Crispr People

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CRISPR People

Henry T. Greely
CRISPR People Book PDF

Author : Henry T. Greely
Publisher : MIT Press
Page : 395 pages
File Size : 46,5 Mb
Release : 2022-03-01
Category : Technology & Engineering
ISBN : 9780262543880

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CRISPR People by Henry T. Greely Pdf

What does the birth of babies whose embryos had gone through genome editing mean--for science and for all of us? In November 2018, the world was shocked to learn that two babies had been born in China with DNA edited while they were embryos—as dramatic a development in genetics as the 1996 cloning of Dolly the sheep. In this book, Hank Greely, a leading authority on law and genetics, tells the fascinating story of this human experiment and its consequences. Greely explains what Chinese scientist He Jiankui did, how he did it, and how the public and other scientists learned about and reacted to this unprecedented genetic intervention. The two babies, nonidentical twin girls, were the first “CRISPR'd” people ever born (CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, is a powerful gene-editing method). Greely not only describes He's experiment and its public rollout (aided by a public relations adviser) but also considers, in a balanced and thoughtful way, the lessons to be drawn both from these CRISPR'd babies and, more broadly, from this kind of human DNA editing—“germline editing” that can be passed on from one generation to the next. Greely doesn't mince words, describing He's experiment as grossly reckless, irresponsible, immoral, and illegal. Although he sees no inherent or unmanageable barriers to human germline editing, he also sees very few good uses for it—other, less risky, technologies can achieve the same benefits. We should consider the implications carefully before we proceed.

Editing Humanity

Kevin Davies
Editing Humanity Book PDF

Author : Kevin Davies
Publisher : Simon and Schuster
Page : 402 pages
File Size : 48,5 Mb
Release : 2020-10-06
Category : Science
ISBN : 9781643133942

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Editing Humanity by Kevin Davies Pdf

One of the world's leading experts on genetics unravels one of the most important breakthroughs in modern science and medicine. IIf our genes are, to a great extent, our destiny, then what would happen if mankind could engineer and alter the very essence of our DNA coding? Millions might be spared the devastating effects of hereditary disease or the challenges of disability, whether it was the pain of sickle-cell anemia to the ravages of Huntington’s disease. But this power to “play God” also raises major ethical questions and poses threats for potential misuse. For decades, these questions have lived exclusively in the realm of science fiction, but as Kevin Davies powerfully reveals in his new book, this is all about to change. Engrossing and page-turning, Editing Humanity takes readers inside the fascinating world of a new gene editing technology called CRISPR, a high-powered genetic toolkit that enables scientists to not only engineer but to edit the DNA of any organism down to the individual building blocks of the genetic code. Davies introduces readers to arguably the most profound scientific breakthrough of our time. He tracks the scientists on the front lines of its research to the patients whose powerful stories bring the narrative movingly to human scale. Though the birth of the “CRISPR babies” in China made international news, there is much more to the story of CRISPR than headlines seemingly ripped from science fiction. In Editing Humanity, Davies sheds light on the implications that this new technology can have on our everyday lives and in the lives of generations to come.

Altered Inheritance

Françoise Baylis
Altered Inheritance Book PDF

Author : Françoise Baylis
Publisher : Harvard University Press
Page : 305 pages
File Size : 48,9 Mb
Release : 2019-09-17
Category : Science
ISBN : 9780674976719

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Altered Inheritance by Françoise Baylis Pdf

With the advent of CRISPR gene-editing technology, designer babies have become a reality. Françoise Baylis insists that scientists alone cannot decide the terms of this new era in human evolution. Members of the public, with diverse interests and perspectives, must have a role in determining our future as a species.

The Code Breaker

Walter Isaacson
The Code Breaker Book PDF

Author : Walter Isaacson
Publisher : Simon and Schuster
Page : 560 pages
File Size : 40,7 Mb
Release : 2021-03-09
Category : Biography & Autobiography
ISBN : 9781982115876

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The Code Breaker by Walter Isaacson Pdf

A Best Book of 2021 by Bloomberg BusinessWeek, Time, and The Washington Post The bestselling author of Leonardo da Vinci and Steve Jobs returns with a “compelling” (The Washington Post) account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies. When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would. Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his codiscovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions. The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code. Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids? After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is an “enthralling detective story” (Oprah Daily) that involves the most profound wonders of nature, from the origins of life to the future of our species.

