Alterations In The Neuronal Cytoskeleton In Alzheimer Disease

Author : George Perry
Publisher : Springer Science & Business Media
Page : 230 pages
File Size : 55,6 Mb
Release : 2012-12-06
Category : Science
ISBN : 9781461316572

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Alterations in the Neuronal Cytoskeleton in Alzheimer Disease by George Perry Pdf

The neuronal cytoskeleton is a complex structure responsive to both intrinsic and extrinsic factors. Defined populations of neurons in the brains of patients with Alzheimer and several other neurodegenerative diseases contain abnormal filamentous accumulations which share elements with the cytoskeleton. Although there is a general consensus that these abnormal filaments do contain cytoskeletal elements, much debate remains regarding which cytoskeletal elements are incorporated and whether the cytoskeletal rearrangement is primary or secondary to other cellular changes. In this book these questions are addressed in a historical perspect ive in light of new data that allows the reinterpretation of previously reported results. Contributions are based on many of the major tech niques of modern biology including biochemistry, molecular biology, electron microscopy and immunocytochemistry. In the view of the editor, this volume is being written at a time when our understanding of the cytopathology of Alzheimer disease is moving from predominantly descriptive to both analytical and mechanistic. I hope that this contribution will provide impetus to speed this transi tion. George Perry Cleveland, Ohio vii ACKNOWLEDGEMENT The support of the Fidia Pharmaceutic Corporation for the computer generated color figure on page 65 is gratefully acknowledged.

Author : C. Laura Sayas,Monica Mendes Sousa,Jesus Avila
Publisher : Frontiers Media SA
Page : 185 pages
File Size : 43,5 Mb
Release : 2020-03-25
Category : Electronic
ISBN : 9782889635528

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Shaping the Brain by Neuronal Cytoskeleton: from Development to Disease and Regeneration by C. Laura Sayas,Monica Mendes Sousa,Jesus Avila Pdf

Author : George Perry
Publisher : Unknown
Page : 244 pages
File Size : 53,7 Mb
Release : 1988-03
Category : Electronic
ISBN : 1461316588

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Alterations in the Neuronal Cytoskeleton in Alzheimer Disease by George Perry Pdf

Author : Kurt Jellinger,Reinhold Schmidt,Manfred Windisch
Publisher : Springer Science & Business Media
Page : 398 pages
File Size : 55,5 Mb
Release : 2002-08-20
Category : Medical
ISBN : 3211837973

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Ageing and Dementia by Kurt Jellinger,Reinhold Schmidt,Manfred Windisch Pdf

Epidemiological studies, modern clinical, neuroimaging, neuropsychological, molecular biological, and genetic studies have considerably enhanced our knowledge about ageing processes of the human brain, its sequelae, diagnostic, and therapeutic possibilities and limits. In addition to Alzheimer's disease and other degenerative dementias, the impact of cerebrovascular lesions and their risk factors in the pathogenesis of cognitive disorders of the aged are increasingly acknowledged, and the recognition of mild cognitive impairment as a frequent initial stage of developing dementia is becoming an increasingly important diagnostic and therapeutic problem. The included papers were presented at the 7th International Symposium in Graz, Sept. 2001 and give a timely overview of the current and future concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and future possiblities of prevention of dementing processes.

Author : J. Robin Harris
Publisher : Springer
Page : 650 pages
File Size : 54,5 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9400754159

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Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease by J. Robin Harris Pdf

This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer’s disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer’s disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.

Author : Dennis Dickson,Roy O. Weller
Publisher : John Wiley & Sons
Page : 497 pages
File Size : 55,7 Mb
Release : 2011-09-09
Category : Medical
ISBN : 9781444341232

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Neurodegeneration by Dennis Dickson,Roy O. Weller Pdf

Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Author : Kurt A. Jellinger,Manfred Windisch
Publisher : Springer Science & Business Media
Page : 283 pages
File Size : 51,7 Mb
Release : 2013-12-01
Category : Medical
ISBN : 9783709168929

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New Trends in the Diagnosis and Therapy of Non-Alzheimer’s Dementia by Kurt A. Jellinger,Manfred Windisch Pdf

This volume gives an overview of the present state of art on the classification, neuropathology, clinical presentation, neuropsychology, diagnosis, neuroimaging and therapeutic possibilities in non-Alzheimer’s dementias, an increasingly important group of CNS diseases, which account for 7 to 30% of dementing disorders in adults and aged subjects, and thus, represent the second most frequent cause of dementia after Alzheimer’s disease. The monograph provides the newest information for neurologists, psychiatrists, dementia research workers, dementia clinicians, neuropathologists, neurobiologists, and practicing physicians.

