Molecular And Biochemical Toxicology

Author : Robert C. Smart,Ernest Hodgson
Publisher : John Wiley & Sons
Page : 1060 pages
File Size : 42,6 Mb
Release : 2018-01-04
Category : Science
ISBN : 9781119042419

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Molecular and Biochemical Toxicology by Robert C. Smart,Ernest Hodgson Pdf

Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. • Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies • Uses a didactic approach with basic biological or theoretical background for the methodology presented • Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology • Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts • “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition

Author : P. David Josephy,Bengt Mannervik
Publisher : Unknown
Page : 620 pages
File Size : 53,5 Mb
Release : 2006
Category : Molecular toxicology
ISBN : 0195176200

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Molecular Toxicology by P. David Josephy,Bengt Mannervik Pdf

The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

Author : Ernest Hodgson,Frank Edwin Guthrie
Publisher : Unknown
Page : 474 pages
File Size : 44,5 Mb
Release : 1980
Category : Biochemical toxicology
ISBN : UOM:39015000307473

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Introduction to Biochemical Toxicology by Ernest Hodgson,Frank Edwin Guthrie Pdf

Author : J.P. Vanden Heuvel,W.F. Greenlee,G.H. Perdew,William B. Mattes
Publisher : Gulf Professional Publishing
Page : 674 pages
File Size : 53,6 Mb
Release : 2002-02-14
Category : Business & Economics
ISBN : 0444508686

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Cellular and Molecular Toxicology by J.P. Vanden Heuvel,W.F. Greenlee,G.H. Perdew,William B. Mattes Pdf

Volume 14 in the series Comprehensive Toxicology extends and complements the previously published 13-volume set. This volume will be available separately. Toxicology is the study of the nature and actions of chemicals on biological systems. In more primitive times, it really was the study of poisons. However, in the early 1500s, it was apparent to Paracelsus that "the dose differentiates a poison and a remedy". Clearly, the two most important tenets of toxicology were established during that time. The level of exposure (dose) and the duration of exposure (time) will determine the degree and nature of a toxicological response. Since that time the discipline of toxicology has made major advances in identifying and characterizing toxicants. The growth of toxicology as a scientific discipline has been driven to a large extent by the use of extremely powerful molecular and cell biology techniques. The overall aim of this volume is to demonstrate how these advances are being used to elucidate causal pathways (or linkages) for potential adverse health consequences of human exposure to environmental chemicals or radiation. A unique feature of this volume is its illustration of how carefully-designed studies of the molecular mechanisms of chemical action provide not only understanding of the potential toxicity of the chemical under investigation, but also new insights into the functioning of the biological system used as an experimental model. Each chapter contains a listing of major peer-reviewed articles and reviews and useful web-sites. In addition, each chapter contains a broad introductory section that outlines the subsequent sections. These Introductory and Overview sections are designed to be stand alone chapters, and may be packaged as a textbook in graduate level courses.

Author : Rudolfs K. Zalups,D. James Koropatnick
Publisher : CRC Press
Page : 608 pages
File Size : 50,7 Mb
Release : 2000-02-24
Category : Medical
ISBN : 0748407987

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Molecular Biology and Toxicology of Metals by Rudolfs K. Zalups,D. James Koropatnick Pdf

Molecular Biology and Toxicology of Metals provides a critical review and analysis of the current state of knowledge of metal ion transport and metabolism in prokaryotic and eukaryotic cellular systems. It covers the latest information on specific metals and the biological molecules with which metals interact. It also details mechanisms in the handling and toxicity of metals in specific organ systems, and the role of metals in cell signalling and gene transcription in target cells. This book is sure to prove a fertile meeting ground for the disciplines of molecular genetics and metal toxicology.

