Biodefense In The Age Of Synthetic Biology

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Biodefense in the Age of Synthetic Biology

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology
Biodefense in the Age of Synthetic Biology Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology
Publisher : National Academies Press
Page : 189 pages
File Size : 46,8 Mb
Release : 2019-01-05
Category : Technology & Engineering
ISBN : 9780309465182

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Biodefense in the Age of Synthetic Biology by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology Pdf

Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.

Biodefense in the Age of Synthetic Biology

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology
Biodefense in the Age of Synthetic Biology Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology
Publisher : National Academies Press
Page : 189 pages
File Size : 41,7 Mb
Release : 2018-12-05
Category : Technology & Engineering
ISBN : 9780309465212

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Biodefense in the Age of Synthetic Biology by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Board on Chemical Sciences and Technology,Committee on Strategies for Identifying and Addressing Potential Biodefense Vulnerabilities Posed by Synthetic Biology Pdf

Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.

Positioning Synthetic Biology to Meet the Challenges of the 21st Century

National Research Council,National Academy of Engineering,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Committee on Science, Technology, and Law
Positioning Synthetic Biology to Meet the Challenges of the 21st Century Book PDF

Author : National Research Council,National Academy of Engineering,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Committee on Science, Technology, and Law
Publisher : National Academies Press
Page : 80 pages
File Size : 40,7 Mb
Release : 2013-08-05
Category : Science
ISBN : 9780309225861

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Positioning Synthetic Biology to Meet the Challenges of the 21st Century by National Research Council,National Academy of Engineering,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Committee on Science, Technology, and Law Pdf

Synthetic biology -- unlike any research discipline that precedes it -- has the potential to bypass the less predictable process of evolution to usher in a new and dynamic way of working with living systems. Ultimately, synthetic biologists hope to design and build engineered biological systems with capabilities that do not exist in natural systems -- capabilities that may ultimately be used for applications in manufacturing, food production, and global health. Importantly, synthetic biology represents an area of science and engineering that raises technical, ethical, regulatory, security, biosafety, intellectual property, and other issues that will be resolved differently in different parts of the world. As a better understanding of the global synthetic biology landscape could lead to tremendous benefits, six academies -- the United Kingdom's Royal Society and Royal Academy of Engineering, the United States' National Academy of Sciences and National Academy of Engineering, and the Chinese Academy of Science and Chinese Academy of Engineering -- organized a series of international symposia on the scientific, technical, and policy issues associated with synthetic biology. Positioning Synthetic Biology to Meet the Challenges of the 21st Century summarizes the symposia proceedings.

Biotechnology Research in an Age of Terrorism

National Research Council,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Research Standards and Practices to Prevent the Destructive Application of Biotechnology
Biotechnology Research in an Age of Terrorism Book PDF

Author : National Research Council,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Research Standards and Practices to Prevent the Destructive Application of Biotechnology
Publisher : National Academies Press
Page : 164 pages
File Size : 52,7 Mb
Release : 2004-03-02
Category : Technology & Engineering
ISBN : 9780309089777

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Biotechnology Research in an Age of Terrorism by National Research Council,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Research Standards and Practices to Prevent the Destructive Application of Biotechnology Pdf

In recent years much has happened to justify an examination of biological research in light of national security concerns. The destructive application of biotechnology research includes activities such as spreading common pathogens or transforming them into even more lethal forms. Policymakers and the scientific community at large must put forth a vigorous and immediate response to this challenge. This new book by the National Research Council recommends that the government expand existing regulations and rely on self-governance by scientists rather than adopt intrusive new policies. One key recommendation of the report is that the government should not attempt to regulate scientific publishing but should trust scientists and journals to screen their papers for security risks, a task some journals have already taken up. With biological information and tools widely distributed, regulating only U.S. researchers would have little effect. A new International Forum on Biosecurity should encourage the adoption of similar measures around the world. Seven types of risky studies would require approval by the Institutional Biosafety Committees that already oversee recombinant DNA research at some 400 U.S. institutions. These "experiments of concern" include making an infectious agent more lethal and rendering vaccines powerless.

