Advances In Nanomedicine For The Delivery Of Therapeutic Nucleic Acids

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Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids

Surendra Nimesh,Ramesh Chandra,Nidhi Gupta
Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids Book PDF

Author : Surendra Nimesh,Ramesh Chandra,Nidhi Gupta
Publisher : Woodhead Publishing
Page : 256 pages
File Size : 47,8 Mb
Release : 2017-04-04
Category : Science
ISBN : 9780081005637

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Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids by Surendra Nimesh,Ramesh Chandra,Nidhi Gupta Pdf

Advances in Nanomedicine for the Delivery of Therapeutic Nucleic Acids addresses several issues related to safe and effective delivery of nucleic acids (NAs) using nanoparticles. A further emphasis would be laid on the mechanism of delivery of NAs, the barriers encountered and the strategies adapted to combat them. An exhaustive account of the advantages as well shortcomings of all the delivery vectors being employed in delivery of various NAs will be provided. On final note the regulatory aspects of nanoparticles mediated NA would be discussed, with focus on their clinical relevance. The design and development of nucleic acid-based therapeutics for the treatment of diseases arising from genetic abnormalities has made significant progress over the past few years. NAs have been widely explored for the treatment of cancer and infectious diseases or to block cell proliferation and thereby caused diseases. Advances in synthetic oligonucleotide chemistry resulted in synthesis of NAs that are relatively stable in in vivo environments. However, cellular targeting and intracellular delivery of NAs still remains a challenge. Further development of NA-based therapeutics depends on the progress of safe and effective carriers for systemic administration. Nanomedicine has facilitated availability of vectors with diminished cytotoxicity and enhanced efficacy which are rapidly emerging as systems of choice. These vectors protect NAs from enzymatic degradation by forming condensed complexes along with targeted tissue and cellular delivery. During the past few years, a myriad reports have appeared reporting delivery of NAs mediated by nanoparticles. This book will provide an overview of nanoparticles being employed in the in vitro and in vivo delivery of therapeutically relevant NAs like DNA, siRNA, LNA, PNA, etc. Provides a complete overview of the applicatiosn of nanomedicine in the delivery of nucleic acids, from characterization of nanoparticles, to in vitro and in vivo studies Discusses delivery issues of less well explored nucleic acids, like PNAs, Ribozymes, DNAzymes, etc. Summarizes the current state of research in nucleic acid delivery and underscores the future of nanomedicine in this field

Nanotechnology for the Delivery of Therapeutic Nucleic Acids

Dan Peer
Nanotechnology for the Delivery of Therapeutic Nucleic Acids Book PDF

Author : Dan Peer
Publisher : CRC Press
Page : 240 pages
File Size : 49,6 Mb
Release : 2013-03-27
Category : Medical
ISBN : 9789814411059

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Nanotechnology for the Delivery of Therapeutic Nucleic Acids by Dan Peer Pdf

Nucleic acid (NA) therapeutics has been extensively studied both in the academia and in the pharmaceutical industry and is still considered the promise for new therapeutic modalities, especially in personalized medicine. The only hurdle that limits the translation of NA therapeutics from an academic idea to the new therapeutic modality is the lack of efficient and safe delivery strategies. Nanotechnology for the Delivery of Therapeutic Nucleic Acids, written by world experts in the field of nanotechnology for NA delivery, the contributing authors bring together the state of the art in delivery strategies with strong emphasis on aspects that are of essence to the pharmaceutical industry, such as stability, general toxicity, immune-toxicity, pharmacokinetics, efficacy, and validation of new drug targets using unique approaches based on exquisite nanotechnology strategies.

Nucleic Acids as Gene Anticancer Drug Delivery Therapy

Loutfy H. Madkour
Nucleic Acids as Gene Anticancer Drug Delivery Therapy Book PDF

Author : Loutfy H. Madkour
Publisher : Academic Press
Page : 650 pages
File Size : 44,8 Mb
Release : 2019-08-27
Category : Business & Economics
ISBN : 9780128197783

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Nucleic Acids as Gene Anticancer Drug Delivery Therapy by Loutfy H. Madkour Pdf

Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy

Therapeutic Oligonucleotides

Jens Kurreck
Therapeutic Oligonucleotides Book PDF

Author : Jens Kurreck
Publisher : Royal Society of Chemistry
Page : 362 pages
File Size : 43,7 Mb
Release : 2008
Category : Medical
ISBN : 9780854041169