Author : Urs A. Boelsterli
Publisher : CRC Press
Page : 424 pages
File Size : 44,7 Mb
Release : 2007-03-23
Category : Medical
ISBN : 0849372720

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Mechanistic Toxicology by Urs A. Boelsterli Pdf

A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics of human toxicology. Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition retains the accessible format of the original to present the general principles that link xenobiotic-induced toxicity with the molecular pathways that underlie these toxic effects. Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at different toxicokinetic and toxicodynamic levels. The book includes references and review articles at the end of each chapter, as well as boxed text for relevant review information on biological, biochemical, molecular, and toxicological background. Linking molecular pathways to more general biomedical contexts, the author ensures that the reader is not lost in the details and instead receives a broad understanding of the processes underlying xenobiotic toxicity. New in the Second Edition Updated chapters Types of toxic responses Disruption of signal transduction by xenobiotics Disruption of mitochondrial function Novel mechanisms derived from systems toxicology

Author : John Timbrell
Publisher : CRC Press
Page : 408 pages
File Size : 43,6 Mb
Release : 1999-10-21
Category : Medical
ISBN : 0748407375

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Principles of Biochemical Toxicology, Third Edition by John Timbrell Pdf

Research into the biochemical basis of toxicology has expanded rapidly over recent years, amidst concerns over the adverse effects of drugs, environmental pollution and occupational hazards. Following on from the acclaimed first two editions of Principles of Biochemical Toxicology, John Timbrell has expanded the text to include: summary sections questions and model answers thoroughly revised artwork These features, plus the new easy-to-read format will make biochemical toxicology more accessible to undergraduates and postgraduates coming across the subject for the first time, particularly when undertaking self-directed study. This comprehensive textbook provides a thorough explanation of dose-response relationships; disposition and metabolism; toxic responses to foreign compounds, and detailed examples to illustrate mechanisms of toxicity. There is also an expanded and updated bibliography, directing the reader to further reading if required. Students and lecturers will find the clear and concise approach, which established this book as the leading textbook in its field, an essential aid to learning and teaching.

Author : Donald C. Malins
Publisher : CRC Press
Page : 553 pages
File Size : 52,5 Mb
Release : 2018-01-18
Category : Science
ISBN : 9781351078320

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Aquatic Toxicology by Donald C. Malins Pdf

Aquatic Toxicology examines research findings on the chronic effects of pollutants on aquatic species. Understanding these chronic effects is vital to determining the impact of small concentrations of pollutants on aquatic life in rivers, estuaries, lakes, and coastal waters. Featuring research from renowned experts in the field, this book evaluates modern techniques in the fields of molecular biology and biochemistry. It is indispensable to aquatic toxicologists, aquatic biochemists, fisheries scientists, industrial chemists, and researchers at federal, state, and university levels.

Author : John Timbrell
Publisher : CRC Press
Page : 405 pages
File Size : 51,8 Mb
Release : 1999-10-21
Category : Medical
ISBN : 9780748407361

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Principles of Biochemical Toxicology, Third Edition by John Timbrell Pdf

Research into the biochemical basis of toxicology has expanded rapidly over recent years, amidst concerns over the adverse effects of drugs, environmental pollution and occupational hazards. Following on from the acclaimed first two editions of Principles of Biochemical Toxicology, John Timbrell has expanded the text to include: summary sections questions and model answers thoroughly revised artwork These features, plus the new easy-to-read format will make biochemical toxicology more accessible to undergraduates and postgraduates coming across the subject for the first time, particularly when undertaking self-directed study. This comprehensive textbook provides a thorough explanation of dose-response relationships; disposition and metabolism; toxic responses to foreign compounds, and detailed examples to illustrate mechanisms of toxicity. There is also an expanded and updated bibliography, directing the reader to further reading if required. Students and lecturers will find the clear and concise approach, which established this book as the leading textbook in its field, an essential aid to learning and teaching.

Author : Douglas M. Templeton,John Duffus,Michael Schwenk
Publisher : Unknown
Page : 450 pages
File Size : 52,6 Mb
Release : 2020-05-19
Category : Medical
ISBN : 1788017714

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Glossary of Terms Used in Molecular Toxicology by Douglas M. Templeton,John Duffus,Michael Schwenk Pdf

This glossary expands upon the Comprehensive Glossary of Terms Used in Toxicology. Like its predecessor, it addresses the need for harmonized toxicology terminology, and has undergone a full, comprehensive and rigorous review by IUPAC Committees. It serves as the reference glossary for students and researchers studying the chemical and molecular biological bases of toxicology, and for those involved in chemicals legislation, regulation and risk assessment. Toxicology uses terminology from many disciplines that have been revolutionized by recent developments in molecular biology and biochemistry, and this glossary provides a compilation of definitions of molecular entities that impact on toxicology. Extensive Notes are included to provide context for many of the proteins and important genes defined, with disambiguation where entities are referred to by different names in the literature. We hope that this will be helpful to students and professionals alike.

