's Research by Sandeep Kumar Singh,Ricardo Maccioni Pdf

A new era in Alzheimer research: Pathogenesis, prevention, diagnosis and treatment is focused on research and perspectives in Alzheimer's Disease offering an update on the challenging aspects of neurodegenerative disorders. Each chapter contains unique and valuable scientific information on the latest progress of research in neurodevelopmental disease. Even after years of research, alzheimer’s disease is still far from being cured; the book addresses the most current issues within the many dimensions relevant to pathogenesis, diagnosis and prevention in under one cover making it useful for researchers, students, and clinicians as well as those in pharmaceuticals. Contains basic knowledge about Alzheimer’s and its cause and related pathology for a better understating of AD. Provides the multidisciplinary research in this area in one source Uniquely describes details of pathological, diagnostics and preventive information for the potential development of novel anti-AD drugs Includes hot topics such as cerebrovascular pathology and lifestyle medicine for the prevention of AD

Advances In Alzheimer S Research

Advances in Alzheimer's Research by Debomoy K. Lahiri Pdf

Recent Advances in Alzheimer Research by Ahmad Salehi,Michael Rafii ,Cristy Phillips Pdf

Advances in Alzheimer's Research by Debomoy K. Lahiri Pdf

Alzheimer's Disease: Pathological and Clinical Findings by Blas Gil-Extremera Pdf

Advances in Research and Treatment for Alzheimer's Disease by Samuel Barrack Pdf

Current State of Alzheimer's Disease Research and Therapeutics by Elias K. Michaelis,Mary Lou Michaelis Pdf

Advances in Alzheimer Research by Debomoy K. Lahiri,Atta-ur-Rahman,M. Iqbal Choudhary,Allen B. Reitz Pdf

Alzheimer’s Disease Research by Christian Behl Pdf

Alzheimer's Disease Drug Development by Jeffrey Cummings,Jefferson Kinney,Howard Fillit Pdf

Research Progress in Alzheimer's Disease and Dementia by Miao-Kun Sun Pdf

Alzheimer's Disease by Khalid Iqbal,Sangram S. Sisodia,Bengt Winblad Pdf

Alzheimer's Disease by George Perry,Jesús Avila,Xiongwei Zhu,Mark A. Smith,Aaron Sorensen Pdf

Advances in Dementia Research and Treatment: 2013 Edition by Anonim Pdf

Advances in Dementia Research by Kurt A. Jellinger,Reinhold Schmidt,Manfred Windisch Pdf

A New Era in Alzheimer's Research by Sandeep Kumar Singh,Ricardo Maccioni Pdf

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