Defense Against Biological Attacks

Sunit K. Singh,Jens H. Kuhn
Defense Against Biological Attacks Book PDF

Author : Sunit K. Singh,Jens H. Kuhn
Publisher : Springer
Page : 327 pages
File Size : 49,6 Mb
Release : 2019-03-30
Category : Medical
ISBN : 9783030030537

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Defense Against Biological Attacks by Sunit K. Singh,Jens H. Kuhn Pdf

This first volume of a two-volume set describes general aspects, such as the historical view on the topic, the role of information distribution and preparedness of health-care systems and preparedness in emergency cases. Part two describes and discusseses in detail the pathogens and toxins that are potentially used for biological attacks. As such, the book is a valuable resource for faculties engaged in molecular biology, genetic engineering, neurology, biodefense, biosafety & biosecurity, virology, and infectious disease programs, as well as professional medical research organizations.

Life Sciences and Related Fields

International Union of Microbiological Societies,International Union of Biochemistry and Molecular Biology,IAPâ¬"The Global Network of Science Academies,Chinese Academy of Sciences,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Trends in Science and Technology Relevant to the Biological Weapons Convention: An International Workshop
Life Sciences and Related Fields Book PDF

Author : International Union of Microbiological Societies,International Union of Biochemistry and Molecular Biology,IAPâ¬"The Global Network of Science Academies,Chinese Academy of Sciences,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Trends in Science and Technology Relevant to the Biological Weapons Convention: An International Workshop
Publisher : National Academies Press
Page : 164 pages
File Size : 47,5 Mb
Release : 2012-01-02
Category : Science
ISBN : 9780309210713

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Life Sciences and Related Fields by International Union of Microbiological Societies,International Union of Biochemistry and Molecular Biology,IAPâ¬"The Global Network of Science Academies,Chinese Academy of Sciences,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on Trends in Science and Technology Relevant to the Biological Weapons Convention: An International Workshop Pdf

During the last decade, national and international scientific organizations have become increasingly engaged in considering how to respond to the biosecurity implications of developments in the life sciences and in assessing trends in science and technology (S&T) relevant to biological and chemical weapons nonproliferation. The latest example is an international workshop, Trends in Science and Technology Relevant to the Biological Weapons Convention, held October 31 - November 3, 2010 at the Institute of Biophysics of the Chinese Academy of Sciences in Beijing. Life Sciences and Related Fields summarizes the workshop, plenary, and breakout discussion sessions held during this convention. Given the immense diversity of current research and development, the report is only able to provide an overview of the areas of science and technology the committee believes are potentially relevant to the future of the Biological and Toxic Weapons Convention (BWC), although there is an effort to identify areas that seemed particularly ripe for further exploration and analysis. The report offers findings and conclusions organized around three fundamental and frequently cited trends in S&T that affect the scope and operation of the convention: The rapid pace of change in the life sciences and related fields; The increasing diffusion of life sciences research capacity and its applications, both internationally and beyond traditional research institutions; and The extent to which additional scientific and technical disciplines beyond biology are increasingly involved in life sciences research. The report does not make recommendations about policy options to respond to the implications of the identified trends. The choice of such responses rests with the 164 States Parties to the Convention, who must take into account multiple factors beyond the project's focus on the state of the science.

Globalization, Biosecurity, and the Future of the Life Sciences

National Research Council,Institute of Medicine,Board on Global Health,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Advances in Technology and the Prevention of Their Application to Next Generation Biowarfare Threats
Globalization Biosecurity and the Future of the Life Sciences Book PDF

Author : National Research Council,Institute of Medicine,Board on Global Health,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Advances in Technology and the Prevention of Their Application to Next Generation Biowarfare Threats
Publisher : National Academies Press
Page : 316 pages
File Size : 49,9 Mb
Release : 2006-06-07
Category : Science
ISBN : 9780309164757

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Globalization, Biosecurity, and the Future of the Life Sciences by National Research Council,Institute of Medicine,Board on Global Health,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Advances in Technology and the Prevention of Their Application to Next Generation Biowarfare Threats Pdf

Biomedical advances have made it possible to identify and manipulate features of living organisms in useful ways-leading to improvements in public health, agriculture, and other areas. The globalization of scientific and technical expertise also means that many scientists and other individuals around the world are generating breakthroughs in the life sciences and related technologies. The risks posed by bioterrorism and the proliferation of biological weapons capabilities have increased concern about how the rapid advances in genetic engineering and biotechnology could enable the production of biological weapons with unique and unpredictable characteristics. Globalization, Biosecurity, and the Future of Life Sciences examines current trends and future objectives of research in public health, life sciences, and biomedical science that contain applications relevant to developments in biological weapons 5 to 10 years into the future and ways to anticipate, identify, and mitigate these dangers.

