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With the advent of CRISPR gene-editing technology, designer babies have become a reality. Françoise Baylis insists that scientists alone cannot decide the terms of this new era in human evolution. Members of the public, with diverse interests and perspectives, must have a role in determining our future as a species.
Understanding Genetics by Genetic Alliance,New York-Mid-Atlantic Consortium for Genetic and Newborn Screening Services Pdf
The purpose of this manual is to provide an educational genetics resource for individuals, families, and health professionals in the New York - Mid-Atlantic region and increase awareness of specialty care in genetics. The manual begins with a basic introduction to genetics concepts, followed by a description of the different types and applications of genetic tests. It also provides information about diagnosis of genetic disease, family history, newborn screening, and genetic counseling. Resources are included to assist in patient care, patient and professional education, and identification of specialty genetics services within the New York - Mid-Atlantic region. At the end of each section, a list of references is provided for additional information. Appendices can be copied for reference and offered to patients. These take-home resources are critical to helping both providers and patients understand some of the basic concepts and applications of genetics and genomics.
The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing Publisher : National Academies Press Page : 239 pages File Size : 54,8 Mb Release : 2021-01-16 Category : Medical ISBN : 9780309671132
Heritable Human Genome Editing by The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing Pdf
Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.
Award-winning physician and New York Times bestselling author Sharon Moalem, MD, PhD, reveals how genetic breakthroughs are completely transforming our understanding of both the world and our lives. Inheritance Conventional wisdom dictates that our genetic destiny is fixed at conception. But Dr. Moalem's groundbreaking book shows us that the human genome is far more fluid and fascinating than your ninth grade biology teacher ever imagined. By bringing us to the bedside of his unique and complex patients, he masterfully demonstrates what rare genetic conditions can teach us all about our own health and well-being. In the brave new world we're rapidly rocketing into, genetic knowledge has become absolutely crucial. Inheritance provides an indispensable roadmap for this journey by teaching you: -Why you may have recovered from the psychological trauma caused by childhood bullying-but your genes may remain scarred for life. -How fructose is the sugar that makes fruits sweet-but if you have certain genes, consuming it can buy you a one-way trip to the coroner's office. -Why ingesting common painkillers is like dosing yourself repeatedly with morphine-if you have a certain set of genes. -How insurance companies legally use your genetic data to predict the risk of disability for you and your children-and how that impacts the coverage decisions they make for your family. -How to have the single most important conversation with your doctor-one that can save your life. And finally: -Why people with rare genetic conditions hold the keys to medical problems affecting millions. In this trailblazing book, Dr. Moalem employs his wide-ranging and entertaining interdisciplinary approach to science and medicine-- explaining how art, history, superheroes, sex workers, and sports stars all help us understand the impact of our lives on our genes, and our genes on our lives. Inheritance will profoundly alter how you view your genes, your health--and your life.
For the last two centuries, literature has tested the authority of the individual and the community. With a historical as well as an interpretative emphasis, Bromwich explores this tension. He shows why the public-mindedness of the eighteenth century is as limited a model for readers now as the individualism of the nineteenth century.
National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct
Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct Publisher : National Academies Press Page : 231 pages File Size : 50,5 Mb Release : 2016-08-28 Category : Science ISBN : 9780309437875
Gene Drives on the Horizon by National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Board on Life Sciences,Committee on Gene Drive Research in Non-Human Organisms: Recommendations for Responsible Conduct Pdf
Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.
National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V)
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V) Publisher : National Academies Page : 436 pages File Size : 55,6 Mb Release : 1990-02-01 Category : Science ISBN : 9780309039956
Health Effects of Exposure to Low Levels of Ionizing Radiation by National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on the Biological Effects of Ionizing Radiation (BEIR V) Pdf
This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
A Dark Inheritance (UFiles, Book 1) by Chris d'Lacey Pdf
From NEW YORK TIMES bestselling author Chris d'Lacey comes a brand-new action-adventure series! When Michael Malone discovers his supernatural ability to alter reality, he is recruited by an organization dedicated to investigating strange and paranormal phenomena. He joins in hopes of finding his father, who mysteriously vanished three years earlier. Michael's first task is to solve the mystery of a dog he rescued from a precarious clifftop -- a mystery that leads him to a strange and sickly classmate and a young girl who was killed in a devastating accident. Stakes are high as Michael learns to harness his newfound ability and uncover the deadly truth about his father's disappearance. A bold and thrilling tale of alternate realities, paranormal mystery, and extraordinary adventure.
