Advances In Synthetic Biology

Author : Vijai Singh
Publisher : Springer Nature
Page : 349 pages
File Size : 46,6 Mb
Release : 2020-04-13
Category : Science
ISBN : 9789811500817

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Advances in Synthetic Biology by Vijai Singh Pdf

This book addresses the design of emerging conceptual tools, technologies and systems including novel synthetic parts, devices, circuits, oscillators, biological gates, and small regulatory RNAs (riboregulators and riboswitches), which serve as versatile control elements for regulating gene expression. Synthetic biology, a rapidly growing field that involves the application of engineering principles in biology, is now being used to develop novel systems for a wide range of applications including diagnostics, cell reprogramming, therapeutics, enzymes, vaccines, biomaterials, biofuels, fine chemicals and many more. The book subsequently summarizes recent developments in technologies for assembling synthetic genomes, minimal genomes, synthetic biology toolboxes, CRISPR-Cas systems, cell-free protein synthesis systems and microfluidics. Accordingly, it offers a valuable resource not only for beginners in synthetic biology, but also for researchers, students, scientists, clinicians, stakeholders and policymakers interested in the potential held by synthetic biology.

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology
Publisher : National Academies Press
Page : 189 pages
File Size : 48,6 Mb
Release : 2019-01-05
Category : Technology & Engineering
ISBN : 9780309465182

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Biodefense in the Age of Synthetic Biology by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology Pdf

Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.

Author : Christina Smolke
Publisher : John Wiley & Sons
Page : 426 pages
File Size : 42,8 Mb
Release : 2018-06-05
Category : Science
ISBN : 9783527330751

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Synthetic Biology by Christina Smolke Pdf

A review of the interdisciplinary field of synthetic biology, from genome design to spatial engineering. Written by an international panel of experts, Synthetic Biology draws from various areas of research in biology and engineering and explores the current applications to provide an authoritative overview of this burgeoning field. The text reviews the synthesis of DNA and genome engineering and offers a discussion of the parts and devices that control protein expression and activity. The authors include information on the devices that support spatial engineering, RNA switches and explore the early applications of synthetic biology in protein synthesis, generation of pathway libraries, and immunotherapy. Filled with the most recent research, compelling discussions, and unique perspectives, Synthetic Biology offers an important resource for understanding how this new branch of science can improve on applications for industry or biological research.

Author : Hennig Stefan,Delaplace Franck
Publisher : Unknown
Page : 128 pages
File Size : 49,5 Mb
Release : 2016-10
Category : Electronic
ISBN : 1618962876

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Advances in Synthetic Biology by Hennig Stefan,Delaplace Franck Pdf

Author : National Research Council,National Academy of Engineering,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Committee on Science, Technology, and Law
Publisher : National Academies Press
Page : 80 pages
File Size : 44,8 Mb
Release : 2013-08-05
Category : Science
ISBN : 9780309225861

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Positioning Synthetic Biology to Meet the Challenges of the 21st Century by National Research Council,National Academy of Engineering,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Committee on Science, Technology, and Law Pdf

Synthetic biology -- unlike any research discipline that precedes it -- has the potential to bypass the less predictable process of evolution to usher in a new and dynamic way of working with living systems. Ultimately, synthetic biologists hope to design and build engineered biological systems with capabilities that do not exist in natural systems -- capabilities that may ultimately be used for applications in manufacturing, food production, and global health. Importantly, synthetic biology represents an area of science and engineering that raises technical, ethical, regulatory, security, biosafety, intellectual property, and other issues that will be resolved differently in different parts of the world. As a better understanding of the global synthetic biology landscape could lead to tremendous benefits, six academies -- the United Kingdom's Royal Society and Royal Academy of Engineering, the United States' National Academy of Sciences and National Academy of Engineering, and the Chinese Academy of Science and Chinese Academy of Engineering -- organized a series of international symposia on the scientific, technical, and policy issues associated with synthetic biology. Positioning Synthetic Biology to Meet the Challenges of the 21st Century summarizes the symposia proceedings.