Gene Drives on the Horizon

National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct
Gene Drives on the Horizon Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct
Publisher : National Academies Press
Page : 231 pages
File Size : 46,6 Mb
Release : 2016-08-28
Category : Science
ISBN : 9780309437875

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Gene Drives on the Horizon by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct Pdf

Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

Science and Security in a Post 9/11 World

National Research Council,Policy and Global Affairs,Committee on Science, Technology, and Law,Committee on a New Government-University Partnership for Science and Security
Science and Security in a Post 9 11 World Book PDF

Author : National Research Council,Policy and Global Affairs,Committee on Science, Technology, and Law,Committee on a New Government-University Partnership for Science and Security
Publisher : National Academies Press
Page : 136 pages
File Size : 49,5 Mb
Release : 2007-10-10
Category : Political Science
ISBN : 9780309179553

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Science and Security in a Post 9/11 World by National Research Council,Policy and Global Affairs,Committee on Science, Technology, and Law,Committee on a New Government-University Partnership for Science and Security Pdf

Based on a series of regional meetings on university campuses with officials from the national security community and academic research institutions, this report identifies specific actions that should be taken to maintain a thriving scientific research environment in an era of heightened security concerns. Actions include maintaining the open exchange of scientific information, fostering a productive environment for international scholars in the U.S., reexamining federal definitions of sensitive but unclassified research, and reviewing policies on deemed export controls. The federal government should establish a standing entity, preferably a Science and Security Commission, that would review policies regarding the exchange of information and the participation of foreign-born scientists and students in research.

Handbook on Biological Warfare Preparedness

S.J.S. Flora,Vidhu Pachauri
Handbook on Biological Warfare Preparedness Book PDF

Author : S.J.S. Flora,Vidhu Pachauri
Publisher : Academic Press
Page : 306 pages
File Size : 42,6 Mb
Release : 2019-10-05
Category : Medical
ISBN : 9780128120552

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Handbook on Biological Warfare Preparedness by S.J.S. Flora,Vidhu Pachauri Pdf

Handbook on Biological Warfare Preparedness provides detailed information on biological warfare agents and their mode of transmission and spread. In addition, it explains methods of detection and medical countermeasures, including vaccine and post-exposure therapeutics, with specific sections detailing diseases, their transmission, clinical signs and symptoms, diagnosis, treatment, vaccines, prevention and management. This book is useful reading for researchers and advanced students in toxicology, but it will also prove helpful for medical students, civil administration, medical doctors, first responders and security forces. As the highly unpredictable nature of any event involving biological warfare agents has given rise to the need for the rapid development of accurate detection systems, this book is a timely resource on the topic. Introduces different bacterial and viral agents, including Ebola and other emerging threats and toxins Discusses medical countermeasures, including vaccines and post-exposure therapeutics Includes a comprehensive review of current methods of detection

A Survey of Attitudes and Actions on Dual Use Research in the Life Sciences

American Association for the Advancement of Science,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Assessing Fundamental Attitudes of Life Scientists as a Basis for Biosecurity Education
A Survey of Attitudes and Actions on Dual Use Research in the Life Sciences Book PDF

Author : American Association for the Advancement of Science,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Assessing Fundamental Attitudes of Life Scientists as a Basis for Biosecurity Education
Publisher : National Academies Press
Page : 189 pages
File Size : 40,7 Mb
Release : 2009-07-14
Category : Political Science
ISBN : 9780309141802

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A Survey of Attitudes and Actions on Dual Use Research in the Life Sciences by American Association for the Advancement of Science,National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Development, Security, and Cooperation,Committee on Assessing Fundamental Attitudes of Life Scientists as a Basis for Biosecurity Education Pdf

The same technologies that fuel scientific advances also pose potential risks-that the knowledge, tools, and techniques gained through legitimate biotechnology research could be misused to create biological weapons or for bioterrorism. This is often called the dual use dilemma of the life sciences. Yet even research with the greatest potential for misuse may offer significant benefits. Determining how to constrain the danger without harming essential scientific research is critical for national security as well as prosperity and well-being. This book discusses a 2007 survey of American Association for the Advancement of Science (AAAS) members in the life sciences about their knowledge of dual use issues and attitudes about their responsibilities to help mitigate the risks of misuse of their research. Overall, the results suggest that there may be considerable support for approaches to oversight that rely on measures that are developed and implemented by the scientific community itself. The responses also suggest that there is a need to clarify the scope of research activities of concern and to provide guidance about what actions scientists can take to reduce the risk that their research will be misused by those with malicious intent.