Author : Hirokawa
Publisher : CRC Press
Page : 360 pages
File Size : 55,9 Mb
Release : 1994-01-12
Category : Science
ISBN : 0849377412

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Neuronal Cytoskeleton by Hirokawa Pdf

This book discusses the primary functions of microtubule-associated proteins (MAPs) such as MAP2 and tau in neuronal morphogenesis, as well as relationships between neuronal differentiation and the expression of neuronal intermediate filaments (nestin, alpha internexin, and neurofilament triplet proteins). It emphasizes the importance of several cytoskeletal proteins for neuronal differentiation and morphogenesis, organelle transport, and synaptic functions. The book considers the involvement of tau MAPs in the formation of paired helical filaments in Alzheimer's disease, and it examines the mechanisms of organelle transports and molecular motors such as kinesin, braindynein, and kinesin superfamily proteins. Cytoskeletal proteins involved in synaptic formation and transmitter release and new synaptic junctional-associated proteins are explored as well.

Author : Wilma Wasco,Rudolph Tanzi
Publisher : Springer Science & Business Media
Page : 313 pages
File Size : 50,5 Mb
Release : 1996-11-01
Category : Medical
ISBN : 9781592594719

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Molecular Mechanisms of Dementia by Wilma Wasco,Rudolph Tanzi Pdf

The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.

Author : Vincent J. Cristofalo,M. Powell Lawton
Publisher : Springer
Page : 235 pages
File Size : 47,5 Mb
Release : 2013-12-17
Category : Medical
ISBN : 9783662384459

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Special Focus on the Biology of Aging by Vincent J. Cristofalo,M. Powell Lawton Pdf

Author : Anonim
Publisher : Unknown
Page : 1064 pages
File Size : 46,5 Mb
Release : 1992
Category : Medicine
ISBN : MINN:31951P00216728F

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Biomedical Index to PHS-supported Research: pt. A. Subject access A-H by Anonim Pdf

Author : Uday Kishore
Publisher : BoD – Books on Demand
Page : 642 pages
File Size : 45,5 Mb
Release : 2013-05-15
Category : Medical
ISBN : 9789535110880

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Neurodegenerative Diseases by Uday Kishore Pdf

This book highlights the pathophysiological complexities of the mechanisms and factors that are likely to be involved in a range of neuroinflammatory and neurodegenerative diseases including Alzheimer's disease, other Dementia, Parkinson Diseases and Multiple Sclerosis. The spectrum of diverse factors involved in neurodegeneration, such as protein aggregation, oxidative stress, caspases and secretase, regulators, cholesterol, zinc, microglia, astrocytes, oligodendrocytes, etc, have been discussed in the context of disease progression. In addition, novel approaches to therapeutic interventions have also been presented. It is hoped that students, scientists and clinicians shall find this very informative book immensely useful and thought-provoking.

Author : Steven Specter,Mauro Bendinelli,Herman Friedman
Publisher : Springer Science & Business Media
Page : 360 pages
File Size : 55,6 Mb
Release : 2012-12-06
Category : Medical
ISBN : 9781468458862

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Neuropathogenic Viruses and Immunity by Steven Specter,Mauro Bendinelli,Herman Friedman Pdf

There has been a tremendous increase in interest in the neuropathogenicity of viruses during the past decade as we have come to recognize that the human immunodeficiency virus, which causes the acquired immunodeficiency syndrome (AIDS), can infect glial cells and cause neurological disease. Yet this increase has not been limited to AIDS but has extended to viruses that infect either or both the central and peripheral nervous systems. The changes examined here include both neurological and psychological diseases or syndromes. Moreover, the chapters in this volume review the interaction of the host immune system with the viruses examined and how such interactions may increase or decrease the neuropatho genicity of the viruses. Questions regarding viral neuropathogenesis include: (I) What is the mode of transmission of virus to the nervous system? (2) What types of cells are infected, and do they contain receptors for the virus? (3) What is the extent of damage that results from viral infection? (4) What are the immunologic mecha nisms by which damage is mediated or limited? Many of these questions remain unanswered, but this volume delves into efforts to provide some answers.

Author : Hermann J. Gertz,Thomas Arendt
Publisher : Springer Science & Business Media
Page : 313 pages
File Size : 55,9 Mb
Release : 2013-06-29
Category : Medical
ISBN : 9783709175088

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Alzheimer’s Disease - From Basic Research to Clinical Applications by Hermann J. Gertz,Thomas Arendt Pdf

As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Alzheimer’s disease as the most common cause of dementia in the elderly remains a sentinal problem and its underlying pathology is still poorly understood. Available therapeutic strategies require considerable refinement and the development of new therapeutic strategies need input from basic research. Thus continued efforts are necessary both to understand basic mechanisms of the condition and to achieve more powerfull therapies. This volume brings together the reports of basic scientists and clinical investigators. The chapters provide a spectrum of information valuable for clinicians and scientists. This issue bridges the gap between laboratory work in basic science and the development of urgently needed therapeutic strategies. Areas presented are the molecular and cellular biology of the disease, pathogenetic mechanisms and potential therapeutic targets, genetics, risk factors, strategies of prevention and treatment as well as practical aspects of medical and social care for patients with Alzheimer’s disease.

Author : Adelman,Smith
Publisher : Springer Science & Business Media
Page : 164 pages
File Size : 47,9 Mb
Release : 2013-11-11
Category : Science
ISBN : 9781489967541

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Neuroscience Year by Adelman,Smith Pdf