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Therapeutic Oligonucleotides by Jens Kurreck Pdf

This book provides a compelling overall update on current status of RNA interference

Advances in Nanomaterials-based Cell Biology Research

Yunfeng Lin,Ronghui Zhou
Advances in Nanomaterials based Cell Biology Research Book PDF

Author : Yunfeng Lin,Ronghui Zhou
Publisher : Springer Nature
Page : 227 pages
File Size : 55,5 Mb
Release : 2021-08-20
Category : Medical
ISBN : 9789811626661

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Advances in Nanomaterials-based Cell Biology Research by Yunfeng Lin,Ronghui Zhou Pdf

This book aims to comprehensively summarize the current research status of nanomaterials and cell biology. It highlights the biological effects and biomedical applications of nanomaterials for specific diseases, bone tissue engineering, and skeletal muscle regeneration. It also provides the details of the biomedical applications of nucleic acid nanomaterials in drug delivery carriers, antimicrobial therapy, vaccine, and neurodegenerative diseases. Therefore, this book renders the audience a better understanding of nanomaterials along with the diverse applications in the cell biology field from recent works to perspectives.

Nanomedicine for Drug Delivery and Therapeutics

Ajay Kumar Mishra
Nanomedicine for Drug Delivery and Therapeutics Book PDF

Author : Ajay Kumar Mishra
Publisher : John Wiley & Sons
Page : 0 pages
File Size : 49,7 Mb
Release : 2013-01-22
Category : Science
ISBN : 9781118414095

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Nanomedicine for Drug Delivery and Therapeutics by Ajay Kumar Mishra Pdf

This book describes a broad area of nanomedicine which involves mainly applications, diseases, and diagnostics. The comprehensive coverage provides researchers, academics, and health specialists with a great tool, that includes techniques applicable to various uses.

Nucleic Acid Nanotheranostics

Marco Filice,Jesús Ruiz-Cabello
Nucleic Acid Nanotheranostics Book PDF

Author : Marco Filice,Jesús Ruiz-Cabello
Publisher : Elsevier
Page : 491 pages
File Size : 40,8 Mb
Release : 2019-02-26
Category : Technology & Engineering
ISBN : 9780128144718

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Nucleic Acid Nanotheranostics by Marco Filice,Jesús Ruiz-Cabello Pdf

Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient’s cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge. Provides a unique source of knowledge (theoretical as well as practical) on nanotheranostic materials for gene therapy at all levels and related scientific areas Covers the pros and cons related to viral and nanomaterial-based delivery of nucleic acids in terms of biosafety, carrier selection, synthesis and bioimaging Presents the only book to include an analysis of nanoformulations approved for clinical use

Polymers and Nanomaterials for Gene Therapy

Ravin Narain
Polymers and Nanomaterials for Gene Therapy Book PDF

Author : Ravin Narain
Publisher : Woodhead Publishing
Page : 302 pages
File Size : 45,9 Mb
Release : 2016-01-09
Category : Science
ISBN : 9780081005217

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Polymers and Nanomaterials for Gene Therapy by Ravin Narain Pdf

Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications

RNA Nanotechnology

Bin Wang
RNA Nanotechnology Book PDF

Author : Bin Wang
Publisher : CRC Press
Page : 466 pages
File Size : 54,5 Mb
Release : 2014-04-02
Category : Medical
ISBN : 9789814411653

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RNA Nanotechnology by Bin Wang Pdf

In the past few decades there has been incredible growth in "bionano"-related research, which has been accompanied by numerous publications in this field. Although various compilations address topics related to deoxyribonucleic acid (DNA) and protein, there are few books that focus on determining the structure of ribonucleic acid (RNA) and using RNA as building blocks to construct nanoarchitectures for biomedical and healthcare applications. RNA Nanotechnology is a comprehensive volume that details both the traditional approaches and the latest developments in the field of RNA-related technology. This book targets a wide audience: a broad introduction provides a solid academic background for students, researchers, and scientists who are unfamiliar with the subject, while the in-depth descriptions and discussions are useful for advanced professionals. The book opens with reviews on the basic aspects of RNA biology, computational approaches for predicting RNA structures, and traditional and emerging experimental approaches for probing RNA structures. This section is followed by explorations of the latest research and discoveries in RNA nanotechnology, including the design and construction of RNA-based nanostructures. The final segment of the book includes descriptions and discussions of the potential biological and therapeutic applications of small RNA molecules, such as small/short interfering RNAs (siRNAs), microRNAs (miRNAs), RNA aptamers, and ribozymes.