Human Genome Editing

National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Human Genome Editing Book PDF

Author : National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
Publisher : National Academies Press
Page : 329 pages
File Size : 47,8 Mb
Release : 2017-08-13
Category : Medical
ISBN : 9780309452885

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Human Genome Editing by National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations Pdf

Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Heritable Human Genome Editing

The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Heritable Human Genome Editing Book PDF

Author : The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing
Publisher : National Academies Press
Page : 239 pages
File Size : 43,5 Mb
Release : 2021-01-16
Category : Medical
ISBN : 9780309671132

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Heritable Human Genome Editing by The Royal Society,National Academy of Sciences,National Academy of Medicine,International Commission on the Clinical Use of Human Germline Genome Editing Pdf

Heritable human genome editing - making changes to the genetic material of eggs, sperm, or any cells that lead to their development, including the cells of early embryos, and establishing a pregnancy - raises not only scientific and medical considerations but also a host of ethical, moral, and societal issues. Human embryos whose genomes have been edited should not be used to create a pregnancy until it is established that precise genomic changes can be made reliably and without introducing undesired changes - criteria that have not yet been met, says Heritable Human Genome Editing. From an international commission of the U.S. National Academy of Medicine, U.S. National Academy of Sciences, and the U.K.'s Royal Society, the report considers potential benefits, harms, and uncertainties associated with genome editing technologies and defines a translational pathway from rigorous preclinical research to initial clinical uses, should a country decide to permit such uses. The report specifies stringent preclinical and clinical requirements for establishing safety and efficacy, and for undertaking long-term monitoring of outcomes. Extensive national and international dialogue is needed before any country decides whether to permit clinical use of this technology, according to the report, which identifies essential elements of national and international scientific governance and oversight.

Modern Prometheus

Jim Kozubek
Modern Prometheus Book PDF

Author : Jim Kozubek
Publisher : Cambridge University Press
Page : 453 pages
File Size : 49,8 Mb
Release : 2016-10-18
Category : Law
ISBN : 9781107172166

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Modern Prometheus by Jim Kozubek Pdf

This book tells the dramatic story of Crispr and the potential impact of this gene-editing technology.

A Crack In Creation

Jennifer A. Doudna,Samuel H. Sternberg
A Crack In Creation Book PDF

Author : Jennifer A. Doudna,Samuel H. Sternberg
Publisher : HarperCollins
Page : 307 pages
File Size : 46,7 Mb
Release : 2017-06-13
Category : Science
ISBN : 9780544716964

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A Crack In Creation by Jennifer A. Doudna,Samuel H. Sternberg Pdf

BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY | Finalist for the Los Angeles Times Book Prize “A powerful mix of science and ethics . . . This book is required reading for every concerned citizen—the material it covers should be discussed in schools, colleges, and universities throughout the country.”— New York Review of Books Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna—who has since won the Nobel Prize for her CRISPR research—shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life. “The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas “An invaluable account . . . We owe Doudna several times over.” — Guardian

CRISPR

Yolanda Ridge
CRISPR Book PDF

Author : Yolanda Ridge
Publisher : Annick Press
Page : 174 pages
File Size : 45,7 Mb
Release : 2020-09-08
Category : Young Adult Nonfiction
ISBN : 9781773214252

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CRISPR by Yolanda Ridge Pdf

We can change the world with gene editing—but should we? CRISPR stands for clustered regularly interspaced short palindromic repeats. If it sounds complicated, it is—but it’s also one of the most powerful ways we can shape the future. And it’s poised to completely upend the way we think about science. Author Yolanda Ridge tackles this topic in a friendly and accessible tone, with two introductory chapters covering the basics of DNA and gene editing before taking readers through the ways that this ground-breaking science could affect them by potentially: • eliminating diseases like malaria and cancer, • improving the stability of our food supply, and • helping to manage conservation efforts for threatened animals and environments. But all of these possible advancements come with risks, the biggest being that the consequences are unknown. Chapters end with “Stop, Go, Yield” sections encouraging readers to consider the pros and cons of using CRISPR. “Cutting Questions” give readers the opportunity to further reflect on the ethics of the science. CRISPR is a game changer. This important book, with detailed scientific illustrations, brings much needed clarity to a topic that will affect readers for generations to come. *A Junior Library Guild Gold Standard Selection

