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Author : Carlos A. Vaccaro,Mev Dominguez-Valentin,Walter Hernán Pavicic
Publisher : Frontiers Media SA
Page : 108 pages
File Size : 52,9 Mb
Release : 2023-01-27
Category : Medical
ISBN : 9782832512128
Author : Jorge Melendez-Zajgla,Farhadul Islam
Publisher : Frontiers Media SA
Page : 135 pages
File Size : 42,7 Mb
Release : 2023-10-19
Category : Medical
ISBN : 9782832536117
Author : John D. Potter,Noralane M. Lindor
Publisher : Springer
Page : 309 pages
File Size : 43,7 Mb
Release : 2008-12-08
Category : Medical
ISBN : 0387095675
Genetic susceptibility refers to how variations in a person’s genes increase or decrease his or her susceptibility to environmental factors, such as chemicals, radiation and lifestyle (diet and smoking). This volume will explore the latest findings in the area of genetic susceptibility to gastrointestinal cancers, focusing on molecular epidemiology, DNA repair, and gene-environment interactions to identify factors that affect the incidence of GI cancers. Topics will include germline susceptibility, including Mendelian patterns of inheritance and gene-environment interactions that lead to cancer etiology.
Author : B.A. Ponder,M.J. Waring
Publisher : Springer Science & Business Media
Page : 222 pages
File Size : 40,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9789401106771
It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.
Author : Laura Valle,Stephen B. Gruber,Gabriel Capellá
Publisher : Springer
Page : 505 pages
File Size : 55,5 Mb
Release : 2018-05-04
Category : Medical
ISBN : 9783319742595
This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.
Author : G. Klöppel,E. Solcia,D.S. Longnecker,C. Capella,LESLIE Sobin
Publisher : Springer Science & Business Media
Page : 61 pages
File Size : 45,7 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9783642610240
In Collaboration with Pathologists in 7 Countries
Author : Miguel A. Rodriguez-Bigas,Raul Cutait,Patrick M. Lynch,Ian Tomlinson,Hans F.A. Vasen
Publisher : Springer Science & Business Media
Page : 630 pages
File Size : 46,8 Mb
Release : 2010-09-10
Category : Medical
ISBN : 144196603X
Colorectal cancer is the third most commonly diagnosed cancer in the US and the third most recently linked to cancer deaths. The national annual incidence rate of colorectal cancer is approximately 148,000+, striking slightly more females than males. The lifetime risk of colorectal cancer is 5-6%, however patients with a familial risk (with two or more first or second degree relatives) make up 20% of the patients. Persons who carry genetic mutations linked to hereditary colorectal cancer are the most likely to develop the disease.
Author : Joji Utsunomiya,Henry T. Lynch
Publisher : Springer Science & Business Media
Page : 564 pages
File Size : 51,6 Mb
Release : 2013-11-27
Category : Medical
ISBN : 9784431683377
Since the success in chemical induction of cancer in rabbit's ear skin by K. Yamagiwa in 1915, oncologists of the world have come to believe that they can only solve their problems by means of animal experimen tation. The importance of environmental factors became moreevident in 1935 when T. Yoshida and T. Sasaki introduced azodye hepatocarcino genesis in rats. In the domain of the gastrointestinal tract, T. Sugimura has more recently accumulated enough evidence to indicate that locally active chemical mutagens are carcinogenic. In contrast, principal approaches to colorectal tumors have been quite different: emphasis has been placed on gene identification. Long before cancer of the large bowel was recognized, importance of the roles of adenomatosis coli and its familial occurrence attracted the attention of epidemiologists and geneticists. Morphological characteri zation and analysis of hereditary trends of human material have already bad a long history, and recently detailed analysis of genetic material has become feasible in the wake of rapid development in our knowledge of the oncoviruses, oncogenes, suppressor genes, chromosomal and DNA mapping, molecular mutation and so on. lt is true that in colorectal pathology, and in no other field, these areas of research have been explored more extensively and decisively. The identification of previ ously ill-defined lesions such as precancers and benign neoplasms have been improved because sequential changes can be observed in multiple samples spread over a wide area and followed up in due course.
