Advances In Molecular Toxicology

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Advances in Molecular Toxicology

Anonim
Advances in Molecular Toxicology Book PDF

Author : Anonim
Publisher : Newnes
Page : 254 pages
File Size : 40,9 Mb
Release : 2013-08-12
Category : Medical
ISBN : 9780444626554

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Advances in Molecular Toxicology by Anonim Pdf

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed. Cutting-edge reviews by leading workers in the discipline In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Molecular Toxicology

P. David Josephy,Bengt Mannervik
Molecular Toxicology Book PDF

Author : P. David Josephy,Bengt Mannervik
Publisher : Unknown
Page : 620 pages
File Size : 46,5 Mb
Release : 2006
Category : Molecular toxicology
ISBN : 0195176200

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Molecular Toxicology by P. David Josephy,Bengt Mannervik Pdf

The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

Advances in Molecular Toxicology

Anonim
Advances in Molecular Toxicology Book PDF

Author : Anonim
Publisher : Elsevier Science
Page : 200 pages
File Size : 41,8 Mb
Release : 2006-12-23
Category : Medical
ISBN : 0444528423

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Advances in Molecular Toxicology by Anonim Pdf

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. * Cutting edge reviews by leading workers in the discipline. * In depth dissection of molecular aspects of interest to a broad range of scientists, physisicans and any student in the allied disciplines. * Leading edge applications of technological innovations in the chemistry, biochemistry and molecular medicine.

Advances in Molecular Toxicology

Anonim
Advances in Molecular Toxicology Book PDF

Author : Anonim
Publisher : Academic Press
Page : 290 pages
File Size : 44,9 Mb
Release : 2017-09-15
Category : Medical
ISBN : 9780128125236

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Advances in Molecular Toxicology by Anonim Pdf

Advances in Molecular Toxicology, Volume 11, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field. Provides cutting-edge reviews by leading workers in the discipline Includes in-depth dissection of the molecular aspects that are of interest to a broad range of scientists, physicians and any student in the allied disciplines Presents leading-edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Advances in Molecular Toxicology

Anonim
Advances in Molecular Toxicology Book PDF

Author : Anonim
Publisher : Elsevier Science
Page : 200 pages
File Size : 43,6 Mb
Release : 2006-12-23
Category : Medical
ISBN : 0444528423

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Advances in Molecular Toxicology by Anonim Pdf

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. * Cutting edge reviews by leading workers in the discipline. * In depth dissection of molecular aspects of interest to a broad range of scientists, physisicans and any student in the allied disciplines. * Leading edge applications of technological innovations in the chemistry, biochemistry and molecular medicine.

Cellular and Molecular Toxicology

J.P. Vanden Heuvel,W.F. Greenlee,G.H. Perdew,William B. Mattes
Cellular and Molecular Toxicology Book PDF

Author : J.P. Vanden Heuvel,W.F. Greenlee,G.H. Perdew,William B. Mattes
Publisher : Gulf Professional Publishing
Page : 674 pages
File Size : 46,6 Mb
Release : 2002-02-14
Category : Business & Economics
ISBN : 0444508686

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Cellular and Molecular Toxicology by J.P. Vanden Heuvel,W.F. Greenlee,G.H. Perdew,William B. Mattes Pdf

Volume 14 in the series Comprehensive Toxicology extends and complements the previously published 13-volume set. This volume will be available separately. Toxicology is the study of the nature and actions of chemicals on biological systems. In more primitive times, it really was the study of poisons. However, in the early 1500s, it was apparent to Paracelsus that "the dose differentiates a poison and a remedy". Clearly, the two most important tenets of toxicology were established during that time. The level of exposure (dose) and the duration of exposure (time) will determine the degree and nature of a toxicological response. Since that time the discipline of toxicology has made major advances in identifying and characterizing toxicants. The growth of toxicology as a scientific discipline has been driven to a large extent by the use of extremely powerful molecular and cell biology techniques. The overall aim of this volume is to demonstrate how these advances are being used to elucidate causal pathways (or linkages) for potential adverse health consequences of human exposure to environmental chemicals or radiation. A unique feature of this volume is its illustration of how carefully-designed studies of the molecular mechanisms of chemical action provide not only understanding of the potential toxicity of the chemical under investigation, but also new insights into the functioning of the biological system used as an experimental model. Each chapter contains a listing of major peer-reviewed articles and reviews and useful web-sites. In addition, each chapter contains a broad introductory section that outlines the subsequent sections. These Introductory and Overview sections are designed to be stand alone chapters, and may be packaged as a textbook in graduate level courses.