Anticipatory Ethics and The Use of CRISPR in Humans

Michael W. Nestor,Richard L. Wilson
Anticipatory Ethics and The Use of CRISPR in Humans Book PDF

Author : Michael W. Nestor,Richard L. Wilson
Publisher : Springer Nature
Page : 156 pages
File Size : 55,5 Mb
Release : 2022-05-20
Category : Medical
ISBN : 9783030983680

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Anticipatory Ethics and The Use of CRISPR in Humans by Michael W. Nestor,Richard L. Wilson Pdf

The future of gene editing in humans will involve the use of CRISPR. How we think about the combination of the scientific, ethical, and moral aspects of this technology is paramount to the success or failure of CRISPR in humans. Unfortunately, the current scientific discussion around CRISPR in humans has left ethics trailing behind due to the rapid pace of innovation. New modes of ethics and stakeholder participation are needed to keep pace with rapid scientific advances and provide the necessary policy and ethical frameworks necessary to help CRISPR flourish as an important health care tool to treat human disease. This requires intense interdisciplinary collaboration and discussion between scientists and philosophers, policymakers and legal scholars, and the public. Dr. Michael W. Nestor (a neuroscientist who actively uses CRISPR in pre-clinical research) and Professor Richard Wilson (a philosopher who focuses on anticipatory ethics) set out to develop a new ethical approach considering the use of CRISPR in human targeted therapies. The field of anticipatory ethics is uniquely poised to tackle questions in fast-evolving technical areas where the pace of innovation outstrips traditional philosophical approaches. Furthermore, because of its “anticipatory” nature, this type of analysis provides the opportunity to look ahead and into the future concerning potential uses of CRISPR in humans, uses that are not currently possible. Nestor and Wilson collaborate both scientifically and philosophically in this book to forecast potential outcomes as the scientific and medical community goes beyond using CRISPR to correct genes that underlie diseases where a single gene is involved. Instead, Nestor and Wilson envision CRISPR in complex, multigenic disorders with a specific focus on the use of CRISPR to edit genes involved in mental traits like IQ or other cognitive characteristics. They argue that the use of CRISPR to modify genes that are potentially important for mental traits represents a particular category for special consideration from scientists, policymakers, the public, and other stakeholders. Nestor and Wilson explain why using CRISPR to alter mental states is very different from treating a disease like cancer by combining the latest scientific advancements with anticipatory ethics and philosophical phenomenology. Their analysis considers the role that mental states play in personhood and the lived experience-as genes that can change mental/cognitive attributes like IQ have wide-ranging effects on the lived experience in ways that are categorically different from other attributes. This book was written to set a non-exhaustive framework for shared understanding and discussion across disciplines and appeal to scientists and non-scientists alike. This appeal is made inclusively, inviting all stakeholders to engage in active dialogue about the appropriate context for using CRISPR and other gene-editing technologies in humans. It provides policy analysis and recommendations for assuring the most inclusive, equitable, and ethically sound use of CRISPR in humans, concerning its positive potential to treat mental conditions like depression, schizophrenia, Alzheimer’s disease, autism, and the potential to induce other cognitive enhancements.