Nanotechnology in Medicine

Mahendra Rai,Mrunali Patel,Rashmin Patel
Nanotechnology in Medicine Book PDF

Author : Mahendra Rai,Mrunali Patel,Rashmin Patel
Publisher : John Wiley & Sons
Page : 448 pages
File Size : 54,6 Mb
Release : 2021-10-19
Category : Science
ISBN : 9781119769880

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Nanotechnology in Medicine by Mahendra Rai,Mrunali Patel,Rashmin Patel Pdf

NANOTECHNOLOGY IN MEDICINE Discover thorough insights into the toxicology of nanomaterials used in medicine In Nanotechnology in Medicine: Toxicity and Safety, an expert team of nanotechnologists delivers a robust and up-to-date review of current and future applications of nanotechnology in medicine with a special focus on neurodegenerative diseases, cancer, diagnostics, nano-nutraceuticals, dermatology, and gene therapy. The editors offer resources that address nanomaterial safety, which tends to be the greatest hurdle to obtaining the benefits of nanomedicine in healthcare. The book is a one-stop resource for recent and comprehensive information on the toxico logical and safety aspects of nanotechnology used in human health and medicine. It provides readers with cutting-edge techniques for delivering therapeutic agents into targeted cellular compartments, cells, tissues, and organs by using nanoparticulate carriers. The book also offers methodological considerations for toxicity, safety, and risk assessment. Nanotechnology in Medicine: Toxicity and Safety also provides readers with: A thorough introduction to the nanotoxicological aspects of nanomedicine, including translational nanomedicine and nanomedicine personalization Comprehensive introductions to nanoparticle toxicity and safety, including selenium nanoparticles and metallic nanoparticles Practical discussions of nanotoxicology and drug delivery, including gene delivery using nanocarriers and the use of nanomaterials for ocular delivery applications In-depth examinations of nanotechnology ethics and the regulatory framework of nanotechnology and medicine Perfect for researchers, post-doctoral candidates, and specialists in the fields of nanotechnology, nanomaterials, and nanocarriers, Nanotechnology in Medicine: Toxicity and Safety will also prove to be an indispensable part of the libraries of nanoengineering, nanomedicine, and biopharmaceutical professionals and nanobiotechnologists.

Cancer Therapy

Surendra Nimesh,Nidhi Gupta,Guilherme Carneiro
Cancer Therapy Book PDF

Author : Surendra Nimesh,Nidhi Gupta,Guilherme Carneiro
Publisher : Elsevier
Page : 552 pages
File Size : 46,8 Mb
Release : 2024-05-31
Category : Medical
ISBN : 9780443154027

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Cancer Therapy by Surendra Nimesh,Nidhi Gupta,Guilherme Carneiro Pdf

While there have been a large number of ongoing research projects and publications on the treatment of cancer, there is a limited number of books related to nanotechnology with emphasis on polymeric nanoparticles in cancer therapy. The book, covering all of the recent research work done on this basis, enlightens researchers and students with the benefits of polymeric nanomaterials in cancer. This book provides exhaustive knowledge on polymeric nanoparticles and cancer. Provides a complete overview of the application of different polymeric nanoparticles in cancer therapeutics: from characterization of nanoparticles to in vitro and in vivo studies. Contains a detailed description of the delivery of therapeutic molecules with different polymers realized with nanomedicine in cancer therapeutics. Discusses newly developed promising polymers in cancer. Describes polymeric nanoparticle and their role in theranostics pertaining to cancer. Reviews clinical relevance of different polymeric formulations in the field of cancer

Silk-based Drug Delivery Systems

Elia Bari ,Sara Perteghella,Maria Luisa Torre
Silk based Drug Delivery Systems Book PDF

Author : Elia Bari ,Sara Perteghella,Maria Luisa Torre
Publisher : Royal Society of Chemistry
Page : 243 pages
File Size : 51,6 Mb
Release : 2020-10-07
Category : Science
ISBN : 9781788017725

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Silk-based Drug Delivery Systems by Elia Bari ,Sara Perteghella,Maria Luisa Torre Pdf

Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.