Author : Vikram Singh,Pawan K. Dhar
Publisher : Springer
Page : 385 pages
File Size : 50,5 Mb
Release : 2014-12-15
Category : Science
ISBN : 9789401795142

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Systems and Synthetic Biology by Vikram Singh,Pawan K. Dhar Pdf

This textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M.Sc. and Ph.D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section will deal with systems biology – in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section deals with the engineering concepts, design strategies of the biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell will be described. Finally, the book will offer expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.

Author : Daniel G. Gibson,Clyde A. Hutchison (III),Hamilton Othanel Smith,J. Craig Venter
Publisher : Perspectives Cshl
Page : 0 pages
File Size : 44,6 Mb
Release : 2017
Category : Science
ISBN : 1621821188

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Synthetic Biology by Daniel G. Gibson,Clyde A. Hutchison (III),Hamilton Othanel Smith,J. Craig Venter Pdf

Synthetic biology involves the rational design and construction of biological components and systemsfrom genetic elements and metabolic pathways to entirely new organisms. Progress in this field has been rapid, and it promises to significantly expand our capabilities in biotechnology, medicine, and agriculture. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the tools and techniques employed by synthetic biologists, how these may be used to develop new drugs, diagnostic approaches, food sources, and clean energy, and what the field of synthetic biology has taught us about natural living systems. The contributors discuss advances in DNA synthesis and assembly, genome editing (e.g., CRISPR/Cas9), and artificial genetic systems. Progress in designing complex genetic switches and circuits, expanding the genetic code, modifying cellular organization, producing proteins using cell-free systems, and developing biodesign automation tools is also covered. The authors also explore ways to produce new organisms and products that have particular attributesfor example, microbial "molecular factories," synthetic organs and tissues, and plants with novel traits. This volume is an essential resource for molecular, cell, and systems biologists who seek to engineer living systems for human benefit.

Author : Arshad, Muhammad
Publisher : IGI Global
Page : 481 pages
File Size : 47,7 Mb
Release : 2023-10-02
Category : Science
ISBN : 9781668465783

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Applications of Synthetic Biology in Health, Energy, and Environment by Arshad, Muhammad Pdf

The application of genetic engineering techniques by redesigning and repurposing biological systems for novel biotechnical applications has paved the way for the field of synthetic biology. This field boosted the evolution and discovery of various novel technologies essential to the conquest of biological problems related to health, disease, the environment, and energy. The field of synthetic biology is growing rapidly, and further research is required. Applications of Synthetic Biology in Health, Energy, and Environment deliberates on principles and the advancement of synthetic biology and their translation in the fields of health, disease, energy, and the environment. Covering topics such as climate change, bioremediation, and smart drugs, this premier reference source is an excellent resource for students and educators of higher education, industrialists, medical professionals, hospital administrators, policymakers, environmental scientists, pharmacists, librarians, researchers, and academicians.

Author : Huimin Zhao
Publisher : Academic Press
Page : 352 pages
File Size : 46,8 Mb
Release : 2013-03-21
Category : Science
ISBN : 9780123978202

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Synthetic Biology by Huimin Zhao Pdf

Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems. Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems. Includes contributions from leaders in the field presents examples of ambitious synthetic biology efforts including creation of artificial cells from scratch, cell-free synthesis of chemicals, fuels, and proteins, engineering of artificial photosynthesis for biofuels production, and creation of unnatural living organisms Describes the latest state-of-the-art tools developed for low-cost synthesis of ever-increasing sizes of DNA and efficient modification of proteins, pathways, and genomes Highlights key technologies for analyzing biological systems at the genomic, proteomic, and metabolomic levels which are especially valuable in pathway, whole cell, and multi-cell applications Details mathematical modeling tools and computational tools which can dramatically increase the speed of the design process as well as reduce the cost of development.

Author : Institute of Medicine,Board on Global Health,Forum on Microbial Threats
Publisher : National Academies Press
Page : 570 pages
File Size : 51,5 Mb
Release : 2011-12-30
Category : Science
ISBN : 9780309219396

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The Science and Applications of Synthetic and Systems Biology by Institute of Medicine,Board on Global Health,Forum on Microbial Threats Pdf

Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.