Advances in Molecular Toxicology

Anonim
Advances in Molecular Toxicology Book PDF

Author : Anonim
Publisher : Academic Press
Page : 0 pages
File Size : 46,9 Mb
Release : 2015-10-11
Category : Medical
ISBN : 0128022299

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Advances in Molecular Toxicology by Anonim Pdf

Advances in Molecular Toxicology features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment and produced by the human body manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field.

Molecular and Biochemical Toxicology

Robert C. Smart,Ernest Hodgson
Molecular and Biochemical Toxicology Book PDF

Author : Robert C. Smart,Ernest Hodgson
Publisher : John Wiley & Sons
Page : 1060 pages
File Size : 50,9 Mb
Release : 2018-01-04
Category : Science
ISBN : 9781119042419

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Molecular and Biochemical Toxicology by Robert C. Smart,Ernest Hodgson Pdf

Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. • Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies • Uses a didactic approach with basic biological or theoretical background for the methodology presented • Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology • Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts • “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition

Advances in Computational Toxicology

Huixiao Hong
Advances in Computational Toxicology Book PDF

Author : Huixiao Hong
Publisher : Springer
Page : 412 pages
File Size : 45,5 Mb
Release : 2019-05-21
Category : Science
ISBN : 9783030164430

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Advances in Computational Toxicology by Huixiao Hong Pdf

This book provides a comprehensive review of both traditional and cutting-edge methodologies that are currently used in computational toxicology and specifically features its application in regulatory decision making. The authors from various government agencies such as FDA, NCATS and NIEHS industry, and academic institutes share their real-world experience and discuss most current practices in computational toxicology and potential applications in regulatory science. Among the topics covered are molecular modeling and molecular dynamics simulations, machine learning methods for toxicity analysis, network-based approaches for the assessment of drug toxicity and toxicogenomic analyses. Offering a valuable reference guide to computational toxicology and potential applications in regulatory science, this book will appeal to chemists, toxicologists, drug discovery and development researchers as well as to regulatory scientists, government reviewers and graduate students interested in this field.

Molecular Toxicology

Nick Plant
Molecular Toxicology Book PDF

Author : Nick Plant
Publisher : Taylor & Francis
Page : 164 pages
File Size : 52,9 Mb
Release : 2021-02-27
Category : Science
ISBN : 9781000107005

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Molecular Toxicology by Nick Plant Pdf

Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e.g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics.

PCR Protocols in Molecular Toxicology

John P. Vanden Heuvel
PCR Protocols in Molecular Toxicology Book PDF

Author : John P. Vanden Heuvel
Publisher : CRC Press
Page : 258 pages
File Size : 45,6 Mb
Release : 2019-05-07
Category : Medical
ISBN : 1439805806

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PCR Protocols in Molecular Toxicology by John P. Vanden Heuvel Pdf

Molecular toxicology is an emerging discipline that utilizes molecular and cell biology to understand how drugs and chemicals result in their unwanted effects. PCR Protocols in Molecular Toxicology is a practical guide to the use of polymerase chain reaction (PCR) to help examine, on a molecular and cellular level, how toxic responses are manifested. It offers a basic understanding of PCR and its optimization, as well as describing specific, high-impact areas of molecular toxicology and recent advances. The following techniques are described in detail: Quantitative reverse transcriptase PCR and methods to examine gene expression Differential display cloning Cloning and library screening by PCR Genotype and polymorphism analysis of drug and toxicant metabolizing enzymes Basic, non-PCR based molecular biology methods PCR Protocols in Molecular Toxicology will aid both novices and experienced PCR practitioners in using PCR to its fullest potential.