Author : Ernest Hodgson,Patricia E. Levi
Publisher : McGraw-Hill/Appleton & Lange
Page : 632 pages
File Size : 44,9 Mb
Release : 1994
Category : Medical
ISBN : UOM:39015031886735

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Introduction to Biochemical Toxicology by Ernest Hodgson,Patricia E. Levi Pdf

Recent applications of new molecular and cellular techniques have greatly expanded our knowledge of how toxicants produce their adverse effects. As a consequence, the time has come for a substantial revision of Professor Ernest Hodgson's classic reference in the field. This Third Edition now contains updated overview chapters on immunochemical and molecular techniques. It also features entirely new chapters covering such crucial topics as immunotoxicology, cutaneous toxicology, reproductive and developmental toxicology, and molecular epidemiology.

Author : R. Michael Roe,James Dale Burton,Ronald J. Kuhr
Publisher : IOS Press
Page : 224 pages
File Size : 52,9 Mb
Release : 1997
Category : Technology & Engineering
ISBN : 9051993110

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Herbicide Activity by R. Michael Roe,James Dale Burton,Ronald J. Kuhr Pdf

Developments in the understanding of herbicide activity and toxicology have expanded tremendously in the past fifteen years. Research on the mechanism of action of most major classes of herbicide chemistry has provided scientists with excellent insight into enzyme targets. More recently, developments in molecular biology have provided information about herbicide action at the genetic level. Less well understood are the toxicological aspects of herbicide activity that culminate in plant injury or death. Toxicology, Biochemistry and Molecular Biology of Herbicide Activity is a review of the recent literature on most of the major classes of herbicide chemistry in commercial use. The chapters include information about different aspects of herbicide activity related to photosynthesis, inhibition of amino acid biosynthesis, disruption of cell division and microtubule assembly, activity of phytohormone (auxin) mimics, inhibition of fatty acid biosynthesis and some developments in the understanding of herbicide resistance.

Author : Ernest Hodgson,Patricia E. Levi
Publisher : McGraw-Hill Medical Publishing
Page : 518 pages
File Size : 44,9 Mb
Release : 1997
Category : Medical
ISBN : UOM:39015041081293

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A Textbook of Modern Toxicology by Ernest Hodgson,Patricia E. Levi Pdf

This revised edition reflects changes in the core curriculum subjects covered in the basic toxicology course for graduate students. Designed as an introductory textbook, it emphasizes the fundamental basis of toxic action at the cellular and molecular levels and lays the foundation for specialized courses in toxicology. Additional topics include metabolic activation and cellular protection, clinical toxicology diagnosis and treatment, ecosystems, environmental toxicology, ecotoxicology, case histories, and future consideration for environmental and human health.

Author : Ernest Hodgson
Publisher : Academic Press
Page : 452 pages
File Size : 50,7 Mb
Release : 2012-09-28
Category : Medical
ISBN : 9780124158139

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Toxicology and Human Environments by Ernest Hodgson Pdf

Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments. The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis. Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them

Author : Lewis L. Smith,Francesco De Matteis
Publisher : CRC Press
Page : 262 pages
File Size : 51,9 Mb
Release : 2019-06-04
Category : Medical
ISBN : 9781000012828

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Molecular and Cellular Mechanisms of Toxicity by Lewis L. Smith,Francesco De Matteis Pdf

First Published in 1995: Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology. The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen, fibers and aflatoxins. The second section discusses the interactions of carcinogens with DNA, and other targets, and their relevance to both molecular dosimetry of exposure and development of cancer. The final part is concerned with cellular and genetic aspects and includes coverage of some of the most recent and rapidly developing problems in toxicology.