What does the birth of babies whose embryos had gone through genome editing mean--for science and for all of us? In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos—as dramatic a development in genetics as the 1996 cloning of Dolly the sheep. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention. The two babies, nonidentical twin girls, were the first “CRISPR'd” people ever born (CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, is a powerful gene-editing method). Greely not only describes He's experiment and its public rollout (aided by a public relations adviser) but also considers, in a balanced and thoughtful way, the lessons to be drawn both from these CRISPR'd babies and, more broadly, from this kind of human DNA editing—“germline editing” that can be passed on from one generation to the next. Greely doesn't mince words, describing He's experiment as grossly reckless, irresponsible, immoral, and illegal. Although he sees no inherent or unmanageable barriers to human germline editing, he also sees very few good uses for it—other, less risky, technologies can achieve the same benefits. We should consider the implications carefully before we proceed.
The Inheritance of Presupposition by John Dinsmore Pdf
This work presents a procedural account of the so-called ‘projection problem’ for presupposition. It is assumed that presuppositions embedded in complex sentences are subject to no projection rules or ad-hoc conditions whatever, but are in fact satisfied in appropriate contexts in a completely uniform way. It is demonstrated that the apparent filtering, alteration, or preservation of an embedded presupposition is in every case a logical consequence of a general, independently motivated model of language processing and knowledge representation. It is shown in detail that turning the ‘projection problem’ upside-down in this way leads to a far more explanatory and descriptively adequate account than any previously proposed.
Environmental Epigenetics by L. Joseph Su,Tung-chin Chiang Pdf
This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.
Beauty, like truth, is enduring. But only one can set you free. The Inheritance of Beauty is a rich and enchanting story about 92-year-old George, forced to watch his beloved wife Maggie fade from Alzheimer’s—until a stranger arrives at their nursing home to bring the tragic past crashing back. Maggie Black came of age in the lush, fragrant lowcountry of South Carolina—spending her days with her beloved brother and the childhood sweetheart she would grow up to marry. But when a stranger arrived on the train one summer, Maggie couldn’t imagine the evil he would bring with him. And though she escaped with her life, the ramifications of that fateful summer would alter all of their lives forever. Now, some eighty years later, Maggie and her husband George are spending their remaining days in a nursing home, helpless as age slowly robs Maggie of her ability to communicate. When a mysterious package arrives, followed closely by a stranger whose identity haunts them, Maggie and George are hemmed in by a history they’d rather forget. As the truth reveals itself, George knows he must face the past and its lifetime of repercussions. It’s the only way to free himself and his precious wife—if it’s not too late. But George isn't sure how many lives were affected by the stranger in Levy . . . or why life must come full-circle now when he's running out of time Haunting southern fiction told through alternating points of view in the present and 1929 Includes discussion questions for book clubs Also by Nicole Seitz: Saving Cicadas,A Hundred Years of Happiness, and Trouble the Water
Award-winning psychoanalyst Dr. Galit Atlas draws on her patients' stories—and her own life experiences—to shed light on how generational trauma affects our lives in this "intimate, textured, compassionate" book (Jon Kabat-Zinn, author of The Healing Power of Mindfulness). The people we love and those who raised us live inside us; we experience their emotional pain, we dream their memories, and these things shape our lives in ways we don’t always recognize. Emotional Inheritance is about family secrets that keep us from living to our full potential, create gaps between what we want for ourselves and what we are able to have, and haunt us like ghosts. In this transformative book, Galit Atlas entwines the stories of her patients, her own stories, and decades of research to help us identify the links between our life struggles and the “emotional inheritance” we all carry. For it is only by following the traces those ghosts leave that we can truly change our destiny.
National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations Publisher : National Academies Press Page : 329 pages File Size : 55,8 Mb Release : 2017-08-13 Category : Medical ISBN : 9780309452885
Human Genome Editing by National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations Pdf
Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.