Advances in Molecular Toxicology

Jason Matthews,Shaimaa Ahmed
Advances in Molecular Toxicology Book PDF

Author : Jason Matthews,Shaimaa Ahmed
Publisher : Elsevier Inc. Chapters
Page : 254 pages
File Size : 40,9 Mb
Release : 2013-08-12
Category : Medical
ISBN : 9780128084939

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Advances in Molecular Toxicology by Jason Matthews,Shaimaa Ahmed Pdf

The aryl hydrocarbon receptor (AHR) and estrogen receptors (ERs) are ligand-activated transcription factors and members of the basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) and nuclear receptor (NR) superfamilies, respectively. The bHLH-PAS and NRs regulate many vital physiological processes including metabolism, circadian rhythm, differentiation, development, and reproduction. However, both receptor families are also associated with numerous human diseases. Reciprocal crosstalk between AHR and ERs is proposed to both positively and negatively impact human health. ERs are the most important targets in the treatment of breast cancer. The AHR, which is activated by many environmental pollutants, natural/dietary compounds, and endogenous substances, is a negative regulator of ER function. The role of ERα in AHR signaling is less clear as it is known to exhibit cell-type and promoter-specific differences. In this chapter, we will highlight the current understanding of AHR and ER crosstalk and toxicity.

Advances in Molecular Toxicology

Anonim
Advances in Molecular Toxicology Book PDF

Author : Anonim
Publisher : Elsevier
Page : 248 pages
File Size : 44,5 Mb
Release : 2009-08-12
Category : Medical
ISBN : 0080886264

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Advances in Molecular Toxicology by Anonim Pdf

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. * Cutting-edge reviews by leading workers in the discipline * In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines * Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Advances in Molecular Toxicology

Sushmita Sen,Jeffrey M. Field
Advances in Molecular Toxicology Book PDF

Author : Sushmita Sen,Jeffrey M. Field
Publisher : Elsevier Inc. Chapters
Page : 254 pages
File Size : 46,6 Mb
Release : 2013-08-12
Category : Medical
ISBN : 9780128084953

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Advances in Molecular Toxicology by Sushmita Sen,Jeffrey M. Field Pdf

Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants, so widespread that it is impossible for anyone to avoid exposure to them. They are the products of partial combustion, and exposure comes from the fossil fuels that we use to drive our cars, cook our food, warm our home, and fuel our industry. Other exposure comes from tobacco smoke and oil spills. PAHs are responsible for more cancers, primarily lung cancers, than any other carcinogen. The most studied PAHs are unsubstituted multi-ring structures. These compounds are not DNA reactive, and must be modified to become carcinogenic. Metabolic pathways modify PAH during the detoxification process. Three pathways have been extensively documented: the diol-epoxide pathway, the radical cation pathway, and the o-quinone pathway. Some PAHs are generated during combustion in oxygenated forms, usually as quinones. Quinones also form as PAHs are exposed to sunlight, for example, in an oil spill. These metabolic products damage DNA through distinct mechanisms: diol epoxides form bulky adducts with DNA, radical cations form depurinating adducts and quinones undergo futile redox cycling to generate reactive oxygen. Here, we discuss the evidence for these pathways in PAH carcinogenesis.

Advances in Molecular Toxicology

Sigeng Chen,John R. Cashman
Advances in Molecular Toxicology Book PDF

Author : Sigeng Chen,John R. Cashman
Publisher : Elsevier Inc. Chapters
Page : 254 pages
File Size : 49,5 Mb
Release : 2013-08-12
Category : Medical
ISBN : 9780128084984

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Advances in Molecular Toxicology by Sigeng Chen,John R. Cashman Pdf

Organophosphate (OP) exposure continues to be a threat to both civilian and military personnel. Sensitive and specific methods for the detection and remediation are needed not only for public health but also for farmers who are exposed to OPs frequently. Although detection approaches based on a mass spectrometry are sensitive and reliable, they require expensive equipment and expert operators. In addition, instrumentation such as mass spectrometer cannot be easily deployed in the field. Attempts to make point-of-care approaches have been the trend in both detecting and rescuing OP exposure in the current research of OP toxicity. This chapter will discuss some recent progress reported concerning the immunodetection of OP exposure and improved antidote therapy in the remediation of OP exposure.