Bio-Inspired Innovation and National Security

National Defense University
Bio Inspired Innovation and National Security Book PDF

Author : National Defense University
Publisher : NDU Press
Page : 356 pages
File Size : 52,7 Mb
Release : 2010-10
Category : History
ISBN : 9781780390406

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Bio-Inspired Innovation and National Security by National Defense University Pdf

Despite the vital importance of the emerging area of biotechnology and its role in defense planning and policymaking, no definitive book has been written on the topic for the defense policymaker, the military student, and the private-sector bioscientist interested in the "emerging opportunities market" of national security. This edited volume is intended to help close this gap and provide the necessary backdrop for thinking strategically about biology in defense planning and policymaking. This volume is about applications of the biological sciences, here called "biologically inspired innovations," to the military. Rather than treating biology as a series of threats to be dealt with, such innovations generally approach the biological sciences as a set of opportunities for the military to gain strategic advantage over adversaries. These opportunities range from looking at everything from genes to brains, from enhancing human performance to creating renewable energy, from sensing the environment around us to harnessing its power.

Synthetic Biology in Australia

Peter Gray,Sue Meek,Paul Griffiths,Joseph Trapani,Ian Small,Claudia Vickers,Catherine Waldby
Synthetic Biology in Australia Book PDF

Author : Peter Gray,Sue Meek,Paul Griffiths,Joseph Trapani,Ian Small,Claudia Vickers,Catherine Waldby
Publisher : Unknown
Page : 128 pages
File Size : 55,9 Mb
Release : 2018-09-04
Category : Electronic
ISBN : 0648330303

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Synthetic Biology in Australia by Peter Gray,Sue Meek,Paul Griffiths,Joseph Trapani,Ian Small,Claudia Vickers,Catherine Waldby Pdf

Synthetic Biology in Australia: An outlook to 2030 explores the opportunities and issues that synthetic biology will be likely to exert in Australia in the coming decade. It examines synthetic biology from varying perspectives: its emergence and increasing importance in mainstream research, commercial and industrial applications; Australia's contribution to the global efforts to use this technology to benefit humankind - which in an increasingly populous world is being challenged by climate change, increasing energy demand, food security, environmental degradation, invasive pests and diseases; and finally, by considering the social, ethical and regulatory frameworks that will be needed to inform and govern synthetic biology in Australia.

Human Genome Editing

National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Human Genome Editing Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publisher : National Academies Press
Page : 329 pages
File Size : 43,7 Mb
Release : 2017-08-13
Category : Medical
ISBN : 9780309452885

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Human Genome Editing by National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations Pdf

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Ethical and Philosophical Consideration of the Dual-Use Dilemma in the Biological Sciences

Seumas Miller,Michael J. Selgelid
Ethical and Philosophical Consideration of the Dual Use Dilemma in the Biological Sciences Book PDF

Author : Seumas Miller,Michael J. Selgelid
Publisher : Springer Science & Business Media
Page : 79 pages
File Size : 48,8 Mb
Release : 2008-07-30
Category : Philosophy
ISBN : 9781402083129

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Ethical and Philosophical Consideration of the Dual-Use Dilemma in the Biological Sciences by Seumas Miller,Michael J. Selgelid Pdf

What Is the Dual-Use Dilemma? The so-called “dual-use dilemma” arises in the context of research in the biological and other sciences as a consequence of the fact that one and the same piece of sci- tific research sometimes has the potential to be used for harm as well as for good. A dual-use dilemma is an ethical dilemma, and an ethical dilemma for the researcher (and for those who have the power or authority to assist or impede the researcher’s work, e. g. , governments). It is an ethical dilemma since it is about promoting good in the context of the potential for also causing harm, e. g. , the p- motion of health in the context of providing the wherewithal for the killing of in- cents. It is an ethical dilemma for the researcher not because he or she is aiming at anything other than a good outcome; typically, the researcher intends no harm, but only good. Rather, the dilemma arises for the researcher because of the potential actions of others. Malevolent non-researchers might steal dangerous biological agents produced by the researcher; alternatively, other researchers—or at least their governments or leadership—might use the results of the original researcher’s work for malevolent purposes. The malevolent purposes in question include bioterrorism, biowarfare and blackmail for financial gain.