Author : Graeme P. Young,Paul Rozen,Bernard Levin
Publisher : W.B. Saunders Company
Page : 410 pages
File Size : 42,9 Mb
Release : 1996
Category : Medical
ISBN : UOM:39015057704242
This is an overview of the issues involved in prevention and early detection of colorectal cancer providing up-to-date, practical advice for clinicians. Possible management strategies for those at risk are provided, taking into account the biological principles of colorectal cancer development, epidemiological data and emerging genetic information, as well as social and environmental factors.
Author : Naveen Kumar Vishvakarma,Ganji Purnachandra Nagaraju,Dhananjay Shukla
Publisher : Springer Nature
Page : 453 pages
File Size : 49,5 Mb
Release : 2021-06-04
Category : Medical
ISBN : 9783030646684
Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the second of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutics, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.
Author : Henry T. Lynch,Takeshi Hirayama
Publisher : CRC Press
Page : 376 pages
File Size : 52,8 Mb
Release : 1989-06-30
Category : Medical
ISBN : 0849367565
This multi-authored book provides a unique accounting of the cancer problem from the standpoint of those primary genetic factors which may be interacting with myriad environmental exposures in cancer etiology. It provides a comprehensive coverage of cancer of all anatomical sites in conjunction with a genetic/environmental thrust. It includes a survey chapter dealing with the role of primary genetic factors in cancer of differing anatomic sites and a similar comprehensive survey chapter tracing the history of epidemiology, with focus upon multiple anatomic sites, including classical epidemiologic cancer models such as cigarette smoking, asbestos, vinyl chloride, and uranium exposure. Chapters are devoted to tumor biomarkers and their applicability to cancer of multiple anatomic sites. Clinical correlation will involve surveillance/management programsand focus on high-risk groups-such as those involving primary genetic or environmental factors and/or their interaction. The development of registries involving families with differing hereditary cancer syndromes are considered. Also, many chapters are devoted to environmental protective measures, as well as the need for more responsibility for coverage of patients at inordinately high risk for cancer by third party carriers. Other chapters address segregation and linkage analysis, oncogenes, cytogenetics, and other biomarkers. This book will be of interest to general clinicians, oncologists, surgeons, geneticists, and carcinogenesis investigators.
Author : Paul A. Schulte,Frederica P. Perera
Publisher : Academic Press
Page : 588 pages
File Size : 44,7 Mb
Release : 2012-12-02
Category : Science
ISBN : 9780323138574
This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.
Author : Albert Altchek,Liane Deligdisch,Nathan Kase
Publisher : Elsevier
Page : 568 pages
File Size : 45,8 Mb
Release : 2003-09-04
Category : Medical
ISBN : 9780080494517
This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. KEY FEATURES * Includes updated information on early diagnosis of ovarian cancer * Reviews new diagnostic techniques for ovarian disorders * Discusses latest information on reproductive technology * Presents translational treatment linking laboratory research with clinical medicine
Author : Kenneth W. Kinzler
Publisher : McGraw Hill Professional
Page : 358 pages
File Size : 44,7 Mb
Release : 2002
Category : Cancer
ISBN : 0071370501
-- Current coverage of diagnosis and treatment on a wide spectrum of active cancer research.
Author : Jindong Chen
Publisher : BoD – Books on Demand
Page : 130 pages
File Size : 46,7 Mb
Release : 2018-05-16
Category : Medical
ISBN : 9781789231007
With international experts sharing their experience and knowledge on these different aspects in the management of colorectal cancer, this book has this opportunity to offer all physicians treating colorectal cancer, as well as researchers, updated information concerning the biology, diagnosis, screening, and treatment of colorectal carcinoma. This book provides a detailed evaluation of diagnostic modalities, in-depth analysis of screening for colorectal cancer, recent advances in treatment, and principles and trends in the management of colorectal cancer. This updated knowledge will be an interesting and informative read for any clinician involved in the management of patients with colorectal cancer. In addition, readers such as related physicians, researchers, and colorectal cancer patients are potential beneficiaries of this book.