Blueprint, with a new afterword

Robert Plomin
Blueprint with a new afterword Book PDF

Author : Robert Plomin
Publisher : MIT Press
Page : 296 pages
File Size : 50,8 Mb
Release : 2019-07-16
Category : Science
ISBN : 9780262357760

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Blueprint, with a new afterword by Robert Plomin Pdf

A top behavioral geneticist makes the case that DNA inherited from our parents at the moment of conception can predict our psychological strengths and weaknesses. In Blueprint, behavioral geneticist Robert Plomin describes how the DNA revolution has made DNA personal by giving us the power to predict our psychological strengths and weaknesses from birth. A century of genetic research shows that DNA differences inherited from our parents are the consistent lifelong sources of our psychological individuality—the blueprint that makes us who we are. Plomin reports that genetics explains more about the psychological differences among people than all other factors combined. Nature, not nurture, is what makes us who we are. Plomin explores the implications of these findings, drawing some provocative conclusions—among them that parenting styles don't really affect children's outcomes once genetics is taken into effect. This book offers readers a unique insider's view of the exciting synergies that came from combining genetics and psychology. The paperback edition has a new afterword by the author.

The Mutant Project

Eben Kirksey
The Mutant Project Book PDF

Author : Eben Kirksey
Publisher : Policy Press
Page : 304 pages
File Size : 47,5 Mb
Release : 2021-03-03
Category : Science
ISBN : 9781529217292

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The Mutant Project by Eben Kirksey Pdf

Prologue: The World on Notice -- 1: I'm Quite Glad That I Wasn't First -- 2: A Typical Shenzhen Story -- 3: The Best Humans Haven't Been Produced Yet -- 4: Winner Takes All -- 5: Look at Those Muscles, Look at That Butt -- 6: A Moral Choice -- 7: Will I Have to Mortgage My House? -- 8: The Cancer Moonshot -- 9: Free Health Care for All -- 10: Silence = Death -- 11: Immortality Has to Be the Goal --12: I Don't Want to Walk, I Want to Fly -- 13: High-Quality Children -- 14: #Transracial -- 15: American Medicine and Only for You -- 16: He Was Busy, Busy, Always Doing Research -- 17: A Hammer, Looking for a Nail -- 18: Beautiful Lies -- 19: Two Healthy Baby Girls? -- 20: Mixed Wisdom -- 21: They Are Moving Forward -- 22: Chinese Scientists Are Creating CRISPR Babies -- 23: Bubbles Vanishing into Air -- 24: The Horse has Already Bolted -- Epilogue: We Have Never Been Human.

CRISPR-Cas Systems

Rodolphe Barrangou,John van der Oost
CRISPR Cas Systems Book PDF

Author : Rodolphe Barrangou,John van der Oost
Publisher : Springer Science & Business Media
Page : 300 pages
File Size : 43,6 Mb
Release : 2012-12-13
Category : Science
ISBN : 9783642346576

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CRISPR-Cas Systems by Rodolphe Barrangou,John van der Oost Pdf

CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

CRISPR

Xin Wang
CRISPR Book PDF

Author : Xin Wang
Publisher : Nova Biomedical Books
Page : 0 pages
File Size : 43,7 Mb
Release : 2017
Category : CRISPR (Genetics)
ISBN : 1536129461

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CRISPR by Xin Wang Pdf

Genome editing using CRISPR has been identified as one breakthrough technology in recent research. Today, it is difficult to open a journal or a newspaper without reading about the application of CRISPR gene editing technology to basic research, public health, therapeutics or diagnostics. Although some problems of CRISPR remain to be solved, such as bio-safety and ethical issues, it may change peoples futures. This book is to meet the needs of basic molecular biochemists, pharmacologists, medical students, clinical practitioners and scientists, as well as a broad spectrum of readers who wish to understand the advances in research and applications of CRISPR. The contributing authors are basic scientists as well as students who major in biochemistry and pharmacology. The book presents the current research in the CRISPR model, focusing on its advances and applications. Topics discussed in this compilation include: Targeting of hepatic diseases using CRISPR; applications and advances of CRISPR in animal models; gene targeting on the Cyp2c Locus in rats via CRISPR; applications of CRISPR for therapy in human genetic diseases; utilization of CRISPR in gene function and drug target validation; applications of CRISPR in plant genome editing; and genome editing on human embryos using CRISPR.

Gene Therapy for Cancer

Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Gene Therapy for Cancer Book PDF

Author : Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher
Publisher : Springer Science & Business Media
Page : 469 pages
File Size : 52,5 Mb
Release : 2007-10-26
Category : Medical
ISBN : 9781597452229

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Gene Therapy for Cancer by Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher Pdf

The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.