Fullerens, Graphenes and Nanotubes

Alexandru Mihai Grumezescu
Fullerens Graphenes and Nanotubes Book PDF

Author : Alexandru Mihai Grumezescu
Publisher : William Andrew
Page : 724 pages
File Size : 44,8 Mb
Release : 2018-05-28
Category : Science
ISBN : 9780128136928

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Fullerens, Graphenes and Nanotubes by Alexandru Mihai Grumezescu Pdf

Fullerens, Graphenes and Nanotubes: A Pharmaceutical Approach shows how carbon nanomaterials are used in the pharmaceutical industry. While there are various books on the carbonaceous nanomaterials available on the market, none approach the subject from a pharmaceutical point-of-view. In this context, the book covers different applications of carbonaceous nanomaterials. Chapters examine different types of carbon nanomaterials and explore how they are used in such areas as cancer treatments, pulse sensing and prosthetics. Readers will find this book to be a valuable reference resource for those working in the areas of carbon materials, nanomaterials and pharmaceutical science. Explains how the unique properties of carbon-based nanomaterials allow them to be used to create effective drug delivery systems Covers how carbon-based nanomaterials should be prepared for use in pharmaceutical applications Discusses the relative toxicity of a range of carbon-based nanomaterials Considers the safety of their use in different types of drugs

Drug Delivery Nanosystems

Natassa Pippa,Costas Demetzos,Stergios Pispas
Drug Delivery Nanosystems Book PDF

Author : Natassa Pippa,Costas Demetzos,Stergios Pispas
Publisher : CRC Press
Page : 418 pages
File Size : 52,7 Mb
Release : 2019-01-15
Category : Medical
ISBN : 9780429955228

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Drug Delivery Nanosystems by Natassa Pippa,Costas Demetzos,Stergios Pispas Pdf

Nanotechnology seeks to exploit distinct technological advances controlling the structure of nanoscale biomaterials at a nanodimensional scale approaching individual molecules and their aggregates or supramolecular structures. The term "nanomedicine" is used to describe those technologies under the umbrella of nanotechnology that have therapeutic applications in human health. This book presents recent trends and research achievements in the field of pharmaceutical nanotechnology and advanced drug delivery nanosystems, especially for theranostic purposes. The applications of drug delivery nanosystems considered carriers of active pharmaceutical ingredients (APIs) (e.g., proteins, peptides, and nucleic acids) are analyzed on the basis of technology, preparation protocols, and biomedical applications. The book also extensively reports on the principles, design protocols, and applications of nanosystems in drug delivery, imaging, and targeting of active molecules of pharmaceutical interest.

Nucleic Acid Nanotechnology

Jørgen Kjems,Elena Ferapontova,Kurt V. Gothelf
Nucleic Acid Nanotechnology Book PDF

Author : Jørgen Kjems,Elena Ferapontova,Kurt V. Gothelf
Publisher : Springer Science & Business Media
Page : 339 pages
File Size : 45,8 Mb
Release : 2013-10-19
Category : Science
ISBN : 9783642388156

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Nucleic Acid Nanotechnology by Jørgen Kjems,Elena Ferapontova,Kurt V. Gothelf Pdf

This volume on nucleic acid nanotechnology offers authoritative, up-to-date and comprehensive coverage of nanotechnological studies and applications of nucleic acids. It provides reviews of various aspects of nucleic acid nanotechnology, each written by an internationally leading expert in the field, and presents state-of-the-art and recent advances in nucleic acid synthetic modifications, nanoscale design, manipulation and current and future applications in bioengineering, medicine, electronics, genetic analysis, chemistry, molecular biology, surface and material sciences. It examines how nucleic acid research is merging with nanotechnology, allowing the nanoscale properties of nucleic acid to be exploited in performing challenging nanotechnological tasks, from nanorobotics and nanosensing to nucleic acid computing. This book will above all benefit anyone who is interested in nanotechnological concepts of nucleic acid design and applications, and offers a valuable resource for teaching these concepts. It is essential reading for a broad audience of scientists both in academia and industry who wish to expand their expertise on the potential of nucleic acid functions and applications.