Author : Gavin Williams,Mélanie Hall
Publisher : Royal Society of Chemistry
Page : 594 pages
File Size : 52,9 Mb
Release : 2018-05-31
Category : Science
ISBN : 9781788014533

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Modern Biocatalysis by Gavin Williams,Mélanie Hall Pdf

The synergy between synthetic biology and biocatalysis is emerging as an important trend for future sustainable processes. This book reviews all modern and novel techniques successfully implemented in biocatalysis, in an effort to provide better performing enzymatic systems and novel biosynthetic routes to (non-)natural products. This includes the use of molecular techniques in protein design and engineering, construction of artificial metabolic pathways, and application of computational methods for enzyme discovery and design. Stress is placed on current ‘hot’ topics in biocatalysis, where recent advances in research are defining new grounds in enzyme-catalyzed processes. With contributions from leading academics around the world, this book makes a ground-breaking contribution to this progressive field and is essential reading for graduates and researchers investigating (bio)catalysis, enzyme engineering, chemical biology, and synthetic biology.

Author : Luan Luong Chu,Jae Kyung Sohng,Dipesh Dhakal,Jingwen Zhou
Publisher : Frontiers Media SA
Page : 125 pages
File Size : 55,7 Mb
Release : 2022-02-09
Category : Science
ISBN : 9782889743094

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Recent Advances in Application of Synthetic Biology for Production of Bioactive Compounds by Luan Luong Chu,Jae Kyung Sohng,Dipesh Dhakal,Jingwen Zhou Pdf

Author : Paul S. FREEMONT,Richard I. KITNEY
Publisher : World Scientific
Page : 194 pages
File Size : 55,5 Mb
Release : 2015-08-24
Category : Science
ISBN : 9781783268801

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Synthetic Biology - a Primer (revised Edition) by Paul S. FREEMONT,Richard I. KITNEY Pdf

Synthetic Biology -- A Primer (Revised Edition) presents an updated overview of the field of synthetic biology and the foundational concepts on which it is built. This revised edition includes new literature references, working and updated URL links, plus some new figures and text where progress in the field has been made.The book introduces readers to fundamental concepts in molecular biology and engineering and then explores the two major themes for synthetic biology, namely 'bottom-up' and 'top-down' engineering approaches. 'Top-down' engineering uses a conceptual framework of systematic design and engineering principles focused around the Design-Build-Test cycle and mathematical modelling. The 'bottom-up' approach involves the design and building of synthetic protocells using basic chemical and biochemical building blocks from scratch exploring the fundamental basis of living systems.Examples of cutting-edge applications designed using synthetic biology principles are presented, including: The book also describes the Internationally Genetically Engineered Machine (iGEM) competition, which brings together students and young researchers from around the world to carry out summer projects in synthetic biology. Finally, the primer includes a chapter on the ethical, legal and societal issues surrounding synthetic biology, illustrating the integration of social sciences into synthetic biology research.Final year undergraduates, postgraduates and established researchers interested in learning about the interdisciplinary field of synthetic biology will benefit from this up-to-date primer on synthetic biology.

Author : OECD
Publisher : OECD Publishing
Page : 48 pages
File Size : 54,5 Mb
Release : 2010-05-11
Category : Electronic
ISBN : 9789264086265

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Symposium on Opportunities and Challenges in the Emerging Field of Synthetic Biology Synthesis Report by OECD Pdf

The international symposium entitled “Opportunities and Challenges in the Emerging Field of Synthetic Biology” was held in July 2009 in Washington, DC under the auspices of the United States National Academies, the Organisation for Economic ...

Author : George M Church,Edward Regis
Publisher : Basic Books
Page : 305 pages
File Size : 51,7 Mb
Release : 2014-04-08
Category : Science
ISBN : 9780465038657

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Regenesis by George M Church,Edward Regis Pdf

A Harvard biologist and master inventor explores how new biotechnologies will enable us to bring species back from the dead, unlock vast supplies of renewable energy, and extend human life. In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies-far from the out-of-control nightmare depicted in science fiction-have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.